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RO81936B - Procedeu pentru prepararea unor derivati ai acidului 7 beta -aminotiazolil- acetamido-3-cefem-4-carboxilic - Google Patents

Procedeu pentru prepararea unor derivati ai acidului 7 beta -aminotiazolil- acetamido-3-cefem-4-carboxilic

Info

Publication number
RO81936B
RO81936B RO105231A RO10523179A RO81936B RO 81936 B RO81936 B RO 81936B RO 105231 A RO105231 A RO 105231A RO 10523179 A RO10523179 A RO 10523179A RO 81936 B RO81936 B RO 81936B
Authority
RO
Romania
Prior art keywords
aminothiazolylacetamido
cephem
beta
preparation
carboxylic acid
Prior art date
Application number
RO105231A
Other languages
English (en)
Other versions
RO81936A (ro
Inventor
Riccardo Scartazzini
Rene Wiederkehr
Original Assignee
Ciba-Geigy A.G.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba-Geigy A.G. filed Critical Ciba-Geigy A.G.
Publication of RO81936B publication Critical patent/RO81936B/ro
Publication of RO81936A publication Critical patent/RO81936A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati ai acidului 7 beta-aminotiazolilacetamido-3-cefem-4-carboxilic cu formula generala I: (vezi formula) în care substituentul R reprezinta o grupa aciloximetil aleasa dintre pivaloiloximetil si hexanoilximetil, în care o sare de metal alcalin a unui acid cu formula II: (vezi formula) în care X este metal alcalin si grupa amino este eventual, protejata, se trateaza cu o halogenura aleasa dintre clorura de pivaloilloximetil si iodura de hexanoiloximetil, eventual în prezenta de iodura de sodiu, într-un solvent inert ales dintre acetona si dimetilformamida, la o temperatura cuprinsa între -40 degree C si temperatura camerei, dupa care compusul în care grupa amino este protejata se scindeaza, în mod cunoscut, pentru îndepartarea grupei de protectie, iar compusul cu formula I obtinut se transforma daca se doreste într-o sare acceptabila farmaceutic.
RO79105231A 1978-07-07 1979-07-04 Procedeu pentru prepararea unor derivati ai acidului 7 beta-aminotiazolilacetamido-3-cefem-4-carboxilic RO81936A (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH742278 1978-07-07
CH1301678 1978-12-21

Publications (2)

Publication Number Publication Date
RO81936B true RO81936B (ro) 1983-05-30
RO81936A RO81936A (ro) 1983-06-01

Family

ID=25701313

Family Applications (3)

Application Number Title Priority Date Filing Date
RO79105231A RO81936A (ro) 1978-07-07 1979-07-04 Procedeu pentru prepararea unor derivati ai acidului 7 beta-aminotiazolilacetamido-3-cefem-4-carboxilic
RO7998045A RO77940A (ro) 1978-07-07 1979-07-04 Procedeu pentru prepararea unor derivati ai acidului 7beta-aminotiazolilacetamido-3-cefem-4-carboxilic
RO79105230A RO81937A (ro) 1978-07-07 1979-07-04 Procedeu pentru prepararea unor derivati ai acidului 7 beta-aminotiazolilacetamido-3-cefem-4-carboxilic

Family Applications After (2)

Application Number Title Priority Date Filing Date
RO7998045A RO77940A (ro) 1978-07-07 1979-07-04 Procedeu pentru prepararea unor derivati ai acidului 7beta-aminotiazolilacetamido-3-cefem-4-carboxilic
RO79105230A RO81937A (ro) 1978-07-07 1979-07-04 Procedeu pentru prepararea unor derivati ai acidului 7 beta-aminotiazolilacetamido-3-cefem-4-carboxilic

Country Status (17)

Country Link
EP (1) EP0008343B1 (ro)
BG (8) BG34458A3 (ro)
CS (3) CS216935B2 (ro)
DD (1) DD144779A5 (ro)
DK (1) DK286779A (ro)
EG (1) EG14607A (ro)
ES (1) ES482194A1 (ro)
FI (1) FI792112A (ro)
GR (1) GR73032B (ro)
HU (1) HU182020B (ro)
IL (1) IL57735A (ro)
MA (1) MA18686A1 (ro)
NO (1) NO792265L (ro)
OA (1) OA06287A (ro)
PL (1) PL216945A1 (ro)
PT (1) PT69884A (ro)
RO (3) RO81936A (ro)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78221B (ro) * 1980-02-01 1984-09-26 Ciba Geigy Ag
EP0054512A3 (de) * 1980-12-12 1983-08-03 Ciba-Geigy Ag Cephalosporinester, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
IT1142096B (it) * 1980-12-15 1986-10-08 Fujisawa Pharmaceutical Co Derivati dell'acido 7-acilammino cefalosporanico e procedimenti per la loro preparazione
JPS57193489A (en) * 1981-05-21 1982-11-27 Fujisawa Pharmaceut Co Ltd Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation
WO1984001949A1 (en) * 1982-11-10 1984-05-24 Kyoto Pharma Ind Cephalosporin derivatives, process and their preparation, and prophylactic and treating agent against bacterial infection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI771866A (ro) * 1976-06-28 1977-12-29 Fujisawa Pharmaceutical Co
ES467601A1 (es) * 1977-03-12 1979-06-16 Hoechst Ag Procedimiento para la preparacion de derivados de cefem.
US4370326A (en) * 1977-09-13 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and composition

Also Published As

Publication number Publication date
BG34461A3 (en) 1983-09-15
OA06287A (fr) 1981-06-30
BG34455A3 (en) 1983-09-15
RO81937B (ro) 1983-05-30
EP0008343A1 (de) 1980-03-05
PL216945A1 (ro) 1980-03-24
EG14607A (en) 1985-03-31
EP0008343B1 (de) 1983-04-06
DK286779A (da) 1980-01-08
ES482194A1 (es) 1980-04-01
FI792112A (fi) 1980-01-08
RO81936A (ro) 1983-06-01
CS216935B2 (en) 1982-12-31
HU182020B (en) 1983-12-28
PT69884A (en) 1979-08-01
BG34458A3 (en) 1983-09-15
BG34457A3 (en) 1983-09-15
BG34456A3 (en) 1983-09-15
RO81937A (ro) 1983-06-01
DD144779A5 (de) 1980-11-05
BG34454A3 (en) 1983-09-15
NO792265L (no) 1980-01-08
BG34460A3 (en) 1983-09-15
BG34459A3 (en) 1983-09-15
RO77940A (ro) 1981-12-25
CS216937B2 (en) 1982-12-31
IL57735A (en) 1985-03-31
CS216938B2 (en) 1982-12-31
MA18686A1 (fr) 1980-10-01
GR73032B (ro) 1984-01-26

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