RO201100020U1

RO201100020U1 - Nutritional supplement enhancing lower urinary tract epithelial protection to repeated infections

Info

Publication number: RO201100020U1
Application number: ROU201100020U
Authority: RO
Inventors: Richard Reichenbach; Vilim Simanek; Jitka Ulrichova
Original assignee: Walmark, A.S.
Priority date: 2011-03-07
Filing date: 2011-05-10
Publication date: 2012-07-30
Also published as: LV14567A; PL394996A1; LV14567B; CZ22065U1; SK500482011U1; BG1474U1; SK5984Y1

Abstract

The invention relates to a nutritional supplement having the effect of protecting the epithelium of lower urinary tract from repeated bacterial infections. According to the invention, the supplement comprises, as an active substance, red billberry lyophilized powder, a mixture of vitamin D2 and vitamin D3, a usual carrier, water as a solvent, and specific additives.

Description

RO 2011 00020 U1RO 2011 00020 U1

Supliment nutritiv care sporeşte protecţia epiteliului căilor urinare inferioare de infecţiile repetate.Nutritional supplement that increases the protection of urinary epithelium inferior to repeated infections.

Soluţia tehnică se referă la suplimentul nutritiv cu efect asupra protecţiei epiteliului căilor urinare inferioare de infecţiile bacteriene repetate, care conţine un amestec fizic de fructe liofilizate şi/sau suc de merişoare (Vaccinium macrocarpon) şi vitamina D2/D3 (ergocalciferol/cholecalciferol). Acţiunea sa se manifestă prin sporirea rezistenţei suprafeţei, adică a epiteliului căilor urinare faţă de colonizarea cu bacterii uro-patogene.The technical solution refers to the nutritional supplement with an effect on the protection of the lower urinary epithelium inferior to repeated bacterial infections containing a physical mixture of lyophilized fruits and / or cranberry juice (Vaccinium macrocarpon) and vitamin D2 / D3 (ergocalciferol / cholecalciferol). Its action is manifested by increased resistance of the surface, i.e. the urinary tract epithelium to colonization with uro-pathogenic bacteria.

Fructele de Vaccinium macrocarpon (merişor) şi/sau sucul lor au fost folosite de secole de către locuitorii băştinaşi de pe continentul nord-american la tratarea bolilor infecţioase ale căilor urinare inferioare la ambele sexe. Efectul farmacologic al substanţelor conţinute în fructele de merişor se bazează pe inhibiţia aderării bacteriilor uro-patogene la epiteliul căilor urinare. Pentru efectul său anti aderent, acest fruct a devenit un aliment foarte căutat, respectiv un supliment nutritiv şi în Europa. Substanţele conţinute de merişor mai au efecte antioxidante şi antiinflamatoare, inhibă formarea de biofilm cu bacterii patogene pe epiteliul mucoasei stomacului şi al aparatului urinar. (Howell AB (2007) Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Mol Nutr Food Res 51,732-737; Howell AB et al. (2010)Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infectious DiseaseslO, 94; Shmuely H, YahavJ, Samra Zet al. (2007) Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor. Mol Nutr Food Res 51,746-751; Yamanaka A, Kimizuka R, Kato T, Okuda K. (2004) Inhibitory effects of cranberry juice on attachment of oral streptococci and biofilm formation. Oral Microbiol Immunol 19, 150-154; Jepson RG, Craig JC (2008) Cranberries for preventing urinary tract infections. Cochrane Database Systemic Reviews, issue 4, CD001321).Vaccinium macrocarpone and / or juice has been used for centuries by native inhabitants on the North American continent to treat infectious lower urinary tract infections in both genders. The pharmacological effect of the substances contained in cranberry fruit is based on the inhibition of the adhesion of uro-pathogenic bacteria to the urinary tract epithelium. For its anti-stick effect, this fruit has become a highly sought-after food, and a nutritional supplement in Europe as well. Cranberry-containing substances also have antioxidant and anti-inflammatory effects, inhibit the formation of pathogenic bacteria biofilm on the stomach mucosal epithelium and the urinary system. (Howell AB (2007)) Bioactive compounds in cranberries and their role in the prevention of urinary tract infections, Mol Nutr Food Res 51,732-737, Howell AB et al., (2010) Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption (2007) Effect of cranberry juice on the eradication of Helicobacter pylori in patients treated with antibiotics and a proton (2004) Inhibitory effects of cranberry juice on the attachment of oral streptococci and biofilm formation Oral Microbiol Immunol 19, 150-154, Jepson RG, Craig JC (2008) Cranberries for prevention of urinary tract infections, Cochrane Database Systemic Reviews, issue 4, CD001321).

