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RO81766B - Procedeu pentru prepararea unor fenilalchilamine - Google Patents

Procedeu pentru prepararea unor fenilalchilamine

Info

Publication number
RO81766B
RO81766B RO86026A RO8602675A RO81766B RO 81766 B RO81766 B RO 81766B RO 86026 A RO86026 A RO 86026A RO 8602675 A RO8602675 A RO 8602675A RO 81766 B RO81766 B RO 81766B
Authority
RO
Romania
Prior art keywords
group
general formula
halogen
converted
addition salts
Prior art date
Application number
RO86026A
Other languages
English (en)
Other versions
RO81766A (ro
Inventor
Kurt Schromm
Anton Mentrup
Ernst Otto Renth
Pichler Ludwing
Original Assignee
C.H. Boehringer Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn filed Critical C.H. Boehringer Sohn
Publication of RO81766B publication Critical patent/RO81766B/ro
Publication of RO81766A publication Critical patent/RO81766A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor fenilalchilamine cu formula generala I: (vezi formula) în care R1 reprezinta o grupa -(CH2)n-R3, în care n este 1 sau 2, R3 reprezinta un atom de hidrogen sau grupa benzoil sau R1 este grupa -CO-R5 în care R5 reprezinta un atom de hidrogen, grupa -CH2-NH2 sau grupa -CH2-NH-OH2-C6H5, R2 reprezinta grupa nitro sau grupa -NH-CO-CH3 sau -NH-CO-NH2, consta în aceea ca, un compus cu formula generala II: (vezi formula) în care R2 are semnificatiile sus mentionate este condensat cu un derivat de acid carboxilic cu formula generala III: (vezi formula) în care X reprezinta un atom de halogen sau o grupa OR4, în care R4 este alchil inferior si R1 are semnificatia de mai sus, la fierbere si, în cazul în care X este halogen, în prezenta de carbonat de potasiu ca agent de captare a acidului halogenhidric si produsul obtinut, cînd se obtine de racemati se poate scinda eventual în antipozii optici respectivi si bazele cu formula generala I obtinute se transforma în sarurile lor de aditie cu acizii, obtinuti se transforma în bazele lor libere corespunzatoare sau în saruri de aditie cu alti acizi.
RO7586026A 1974-04-27 1975-04-25 Procedeu pentru prepararea unor fenilalchilamine RO81766A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2420618A DE2420618C2 (de) 1974-04-27 1974-04-27 Aminoalkylanilide, Verfahren zu ihrer Herstellung sowie pharmazeutische Zubereitungen, die diese Aminoalkylanilide enthalten

Publications (2)

Publication Number Publication Date
RO81766B true RO81766B (ro) 1983-05-30
RO81766A RO81766A (ro) 1983-06-01

Family

ID=5914207

Family Applications (2)

Application Number Title Priority Date Filing Date
RO7586026A RO81766A (ro) 1974-04-27 1975-04-25 Procedeu pentru prepararea unor fenilalchilamine
RO7582093A RO70894A (ro) 1974-04-27 1975-04-25 Procedeu pentru prepararea unor fenilalchilamine

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO7582093A RO70894A (ro) 1974-04-27 1975-04-25 Procedeu pentru prepararea unor fenilalchilamine

Country Status (27)

