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RO92676B - Procedeu pentru prepararea dl-beta-arilaminoacizilor - Google Patents

Procedeu pentru prepararea dl-beta-arilaminoacizilor

Info

Publication number
RO92676B
RO92676B RO117934A RO11793485A RO92676B RO 92676 B RO92676 B RO 92676B RO 117934 A RO117934 A RO 117934A RO 11793485 A RO11793485 A RO 11793485A RO 92676 B RO92676 B RO 92676B
Authority
RO
Romania
Prior art keywords
sub
aryl
general formula
general
excess
Prior art date
Application number
RO117934A
Other languages
English (en)
Other versions
RO92676A (ro
Inventor
Hosztafi Sandor
Timar Tibor
Salamon Zoltan
Fabian Ilona
Nagy Vajda Juliana
Original Assignee
Alkaloida Vegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkaloida Vegyeszeti Gyar filed Critical Alkaloida Vegyeszeti Gyar
Publication of RO92676A publication Critical patent/RO92676A/ro
Publication of RO92676B publication Critical patent/RO92676B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea DL-beta-aril-aminoacizilor cu formula generala: (vezi formula) în care R1, R1 si R2 reprezinta hidrogen, halogen, alchil cu 1..6 atomi de carbon, alcoxi cu 1..6 atomi de carbon, nitro sau dialchilamino cu 1..4 atomi de carbon; cu conditia ca, în cazul derivatilor monosubstituiti, R si R1 înseamna hidrogen si R2 are semnificatia de mai sus si este situata fata de grupa metilenica în pozitia 2, 3 sau 4; respectiv, în cazul derivatiilor disubstituiti R înseamna hidrogen si R1 si R2 au semnificatia de mai sus si se leaga la grupa metilenica în pozitiile 2,3; 2, 4; 2,6; 3,4 sau 3,5, respectiv, în catul derivatiilor trisubstituiti R, R1si R2 au semnificatia de mai sus si ocipa fata de grupa metilenica pozitiile 2,3 4; 2,3,5; 2,3,6; 3,4,5; sau 3, 4, 6, care consta în aceea ca solutia apoasa de glicina si a unui exces de uree se încalzeste la fierbere, amestecul se supune unei ciclizari acide; hidantoina obtinuta cu formula I este încalzita la fierbere, cu o aldehida aromatica în solutia apoasa, în prezenta unei cantitati în exces de etanolamina sau morfolina, 5-ariliden-hidantoina formata este redusa cantitativ într-un mediu alcalin diluat, în prezenta unui catalizator de nichel-Raney sau paladiu si produsul este trecut prin hidroliza alcalina, cu un randament bun, în DL-beta-aril-aminoacidul.
RO117934A 1984-03-12 1985-03-11 Procedeu pentru prepararea dl-beta-arilaminoacizilor RO92676B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU84981A HU204026B (en) 1984-03-12 1984-03-12 Process for producing di-beta-substituted phenylamino acids

Publications (2)

Publication Number Publication Date
RO92676A RO92676A (ro) 1987-11-30
RO92676B true RO92676B (ro) 1987-12-01

Family

ID=10952297

Family Applications (1)

Application Number Title Priority Date Filing Date
RO117934A RO92676B (ro) 1984-03-12 1985-03-11 Procedeu pentru prepararea dl-beta-arilaminoacizilor

Country Status (18)

