RS54595B1 - Derivati 2-okso-1-pirolidinil imidazotiadiazola - Google Patents
Derivati 2-okso-1-pirolidinil imidazotiadiazolaInfo
- Publication number
- RS54595B1 RS54595B1 RS20160156A RSP20160156A RS54595B1 RS 54595 B1 RS54595 B1 RS 54595B1 RS 20160156 A RS20160156 A RS 20160156A RS P20160156 A RSP20160156 A RS P20160156A RS 54595 B1 RS54595 B1 RS 54595B1
- Authority
- RS
- Serbia
- Prior art keywords
- oxo
- alkyl containing
- imidazothiadiazole derivatives
- halogen
- pyrrolidinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Derivati 2-okso-1 -pirolidinil imidazotiadiazola prema formuli I, njihovi geometrijski izomeri, enantiomeri, dijastereoizomeri i smeše, ili njihove farmaceutski prihvatljive soli,gde jeR1 C1-4 alkil koji sadrži najmanje jedan halogeni supstituent;R2 je ili halogen ili C1-4 alkil koji sadrži najmanje jedan halogeni supstituent;R3 je C1-4 alkil koji sadrži najmanje jedan hidroksi ili alkoksi supstituent, jedinjenja formule (I) koja su opciono deuterisana na bilo kojoj poziciji.Prijava sadrži još 8 patentnih zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09173912 | 2009-10-23 | ||
| PCT/EP2010/006434 WO2011047860A1 (en) | 2009-10-23 | 2010-10-21 | 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS54595B1 true RS54595B1 (sr) | 2016-08-31 |
Family
ID=42034570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20160156A RS54595B1 (sr) | 2009-10-23 | 2010-10-21 | Derivati 2-okso-1-pirolidinil imidazotiadiazola |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8822508B2 (sr) |
| EP (1) | EP2491045B1 (sr) |
| JP (1) | JP5808020B2 (sr) |
| KR (1) | KR20120102058A (sr) |
| CN (1) | CN102574869A (sr) |
| AR (1) | AR078722A1 (sr) |
| AU (1) | AU2010310100B2 (sr) |
| BR (1) | BR112012009310B8 (sr) |
| CA (1) | CA2778194C (sr) |
| CL (1) | CL2012001031A1 (sr) |
| CY (1) | CY1117288T1 (sr) |
| DK (1) | DK2491045T3 (sr) |
| EA (1) | EA201200616A1 (sr) |
| ES (1) | ES2565515T3 (sr) |
| HR (1) | HRP20160263T1 (sr) |
| HU (1) | HUE028668T2 (sr) |
| IL (1) | IL218696A0 (sr) |
| IN (1) | IN2012DN02793A (sr) |
| MA (1) | MA33679B1 (sr) |
| ME (1) | ME02355B (sr) |
| MX (1) | MX347070B (sr) |
| PE (1) | PE20121562A1 (sr) |
| PH (1) | PH12012500570A1 (sr) |
| PL (1) | PL2491045T3 (sr) |
| RS (1) | RS54595B1 (sr) |
| SI (1) | SI2491045T1 (sr) |
| SM (1) | SMT201600076B (sr) |
| TN (1) | TN2012000147A1 (sr) |
| TW (1) | TW201118103A (sr) |
| WO (1) | WO2011047860A1 (sr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8957218B2 (en) * | 2011-04-18 | 2015-02-17 | Ucb Pharma S.A. | 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives |
| US9581654B2 (en) | 2013-02-12 | 2017-02-28 | Johnson Controls Technology Company | Vehicle battery monitoring system |
| SG11201605742TA (en) | 2014-01-21 | 2016-08-30 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| IL279202B2 (en) | 2014-01-21 | 2023-09-01 | Janssen Pharmaceutica Nv | Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use |
| ES2895373T3 (es) | 2017-07-10 | 2022-02-21 | UCB Biopharma SRL | Derivados de 2-oxo-1-imidazolidinil imidazotiadiazol |
| BR112019028078A2 (pt) * | 2017-07-10 | 2020-07-28 | UCB Biopharma SRL | derivados de 2-oxo-1,3-oxazolidinil imidazotiadiazol |
| CN107827870B (zh) * | 2017-10-24 | 2019-11-08 | 江苏仁明生物科技有限公司 | 一种正电子药物[18f]fpmmp及其制备方法与中间体 |
| EP3724198B1 (en) | 2017-12-12 | 2022-02-16 | UCB Biopharma SRL | 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives |
| US11286266B2 (en) | 2018-05-08 | 2022-03-29 | UCB Biopharma SRL | 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives |
| CN113549052B (zh) * | 2021-07-09 | 2022-09-02 | 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) | 4-苯基-1-（吡啶-4-基甲基）吡咯烷-2-酮衍生物及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8412357D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8412358D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| ES2323313T3 (es) * | 2003-12-02 | 2009-07-13 | Ucb Pharma, S.A. | Derivados de imidazol, procedimientos para prepararlos y sus usos. |
| CA2610695A1 (en) * | 2005-06-01 | 2006-12-07 | Ucb Pharma, S.A. | 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system |
-
2010
- 2010-10-21 ES ES10781818.9T patent/ES2565515T3/es active Active
- 2010-10-21 TW TW099135866A patent/TW201118103A/zh unknown