Country Link
US (1) US4015011A (ro)
JP (1) JPS5828269B2 (ro)
AT (1) AT350529B (ro)
BE (1) BE828430A (ro)
BG (2) BG27738A3 (ro)
CA (1) CA1061357A (ro)
CH (3) CH614697A5 (ro)
CS (2) CS216828B2 (ro)
DD (1) DD122374A5 (ro)
DE (1) DE2420618C2 (ro)
DK (1) DK180675A (ro)
ES (7) ES437032A1 (ro)
FI (1) FI63931C (ro)
FR (1) FR2268520B1 (ro)
GB (1) GB1501436A (ro)
HU (1) HU172615B (ro)
IE (1) IE42119B1 (ro)
IL (1) IL47170A (ro)
NL (1) NL7504917A (ro)
NO (1) NO141207C (ro)
PH (2) PH11982A (ro)
PL (2) PL96224B1 (ro)
RO (2) RO81766A (ro)
SE (2) SE411205B (ro)
SU (2) SU555843A3 (ro)
YU (1) YU105275A (ro)
ZA (1) ZA752685B (ro)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163060A (en) * 1974-04-08 1979-07-31 U.S. Philips Corporation Aralkylamino carboxylic acids and derivatives having spasmolytic activity
US4146645A (en) * 1974-04-27 1979-03-27 Boehringer Ingelheim Gmbh Hypertensive phenylalkylamines and salts thereof
US4145363A (en) * 1975-02-05 1979-03-20 Yamanouchi Pharmaceutical Co., Ltd. 4-Carbamoylamino-α-aminomethylbenzyl alcohol derivatives
US4088785A (en) * 1976-03-25 1978-05-09 William H. Rorer, Inc. Amidinoureas for the treatment of cardinascular disorders
US4754047A (en) * 1979-08-16 1988-06-28 American Cyanamid Company Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and/or improving the efficiency of feed utilization thereby
US4477470A (en) * 1983-10-20 1984-10-16 Smithkline Beckman Corporation Method for producing diuresis using m-amino-α-methylphenethylamine
JPS6155683U (ro) * 1984-09-17 1986-04-14
JPS61130876U (ro) * 1984-09-18 1986-08-15
AU4945185A (en) * 1984-11-08 1986-05-15 Syntex (U.S.A.) Inc. Dialkyl aminoethylaniline derivatives
US4752621A (en) * 1985-04-11 1988-06-21 Syntex (U.S.A.) Inc. Arylalkyl amines useful for lowering intraocular pressure
US4798687A (en) * 1987-02-06 1989-01-17 Pennwalt Corporation 2-Amino-N-[1,2-Diphenyl-1-(thifluoromethyl)ethyl]acetamide derivatives
JPH01116184U (ro) * 1988-01-29 1989-08-04
JPH01116183U (ro) * 1988-01-29 1989-08-04
US5741818A (en) 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
BR9809288A (pt) 1997-04-22 2001-08-07 Cocensys Inc Semicarbazonas e tiosemicarbazonas substituìdas carbocìclicas e heterocìclicas e utilização das mesmas
ATE299489T1 (de) * 1997-08-05 2005-07-15 Pola Chem Ind Inc Aminderivate und verfahren zu ihrer herstellung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL123536C (ro) * 1963-07-09

Also Published As

Publication number Publication date
DE2420618C2 (de) 1982-09-16
FR2268520B1 (ro) 1982-02-12
ZA752685B (en) 1976-12-29
HU172615B (hu) 1978-11-28
AU8051075A (en) 1976-10-28
YU105275A (en) 1982-02-28
ES452511A1 (es) 1977-11-01
IE42119L (en) 1975-10-27
JPS5828269B2 (ja) 1983-06-15
BG26372A4 (bg) 1979-03-15
IL47170A (en) 1980-07-31
PH11982A (en) 1978-10-04
ES452512A1 (es) 1977-11-01
FR2268520A1 (ro) 1975-11-21
US4015011A (en) 1977-03-29
CS216828B2 (en) 1982-11-26
SU555843A3 (ru) 1977-04-25
CH616146A5 (ro) 1980-03-14
NO141207C (no) 1980-01-30
CH614697A5 (ro) 1979-12-14
BG27738A3 (en) 1979-12-12
CS216827B2 (en) 1982-11-26
ES452513A1 (es) 1977-11-01
BE828430A (fr) 1975-10-27
FI751199A (ro) 1975-10-28
IL47170A0 (en) 1975-06-25
NO141207B (no) 1979-10-22
ES452515A1 (es) 1977-11-01
DD122374A5 (ro) 1976-10-05
ES452514A1 (es) 1977-11-01
FI63931B (fi) 1983-05-31
IE42119B1 (en) 1980-06-04
SE411205B (sv) 1979-12-10
NO751491L (ro) 1975-10-28
JPS50149630A (ro) 1975-11-29
ATA247875A (de) 1978-11-15
GB1501436A (en) 1978-02-15
PL96224B1 (pl) 1977-12-31
RO81766A (ro) 1983-06-01
SU606549A3 (ru) 1978-05-05
SE7504858L (sv) 1975-10-28
ES437032A1 (es) 1977-04-16
FI63931C (fi) 1983-09-12
DK180675A (da) 1975-10-28
CH616401A5 (ro) 1980-03-31
PH14732A (en) 1981-11-19
AT350529B (de) 1979-06-11
SE7810002L (sv) 1978-09-22
CA1061357A (en) 1979-08-28
ES452510A1 (es) 1977-11-01
NL7504917A (nl) 1975-10-29
DE2420618A1 (de) 1975-11-13
PL96308B1 (pl) 1977-12-31
RO70894A (ro) 1982-02-26

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