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RS20050522A - Protein kinase inhibiting tricyclic compounds that increase the effects of anti-neoplastic agents and therapeutic radiation - Google Patents

Protein kinase inhibiting tricyclic compounds that increase the effects of anti-neoplastic agents and therapeutic radiation

Info

Publication number
RS20050522A
RS20050522A YUP-2005/0522A YUP20050522A RS20050522A RS 20050522 A RS20050522 A RS 20050522A YU P20050522 A YUP20050522 A YU P20050522A RS 20050522 A RS20050522 A RS 20050522A
Authority
RS
Serbia
Prior art keywords
protein kinase
therapeutic radiation
effects
increase
tricyclic compounds
Prior art date
Application number
YUP-2005/0522A
Other languages
English (en)
Inventor
Sacha Ninković
Michael Joh Bennett
Eugene Yuanjin Rui
Fen Wang
Suzanne Pritchett Benedict
Min Teng
Yong Wang
Jinjiang Zhu
Original Assignee
Pfizer Inc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc., filed Critical Pfizer Inc.,
Publication of RS20050522A publication Critical patent/RS20050522A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Triciklična jedinjenja koja inhibiraju protein kinazu kao što je CHK-1, sa sledećom formulom (gde su R2, R3 i R4 kao što je odredjeno u specifikaciji) Farmaceutske kompozicije koje sadrže efikasne količine pomenutih jedinjenja ili njihovih soli, korisne su kao pojedinačni agens ili u kombinaciji sa antineoplastičnim agensom ili terapeutskim zračenjem koje ima anti-neoplastični efekat, za lečenje bolesti ili stanja kao što su kanceri.
YUP-2005/0522A 2003-01-09 2004-01-05 Protein kinase inhibiting tricyclic compounds that increase the effects of anti-neoplastic agents and therapeutic radiation RS20050522A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09
PCT/IB2004/000026 WO2004063198A1 (en) 2003-01-09 2004-01-05 Diazepinoindole derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
RS20050522A true RS20050522A (en) 2007-12-31

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2005/0522A RS20050522A (en) 2003-01-09 2004-01-05 Protein kinase inhibiting tricyclic compounds that increase the effects of anti-neoplastic agents and therapeutic radiation

Country Status (35)

Country Link
US (3) US6967198B2 (sr)
EP (2) EP1947102A1 (sr)
JP (1) JP3990718B2 (sr)
KR (1) KR100697746B1 (sr)
CN (1) CN1759118B (sr)
AP (1) AP2048A (sr)
AT (1) ATE404564T1 (sr)
AU (1) AU2004203977B2 (sr)
BR (1) BRPI0406701A (sr)
CA (1) CA2512683C (sr)
CR (1) CR7899A (sr)
CY (1) CY1108408T1 (sr)
DE (1) DE602004015724D1 (sr)
DK (1) DK1585749T3 (sr)
EA (1) EA009337B1 (sr)
EC (1) ECSP055911A (sr)
ES (1) ES2309484T3 (sr)
GE (1) GEP20084367B (sr)
HK (1) HK1086257A1 (sr)
HR (1) HRP20050624A2 (sr)
IL (1) IL169082A (sr)
IS (1) IS7884A (sr)
MA (1) MA27703A1 (sr)
MX (1) MXPA05007352A (sr)
NO (1) NO20053775L (sr)
NZ (1) NZ540638A (sr)
OA (1) OA13017A (sr)
PL (1) PL378372A1 (sr)
PT (1) PT1585749E (sr)
RS (1) RS20050522A (sr)
SI (1) SI1585749T1 (sr)
TN (1) TNSN05176A1 (sr)
UA (1) UA80733C2 (sr)
WO (1) WO2004063198A1 (sr)
ZA (1) ZA200504674B (sr)

