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RO83981B1 - 1,1'-oxybis-(4 n-benzamido)-benzene derivatives and process for preparing the same - Google Patents

1,1'-oxybis-(4 n-benzamido)-benzene derivatives and process for preparing the same

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Publication number
RO83981B1
RO83981B1 RO106358A RO10635882A RO83981B1 RO 83981 B1 RO83981 B1 RO 83981B1 RO 106358 A RO106358 A RO 106358A RO 10635882 A RO10635882 A RO 10635882A RO 83981 B1 RO83981 B1 RO 83981B1
Authority
RO
Romania
Prior art keywords
methoxy
hydrogen
oxybis
benzamido
preparing
Prior art date
Application number
RO106358A
Other languages
Romanian (ro)
Other versions
RO83981A2 (en
Inventor
Elisabeta Raluca Bogza
Ecaterina Ioana Cunescu
Stefan Cilianu-Bibian
Alexandru Carstea
CONSTANTIN EMIL SîRBU
Original Assignee
Institutul De Cercetari Chimico-Farmaceutice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institutul De Cercetari Chimico-Farmaceutice filed Critical Institutul De Cercetari Chimico-Farmaceutice
Priority to RO106358A priority Critical patent/RO83981B1/en
Publication of RO83981A2 publication Critical patent/RO83981A2/en
Publication of RO83981B1 publication Critical patent/RO83981B1/en

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Abstract

Inventia se refera la noi derivati cu formula generala I: (vezi formula) în care R1 este hidrogen, hidroxi, metoxi sau etoxi, R2 este hidrogen, metil sau metoxi, R3 este hidrogen, clor, amino, metoxi sau etoxi, R4 este hidrogen, clor sau metoxi si sunt substante cristaline, albe cu puncte de topire în intervalul 57...186 degree C care se obtin prin aceea ca, 1,1'-oxi-bis-(2-clor-4-amino-3'-metil)-benzenul se trateaza cu acizi benzoici substituiti cu formula generala II: (vezi formula) în care R1, R2, R3, R4, R5 au semnificatiile mentionate mai sus, în prezenta de triclorura de fosfor, la temperatura de reflux.The invention relates to novel derivatives of general formula I wherein R1 is hydrogen, hydroxy, methoxy or ethoxy, R2 is hydrogen, methyl or methoxy, R3 is hydrogen, chloro, amino, methoxy or ethoxy, R4 is hydrogen , chlorine or methoxy and are crystalline white crystals having melting points ranging from 57 to 186 ° C, which are obtained by reacting 1,1'-oxybis (2-chloro-4-amino-3 ' -methyl) -benzene is treated with substituted benzoic acids of the general formula II wherein R1, R2, R3, R4, R5 are as defined above, in the presence of phosphorus trichloride, at reflux temperature.

RO106358A 1982-01-19 1982-01-19 1,1'-oxybis-(4 n-benzamido)-benzene derivatives and process for preparing the same RO83981B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RO106358A RO83981B1 (en) 1982-01-19 1982-01-19 1,1'-oxybis-(4 n-benzamido)-benzene derivatives and process for preparing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO106358A RO83981B1 (en) 1982-01-19 1982-01-19 1,1'-oxybis-(4 n-benzamido)-benzene derivatives and process for preparing the same

Publications (2)

Publication Number Publication Date
RO83981A2 RO83981A2 (en) 1984-04-12
RO83981B1 true RO83981B1 (en) 1984-05-30

Family

ID=20110973

Family Applications (1)

Application Number Title Priority Date Filing Date
RO106358A RO83981B1 (en) 1982-01-19 1982-01-19 1,1'-oxybis-(4 n-benzamido)-benzene derivatives and process for preparing the same

Country Status (1)

Country Link
RO (1) RO83981B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9353099B2 (en) 2010-04-27 2016-05-31 Calcimedica, Inc. Compounds that modulate intracellular calcium

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9353099B2 (en) 2010-04-27 2016-05-31 Calcimedica, Inc. Compounds that modulate intracellular calcium

Also Published As

Publication number Publication date
RO83981A2 (en) 1984-04-12

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