RO83309A - Procedeu pentru prepararea (-)-n-metil-3-(2-metil-fenoxi)-3-fenilpropilaminei - Google Patents

Procedeu pentru prepararea (-)-n-metil-3-(2-metil-fenoxi)-3-fenilpropilaminei

Info

Publication number: RO83309A
Authority: RO; Romania
Prior art keywords: methyl; phenylpropylamine; phenoxy; preparation; enantiomer
Prior art date: 1980-11-14

Application number

RO81105785A

Other languages

English (en)

French (fr)

Other versions

RO83309B (ro

Inventor

Bennie J Foster

Edwuard R Lavagnino

Original Assignee

Eli Lilly And Co,Us

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-11-14

Filing date

1981-11-12

Publication date

1984-02-21

1981-11-12 Application filed by Eli Lilly And Co,Us filed Critical Eli Lilly And Co,Us

1984-02-21 Publication of RO83309A publication Critical patent/RO83309A/ro

1984-02-28 Publication of RO83309B publication Critical patent/RO83309B/ro

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Luminescent Compositions (AREA)
Photoreceptors In Electrophotography (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)
Anti-Oxidant Or Stabilizer Compositions (AREA)
Indole Compounds (AREA)

RO105785A 1980-11-14 1981-11-12 Procedeu pentru prepararea (-)-n-metil-3-(2-metil-fenoxi)-3-fenilpropilaminei RO83309B (ro)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US20649880A	1980-11-14	1980-11-14

Publications (2)

Publication Number	Publication Date
RO83309A true RO83309A (ro)	1984-02-21
RO83309B RO83309B (ro)	1984-02-28

Family

ID=22766667

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RO105785A RO83309B (ro)	1980-11-14	1981-11-12	Procedeu pentru prepararea (-)-n-metil-3-(2-metil-fenoxi)-3-fenilpropilaminei

Country Status (28)

