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RS49526B - Derivati triazola korisni u terapiji - Google Patents

Derivati triazola korisni u terapiji

Info

Publication number
RS49526B
RS49526B YU2997A YU2997A RS49526B RS 49526 B RS49526 B RS 49526B YU 2997 A YU2997 A YU 2997A YU 2997 A YU2997 A YU 2997A RS 49526 B RS49526 B RS 49526B
Authority
RS
Serbia
Prior art keywords
phenyl substituted
therapy
halogen
group
triazole derivatives
Prior art date
Application number
YU2997A
Other languages
English (en)
Inventor
Stuart Green
Peter T. Stephenson
Charles W. Murtiashaw
Original Assignee
Pfizer Research And Development Company N.V./S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Research And Development Company N.V./S.A. filed Critical Pfizer Research And Development Company N.V./S.A.
Publication of YU2997A publication Critical patent/YU2997A/sh
Publication of RS49526B publication Critical patent/RS49526B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. Jedinjenje formule I: R1-OP(O)(OH)2 (I) gde R1 predstavlja ne-hidroksi deo antifungalnog jedinjenja triazola koje sadrži tercijarnu hidroksi grupu; ili njegova farmaceutski prihvatljiva so. 2. Jedinjenje prema zahevu 1, naznačeno time, što je R1 grupa formule Ia: gde R2 predstavlja fenil supstituisan jednim ili više halogenih atoma; R3 predstavlja H ili CH3; R3a predstavlja H, ili zajedno sa R3 može predstavljati =CH2 i R4 predstavlja 5- ili 6-člani heterociklični prsten koji sadrži azot, koji je po potrebi supstituisan jednom ili više grupa odabranih od halogena, =O, fenila supstituisanog jednom grupom odabranom od CN i (C6H4)-OCH2CF2CHF2 ili CH=CH-(C6H4)-OCH2CF2CHF2 ili fenil supstituisan jednom ili više grupa odabranih od halogena i metilpirazolila. Prijava sadrži još 5 zavisnih patentnih zahteva, 6 nezavisnih patentnih zahteva i 1 zavisan patentni zahtev.
YU2997A 1996-02-02 1997-01-28 Derivati triazola korisni u terapiji RS49526B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9602080.5A GB9602080D0 (en) 1996-02-02 1996-02-02 Pharmaceutical compounds

Publications (2)

Publication Number Publication Date
YU2997A YU2997A (sh) 2000-10-30
RS49526B true RS49526B (sr) 2006-12-15

Family

ID=10787975

Family Applications (1)

Application Number Title Priority Date Filing Date
YU2997A RS49526B (sr) 1996-02-02 1997-01-28 Derivati triazola korisni u terapiji

Country Status (43)

Country Link
US (4) US6790957B2 (sr)
EP (1) EP0880533B1 (sr)
JP (1) JP2959846B2 (sr)
KR (1) KR100283546B1 (sr)
CN (1) CN1085213C (sr)
AP (1) AP678A (sr)
AT (1) ATE219089T1 (sr)
AU (1) AU709781B2 (sr)
BG (1) BG63946B1 (sr)
BR (1) BR9707257A (sr)
CA (1) CA2240777C (sr)
CO (1) CO4761066A1 (sr)
CZ (1) CZ291431B6 (sr)
DE (1) DE69713284T2 (sr)
DK (1) DK0880533T3 (sr)
DZ (1) DZ2172A1 (sr)
ES (1) ES2175336T3 (sr)
GB (1) GB9602080D0 (sr)
GT (1) GT199700016A (sr)
HK (1) HK1018217A1 (sr)
HN (1) HN1997000012A (sr)
HR (1) HRP970063B1 (sr)
HU (1) HU226133B1 (sr)
ID (1) ID15858A (sr)
IL (3) IL124865A (sr)
IS (1) IS1995B (sr)
MY (1) MY116849A (sr)
NO (1) NO323771B1 (sr)
NZ (1) NZ330654A (sr)
OA (1) OA10711A (sr)
PL (1) PL187237B1 (sr)
PT (1) PT880533E (sr)
RS (1) RS49526B (sr)
RU (1) RU2176244C2 (sr)
SA (1) SA97170578B1 (sr)
SI (1) SI0880533T1 (sr)
SK (1) SK283136B6 (sr)
TN (1) TNSN97023A1 (sr)
TR (1) TR199801440T2 (sr)
TW (1) TW434247B (sr)
UA (1) UA46828C2 (sr)
WO (1) WO1997028169A1 (sr)
ZA (1) ZA97826B (sr)

