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RS20201065A1 - Planarna elektroda za biosenzore realizovana primenom ponavljajuće fraktalne geometrije - Google Patents

Planarna elektroda za biosenzore realizovana primenom ponavljajuće fraktalne geometrije

Info

Publication number
RS20201065A1
RS20201065A1 RS20201065A RSP20201065A RS20201065A1 RS 20201065 A1 RS20201065 A1 RS 20201065A1 RS 20201065 A RS20201065 A RS 20201065A RS P20201065 A RSP20201065 A RS P20201065A RS 20201065 A1 RS20201065 A1 RS 20201065A1
Authority
RS
Serbia
Prior art keywords
repetitive
geometry
fractal
biosensors
realized
Prior art date
Application number
RS20201065A
Other languages
English (en)
Inventor
Vasa Dr Radonić
Jasmina Dr Vidić
Marko Dr Radović
Ivana Dr Gađanski
Original Assignee
Inst Biosens Istrazivacko Razvojni Inst Za Informacione Tehnologije Biosistema
Institut National De Recherche Pour Lagriculture Lalimentation Et Lenvironnement
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Biosens Istrazivacko Razvojni Inst Za Informacione Tehnologije Biosistema, Institut National De Recherche Pour Lagriculture Lalimentation Et Lenvironnement filed Critical Inst Biosens Istrazivacko Razvojni Inst Za Informacione Tehnologije Biosistema
Priority to RS20201065A priority Critical patent/RS20201065A1/sr
Priority to PCT/RS2021/000011 priority patent/WO2022050860A1/en
Priority to EP21806053.1A priority patent/EP4213929A1/en
Publication of RS20201065A1 publication Critical patent/RS20201065A1/sr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

Planarna elektroda za biosenzore realizovana primenom ponavljajuće fraktalne geometrije ima za novost način konstrukcije sistema od tri elektrode biosenzora putem metoda ponavljajuće geometrije do nivoa trećeg reda. Sama realizacija pronalaska uključuje ponavljajuću geometriju 1. reda Sijerpinskih fraktala, ali pronalazak se odnosi i na ponavljajuću geometriju Kohove krive, Peanove krive i Hilbertove krive, a od geometrijskih oblika uključuje tri najviše zastupljena oblika kvadrat, krug i trougao. Ponavljajuća geometrija je osnova inovativnosti pronalaska, jer izmena dizajna planarne elektrode sa svojim parametrima, o kojima će biti reči u detaljnom opisu, kao i reda fraktala, značajno doprinosi povećanoj osetljivosti biosenzora. Biosenzor pronalaska je realizovan LTCC tehnologijom i sito štampe tj. za podlogu od koga je napravljena elektroda biosenzora koristi se keramika na koju se sito štampom nanosi zlato, mada pronalazak uključuje i srebro, platinu i karbonske paste, ali i druge tehnologije izrade kao i materijale podloge i dalju funkcionalizaciju površina elektroda. Na nesinterovane keramičke trake isečene laserom primenom procesa sitoštampe, preko specifično dizajniranih maski primenom fotopostupka, nanosi se provodna pasta u inovativni fraktalni oblik. Nesinterovane trake se posle toga laminiraju radi mehaničke čvrstoće i peku radi procesa sinterovanja same paste i podloge. Zatim se elektrode mogu funkcionalizovati odgovarajućim bioreceptorima, koji ne utiču na samu osetljivost, već na specifičnost prepoznavanja analita.
RS20201065A 2020-09-04 2020-09-04 Planarna elektroda za biosenzore realizovana primenom ponavljajuće fraktalne geometrije RS20201065A1 (sr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
RS20201065A RS20201065A1 (sr) 2020-09-04 2020-09-04 Planarna elektroda za biosenzore realizovana primenom ponavljajuće fraktalne geometrije
PCT/RS2021/000011 WO2022050860A1 (en) 2020-09-04 2021-08-30 Planar electrode for biosensors realized using repetitive fractal geometry
EP21806053.1A EP4213929A1 (en) 2020-09-04 2021-08-30 Planar electrode for biosensors realized using repetitive fractal geometry

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RS20201065A RS20201065A1 (sr) 2020-09-04 2020-09-04 Planarna elektroda za biosenzore realizovana primenom ponavljajuće fraktalne geometrije

Publications (1)

Publication Number Publication Date
RS20201065A1 true RS20201065A1 (sr) 2022-03-31

Family

ID=78592902

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20201065A RS20201065A1 (sr) 2020-09-04 2020-09-04 Planarna elektroda za biosenzore realizovana primenom ponavljajuće fraktalne geometrije

Country Status (3)

Country Link
EP (1) EP4213929A1 (sr)
RS (1) RS20201065A1 (sr)
WO (1) WO2022050860A1 (sr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250076242A1 (en) * 2023-07-11 2025-03-06 King Faisal University Ultrasensitive and selective sensors for glucose detection based on thiol-functionalized heterogenous gold/graphene/copper film

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050147964A1 (en) 2003-12-30 2005-07-07 Intel Corporation Methods for identifying a peptide that binds a geometrical shape
US8005526B2 (en) 2005-08-31 2011-08-23 The Regents Of The University Of Michigan Biologically integrated electrode devices
US7516002B2 (en) 2006-01-10 2009-04-07 Guardian Industries Corp. Rain sensor for detecting rain or other material on window of a vehicle or on other surface
EP3279651B1 (en) 2008-09-02 2019-06-12 The Governing Council Of The University Of Toronto Methods using microelectrodes and biosensing devices incorporating the same
WO2012109157A2 (en) 2011-02-07 2012-08-16 The Governing Council Of The University Of Toronto Bioprobes and methods of use thereof
CN105340369A (zh) 2013-02-06 2016-02-17 伊利诺伊大学评议会 具有容纳室的可拉伸的电子系统
US9613911B2 (en) 2013-02-06 2017-04-04 The Board Of Trustees Of The University Of Illinois Self-similar and fractal design for stretchable electronics
JP6450757B2 (ja) * 2013-07-24 2019-01-09 カリフォルニア インスティチュート オブ テクノロジー 埋め込み型完全集積化電気化学センサの設計及び作製
WO2015157855A1 (en) * 2014-04-15 2015-10-22 Gandhi Harry Functional contact lens and related systems and methods
US20160235347A1 (en) * 2015-02-13 2016-08-18 Maarij Baig Artificial sensors and methods of manufacture thereof
US11609472B2 (en) 2016-12-29 2023-03-21 Ador Diagnostics S.R.L. Electrophoretic chip for electrophoretic applications
US20190030318A1 (en) 2017-07-27 2019-01-31 Purdue Research Foundation Fractal geometry microelectrodes and uses thereof

Also Published As

Publication number Publication date
WO2022050860A1 (en) 2022-03-10
EP4213929A1 (en) 2023-07-26

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