Vitamina D este o moleculă cheie de semnal (un hormon) în reglarea metabolismului (homeostazei) de calciu în organism, mineralizarea ţesutului osos, influenţarea densităţii şi remodelării lui. Nivelul fiziologic de 25-hydroxyvitamină D la vârsta copilăriei este necesar pentru creşterea oaselor, la maturitate pentru calitatea 1 RO 2011 00020 U1 ţesutului osos, iar la vârsta senioratului pentru încetinirea procesului de osteoporoză şi micşorarea riscului de fracturi ale oaselor. Un nivel scăzut de 25-hydroxyvitamină D în sânge este legat de sporirea riscului de apariţie a cancerului la intestinul gros, de apariţia bolilor autoimunitare, a diabetului de tip 1 şi a unei serii de boli cardiovasculare. In cadrul unui experiment clinic s-a demonstrat că suplimentarea de vitamină D sporeşte protecţia antibacteriană a epiteliului căilor urinare inferioare şi a vezicii urinare prin inducţia expresă a genei răspunzătoare de sinteza catelicidinei. Această peptidă împiedică colonizarea bacteriilor uro patogene în aparatul urinar (Cavalier E et al. (2009) Vitamin D: current status and perspectives. Clin Chem Lab Med 47(2), 120-127; Rosen CJ (2011) Vitamin D insufficiency. N Engl J Med 364,248-254; Souberbielle J-C et al. (2010) Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practise. Autoimmunity Reviews 9, 709-715; Hertting O (2010) Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLOS one 5(12), e15580).Vitamin D is a key molecule of signal (a hormone) in regulating calcium (homeostasis) calcium in the body, mineralization of bone tissue, influencing its density and remodeling. The physiological level of 25-hydroxyvitamin D in childhood is required for bone growth, maturation for bone quality, and seniority for slowing the osteoporosis process and reducing the risk of bone fractures. A low level of 25-hydroxyvitamin D in the blood is associated with an increased risk of cancer in the large intestine, autoimmune diseases, type 1 diabetes and a range of cardiovascular diseases. In a clinical experiment, vitamin D supplementation has been shown to enhance antibacterial protection of the lower urinary tract epithelium and urinary bladder by expressing the gene responsible for catechidine synthesis. This peptide prevents the colonization of urogenic bacteria in the urinary tract (Cavalier E et al., 2009) Vitamin D: Current status and perspectives, Clin Chem Lab Med 47 (2), 120-127, Rosen CJ (2011) Vitamin D insufficiency. Engl J Med 364,248-254; Souberbielle JC et al. (2010) Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for Clinical Practice, Autoimmunity Reviews 9, 709-715, Hertting O (2010) the human antimicrobial peptide cathelicidin in the urinary bladder, PLOS one 5 (12), e15580).