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US7323572B2 (en) 2002-07-16 2008-01-29 Pfizer Inc Process for controlling the hydrate mix of a compound
WO2005006860A2 (en) * 2003-07-18 2005-01-27 The Board Of Governors For Higher Education State Of Rhode Island And Providence Plantations Azole derivatives and methods for making the same
KR20070085093A (ko) * 2004-03-24 2007-08-27 파스젠, 엘엘씨. Ａｍｐ-활성화 단백질 키나아제의 약리학적 저해에 의한신규한 신경 보호 방법
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JP5046959B2 (ja) * 2005-12-20 2012-10-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 水溶性アゾールプロドラッグの製造方法
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CN101575330B (zh) * 2008-05-05 2012-10-31 丽珠医药集团股份有限公司 伏立康唑广谱抗真菌药物化合物、其组合物及用途
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EA032840B8 (ru) 2011-06-22 2020-06-18 Вайоми Терапеутикс Лимитед Пролекарства на основе конъюгатов противогрибковых агентов и их применение
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EA026209B1 (ru) 2012-01-20 2017-03-31 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
RS59960B1 (sr) * 2012-03-19 2020-03-31 Cidara Therapeutics Inc Dozni režimi za jedinjenja klase ehinokandina
CN103864844B (zh) * 2012-12-09 2016-10-05 正大天晴药业集团股份有限公司 一种福司氟康唑的制备方法
CN103304600B (zh) * 2013-03-04 2018-05-25 陕西合成药业股份有限公司 一种伏立康唑磷酸酯三水合物及其制备方法和用途
WO2014182368A2 (en) 2013-03-14 2014-11-13 Fresenius Kabi Usa, Llc Voriconazole formulations
RU2719579C2 (ru) * 2013-03-14 2020-04-21 Сидара Терапьютикс, Инк. Режимы дозирования для соединений класса эхинокандинов
EA201592236A1 (ru) 2013-06-04 2016-06-30 Вайом Байосайнсиз Пвт. Лтд. Частицы с нанесенным покрытием и композиции, включающие такие частицы
CN103524560A (zh) * 2013-09-28 2014-01-22 陕西合成药业有限公司 伏立康磷酸酯钠水合物及其多晶型
CN104650140B (zh) * 2013-11-18 2017-11-10 正大天晴药业集团股份有限公司 一种高纯度福司氟康唑的制备方法
BR112016017690A2 (pt) 2014-01-29 2017-08-08 Vyome Biosciences Pvt Ltd Tratamentos para acne resistente
CN104860992A (zh) * 2014-02-25 2015-08-26 陕西合成药业股份有限公司 一种高纯度福司氟康唑制备方法
CN105985377A (zh) * 2015-02-09 2016-10-05 陕西合成药业股份有限公司 一种福司氟康唑盐水合物及其制备方法
CN106279280A (zh) * 2015-05-25 2017-01-04 西藏卫信康医药股份有限公司 一种化合物及其制备方法和应用
CN106518922A (zh) * 2015-09-12 2017-03-22 陕西合成药业股份有限公司 一种三唑类化合物及其制备方法和用途
CN106546668A (zh) * 2015-09-22 2017-03-29 陕西合成药业股份有限公司 一种分离福司氟康唑或其药用盐有关物质的hplc方法
CN105237569B (zh) * 2015-10-21 2017-07-25 西南科技大学 一种制备2，4‑二氟‑α，α‑二（1氢‑1，2，4‑三唑‑1‑基甲基）苯甲醇磷酸二苄酯的合成方法
CN105753902B (zh) * 2016-04-11 2017-08-25 浙江诚意药业股份有限公司 一种福司氟康唑的制备方法
CN108676031A (zh) * 2018-05-29 2018-10-19 重庆威鹏药业有限公司 水溶性三唑类抗真菌膦酸化合物及其制备方法和应用
CN111171075B (zh) * 2020-04-03 2022-07-12 北京四环生物制药有限公司 一种福司氟康唑的制备方法