Country	Link
EP (1)	EP0052492B1 (ro)
JP (3)	JPS57114555A (ro)
KR (1)	KR830007508A (ro)
AT (1)	ATE6422T1 (ro)
AU (1)	AU540707B2 (ro)
CA (1)	CA1181430A (ro)
CS (1)	CS227019B2 (ro)
CY (1)	CY1350A (ro)
DD (1)	DD201139A5 (ro)
DE (1)	DE3162445D1 (ro)
DK (1)	DK161887C (ro)
EG (1)	EG15458A (ro)
ES (1)	ES8206440A1 (ro)
FI (1)	FI77018C (ro)
GB (1)	GB2087883A (ro)
GR (1)	GR75395B (ro)
HK (1)	HK16087A (ro)
HU (1)	HU185475B (ro)
IE (1)	IE52170B1 (ro)
IL (1)	IL64288A (ro)
MY (1)	MY8700709A (ro)
NZ (1)	NZ198953A (ro)
PH (1)	PH17424A (ro)
PL (1)	PL233786A1 (ro)
PT (1)	PT73982B (ro)
RO (1)	RO83309B (ro)
SU (1)	SU1068034A3 (ro)
ZA (1)	ZA817863B (ro)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4777291A (en) *	1985-02-27	1988-10-11	Eli Lilly And Company	Racemization process
US4797286A (en) *	1985-11-12	1989-01-10	Eli Lilly And Company	Orally administerable sustained release pharmaceutical formulations
US5112619A (en) *	1985-11-12	1992-05-12	Eli Lilly And Company	Orally administerable sustained release pharmaceutical formulation
GB8823405D0 (en) *	1988-10-05	1988-11-09	Erba Carlo Spa	Aryloxy-arythio-heteraryloxy-heteroarylthio-alkenylene derivatives of amines
DK258389D0 (da) *	1989-05-26	1989-05-26	Ferrosan As	Aryloxyphenylpropylaminer, deres fremstilling og anvendelse
CA2061665C (en) *	1991-02-25	2002-04-16	Mark Mortensen Foreman	Treatment of lower urinary tract disorders
CA2112487C (en) *	1991-06-26	2003-04-15	James W. Young	Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
JPH07500812A (ja) *	1991-11-15	1995-01-26	セプラコア，インコーポレーテッド	純粋なフルオキセチンのｓ（＋）異性体を用いる方法および組成物
JPH07501547A (ja) *	1991-11-26	1995-02-16	セプラコア，インコーポレーテッド	光学的に純粋な（−）アムロジピンを用いる，高血圧，狭心症および他の疾患を治療するための方法および組成物
EP0576766A1 (en) *	1992-06-29	1994-01-05	Novo Nordisk A/S	Propanolamine derivatives, their preparation and use
TW344661B (en) *	1993-11-24	1998-11-11	Lilly Co Eli	Pharmaceutical composition for treatment of incontinence
US8071128B2 (en)	1996-06-14	2011-12-06	Kyowa Hakko Kirin Co., Ltd.	Intrabuccally rapidly disintegrating tablet and a production method of the tablets
JP2002538102A (ja)	1999-03-01	2002-11-12	セプラコアインコーポレーテッド	光学的に純粋なｒ（＋）オンダンセトロンを使用する無呼吸および無呼吸障害の治療方法
WO2000058262A1 (en) *	1999-03-29	2000-10-05	Eli Lilly And Company	Stereospecific method for preparing tomoxetine and intermediates thereof
DE60023870T2 (de)	1999-04-09	2006-06-14	Lilly Co Eli	Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte
DE19955190A1 (de) *	1999-11-16	2001-06-21	Sanol Arznei Schwarz Gmbh	Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen
WO2003079972A2 (en)	2002-02-22	2003-10-02	New River Parmaceuticals Inc.	Active agent delivery systems and methods for protecting and administering active agents
US9358214B2 (en)	2001-10-04	2016-06-07	Adare Pharmaceuticals, Inc.	Timed, sustained release systems for propranolol
GB0229583D0 (en)	2002-12-19	2003-01-22	Cipla Ltd	A process for preparing duloxetine and intermediates for use therein
US8367111B2 (en)	2002-12-31	2013-02-05	Aptalis Pharmatech, Inc.	Extended release dosage forms of propranolol hydrochloride
US8545881B2 (en)	2004-04-19	2013-10-01	Eurand Pharmaceuticals, Ltd.	Orally disintegrating tablets and methods of manufacture
US7355078B2 (en)	2004-06-28	2008-04-08	Teva Pharmaceutical Fine Chemicals S.R.L.	Processes for the preparation of tomoxetine
US7439399B2 (en) *	2004-06-28	2008-10-21	Teva Pharmaceutical Fine Chemicals	Processes for the preparation of atomoxetine hydrochloride
CN1976894A (zh)	2004-07-22	2007-06-06	特瓦药物精化学品股份有限公司	阿托莫西汀盐酸盐的多形体
US8747895B2 (en)	2004-09-13	2014-06-10	Aptalis Pharmatech, Inc.	Orally disintegrating tablets of atomoxetine
US9884014B2 (en)	2004-10-12	2018-02-06	Adare Pharmaceuticals, Inc.	Taste-masked pharmaceutical compositions
EP1802285B1 (en)	2004-10-21	2013-02-27	Aptalis Pharmatech, Inc.	Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
EP1751085A1 (en) *	2005-04-05	2007-02-14	Teva Pharmaceutical Fine Chemicals S.R.L.	Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability
EP1889828A1 (en) *	2005-04-05	2008-02-20	Teva Pharmaceutical Fine Chemicals S.R.L.	Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability
US9161918B2 (en)	2005-05-02	2015-10-20	Adare Pharmaceuticals, Inc.	Timed, pulsatile release systems
US7485754B2 (en)	2005-07-08	2009-02-03	Apotex Pharmachem Inc.	Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers
CZ296345B6 (cs) *	2005-07-21	2006-02-15	Zentiva, A. S	Zpusob výroby hydrochloridu (R)-N-methyl-3-(2-methylfenoxy)-3-fenylpropylaminu (atomoxetinu)
EP1798215A1 (en)	2005-12-14	2007-06-20	SOLMAG S.p.A.	Polymorph of atomoxetine hydrochloride in crystalline form
ITMI20061987A1 (it) *	2006-10-16	2008-04-17	Archimica Srl	Processo per la sintesi di arilossipropilammine ed eteroarilossipropilammine.
WO2008062473A1 (en) *	2006-10-31	2008-05-29	Cadila Healthcare Limited	Process for preparing atomoxetine hydrochloride
CN100430370C (zh) *	2006-11-03	2008-11-05	华东理工大学	一种丙胺衍生物及其在制备托莫西汀中的应用
WO2009141833A2 (en) *	2008-04-17	2009-11-26	Ind-Swift Laboratories Limited	An improved process for synthesizing highly pure atomoxetine
EP2506836B1 (en)	2009-12-02	2018-02-14	Adare Pharmaceuticals S.R.L.	Fexofenadine microcapsules and compositions containing them
PL2838510T3 (pl)	2013-11-08	2017-09-29	Eli Lilly And Company	Roztwór atomoksetyny
GR1008531B (el)	2014-03-21	2015-07-13	Λαμδα Φαρμακευτικα Εργαστηρια Εφαμροσμενης Ερευνας Και Αναπτυξης Α.Ε.,	Ποσιμα διαλυματα που περιεχουν υδροχλωρικη ατομοξετινη
EP3069715A1 (en)	2015-03-20	2016-09-21	Salmon Pharma GmbH	Immediate release dosage forms of Atomoxetine
CN106916074A (zh) *	2017-02-14	2017-07-04	万特制药(海南)有限公司	盐酸托莫西汀的制备
CN110294680A (zh) *	2018-03-22	2019-10-01	北京深蓝海生物医药科技有限公司	一种盐酸阿托莫西汀的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4194009A (en) *	1974-01-10	1980-03-18	Eli Lilly And Company	Aryloxyphenylpropylamines for obtaining a psychotropic effect
US4018895A (en) *	1974-01-10	1977-04-19	Eli Lilly And Company	Aryloxyphenylpropylamines in treating depression
JPS5283811A (en) *	1976-01-01	1977-07-13	Lilly Co Eli	Aryloxy phenyl propylamines and their salts
GB1596033A (en) *	1978-04-25	1981-08-19	Boots Co Ltd	(-)-(2-methoxyphenyl) ethylamine
JPS5536403A (en) *	1978-07-28	1980-03-14	Nippon Iyakuhin Kogyo Kk	Preparation of 1-benzazonine derivative
IT1113029B (it) *	1979-03-01	1986-01-20	Simes	Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro

1981
- 1981-11-12 PL PL23378681A patent/PL233786A1/xx unknown
- 1981-11-12 CA CA000389954A patent/CA1181430A/en not_active Expired
- 1981-11-12 FI FI813589A patent/FI77018C/fi not_active IP Right Cessation
- 1981-11-12 RO RO105785A patent/RO83309B/ro unknown
- 1981-11-12 PT PT73982A patent/PT73982B/pt not_active IP Right Cessation
- 1981-11-12 GR GR66518A patent/GR75395B/el unknown
- 1981-11-12 ZA ZA817863A patent/ZA817863B/xx unknown
- 1981-11-12 AU AU77427/81A patent/AU540707B2/en not_active Ceased
- 1981-11-12 NZ NZ198953A patent/NZ198953A/en unknown
- 1981-11-13 EP EP81305387A patent/EP0052492B1/en not_active Expired
- 1981-11-13 SU SU813355735A patent/SU1068034A3/ru active
- 1981-11-13 DD DD81234837A patent/DD201139A5/de not_active IP Right Cessation
- 1981-11-13 AT AT81305387T patent/ATE6422T1/de not_active IP Right Cessation
- 1981-11-13 CY CY135081A patent/CY1350A/xx unknown
- 1981-11-13 PH PH26491A patent/PH17424A/en unknown
- 1981-11-13 CS CS818359A patent/CS227019B2/cs unknown
- 1981-11-13 JP JP56182953A patent/JPS57114555A/ja active Granted
- 1981-11-13 HU HU813411A patent/HU185475B/hu not_active IP Right Cessation
- 1981-11-13 GB GB8134282A patent/GB2087883A/en active Pending
- 1981-11-13 IE IE2661/81A patent/IE52170B1/en not_active IP Right Cessation
- 1981-11-13 DK DK502781A patent/DK161887C/da active
- 1981-11-13 DE DE8181305387T patent/DE3162445D1/de not_active Expired
- 1981-11-13 ES ES507142A patent/ES8206440A1/es not_active Expired
- 1981-11-14 EG EG662/81A patent/EG15458A/xx active
- 1981-11-14 KR KR1019810004404A patent/KR830007508A/ko unknown
- 1981-11-15 IL IL64288A patent/IL64288A/xx not_active IP Right Cessation
1987
- 1987-02-19 HK HK160/87A patent/HK16087A/xx not_active IP Right Cessation
- 1987-12-30 MY MY709/87A patent/MY8700709A/xx unknown
1990
- 1990-06-05 JP JP2147167A patent/JPH037251A/ja active Granted
- 1990-06-05 JP JP2147166A patent/JPH037250A/ja active Granted