- 2010-10-21 CA CA2778194A patent/CA2778194C/en active Active
- 2010-10-21 WO PCT/EP2010/006434 patent/WO2011047860A1/en active Application Filing
- 2010-10-21 MX MX2012003839A patent/MX347070B/es active IP Right Grant
- 2010-10-21 AU AU2010310100A patent/AU2010310100B2/en active Active
- 2010-10-21 PL PL10781818T patent/PL2491045T3/pl unknown
- 2010-10-21 SI SI201031137T patent/SI2491045T1/sl unknown
- 2010-10-21 US US13/502,546 patent/US8822508B2/en active Active
- 2010-10-21 EP EP10781818.9A patent/EP2491045B1/en active Active
- 2010-10-21 KR KR1020127013216A patent/KR20120102058A/ko not_active Application Discontinuation
- 2010-10-21 EA EA201200616A patent/EA201200616A1/ru unknown
- 2010-10-21 CN CN2010800476319A patent/CN102574869A/zh active Pending
- 2010-10-21 ME MEP-2016-44A patent/ME02355B/me unknown
- 2010-10-21 RS RS20160156A patent/RS54595B1/sr unknown
- 2010-10-21 PE PE2012000526A patent/PE20121562A1/es not_active Application Discontinuation
- 2010-10-21 JP JP2012534579A patent/JP5808020B2/ja active Active
- 2010-10-21 BR BR112012009310A patent/BR112012009310B8/pt active IP Right Grant
- 2010-10-21 IN IN2793DEN2012 patent/IN2012DN02793A/en unknown
- 2010-10-21 HU HUE10781818A patent/HUE028668T2/en unknown
- 2010-10-21 DK DK10781818.9T patent/DK2491045T3/en active
- 2010-10-21 PH PH1/2012/500570A patent/PH12012500570A1/en unknown
- 2010-10-22 AR ARP100103864A patent/AR078722A1/es unknown
-
2012
- 2012-03-18 IL IL218696A patent/IL218696A0/en unknown
- 2012-03-29 TN TNP2012000147A patent/TN2012000147A1/en unknown
- 2012-04-19 MA MA34783A patent/MA33679B1/fr unknown
- 2012-04-23 CL CL2012001031A patent/CL2012001031A1/es unknown
-
2016
- 2016-03-14 HR HRP20160263TT patent/HRP20160263T1/hr unknown
- 2016-03-15 CY CY20161100217T patent/CY1117288T1/el unknown
- 2016-03-16 SM SM201600076T patent/SMT201600076B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS54595B1 (sr) | Derivati 2-okso-1-pirolidinil imidazotiadiazola | |
| EA201200049A1 (ru) | 1,3-дизамещенные производные имидазолидин-2-она в качестве ингибиторов cyp 17 | |
| RS52261B (sr) | Amidofenoksi indazoli kao korisni inhibitori c-met-a | |
| RS52870B (sr) | Inhibitori prolil hidroksilaze | |
| NO20080865L (no) | Spirokromanonderivater som acetyl-koenzym-A-karboksylase(ACC)inhibitorer | |
| AR082826A2 (es) | Inhibidores heterociclicos de mek, composiciones farmaceuticas que los contienen, usos, y metodos de preparacion de los mismos | |
| RS54526B1 (sr) | Upotreba derivata pirazolospiroketona kao inhibitora acetil-coa karboksilaze | |
| RS52534B (sr) | Makrociklična jedinjenja hinoksalina kao inhibitori hcv ns3 proteaze | |
| RS54260B1 (sr) | Derivati aminodihidrotiazina kao bace inhibitori za tretman alzheimerove bolesti | |
| CR11518A (es) | Compuestos de carbamoilo como inhibidores de dgat1 190 | |
| NO20091553L (no) | Fenylderivater og deres anvendelse som immunmodulatorer | |
| NO20073791L (no) | Pyrazolylaminopyridinderivater anvendbare som kinaseinhibitorer | |
| UY30897A1 (es) | Derivados de pentafluorotiobenzamidoacetonitrilo, composiciones conteniéndolos y aplicaciones | |
| NO20081724L (no) | Stabil farmasoytisk sammensetning omfattende et pyrimidin-sulfamid | |
| CL2012000999A1 (es) | Compuestos derivados de pirazoloespirocetona sustituida, inhibidores de acetil-coa carboxilasa; composicion farmaceutica que los comprende; uso para tratar o retrasar la progresion o el inicio de diabetes tipo 2, higado graso no alcoholico (hgna) o la resistencia hepatica a la insulina. | |
| WO2008036652A3 (en) | Amidines as modulators of indoleamine 2,3-dioxygenase | |
| AR062211A1 (es) | Derivados de 6-carboxi-normorfinano. composiciones farmaceuticas | |
| MA37142A3 (fr) | Dérivés de dihydro-benzo-oxazine et de dihydro-pyrido-oxazine | |
| RS54730B1 (sr) | Inhibitori beta sekretaze | |
| RS52661B (sr) | Terapeutska sredstva | |
| EA200900924A1 (ru) | Циклизованные производные как ингибиторы eg-5 | |
| AR054341A1 (es) | Combinaciones sinergicas de compuestos activos fungicidas | |
| EA200900631A1 (ru) | Замещённые пиразолы и триазолы, как ингибиторы кбв (кинезин-белок веретена) | |
| UY30787A1 (es) | "inhibidores benzoimidazolicos de trpv1" | |
| RS54487B1 (sr) | Derivati 2-oxo-1-imidazolidinil imidazotiadiazol |