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RO84583B - Procedeu pentru prepararea unor derivati de piranona - Google Patents

Procedeu pentru prepararea unor derivati de piranona

Info

Publication number
RO84583B
RO84583B RO108192A RO10819280A RO84583B RO 84583 B RO84583 B RO 84583B RO 108192 A RO108192 A RO 108192A RO 10819280 A RO10819280 A RO 10819280A RO 84583 B RO84583 B RO 84583B
Authority
RO
Romania
Prior art keywords
compound
general formula
preparing
lower alkyl
derivatives
Prior art date
Application number
RO108192A
Other languages
English (en)
Other versions
RO84583A (ro
Inventor
Barry Peter Clark
William James Ross
Alec Todd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of RO84583A publication Critical patent/RO84583A/ro
Publication of RO84583B publication Critical patent/RO84583B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Prezenta inventie se refera la un procedeu pentru prepararea unor derivati de piranona cu formula generala I: (vezi form. in desc.) în care R1 reprezinta o grupare COOR5 în care R5 este hidrogen sau radical alchil inferior R2 este un radical fenil eventual substituit cu un atom halogen cu o grupa hidroxi sau alcoxi inferior R3 reprezinta proprietati farmacologic care consta în aceea ca un compus cu formula generala II: (vezi form. in desc.) în care R2 si R3 au semnificatiile sus-mentionate reactioneaza cu un acid la fierbere ales dintre acid formic sau halogen între 0....110 degree C si daca se doreste produsul în care R5 este alchil inferior se transformaîntr-un compus în care R5 este un atom de hidrogen.
RO108192A 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona RO84583B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7912062 1979-04-05

Publications (2)

Publication Number Publication Date
RO84583A RO84583A (ro) 1984-07-17
RO84583B true RO84583B (ro) 1984-09-30

Family

ID=10504371

Family Applications (3)

Application Number Title Priority Date Filing Date
RO108192A RO84583B (ro) 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona
RO80100748A RO80248A (ro) 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona
RO108190A RO84586B (ro) 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona

Family Applications After (2)

Application Number Title Priority Date Filing Date
RO80100748A RO80248A (ro) 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona
RO108190A RO84586B (ro) 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona

Country Status (32)

Country Link
US (3) US4304728A (ro)
JP (1) JPS55133375A (ro)
AR (4) AR224149A1 (ro)
AT (1) AT371456B (ro)
AU (1) AU536369B2 (ro)
BE (1) BE882643A (ro)
CA (1) CA1142526A (ro)
CH (1) CH645370A5 (ro)
CS (4) CS222186B2 (ro)
DD (1) DD150001A5 (ro)
DE (1) DE3012584A1 (ro)
DK (1) DK142080A (ro)
ES (1) ES490121A0 (ro)
FI (1) FI801019A (ro)
FR (2) FR2453169A1 (ro)
GB (2) GB2047698B (ro)
GR (1) GR67747B (ro)
HU (1) HU182115B (ro)
IE (1) IE49658B1 (ro)
IL (1) IL59747A (ro)
IT (1) IT1143085B (ro)
LU (1) LU82335A1 (ro)
NL (1) NL8002024A (ro)
NZ (1) NZ193344A (ro)
PH (1) PH16517A (ro)
PL (4) PL123699B1 (ro)
PT (1) PT71049A (ro)
RO (3) RO84583B (ro)
SE (1) SE8002514L (ro)
SU (1) SU1083909A3 (ro)
YU (1) YU91980A (ro)
ZA (1) ZA801978B (ro)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644071A (en) * 1984-07-11 1987-02-17 G. D. Searle & Co. Aralkoxy and aryloxyalkoxy kojic acid derivatives
DK59688A (da) * 1987-03-20 1988-09-21 Hoffmann La Roche Styrylketoner
CN1087296C (zh) * 1996-04-26 2002-07-10 第一制药株式会社 制备四氢中氮茚的方法
TW587079B (en) * 1998-09-25 2004-05-11 Almirall Prodesfarma Ag 2-phenylpyran-4-one derivatives
PE20011333A1 (es) * 2000-03-16 2002-01-16 Almirall Prodesfarma Ag Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2
MXPA02012405A (es) * 2000-06-16 2003-06-06 Bristol Myers Squibb Co Inhibidores de integrasa del virus de inmunodeficiencia humana.
ES2213485B1 (es) * 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
US8252938B2 (en) 2009-06-08 2012-08-28 Dow Agrosciences, Llc. Process for the preparation of 6-(aryl)-4-aminopicolinates
US8598086B2 (en) 2009-06-08 2013-12-03 Dow Agrosciences, Llc. 3-halo-(arly)-4-iminotetrahydropicolinates and their use as herbicides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065290A (en) * 1975-07-03 1977-12-27 Eli Lilly And Company Herbicidal β-phenyl-4-piperidinones
US4060533A (en) * 1976-06-25 1977-11-29 Sandoz, Inc. Pyranone carboxamides

Also Published As

Publication number Publication date
PL123699B1 (en) 1982-11-30
FR2493147B1 (ro) 1985-02-15
IE49658B1 (en) 1985-11-13
GB2123813B (en) 1984-07-18
FI801019A (fi) 1980-10-06
GR67747B (ro) 1981-09-16
ZA801978B (en) 1981-09-30
PT71049A (en) 1980-05-01
IT1143085B (it) 1986-10-22
PL223228A1 (ro) 1981-01-30
AR224149A1 (es) 1981-10-30
FR2453169B1 (ro) 1985-03-08
GB2047698A (en) 1980-12-03
CS222199B2 (en) 1983-05-27
US4448787A (en) 1984-05-15
IE800670L (en) 1980-10-05
US4471129A (en) 1984-09-11
RO84583A (ro) 1984-07-17
US4304728A (en) 1981-12-08
HU182115B (en) 1983-12-28
NZ193344A (en) 1983-06-14
AT371456B (de) 1983-06-27
LU82335A1 (fr) 1981-12-02
GB2123813A (en) 1984-02-08
IL59747A0 (en) 1980-06-30
IL59747A (en) 1983-12-30
JPS55133375A (en) 1980-10-17
CS222197B2 (en) 1983-05-27
GB8312569D0 (en) 1983-06-08
DE3012584A1 (de) 1980-10-16
AR224318A1 (es) 1981-11-13
AR226127A1 (es) 1982-05-31
YU91980A (en) 1983-02-28
RO84586B (ro) 1984-09-30
CA1142526A (en) 1983-03-08
AR226126A1 (es) 1982-05-31
PL123812B1 (en) 1982-11-30
SU1083909A3 (ru) 1984-03-30
ATA181980A (de) 1982-11-15
DD150001A5 (de) 1981-08-12
ES8104267A1 (es) 1981-04-01
NL8002024A (nl) 1980-10-07
SE8002514L (sv) 1980-10-06
FR2453169A1 (fr) 1980-10-31
CS222186B2 (en) 1983-05-27
ES490121A0 (es) 1981-04-01
PH16517A (en) 1983-11-08
AU5703280A (en) 1980-10-09
RO84586A (ro) 1984-07-17
CH645370A5 (fr) 1984-09-28
IT8048347A0 (it) 1980-04-04
AU536369B2 (en) 1984-05-03
CS222198B2 (en) 1983-05-27
PL123811B1 (en) 1982-11-30
RO80248A (ro) 1982-12-06
FR2493147A1 (fr) 1982-05-07
DK142080A (da) 1980-10-06
GB2047698B (en) 1983-10-19
PL123813B1 (en) 1982-11-30
BE882643A (fr) 1980-10-03

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