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RO72848B - Procedeu pentru prepararea unor derivati de antibiotic a 204 i - Google Patents

Procedeu pentru prepararea unor derivati de antibiotic a 204 i

Info

Publication number
RO72848B
RO72848B RO82851A RO8285175A RO72848B RO 72848 B RO72848 B RO 72848B RO 82851 A RO82851 A RO 82851A RO 8285175 A RO8285175 A RO 8285175A RO 72848 B RO72848 B RO 72848B
Authority
RO
Romania
Prior art keywords
general formula
preparing
compound
acid
antibiotic
Prior art date
Application number
RO82851A
Other languages
English (en)
Other versions
RO72848A (ro
Inventor
Hamill
Original Assignee
Eli Lilly And Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co filed Critical Eli Lilly And Co
Publication of RO72848B publication Critical patent/RO72848B/ro
Publication of RO72848A publication Critical patent/RO72848A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Feed For Specific Animals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedeu de preparare a antibioticului policiclic cu formula generala I: (vezi formula) în care Y reprezinta 0 sau S; R reprezinta radical alchil cu 1...6 atomi de carbon alchenil cu 2...5 atomi de carbon substituit cu mercapto, haloalchil inferior, caracterizat prin aceea ca se aduce în reactie un compus cu formula generala II, eventual sub forma de sare: (vezi formula) cu un compus cu formula generala III: H-Y-R în care Y si R are semnificatiile aratate mai sus, reactantii fiind luati în raport în greutate de 1:16...40 la temperatura camerei si presiune normala, eventual în prezenta de catalizator acid ales dintre acid clorhidric sau acid paratoluensulfonic, apoi amestecul de reactie este prelucrat în mod cunoscut în vederea separarii produsului de reactie.
RO7582851A 1974-11-15 1975-07-14 Procedeu pentru prepararea unor derivati de antibiotic a 204 i RO72848A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US524178A US3907832A (en) 1974-11-15 1974-11-15 Antibiotic A204I Derivatives

Publications (2)

Publication Number Publication Date
RO72848B true RO72848B (ro) 1983-06-30
RO72848A RO72848A (ro) 1983-07-07

Family

ID=24088092

Family Applications (1)

Application Number Title Priority Date Filing Date
RO7582851A RO72848A (ro) 1974-11-15 1975-07-14 Procedeu pentru prepararea unor derivati de antibiotic a 204 i

Country Status (27)

Country Link
US (1) US3907832A (ro)
JP (3) JPS5925769B2 (ro)
AR (1) AR204870A1 (ro)
AT (1) AT337899B (ro)
BE (1) BE831504A (ro)
BG (1) BG25199A3 (ro)
CA (1) CA1052779A (ro)
CH (1) CH614445A5 (ro)
CS (1) CS190501B2 (ro)
DD (1) DD122091A5 (ro)
DE (1) DE2531114A1 (ro)
DK (1) DK138498B (ro)
EG (1) EG12208A (ro)
ES (1) ES439566A1 (ro)
FR (1) FR2290909A1 (ro)
GB (1) GB1512648A (ro)
HU (1) HU175360B (ro)
IE (1) IE41401B1 (ro)
IL (1) IL47670A (ro)
IT (1) IT1044007B (ro)
NL (1) NL186962C (ro)
PH (1) PH11302A (ro)
PL (1) PL96940B1 (ro)
RO (1) RO72848A (ro)
SE (2) SE422214B (ro)
SU (1) SU565632A3 (ro)
ZA (1) ZA754602B (ro)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2408619A1 (fr) * 1977-10-07 1979-06-08 Rhone Poulenc Ind Nouvelle substance anticoccidienne et sa preparation par culture d'un streptomyces
GB2055094B (en) * 1979-07-11 1984-05-31 Int Minerals & Chem Corp Polyether antibiotic zinc complexes
US4356264A (en) * 1980-04-11 1982-10-26 International Minerals & Chemical Corp. Zinc-containing antibiotic agents
US4378433A (en) * 1980-04-11 1983-03-29 International Minerals & Chemical Corporation Method for producing zinc etheromycin from fermentation broths
US4478935A (en) * 1980-10-08 1984-10-23 International Minerals & Chemical Corp. Manganese-containing antibiotic agents
US4625041A (en) * 1984-02-17 1986-11-25 Pfizer Inc. Acidic polycyclic ether antibiotic
JPH055754Y2 (ro) * 1985-10-11 1993-02-15
US5152995A (en) * 1986-12-18 1992-10-06 Syntex (U.S.A.) Inc. Stable antibiotic ester feed compositions
US5239064A (en) * 1989-05-12 1993-08-24 Eli Lilly And Company A59770 antibiotics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705238A (en) * 1970-09-14 1972-12-05 Lilly Co Eli Antibiotics a204i and a204ii and method for production thereof

Also Published As

Publication number Publication date
SE7508102L (sv) 1976-05-17
SE7807978L (sv) 1978-07-19
US3907832A (en) 1975-09-23
NL186962B (nl) 1990-11-16
AU8306075A (en) 1977-01-20
FR2290909B1 (ro) 1979-08-10
EG12208A (en) 1978-09-30
JPS5925769B2 (ja) 1984-06-21
IT1044007B (it) 1980-02-29
DK138498B (da) 1978-09-18
ZA754602B (en) 1976-07-28
IL47670A (en) 1978-08-31
CA1052779A (en) 1979-04-17
DK138498C (ro) 1979-02-19
GB1512648A (en) 1978-06-01
BE831504A (fr) 1976-01-19
DE2531114C2 (ro) 1987-06-11
JPS6043097B2 (ja) 1985-09-26
DK328475A (ro) 1976-05-16
ATA554975A (de) 1976-11-15
CH614445A5 (ro) 1979-11-30
HU175360B (hu) 1980-07-28
JPS59108720A (ja) 1984-06-23
IE41401L (en) 1976-05-15
PH11302A (en) 1977-11-02
IE41401B1 (en) 1979-12-19
SE422214B (sv) 1982-02-22
AT337899B (de) 1977-07-25
SE431093B (sv) 1984-01-16
BG25199A3 (en) 1978-08-10
NL7508601A (nl) 1976-05-18
JPS6116399B2 (ro) 1986-04-30
SU565632A3 (ru) 1977-07-15
RO72848A (ro) 1983-07-07
FR2290909A1 (fr) 1976-06-11
JPS51125760A (en) 1976-11-02
PL96940B1 (pl) 1978-01-31
DD122091A5 (ro) 1976-09-12
AR204870A1 (es) 1976-03-05
NL186962C (nl) 1991-04-16
CS190501B2 (en) 1979-05-31
IL47670A0 (en) 1975-10-15
DE2531114A1 (de) 1976-05-20
ES439566A1 (es) 1977-06-16
JPS59108798A (ja) 1984-06-23

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