Scopul soluţiei prezentate este aceea de a îmbogăţi piaţa suplimenţilor nutritivi cu un preparat conţinând ca substanţă activă o combinaţie fie de fructe întregi liofilizate de merişor (Vaccinium macrocarpon), fie de suc al lor, ori concentrat uscat din suc, ori extracte de merişor cu vitamina D2/D3 (ergocalciferol/colecalciferol). Scopul acestei combinaţii este de a utiliza sinergismul dintre efectele antiaderente ale merişoarelor şi funcţia de reglare a vitaminei D în sinteza peptidei anti microbiene a catelicidinei în epiteliului căilor urinare şi, în felul acesta, de a proteja tractul urinar de colonizarea cu bacterii uro patogene. Ambele componente nu au efecte secundare. Pe piaţă există produse ce conţin suc de merişoare în combinaţie cu vitaminele A, B, C, D şi E şi sunt oferite sub formă de sucuri, jeleuri de fructe sau gumă de mestecat, aşa cum este descris de ex. în documentele RU 2242145, CN 101590093, EA 200801042 sau US 7056541. Conţinutul de substanţă activă de fructe de merişor Vaccinium macrocarpon şi vitamina D în aceste produse corespunde categoriei de produs alimentar, dar nu şi celui de supliment nutritiv. Conţinutul declarat de vitamina D în compoziţia propusă de supliment nutritiv, pe lângă efectul menţionat, completează deficitul din această vitamină la populaţia din zona central europeană. Hipercalcemia acută, care s-ar produce la doze zilnice de vitamină D mai mari de 10000 IU, adică mai mult de 150 ng 25-hidroxivitamina D în 1 ml de sânge, nu poate fi invocată la administrarea suplimentului nutritiv propus. 2 RO 2011 00020 U1The purpose of the solution presented is to enrich the nutritional supplements market with a preparation containing as active substance a combination of either whole lyophilized cranberry (Vaccinium macrocarpon) or juice or dried juice concentrate or vitamin extracts D2 / D3 (ergocalciferol / colecalciferol). The purpose of this combination is to use the synergism between the anti-adherent effects of cranberries and the function of regulating vitamin D in the synthesis of the anti-microbial peptide of catecholidine in the urinary tract epithelium and thus to protect the urinary tract from colonization with urogenital bacteria. Both components have no side effects. On the market there are products containing cranberry juice in combination with vitamins A, B, C, D and E and are available as juices, fruit jellies or chewing gums, as described eg. in documents RU 2242145, CN 101590093, EA 200801042 or US 7056541. The active substance content of cranberry fruits Vaccinium macrocarpon and vitamin D in these products corresponds to the category of food but not to the nutritional supplement. The declared content of vitamin D in the proposed nutritional supplement composition, in addition to the effect, complements the deficiency of this vitamin in the population of the Central European region. Acute hypercalcemia, which would occur at daily vitamin D doses greater than 10000 IU, ie more than 150 ng of 25-hydroxyvitamin D in 1 ml of blood, can not be invoked with the proposed nutritional supplement. 2 EN 2011 00020 U1

Scopul propus este atins printr-o soluţie tehnică, care reprezintă suplimentul nutritiv cu efect asupra infecţiei bacteriene a căilor urinare inferioare, a cărui esenţă constă în faptul că, pe post de substanţă activă el conţine un amestec de maxim 99,999975 % greutate fructe întregi liofilizate de merişor (Vaccinium macrocarpon), şi/sau de suc al lor, şi/sau de concentrat uscat de suc, şi/sau extracte de merişor şi 0,00000025 până la 0,0694 % greutate vitamina D sub formă de ergocalciferol vitamina D2 sau colecalciferol vitamina D3, sau amestec al lor D2/D3.The proposed goal is achieved by a technical solution, which is the nutritional supplement with effect on bacterial infection of the lower urinary tract, the essence of which consists in the fact that it contains a mixture of 99,999975% whole fruit weight lyophilized cranberry (Vaccinium macrocarpon), and / or juice thereof, and / or dried juice concentrate, and / or cranberry extracts and 0,00000025 to 0,0694% vitamin D in the form of ergocalciferol vitamin D2 or cholecalciferol vitamin D3, or a mixture of D2 / D3.

