[go: up one dir, main page]

RS20060099A - Modified human igf-1r antibodies - Google Patents

Modified human igf-1r antibodies

Info

Publication number
RS20060099A
RS20060099A YUP-2006/0099A YUP20060099A RS20060099A RS 20060099 A RS20060099 A RS 20060099A YU P20060099 A YUP20060099 A YU P20060099A RS 20060099 A RS20060099 A RS 20060099A
Authority
RS
Serbia
Prior art keywords
antibodies
human igf
modified human
igf
replaced
Prior art date
Application number
YUP-2006/0099A
Other languages
English (en)
Inventor
Bruce David Cohen
Vahe Bedian
Original Assignee
Pfizer Products Inc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc., filed Critical Pfizer Products Inc.,
Publication of RS20060099A publication Critical patent/RS20060099A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ovaj pronalazak se odnosi na humana antitela, na primer ona koja su usmerena na receptor humanog IGF-I (IGF-IR), a koja su za tretman kancera, i imaju jedan ili više odabranih mutiranih ostataka zamenjen sa ostacima soja germ ćelija. Zamenjeni ostatak može biti somatska mutacija u regionu frejmvorka.
YUP-2006/0099A 2003-08-13 2004-08-03 Modified human igf-1r antibodies RS20060099A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49520003P 2003-08-13 2003-08-13
PCT/IB2004/002555 WO2005016967A2 (en) 2003-08-13 2004-08-03 Modified human igf-1r antibodies

Publications (1)

Publication Number Publication Date
RS20060099A true RS20060099A (en) 2008-08-07

Family

ID=34193291

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2006/0099A RS20060099A (en) 2003-08-13 2004-08-03 Modified human igf-1r antibodies

Country Status (37)