Country Link
US (1) US4647694A (ro)
EP (1) EP0156582B1 (ro)
JP (1) JPS60204750A (ro)
AT (1) ATE37177T1 (ro)
AU (1) AU3968185A (ro)
BG (1) BG43688A3 (ro)
DD (1) DD232260A5 (ro)
DE (1) DE3564938D1 (ro)
DK (1) DK109985A (ro)
ES (1) ES8601854A1 (ro)
FI (1) FI850970L (ro)
HU (1) HU204026B (ro)
IL (1) IL74389A0 (ro)
NO (1) NO850943L (ro)
PL (1) PL252344A1 (ro)
RO (1) RO92676B (ro)
SU (1) SU1468409A3 (ro)
YU (1) YU39085A (ro)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613691A (en) * 1984-08-17 1986-09-23 Stauffer Chemical Company Preparation of amino acids from unsaturated hydantoins
DE4137581A1 (de) * 1991-11-15 1993-05-19 Degussa Verfahren zur chemischen racemisierung von 5-monosubstituierten hydantoinen, vorrichtung zur durchfuehrung des verfahrens und verwendung der hydantoine
FR2735126B1 (fr) * 1995-06-12 1997-07-18 Rhone Poulenc Rorer Sa Procede de preparation des formes enantiomeres de l'acide amino alkylaminophenylpropanoique
HUP0401439A3 (en) * 2001-09-05 2007-02-28 Solvay Sociutu Anonyme Method for synthesis of 5-(3-pyridylmethylene)-imidazolidine-2,4-dione
ES2837489B2 (es) * 2019-12-31 2022-02-28 Primalchit Solutions S L Mezcla de componentes organicos no polimericos con capacidad retardante de llama, metodo de preparacion y uso

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2479065A (en) * 1945-09-06 1949-08-16 Du Pont Preparation of 5-benzylhydantoin
US2605282A (en) * 1949-02-18 1952-07-29 Dow Chemical Co Process for production of beta-(3, 4-dihydroxyphenyl)-alanine
US2861079A (en) * 1956-06-04 1958-11-18 Dow Chemical Co Process for making unsaturated hydantoins
GB991644A (en) * 1961-10-30 1965-05-12 Rafa House Biolog Lab Ltd Manufacture of hydantoin derivatives
US3190914A (en) * 1963-05-27 1965-06-22 Rexall Drug Chemical Process for the preparation of amino acids
US3215736A (en) * 1964-03-20 1965-11-02 Prod Chim Ind S P C I Soc D Preparation of amino acids
NL128182C (ro) * 1965-11-30
CH483398A (de) * 1966-12-01 1969-12-31 Hoffmann La Roche Verfahren zur Herstellung von Phenylalaninderivaten
GB1310510A (en) * 1969-06-10 1973-03-21 Zundel J Preparation of alpha-aminoacids from hydantoins
GB1456857A (en) * 1972-11-24 1976-12-01 Teijin Ltd Process for the production of hydantoin derivatives
US4175198A (en) * 1976-10-07 1979-11-20 W. R. Grace & Co. 5-Secondary alkylidene hydantoins
JPS54106470A (en) * 1978-02-09 1979-08-21 Ajinomoto Co Inc Preparation of 5-aryl-hydantoin
JPS54106469A (en) * 1978-02-09 1979-08-21 Ajinomoto Co Inc Preparation of 5-aryl-hydantoin
JPS54128572A (en) * 1978-03-25 1979-10-05 Ajinomoto Co Inc Preparation of 5-arylhydantoin
JPS54138559A (en) * 1978-04-19 1979-10-27 Ajinomoto Co Inc Preparation of 5-aryl-hydantoin
DE3013626C2 (de) * 1980-04-09 1985-06-27 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von 5-Arylidenhydantoinen (A)

Also Published As

Publication number Publication date
EP0156582A1 (en) 1985-10-02
ES541070A0 (es) 1985-12-01
US4647694A (en) 1987-03-03
ES8601854A1 (es) 1985-12-01
DK109985A (da) 1985-09-13
ATE37177T1 (de) 1988-09-15
DE3564938D1 (en) 1988-10-20
JPS60204750A (ja) 1985-10-16
FI850970A0 (fi) 1985-03-12
PL252344A1 (en) 1985-11-19
RO92676A (ro) 1987-11-30
FI850970L (fi) 1985-09-13
YU39085A (en) 1987-04-30
AU3968185A (en) 1985-09-19
NO850943L (no) 1985-09-13
DD232260A5 (de) 1986-01-22
IL74389A0 (en) 1985-05-31
HU204026B (en) 1991-11-28
DK109985D0 (da) 1985-03-11
EP0156582B1 (en) 1988-09-14
HUT39717A (en) 1986-10-29
BG43688A3 (en) 1988-07-15
SU1468409A3 (ru) 1989-03-23

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