Intr-o realizare preferata, substanţa activă este amestecată cu de până la 1000x multiplu de vehicul fiziologic nevătămător, eventual completat cu substanţe ajutătoare, atunci când vehiculul nevătămător este format din cel puţin una dintre substanţele alese din grupa fluxanţilor, sau a solvenţilor, sau a purtătorilor, sau este format din diferite variante de amestecuri ale lor şi când eventualele substanţe ajutătoare completate sunt formate din cel puţin una dintre substanţele alese din grupa agenţilor coloidali, sau antioxidanţi, sau coloranţi, sau stabilizatori, sau emulgatori, sau substanţe creatoare de pelicule şi sau este format din diferite variante de amestecuri ale lor.In a preferred embodiment, the active substance is mixed with up to 1000x multiple of the physiologically safe vehicle, optionally supplemented with adjuvants, when the non-harmless vehicle is composed of at least one of the substances selected from the group of the fluxants or solvents, or or is made up of a variety of mixtures thereof, and when any added adjuvants are formed from at least one of the substances selected from the group of colloidal agents or antioxidants or colorants or stabilizers or emulsifiers or film-forming substances; and or consists of different variants of mixtures thereof.

Intr-un caz optim, fluxantul este ales din grupa glicerol sau poliol, solventul din apă sau etanol, iar purtătorul este ales din grupa gelatină sau amidon modificat, sau celuloză şi derivatele ei, sau amidon şi derivatele lui, sau săruri de carbonat de calciu şi carbonat de sodiu, sau săruri de fosfat de calciu, sau caragenan, sau uleiuri vegetale, sau glicerol, sau trigliceride, sau fosfaţi, sau sirop invertit, sau este format din amestecuri ale lor. Mai departe, este avantajos ca agentul coloidal să fie ales din grupa oxid silicios sau stearat de magneziu, sau este format din amestecuri ale lor, antioxidantul este ales din grupa tocoferolilor sau acid de rozmarin, sau ascorbat de sodiu, sau ascorbil palmitat, iar coloranţii sunt aleşi din grupa oxid feric, oxid de titan, sau concentrate de zarzavaturi naturale, sau sunt formaţi din diferite combinaţii ale amestecurilor lor. Şi în final, este bine ca stabilizatorul să fie format din ceară de albine, sau polisorbaţi, sau esteri ai acizilor graşi cu poliglicerol, când emulgatorii sunt aleşi din grupa lecitină, sau sorbitan monostearat, sau sorbitan monooleat, sau sorbitan tristearat, sau sorbitan monolaurat, sau sorbitan monopalmitat şi când substanţele creatoare de pelicule sunt alese din grupa hidroxipropilmetilceluloză, sau hidroxipropilceluloză, sau polietilenglicoli, sau polivinilalcool, sau şelac. 3 RO 2011 00020 U1In an optimal case, the fluxant is selected from the glycerol or polyol group, the solvent in water or ethanol, and the carrier is selected from the group of gelatin or modified starch or cellulose and its derivatives or starch and its derivatives or calcium carbonate salts and sodium carbonate, or calcium phosphate or carrageenan or vegetable oils or glycerol or triglycerides or phosphates or invert syrup, or formed from mixtures thereof. Further, it is advantageous for the colloidal agent to be selected from the group of silicon dioxide or magnesium stearate, or consists of mixtures thereof, the antioxidant is selected from the group of tocopherols or rosmarinic acid or sodium ascorbate or ascorbyl palmitate and the colorants are selected from the group of ferric oxide, titanium oxide, or natural vegetable concentrates, or are formed from various combinations of their mixtures. Finally, it is good that the stabilizer consists of beeswax or polysorbates or polyglycerol fatty acid esters when the emulsifiers are selected from the group lecithin or sorbitan monostearate or sorbitan monooleate or sorbitan tristearate or sorbitan monolaurate , or monopalmitate sorbitan, and when the film-forming substances are selected from the group consisting of hydroxypropylmethylcellulose or hydroxypropylcellulose or polyethylene glycols or polyvinylalcohol or shellac. 3 EN 2011 00020 U1

Suplimentul nutritiv conţine polifenoli, adică antocianine, flavonoide, acizi fenolici şi minerale, vitamine din fructe de merişor, care au o influenţă fiziologică favorabilă asupra căilor urinare inferioare şi care, în combinaţie cu efectele ergocalciferolului vitamina D2, sau colecalciferolului vitamina D3 asigură o scădere a riscului de infecţie a căilor urinare.The nutritional supplement contains polyphenols, ie anthocyanins, flavonoids, phenolic and mineral acids, coconut vitamins, which have a favorable physiological influence on the lower urinary tract and which, combined with the effects of ergocalciferol vitamin D2 or cholecalciferol vitamin D3, the risk of urinary tract infection.