Country Link
US (2) US7371378B2 (sr)
EP (1) EP1656391B1 (sr)
JP (1) JP4638870B2 (sr)
KR (1) KR100825156B1 (sr)
CN (1) CN1835975B (sr)
AP (1) AP2006003510A0 (sr)
AR (1) AR045247A1 (sr)
AT (1) ATE484525T1 (sr)
AU (1) AU2004265152A1 (sr)
BR (1) BRPI0413466A (sr)
CA (1) CA2535071A1 (sr)
CL (1) CL2004002035A1 (sr)
CR (1) CR8233A (sr)
DE (1) DE602004029581D1 (sr)
DK (1) DK1656391T3 (sr)
EA (1) EA200600234A1 (sr)
EC (1) ECSP066359A (sr)
ES (1) ES2351395T3 (sr)
GT (1) GT200400158A (sr)
IL (1) IL173273A (sr)
IS (1) IS8266A (sr)
MA (1) MA27988A1 (sr)
MX (1) MXPA06001634A (sr)
NL (1) NL1026829C2 (sr)
NO (1) NO20060542L (sr)
OA (1) OA13234A (sr)
PA (1) PA8608801A1 (sr)
PE (1) PE20050339A1 (sr)
PL (1) PL1656391T3 (sr)
PT (1) PT1656391E (sr)
RS (1) RS20060099A (sr)
TN (1) TNSN06050A1 (sr)
TW (1) TWI294915B (sr)
UA (1) UA85058C2 (sr)
UY (1) UY28464A1 (sr)
WO (1) WO2005016967A2 (sr)
ZA (1) ZA200601231B (sr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ301712B6 (cs) 2001-01-05 2010-06-02 Pfizer Inc. Protilátka k receptoru IGF-I a farmaceutický prípravek obsahující tuto protilátku
CN100422316C (zh) 2002-05-24 2008-10-01 先灵公司 抗胰岛素样生长因子受体(igfr)的人源中和抗体
EP2365001A3 (en) * 2003-05-01 2012-03-28 Imclone LLC Fully human antibodies directed against the human insulin-like growth factor-1 receptor
RS20060099A (en) * 2003-08-13 2008-08-07 Pfizer Products Inc., Modified human igf-1r antibodies
US7326567B2 (en) 2003-11-12 2008-02-05 Schering Corporation Plasmid system for multigene expression
TW200526684A (en) 2003-11-21 2005-08-16 Schering Corp Anti-IGFR1 antibody therapeutic combinations
KR20070036130A (ko) 2004-07-16 2007-04-02 화이자 프로덕츠 인코포레이티드 항-아이지에프-1알 항체를 사용하는 비-혈액학적악성종양에 대한 조합 치료
FR2873699B1 (fr) * 2004-07-29 2009-08-21 Pierre Fabre Medicament Sa Nouveaux anticorps anti igf ir rt leurs utilisations
ATE493442T1 (de) 2004-12-03 2011-01-15 Schering Corp Biologische marker zur vorauswahl von patienten für die anti-igf1r-therapie
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
GB0500417D0 (en) * 2005-01-10 2005-02-16 Cambridge Antibody Tech Method of mutagenesis
CN101222926B (zh) * 2005-04-15 2013-07-17 默沙东公司 用于治疗或预防癌症的方法和组合物
EP1896505A2 (en) * 2005-06-15 2008-03-12 Schering Corporation Anti-igf1r antibody formulations
WO2006138729A2 (en) 2005-06-17 2006-12-28 Imclone Systems Incorporated Receptor antagonists for treatment of metastatic bone cancer
FR2888850B1 (fr) * 2005-07-22 2013-01-11 Pf Medicament Nouveaux anticorps anti-igf-ir et leurs applications
CA2641310C (en) * 2006-02-03 2013-08-20 Imclone Systems Incorporated Igf-ir antagonists as adjuvants for treatment of prostate cancer
CN101410137A (zh) * 2006-03-28 2009-04-15 霍夫曼-拉罗奇有限公司 抗-igf-1r人单克隆抗体制剂
US7846724B2 (en) 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
CA2653745C (en) * 2006-06-02 2013-11-19 Pfizer Products Inc. Circulating tumor cell assay
AR064464A1 (es) * 2006-12-22 2009-04-01 Genentech Inc Anticuerpos anti - receptor del factor de crecimiento insulinico
GB0702888D0 (en) * 2007-02-14 2007-03-28 Glaxo Group Ltd Novel Antibodies
CA2679548C (en) * 2007-03-02 2015-01-27 Amgen Inc. Methods and compositions for treating tumor diseases
AU2012203443B2 (en) * 2007-03-02 2014-03-06 Amgen Inc. Methods and compositions for treating tumor diseases
EP2136839A4 (en) * 2007-03-22 2010-04-07 Imclone Llc STABLE ANTIBODY FORMULATIONS
EP2145021A2 (en) 2007-05-17 2010-01-20 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators
CA2709029A1 (en) 2007-12-21 2009-07-02 Bianca Eser Stability testing of antibodies
EP2259797A2 (en) * 2008-03-25 2010-12-15 Schering Corporation Methods for treating or preventing colorectal cancer
JP2011519868A (ja) * 2008-05-05 2011-07-14 シェーリング コーポレイション 癌を処置するための化学療法剤の連続投与
EP2356154A4 (en) * 2008-11-06 2012-12-19 Alexion Pharma Inc DEVELOPMENT OF REDUCED IMMUNOGENICITY ANTIBODIES AND METHODS OF MANUFACTURING THEREOF
WO2010099139A2 (en) 2009-02-25 2010-09-02 Osi Pharmaceuticals, Inc. Combination anti-cancer therapy
EP2236139A1 (en) 2009-03-31 2010-10-06 F. Hoffmann-La Roche AG Combination therapy of erlotinib with an anti-IGF-1R antibody, which does not inhibit binding of insulin to the insulin receptor
WO2010146059A2 (en) 2009-06-16 2010-12-23 F. Hoffmann-La Roche Ag Biomarkers for igf-1r inhibitor therapy
TWI513465B (zh) 2009-06-25 2015-12-21 Regeneron Pharma 以ｄｌｌ４拮抗劑與化學治療劑治療癌症之方法
CA2773522C (en) 2009-10-26 2023-04-18 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
EP2494070A2 (en) 2009-10-30 2012-09-05 Bristol-Myers Squibb Company Methods for treating cancer in patients having igf-1r inhibitor resistance
CA2777527C (en) * 2009-12-23 2020-06-23 Esbatech, An Alcon Biomedical Research Unit Llc Method for decreasing immunogenicity
AU2014262201B2 (en) * 2009-12-23 2016-09-15 Novartis Ag Method for decreasing immunogenicity
US20110200595A1 (en) 2010-02-18 2011-08-18 Roche Glycart TREATMENT WITH A HUMANIZED IgG CLASS ANTI EGFR ANTIBODY AND AN ANTIBODY AGAINST INSULIN LIKE GROWTH FACTOR 1 RECEPTOR
WO2011161119A1 (en) 2010-06-22 2011-12-29 F. Hoffmann-La Roche Ag Antibodies against insulin-like growth factor i receptor and uses thereof
CA2804185C (en) 2010-07-12 2017-03-21 Covx Technologies Ireland Limited Multifunctional antibody conjugates
MX2013008833A (es) 2011-02-02 2013-12-06 Amgen Inc Metodos y composiciones relacionadas con la inhibicion de receptor del factor de crecimiento similar a la insulina 1 (igf-1r).
CA3019531A1 (en) 2011-04-19 2012-10-26 Pfizer Inc. Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer
US20140309229A1 (en) 2011-10-13 2014-10-16 Bristol-Myers Squibb Company Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors
AR090410A1 (es) * 2012-01-09 2014-11-12 Covx Technologies Ireland Ltd Anticuerpos mutantes y conjugacion de los mismos
EP2631653A1 (en) 2012-02-24 2013-08-28 Charité - Universitätsmedizin Berlin Identification of modulators of binding properties of antibodies reactive with a member of the insulin receptor family
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
AU2013341349A1 (en) * 2012-11-06 2015-05-21 Medimmune Limited Combination therapies using anti-Pseudomonas Psl and PcrV binding molecules
CN105143262A (zh) 2013-04-29 2015-12-09 豪夫迈·罗氏有限公司 结合人fcrn的修饰的抗体和使用方法
CA2904805A1 (en) 2013-04-29 2014-11-06 F. Hoffmann-La Roche Ag Fc-receptor binding modified asymmetric antibodies and methods of use
CN103319598B (zh) * 2013-05-13 2014-10-22 杭州德同生物技术有限公司 抗胰岛素样生长因子-1受体抗体及其编码基因和应用
CA2932364A1 (en) 2014-01-15 2015-07-23 F. Hoffmann-La Roche Ag Fc-region variants with improved protein a-binding
JP6908709B2 (ja) 2017-01-06 2021-07-28 エービーエル バイオ インコーポレイテッド 抗α−ｓｙｎ抗体およびその使用
IL272227B1 (en) * 2017-07-27 2025-05-01 iTeos Belgium SA Anti-tigit antibodies
EP4403218A3 (en) 2017-12-14 2024-11-06 ABL Bio, Inc. Bispecific antibody to a-syn/igf1r and use thereof