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Also Published As

Publication number Publication date
TNSN97023A1 (fr) 2005-03-15
NO983560L (no) 1998-08-03
US20030144250A1 (en) 2003-07-31
CZ242098A3 (cs) 1999-05-12
YU2997A (sh) 2000-10-30
GT199700016A (es) 1998-07-24
TR199801440T2 (xx) 1998-10-21
JPH10512599A (ja) 1998-12-02
IS1995B (is) 2005-03-15
HRP970063B1 (en) 2001-12-31
US6790957B2 (en) 2004-09-14
SK102298A3 (en) 1999-08-06
US20070027115A1 (en) 2007-02-01
US20050130940A1 (en) 2005-06-16
OA10711A (en) 2001-06-04
WO1997028169A1 (en) 1997-08-07
ID15858A (id) 1997-08-14
CN1210540A (zh) 1999-03-10
CZ291431B6 (cs) 2003-03-12
DK0880533T3 (da) 2002-07-15
NO323771B1 (no) 2007-07-02
HUP9900949A3 (en) 2001-08-28
DE69713284T2 (de) 2003-03-27
GB9602080D0 (en) 1996-04-03
CN1085213C (zh) 2002-05-22
AU1598597A (en) 1997-08-22
ZA97826B (en) 1998-07-31
SI0880533T1 (en) 2002-08-31
US20040236105A1 (en) 2004-11-25
TW434247B (en) 2001-05-16
SK283136B6 (sk) 2003-03-04
PL328436A1 (en) 1999-02-01
HK1018217A1 (en) 1999-12-17
DE69713284D1 (de) 2002-07-18
BG102603A (en) 1999-03-31
IL124865A (en) 2002-03-10
IL133135A0 (en) 2001-03-19
HN1997000012A (es) 1997-06-26
US6977302B2 (en) 2005-12-20
HRP970063A2 (en) 1998-06-30
KR19990082233A (ko) 1999-11-25
CA2240777A1 (en) 1997-08-07
KR100283546B1 (ko) 2001-04-02
AP9700923A0 (en) 1997-01-31
IL124865A0 (en) 1999-01-26
ATE219089T1 (de) 2002-06-15
NO983560D0 (no) 1998-08-03
HUP9900949A2 (hu) 2001-05-28
PL187237B1 (pl) 2004-06-30
EP0880533A1 (en) 1998-12-02
UA46828C2 (uk) 2002-06-17
IS4785A (is) 1998-06-26
ES2175336T3 (es) 2002-11-16
BR9707257A (pt) 1999-04-06
MY116849A (en) 2004-04-30
JP2959846B2 (ja) 1999-10-06
NZ330654A (en) 1999-08-30
BG63946B1 (bg) 2003-07-31
IL133135A (en) 2003-07-06
AU709781B2 (en) 1999-09-09
SA97170578B1 (ar) 2006-01-28
PT880533E (pt) 2002-09-30
DZ2172A1 (fr) 2002-12-01
HU226133B1 (en) 2008-05-28
CA2240777C (en) 2002-06-11
RU2176244C2 (ru) 2001-11-27
EP0880533B1 (en) 2002-06-12
CO4761066A1 (es) 1999-04-27
AP678A (en) 1998-09-28

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