Se dau mai jos exemple de realizare a invenţiei care arata valorificarea concret posibilă a soluţiei tehnice redata de suplimentul nutritiv :Below are examples of embodiments of the invention which show the practical realization of the technical solution of the nutritional supplement:

Exemplul 1 :Example 1:

Supliment nutritiv care sporeşte protecţia epiteliului căilor urinare inferioare de infecţiile repetate, administrat sub formă de capsule dure cu umplutură lichidă, cu greutatea de 530 mg, având următoarea compoziţie: - substanţe active : fruct liofilizat de merişor, sub formă de pulbere ................ 180 mg ergocalciferol vitamina D2 ........................................0,005 mg - vehicul nevătămător: purtător sub formă de amestec din gelatină ......................................... 105 mg ulei vegetal 225,615 mg fluxant sub formă de poliol 12,35 mg solvent sub formă de apă 5,03 mg - substanţe ajutătoare: antioxidant sub formă de ascorbat de sodiu..................... 2 mgNutritional supplement that enhances the protection of the lower urinary epithelium inferior to repeated infections, given as hard capsules with liquid filling, weighing 530 mg, having the following composition: - active substances: lycophyse cranberry powder in the form of powder. ............ 180 mg ergocalciferol vitamin D2 ................................. ....... 0.005 mg - non-lethal vehicle: gelatine carrier .............................. ................ 105 mg of vegetable oil 225,615 mg of polyether fluxer 12,35 mg of water-based solvent 5,03 mg - of adjuvants: antioxidant as sodium ascorbate .... ................. 2 mg

Exemplul 2:Example 2:

Supliment nutritiv care sporeşte protecţia epiteliului căilor urinare inferioare de infecţiile repetate, administrat sub formă de capsule moi cu umplutură pulverulentă, cu greutatea de 735 mg, având următoarea compoziţie: - substanţe active : concentrat uscat de suc de merişor, sub formă de spray....... 200 mg colecalciferol vitamina D3 ..........................................0,005 mg - vehicul nevătămător: purtător sub formă de amestec din gelatină ................................... 142,545 mg ulei de soia 290 mg 4 RO 2011 00020 U1 fluxant sub formă de glicerol .............................. 67,58 mg solvent sub formă de apă ................................... 8,22 mg - substanţe ajutătoare : antioxidant sub formă de acetat de tocoferol..................... 2 mg coloranţi sub formă de oxid feric ............................. 1,65 mg stabilizator sub formă de miere de albine ...........................10 mg emulgator sub formă de lecitină .................................. 13 mg -6-Nutritional supplement that enhances the protection of the lower urinary epithelium inferior to repeated infections, given as soft capsules with a powder filling, weighing 735 mg, having the following composition: - active substances: dried concentrate of cranberry juice in spray form. ..... 200 mg cholecalciferol vitamin D3 ........................................ .0,005 mg - non-lethal vehicle: gelatine carrier ... 142,545 mg soybean oil 290 mg 4 RO 2011 00020 U1 fluxing agent in the form of glycerol .............................. 67,58 mg solvent as water ................................................................. 8,22 mg - aids: antioxidant as tocopherol acetate ..................... 2 mg ferric oxide dyes ............... .............. 1,65 mg bee honey stabilizer ......................... .. 10 mg lecithin emulsifier .............. .................... 13 mg -6-

Exemplul 3:Example 3:

Supliment nutritiv care sporeşte protecţia epiteliului căilor urinare inferioare de infecţiile repetate, administrat sub formă de capsule dure cu umplutură pulverulentă, cu greutatea de 670 mg, având următoarea compoziţie: - substanţe active : pulbere liofilizată de merişor ................... 200 mg amestec de ergocalciferol D2 şi colecalciferol D3 ..........0,0075 mg - vehicul nevătămător: purtător sub formă de gelatină ........................ 148,7925 mg fluxant sub formă de glicerol ............................... 7,60 mg solvent sub formă de apă .................................. 3,60 mg - substanţe ajutătoare : antioxidant sub formă de ascorbat de sodiu................... 2 mg agent coloidal sub formă de oxid silicios ............ 8 mgNutritional supplement that enhances the protection of urinary epithelium inferior to repeated infections, given as hard capsules with powdery filling, weighing 670 mg, having the following composition: - active substances: lycophyse powder of cranberry ......... .......... 200 mg ergocalciferol mixture D2 and colecalciferol D3 .......... 0,0075 mg - non-lethal vehicle: gelatine carrier .......... ... 148.7925 mg of fluxant as glycerol ......................... ...... 7.60 mg water-based solvent .................................. 3 , 60 mg - adjuvants: antioxidant in the form of sodium ascorbate ................... 2 mg colloidal silicon dioxide ........ .... 8 mg

Exemplul 4 :Example 4:

Supliment nutritiv care sporeşte protecţia epiteliului căilor urinare inferioare de infecţiile repetate, administrat sub formă de tabletă sau tabletă filmată, cu greutatea de 550 mg, având următoarea compoziţie: - substanţe active : extract uscat de fructe de merişor ........................... 90 mg ergocalciferol vitamina D2 ........................ 0,005 mg - vehicul nevătămător: purtător sub formă de amestec de: celuloză microcristalină................ 230,045 mg hidrogen fosfat de calciu ......192,50 mg 5 RO 2011 00020 U1 carboximetilceluloză....................... 13,75 mg ulei de seminţe de bumbac ................. 1,50 mg - substanţe ajutătoare : agent coloidal sub formă de amestec de : stearat de magneziu ................... 3,30 mg oxid silicios ......................... 4,80 mg substanţe creatoare de pelicule sub formă de amestec de hidroxipropilmetilceluloză ............. 4,20 mg hidroxipropilceluloză ...................... 3,40 mg coloranţi sub formă de amestec de oxid de titan ................................ 2,50 mg concentrate de zarzavaturi naturale........ 4 mgA nutritional supplement that enhances the protection of the urinary tract epithelium inferior to repeated infections, in the form of a tablet or tablet, weighing 550 mg, having the following composition: - active substances: dried cranberry extract ........ ................... 90 mg ergocalciferol vitamin D2 ........................ 0.005 mg - non-harmless vehicle: carrier as a mixture of: microcrystalline cellulose ... 230,045 mg calcium hydrogen phosphate ...... 192,50 mg 5 EN 2011 00020 U1 carboxymethyl cellulose 13.75 mg cotton seed oil ................. 1.50 mg - adjuvants: colloidal as a mixture of: magnesium stearate ................... 3.30 mg silicon dioxide ...... ................... 4.80 mg film-forming substances in the form of a mixture of hydroxypropylmethylcellulose ............. 4.20 mg hydroxypropylcellulose ...................... 3.40 mg dyes b form of titanium oxide mixture ................................ 2.50 mg natural vegetable concentrates. ...... 4 mg

Exemplul 5 :Example 5:

Supliment nutritiv care sporeşte protecţia epiteliului căilor urinare inferioare de infecţiile repetate, administrat sub formă de sirop, cu greutatea de 5000 mg, având următoarea compoziţie: - substanţe active : concentrat uscat de suc de merişor ................ 200 mg ergocalciferol vitamina D2 ......................................0,005 mg - vehicul nevătămător: . purtător sub formă de sirop invertit ......................4 492,995 mg fluxant sub formă de etanol ...................................5 mg - substanţe ajutătoare : antioxidant sub formă de ascorbat de sodiu .................... 2 mgNutritional supplement that increases the protection of urinary epithelium inferior to repeated infections, given as syrup, with a weight of 5000 mg, with the following composition: - active substances: dried concentrate of cranberry juice ........... 200 mg ergocalciferol vitamin D2 .................................... 0.005 mg undamaged vehicle:. carrier as inverted syrup ........................... 4 492,995 mg fluxant as ethanol .............. ..................... 5 mg - Help substances: antioxidant as sodium ascorbate ................ .... 2 mg