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054561A (en) 1984-02-08 2000-04-25 Chiron Corporation Antigen-binding sites of antibody molecules specific for cancer antigens
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US6657103B1 (en) 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
GB9203459D0 (en) 1992-02-19 1992-04-08 Scotgen Ltd Antibodies with germ-line variable regions
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
ES2153031T4 (es) 1995-04-20 2001-05-16 Pfizer Derivados del acido arilsulfonil hidroxamico como inhibidores de mmp y tnf.
EP1978033A3 (en) 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
IL118626A0 (en) 1996-06-11 1996-10-16 Xtl Biopharmaceuticals Limited Anti HBV antibody
TR199900066T2 (xx) 1996-07-18 1999-04-21 Pfizer Inc. Matriks metalloproteazlar�n fosfinat bazl� inhibit�rleri
SK21499A3 (en) 1996-08-23 2000-05-16 Pfizer Arylsulfonylamino hydroxamic acid derivatives
CA2332331A1 (en) 1998-05-15 1999-11-25 Francisco Robert Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases
EE05627B1 (et) * 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
KR20140094647A (ko) 1999-03-25 2014-07-30 아비에 도이치란트 게엠베하 운트 콤파니 카게 사람 ｉｌ-12에 결합하는 사람 항체 및 이의 제조방법
ES1042735Y (es) 1999-04-07 2000-02-16 Martinez Fernando Martinez Vehiculo tripersonal de accionamiento a pedales.
US20030165502A1 (en) 2000-06-13 2003-09-04 City Of Hope Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth
DE10033869C2 (de) 2000-07-12 2003-07-31 Karlsruhe Forschzent HTS-Kryomagnet und Aufmagnetisierungsverfahren
CZ301712B6 (cs) 2001-01-05 2010-06-02 Pfizer Inc. Protilátka k receptoru IGF-I a farmaceutický prípravek obsahující tuto protilátku
EP1361893B1 (en) 2001-02-19 2012-10-24 Merck Patent GmbH Modified anti-egfr antibodies with reduced immunogenicity
EP1461359B1 (fr) 2002-01-18 2007-03-21 Pierre Fabre Medicament Anticorps anti-igf-ir et leurs applications
DE60329589D1 (de) 2002-04-30 2009-11-19 Kyowa Hakko Kirin Co Ltd Antikörper gegen den humanen "insulin-like" wachstumsfaktor
CN100422316C (zh) * 2002-05-24 2008-10-01 先灵公司 抗胰岛素样生长因子受体(igfr)的人源中和抗体
GB0212303D0 (en) 2002-05-28 2002-07-10 Isis Innovation Molecular targetting of IGF-1 receptor
US7538195B2 (en) 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
MXPA05008617A (es) 2003-02-13 2005-11-04 Pfizer Prod Inc Usos de anticuerpos anti-receptor del factor de crecimiento semejante a la insulina i.
MXPA05009837A (es) 2003-03-14 2005-12-05 Pharmacia Corp Anticuerpos para el receptor del factor de crecimiento tipo insulina-i, para el tratamiento de canceres.
ATE549359T1 (de) 2003-04-02 2012-03-15 Hoffmann La Roche Antikörper gegen den insulinähnlichen wachstumsfaktor i-rezeptor und deren verwendungen
RS20060099A (en) * 2003-08-13 2008-08-07 Pfizer Products Inc., Modified human igf-1r antibodies