Also Published As

Publication number	Publication date
SU1068034A3 (ru)	1984-01-15
ES507142A0 (es)	1982-08-16
EP0052492A1 (en)	1982-05-26
ES8206440A1 (es)	1982-08-16
NZ198953A (en)	1984-10-19
JPH037251A (ja)	1991-01-14
JPH037250A (ja)	1991-01-14
ZA817863B (en)	1983-06-29
IE812661L (en)	1982-05-14
AU7742781A (en)	1982-05-20
JPH0369885B2 (ro)	1991-11-05
JPH046698B2 (ro)	1992-02-06
CY1350A (en)	1987-04-24
IE52170B1 (en)	1987-07-22
DD201139A5 (de)	1983-07-06
PT73982A (en)	1981-12-01
JPH046699B2 (ro)	1992-02-06
KR830007508A (ko)	1983-10-21
IL64288A (en)	1985-04-30
GR75395B (ro)	1984-07-13
ATE6422T1 (de)	1984-03-15
PH17424A (en)	1984-08-08
RO83309B (ro)	1984-02-28
FI77018C (fi)	1989-01-10
EG15458A (en)	1986-09-30
DE3162445D1 (de)	1984-04-05
DK161887B (da)	1991-08-26
CA1181430A (en)	1985-01-22
DK502781A (da)	1982-05-15
MY8700709A (en)	1987-12-31
CS227019B2 (en)	1984-04-16
PL233786A1 (ro)	1982-05-24
AU540707B2 (en)	1984-11-29
GB2087883A (en)	1982-06-03
DK161887C (da)	1992-03-16
PT73982B (en)	1983-11-23
FI77018B (fi)	1988-09-30
FI813589L (fi)	1982-05-15
EP0052492B1 (en)	1984-02-29
IL64288A0 (en)	1982-02-28
HK16087A (en)	1987-02-27
JPS57114555A (en)	1982-07-16
HU185475B (en)	1985-02-28

Publication	Publication Date	Title
RO83309A (ro)	1984-02-21	Procedeu pentru prepararea (-)-n-metil-3-(2-metil-fenoxi)-3-fenilpropilaminei
ES518227A0 (es)	1984-01-01	Procedimiento para preparar nuevos compuestos de cefem.
RO76562A (fr)	1981-04-30	Procede pour la preparation des 3-imidazolilbenzo-1,2,4-triazine-1-oxydes
RO78231A (ro)	1982-02-01	Procedeu pentru prepararea unor 4h-1,3-tiazin-4-one
RO78225A (ro)	1982-02-01	Procedeu pentru prepararea unor 3,4-dihidro-3-oxo-2-chinoxaline
MA18680A1 (fr)	1980-07-01	Cynamides substitues, procede pour leur preparation et leur utlisation comme fongicides
RO77772A (ro)	1981-11-24	Procedeu pentru prepararea unor derivati de acizi 2,2-dimetilcicloropancarboxilici
RO78492A (ro)	1982-02-26	Procedeu pentru prepararea unor derivati ai acizilor 1,3,4-tiadiazoli-2-carboxilici
FR2525219B1 (fr)	1986-04-04	Procede pour la preparation de 4-hydroxy-2-methyl-2h-1,2-benzothiazine-3-carboxamide-1-1-dioxydes
PT77133A (fr)	1983-08-01	Procede pour la preparation de 1,3-dyoxole <4,5-g> quinolines
FR2433009A1 (fr)	1980-03-07	Procede pour la preparation de dicyclopentylene(2,2'-bis(4-alkyl-6-t-butylphenols))
IT7925525A0 (it)	1979-09-06	Processo per la preparazione di2,2'-bis/4-(1,1,3,3-tetrametilbutil) fenol/solfuro.
RO86358A2 (ro)	1985-03-15	Procedeu pentru prepararea unor 1,2,4-triazolil-u-il-propionitrili
IT1123138B (it)	1986-04-30	Processo per la preparazione di 2,2'-bis(fenol 4-sostituito)solfuri
BR8305272A (pt)	1984-05-02	Composto de 1,2,3,4-tetra-hidro-1-aminometil-4-fenil-isoquinolina e processo de preparacao
BE873495A (fr)	1979-07-16	Procede pour la preparation de la 2,4-difluoro-6-amino-s-triazine
RO82505A (ro)	1983-09-26	Procedeu pentru prepararea unor derivati de chinoxalinil-1,4-dioxizi$procedeu pentru prepararea unor derivati de chinoxalinil-1,4-dioxizi
RO89060A (ro)	1986-04-30	Procedeu pentru prepararea unor 6,16-dimetilcorticoide
PT69571A (fr)	1979-06-01	Procede pour la preparation de (2,6-diclorobencilydin-amine)-guanidine
RO74912A2 (ro)	1980-09-30	Procedeu de preparare a unor 2,4-dialchilamino-6-alchiltio-s-triazine
IT8123360A0 (it)	1981-08-04	Processo per la preparazione di2,6)dimetilfenilidrazina o dei suoi sali.
RO83120A2 (ro)	1984-02-21	Procedeu de preparare a 1,1,2-triariletenelor
RO76730A (ro)	1981-06-22	Procedeu pentru prepararea unor derivati de 2,3-dicianpirazina