Suplimentul nutritiv cu efect asupra protecţiei epiteliului căilor urinare inferioare are aplicabilitate industriala prin aceea ca poate fi utilizat în prevenire, în cazul unor inflamaţii acute repetate ale căilor urinare inferioare, datorită unor bacterii uro patogene. Suplimentul nutritiv are şi efect favorabil asupra florei microbiene a aparatului digestiv şi completează deficitul de vitamina D la populaţia actuală. 6The nutritional supplement with effect on lower urinary tract epithelial protection has industrial applicability in that it can be used for prevention in the case of repeated acute inflammation of the lower urinary tract due to urogenital bacteria. The nutritional supplement also has a beneficial effect on the microbial flora of the digestive system and complements vitamin D deficiency in the current population. 6

Claims

The nutritional supplement having an effect on lower urinary tract bacterial infection, characterized in that it is made from a physical mixture having an active substance of maximum 99.999975% by weight of whole lyophilized cranberry fruits (Vaccinium macrocarpon), and / or juice, and / or dried juice concentrate and / or cranberry extracts and 0,00000025 to 0,0694% vitamin D in the form of ergocalciferol vitamin D2 or cholecalciferol vitamin D3 or a mixture thereof D2 / D3.

The nutritional supplement according to claim 1, characterized in that the active substance is mixed with up to 1000x multiple of the non-physiologically safe vehicle, optionally supplemented with adjuvants.

The nutritional supplement according to claim 2, characterized in that the non-lethal vehicle consists of at least one of the substances selected from the group of the fluxants, solvents or the carrier and / or consists of different variants of their mixtures.

The nutritional supplement according to claim 2, characterized in that the auxiliary substances are made up of at least one of the substances selected from the group of colloidal agents or antioxidants or colorants or stabilizers or emulsifiers or substances films and / or consists of different variants of their mixtures.

The nutritional supplement according to claim 3, characterized in that the fluxant is selected from the group of glycerol or polyols.

The nutritional supplement according to claim 3, characterized in that the solvent is water or ethanol.

The nutritional supplement according to claim 3, characterized in that the carrier is selected from the group of gelatin or modified starch or cellulose and their derivatives or starch and derivatives thereof, or calcium carbonate and sodium carbonate salts, 1 RO 2011 00020 U1 or salts of calcium phosphate or carrageenan or vegetable oils or glycerol or triglycerides or phosphates or invert syrup, or consists of mixtures thereof.

The nutritional supplement according to claim 4, characterized in that the colloidal agent is selected from the group of silicon dioxide or magnesium stearate or consists of mixtures thereof.

The nutritional supplement according to claim 4, wherein the antioxidant is selected from the group of tocopherols or rosemary acid or sodium ascorbate or ascorbyl palmitate.

The nutritional supplement according to claim 4, characterized in that the colorants are selected from the group of ferric oxide or titanium oxide or natural vegetable concentrates or are formed from various combinations of their mixtures.

The nutritional supplement according to claim 4, characterized in that the stabilizer consists of beeswax, or polysorbates, or esters of polyglycerol fatty acids.

The nutritional supplement according to claim 4, characterized in that the emulsifiers are selected from the group lecithin or sorbitan monostearate or sorbitan monooleate or sorbitan tristearate or sorbitan monolaurate or sorbitan monopalmitate.

The nutritional supplement according to claim 4, wherein the film-forming substances are selected from the group consisting of hydroxypropylmethylcellulose or hydroxypropylcellulose or polyethylene glycols or polyvinylalcohol or shellac. 2