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RS51143B - Novi benzonaftiridini - Google Patents

Novi benzonaftiridini

Info

Publication number
RS51143B
RS51143B YUP-2005/0181A YUP20050181A RS51143B RS 51143 B RS51143 B RS 51143B YU P20050181 A YUP20050181 A YU P20050181A RS 51143 B RS51143 B RS 51143B
Authority
RS
Serbia
Prior art keywords
novel
benzonaphthyridines
pde3
inhibitors
compounds
Prior art date
Application number
YUP-2005/0181A
Other languages
English (en)
Inventor
Dieter dr. FLOCKERZI
Beate dr. SCHMIDT
Armin Dr. Hatzelmann
Johannes dr. BARSIG
Degenhard Dr. Marx
Hans-Peter dr. KLEY
Rolf-Peter dr. HUMMEL
Felix dr. REUTTER
Original Assignee
Nycomed Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh. filed Critical Nycomed Gmbh.
Publication of RS20050181A publication Critical patent/RS20050181A/sr
Publication of RS51143B publication Critical patent/RS51143B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Toxicology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Jedinjenje prema formuli 1,u kojojRl je l-4C-alkil,R2 je hidroksil, l-4C-alkoksi, 3-7C-cikloalkoksi, 3-7C-cikloalkilmetoksi, ili l-4C-alkoksi koji je potpunoili pretežno supstituisan fluorom, R3 je hidroksil, l-4C-alkoksi, 3-7C-cikloalkoksi, 3-7C-cikloalkilmetoksi, ili l-4C-alkoksi koji je potpunoili pretežno supstituisan fluorom, ili u kojojR2 i R3 su zajedno l-2C-alkilendioksi grupe,R4 je vodonik, halogen, nitro, l-4C-alkil, trifluormetil ili l-4C-alkoksi, R5 je vodonik ili l-8C-alkil,R6 je vodonik, l-8C-alkilkarbonil, 3-7C-cikloalkilkarbonil, 3-7C-cikloalkilmetilkarbonil. Arilkarbonil iliAril-l-4C-alkilkarbonil Aril je fenil ili fenil supstituisan sa R7 i/ili R8, R7 je halogen, nitro, l-4C-alkil ili l-4C-alkoksi, R8 je halogen, nitro, l-4C-alkil ili l-4C-alkoksi, n je l ili 2,njegova so ili njegov N-oksid ili njegova so.Prijava sadrži još 10 patentnih zahteva.
YUP-2005/0181A 2002-09-04 2003-08-29 Novi benzonaftiridini RS51143B (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40768902P 2002-09-04 2002-09-04
EP02019904 2002-09-04
PCT/EP2003/009617 WO2004022557A1 (en) 2002-09-04 2003-08-29 Novel benzonaphthyridines

Publications (2)

Publication Number Publication Date
RS20050181A RS20050181A (en) 2007-06-04
RS51143B true RS51143B (sr) 2010-10-31

Family

ID=56290479

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2005/0181A RS51143B (sr) 2002-09-04 2003-08-29 Novi benzonaftiridini

Country Status (10)

Country Link
EP (1) EP1537109B1 (sr)
JP (1) JP4638736B2 (sr)
AT (1) ATE360021T1 (sr)
AU (1) AU2003264132B2 (sr)
CA (1) CA2496731C (sr)
DE (1) DE60313331T2 (sr)
ES (1) ES2286494T3 (sr)
PL (1) PL373989A1 (sr)
RS (1) RS51143B (sr)
WO (1) WO2004022557A1 (sr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010500969A (ja) * 2006-07-19 2010-01-14 ファーマコフォア，インク． 麻酔薬

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0937074T1 (en) * 1996-11-11 2003-08-31 Altana Pharma Ag Benzonaphthyridines as bronchial therapeutics
SI0988302T1 (en) * 1997-06-03 2003-08-31 Altana Pharma Ag Benzonaphthyridines
JP2002513793A (ja) * 1998-05-05 2002-05-14 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規ｎ−オキシド
PT1377574E (pt) * 2001-02-21 2005-05-31 Byk Gulden Lomberg Chem Fab 6-fenilbenzonaftiridinas

Also Published As

Publication number Publication date
EP1537109B1 (en) 2007-04-18
PL373989A1 (en) 2005-09-19
EP1537109A1 (en) 2005-06-08
JP2005539055A (ja) 2005-12-22
CA2496731C (en) 2011-08-16
AU2003264132A1 (en) 2004-03-29
WO2004022557A1 (en) 2004-03-18
JP4638736B2 (ja) 2011-02-23
ES2286494T3 (es) 2007-12-01
DE60313331D1 (de) 2007-05-31
RS20050181A (en) 2007-06-04
DE60313331T2 (de) 2008-01-03
ATE360021T1 (de) 2007-05-15
AU2003264132B2 (en) 2009-11-19
CA2496731A1 (en) 2004-03-18

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