Also Published As

Publication number Publication date
JP4638870B2 (ja) 2011-02-23
MA27988A1 (fr) 2006-07-03
PT1656391E (pt) 2010-12-06
US7371378B2 (en) 2008-05-13
MXPA06001634A (es) 2006-04-28
PL1656391T3 (pl) 2011-03-31
IL173273A0 (en) 2006-06-11
CL2004002035A1 (es) 2005-06-03
IL173273A (en) 2011-10-31
EA200600234A1 (ru) 2006-08-25
WO2005016967A3 (en) 2005-04-14
CN1835975A (zh) 2006-09-20
OA13234A (en) 2006-12-13
ECSP066359A (es) 2006-10-31
IS8266A (is) 2006-01-26
NO20060542L (no) 2006-05-03
NL1026829A1 (nl) 2005-02-15
ATE484525T1 (de) 2010-10-15
CA2535071A1 (en) 2005-02-24
CR8233A (es) 2007-01-18
AU2004265152A1 (en) 2005-02-24
US7575746B2 (en) 2009-08-18
GT200400158A (es) 2005-07-22
US20080181891A1 (en) 2008-07-31
US20050069539A1 (en) 2005-03-31
TNSN06050A1 (fr) 2007-10-03
JP2007527705A (ja) 2007-10-04
DK1656391T3 (da) 2011-01-03
EP1656391A2 (en) 2006-05-17
NL1026829C2 (nl) 2005-07-05
TW200516145A (en) 2005-05-16
ZA200601231B (en) 2007-05-30
UY28464A1 (es) 2005-03-31
UA85058C2 (ru) 2008-12-25
EP1656391B1 (en) 2010-10-13
KR100825156B1 (ko) 2008-04-24
PA8608801A1 (es) 2005-03-03
CN1835975B (zh) 2012-11-21
AR045247A1 (es) 2005-10-19
AP2006003510A0 (en) 2006-02-28
KR20060035796A (ko) 2006-04-26
WO2005016967A2 (en) 2005-02-24
PE20050339A1 (es) 2005-05-17
DE602004029581D1 (de) 2010-11-25
TWI294915B (en) 2008-03-21
BRPI0413466A (pt) 2006-10-17
ES2351395T3 (es) 2011-02-04

Similar Documents

Publication Publication Date Title
RS20060099A (en) Modified human igf-1r antibodies
IL243812A0 (en) Compounds of diarylhydantoin
MX2007002675A (es) Antagonistas anti-beta7 humanizados y usos para los mismos.
SG170809A1 (en) Diarylthiohydantoin compounds
NZ594466A (en) Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
ZA200701656B (en) Humanized anti-cment antagonists
ATE412748T1 (de) Zusammensetzungen und verfahren zur induktion einer antitumorimmunität
WO2003079977A3 (en) Novel compositions and methods in cancer associated with altered expression of mcm3ap