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ES2309484T3 (es) * 2003-01-09 2008-12-16 Pfizer Inc. Derivados de diazepinoindol como inhibidores de quinasa.
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US9187494B2 (en) 2011-05-06 2015-11-17 Zafgen, Inc. Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
WO2013096687A1 (en) * 2011-12-22 2013-06-27 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer
AU2011384859B2 (en) 2011-12-31 2016-03-17 Beigene, Ltd. Fused tetra or penta-cyclic pyridophthalazinones as PARP inhibitors
EP2797921B1 (en) * 2011-12-31 2017-09-06 BeiGene, Ltd. Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) * 2013-05-22 2018-08-21 開曼群島商百濟神州生物科技有限公司 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
KR20160104612A (ko) 2013-07-26 2016-09-05 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조성물
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KR20170016498A (ko) 2014-06-17 2017-02-13 버텍스 파마슈티칼스 인코포레이티드 Chk1 및 atr 저해제의 병용물을 사용하는 암의 치료 방법
EA037366B1 (ru) 2015-08-25 2021-03-18 Бейджин, Лтд. Способ получения ингибитора parp, кристаллические формы и их применения
MX395066B (es) 2015-09-30 2025-03-24 Vertex Pharma Método para tratar cáncer usando una combinación de agentes que dañan el adn e inhibidores de proteína relacionada con ataxia telangiectasia y rad3 (atr).
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JP6541635B2 (ja) * 2016-10-28 2019-07-10 ベイジーン リミテッド Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン
CN115433187B (zh) 2017-02-28 2023-10-27 百济神州(苏州)生物科技有限公司 稠合的四环或五环二氢二氮杂䓬并咔唑酮的盐的结晶形式组合物及其用途
US11661581B2 (en) * 2017-05-25 2023-05-30 University Of Massachusetts Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
FI3684767T3 (fi) * 2017-09-22 2024-07-22 Jubilant Epipad LLC Heterosyklisiä yhdisteitä pad:n estäjinä
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JP2022523028A (ja) * 2019-01-25 2022-04-21 ヌメディー， インコーポレイテッド 特発性肺線維症を処置するための方法
WO2021018298A1 (zh) * 2019-08-01 2021-02-04 南京明德新药研发有限公司 作为parp抑制剂吲哚并七元酰肟化合物
JP7260718B2 (ja) 2019-11-29 2023-04-18 メッドシャイン ディスカバリー インコーポレイテッド ジアザインドール誘導体及びそのＣｈｋ１阻害剤としての使用
WO2022011458A1 (en) * 2020-07-13 2022-01-20 Ontario Institute For Cancer Research (Oicr) Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof
WO2022022664A1 (zh) * 2020-07-31 2022-02-03 正大天晴药业集团股份有限公司 用作parp抑制剂的吲哚并七元酰肟类似物的结晶及其制备方法

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Also Published As

Publication number Publication date
EA009337B1 (ru) 2007-12-28
DK1585749T3 (da) 2008-09-22
WO2004063198A1 (en) 2004-07-29
IL169082A (en) 2011-02-28
OA13017A (en) 2006-11-10
CY1108408T1 (el) 2014-02-12
CA2512683A1 (en) 2004-07-29
ECSP055911A (es) 2005-11-22
SI1585749T1 (sl) 2008-10-31
PL378372A1 (pl) 2006-04-03
US20060004052A1 (en) 2006-01-05
CN1759118B (zh) 2010-12-08
HK1086257A1 (en) 2006-09-15
AP2005003353A0 (en) 2005-09-30
NZ540638A (en) 2007-12-21
PT1585749E (pt) 2008-10-23
AU2004203977B2 (en) 2010-06-17
EP1947102A1 (en) 2008-07-23
TNSN05176A1 (fr) 2007-06-11
UA80733C2 (en) 2007-10-25
MA27703A1 (fr) 2006-01-02
KR100697746B1 (ko) 2007-03-22
JP3990718B2 (ja) 2007-10-17
US20050075499A1 (en) 2005-04-07
EP1585749A1 (en) 2005-10-19
NO20053775D0 (no) 2005-08-08
EA200500893A1 (ru) 2006-02-24
US20070135415A1 (en) 2007-06-14
ES2309484T3 (es) 2008-12-16
AU2004203977A1 (en) 2004-07-29
CR7899A (es) 2005-08-05
JP2006516274A (ja) 2006-06-29
ZA200504674B (en) 2006-07-26
NO20053775L (no) 2005-09-16
CN1759118A (zh) 2006-04-12
EP1585749B1 (en) 2008-08-13
AP2048A (en) 2009-09-24
HRP20050624A2 (en) 2006-02-28
US6967198B2 (en) 2005-11-22
US7462713B2 (en) 2008-12-09
CA2512683C (en) 2010-03-16
MXPA05007352A (es) 2006-02-17
US7132533B2 (en) 2006-11-07
IS7884A (is) 2005-06-09
ATE404564T1 (de) 2008-08-15
BRPI0406701A (pt) 2005-12-20
DE602004015724D1 (de) 2008-09-25
GEP20084367B (en) 2008-05-13
KR20050092397A (ko) 2005-09-21

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