PT928291E - Derivados de 3-mercaptoacetilamino-1,5-substituido-2-oxo-azepano uteis como inibidores de metaloproteinases matriciais - Google Patents

Derivados de 3-mercaptoacetilamino-1,5-substituido-2-oxo-azepano uteis como inibidores de metaloproteinases matriciais

Info

Publication number: PT928291E
Authority: PT; Portugal
Prior art keywords: mercaptoacetilamamine; oxo; substituted; matrix metaloproteinase; metaloproteinase inhibitors
Prior art date: 1996-09-19

Application number

PT97935308T

Other languages

English (en)

Inventor

Michael J Janusz

Joseph Burkhart

Jiu-Tsair Tsay

Jian Shen

Ramalinga M Dharanipragada

Alan M Warshawsky

Gary A Flynn

Meena V Patel

Douglas W Beight

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-19

Filing date

1997-08-04

Publication date

2003-03-31

1997-08-04 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2003-03-31 Publication of PT928291E publication Critical patent/PT928291E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Heart & Thoracic Surgery (AREA)
Genetics & Genomics (AREA)
Cardiology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

PT97935308T 1996-09-19 1997-08-04 Derivados de 3-mercaptoacetilamino-1,5-substituido-2-oxo-azepano uteis como inibidores de metaloproteinases matriciais PT928291E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71929196A	1996-09-19	1996-09-19

Publications (1)

Publication Number	Publication Date
PT928291E true PT928291E (pt)	2003-03-31

Family

ID=24889504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97935308T PT928291E (pt)	1996-09-19	1997-08-04	Derivados de 3-mercaptoacetilamino-1,5-substituido-2-oxo-azepano uteis como inibidores de metaloproteinases matriciais

Country Status (21)

Country	Link
EP (1)	EP0928291B1 (pt)
JP (1)	JP3962091B2 (pt)
KR (1)	KR100545460B1 (pt)
CN (1)	CN1150205C (pt)
AR (1)	AR009363A1 (pt)
AT (1)	ATE229034T1 (pt)
AU (1)	AU718055B2 (pt)
BR (1)	BR9713207A (pt)
CA (1)	CA2266759C (pt)
DE (1)	DE69717647T2 (pt)
DK (1)	DK0928291T3 (pt)
ES (1)	ES2184126T3 (pt)
HK (1)	HK1020741A1 (pt)
HU (1)	HUP9904165A3 (pt)
IL (2)	IL129035A0 (pt)
NO (1)	NO991316L (pt)
NZ (1)	NZ334490A (pt)
PT (1)	PT928291E (pt)
TW (1)	TW445262B (pt)
WO (1)	WO1998012211A1 (pt)
ZA (1)	ZA978307B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6770640B1 (en)	1998-12-31	2004-08-03	Aventis Pharmaceuticals Inc.	1-Carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of MMP-12
US6486193B2 (en)	1998-12-31	2002-11-26	Aventis Pharmaceuticals Inc.	3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
CA2356689A1 (en) *	1998-12-31	2000-07-13	Michael J. Janusz	1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12
EP1150951A1 (en) *	1998-12-31	2001-11-07	Aventis Pharmaceuticals Inc.	3-substituted pyrrolidines useful as inhibitors of matrix metallo-proteinases
US6344450B1 (en)	1999-02-09	2002-02-05	Bristol-Myers Squibb Company	Lactam compounds and their use as inhibitors of serine proteases and method
US6297233B1 (en)	1999-02-09	2001-10-02	Bristol-Myers Squibb Company	Lactam inhibitors of FXa and method
JP2003513924A (ja)	1999-11-10	2003-04-15	スミスクライン・ビーチャム・コーポレイション	プロテア−ゼ阻害剤
JP2003513971A (ja)	1999-11-10	2003-04-15	スミスクライン・ビーチャム・コーポレイション	プロテア−ゼ阻害剤
US6583137B1 (en)	1999-11-10	2003-06-24	Smithkline Beecham Corporation	Protease inhibitors
US7141607B1 (en)	2000-03-10	2006-11-28	Insite Vision Incorporated	Methods and compositions for treating and inhibiting retinal neovascularization
IL150964A0 (en)	2000-03-21	2003-02-12	Smithkline Beecham Corp	Protease inhibitors
US6511973B2 (en)	2000-08-02	2003-01-28	Bristol-Myers Squibb Co.	Lactam inhibitors of FXa and method
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
US7704521B2 (en)	2007-04-11	2010-04-27	Zinpro Corporation	Rumen protected essential amino acids
US20080255234A1 (en)	2007-04-11	2008-10-16	Zinpro Corporation	Rumen protected lysine
EP3630969B1 (en)	2017-05-31	2023-06-07	BRAIN Biotech AG	Optimization of the expression of serine proteases in host cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0358660B1 (en) *	1987-03-17	1994-05-25	Research Corporation Technologies, Inc.	Synthetic inhibitors of mammalian collagenase
JPH07304746A (ja) *	1994-05-11	1995-11-21	Kanebo Ltd	新規ベンゾアゼピンカルボン酸誘導体
ATE179431T1 (de) *	1994-10-05	1999-05-15	Darwin Discovery Ltd	Peptidische verbindungen und deren therapeutische verwendung als metalloproteinase-inhibitoren
US5672598A (en) *	1995-03-21	1997-09-30	The Procter & Gamble Company	Lactam-containing hydroxamic acids

1997
- 1997-08-04 PT PT97935308T patent/PT928291E/pt unknown
- 1997-08-04 DK DK97935308T patent/DK0928291T3/da active
- 1997-08-04 CN CNB971990247A patent/CN1150205C/zh not_active Expired - Fee Related
- 1997-08-04 BR BR9713207-1A patent/BR9713207A/pt not_active IP Right Cessation
- 1997-08-04 ES ES97935308T patent/ES2184126T3/es not_active Expired - Lifetime
- 1997-08-04 NZ NZ334490A patent/NZ334490A/xx not_active IP Right Cessation
- 1997-08-04 AT AT97935308T patent/ATE229034T1/de active
- 1997-08-04 KR KR1019997002336A patent/KR100545460B1/ko not_active IP Right Cessation
- 1997-08-04 DE DE69717647T patent/DE69717647T2/de not_active Expired - Lifetime
- 1997-08-04 AU AU38278/97A patent/AU718055B2/en not_active Ceased
- 1997-08-04 IL IL12903597A patent/IL129035A0/xx active IP Right Grant
- 1997-08-04 CA CA002266759A patent/CA2266759C/en not_active Expired - Fee Related
- 1997-08-04 HU HU9904165A patent/HUP9904165A3/hu unknown
- 1997-08-04 WO PCT/US1997/013738 patent/WO1998012211A1/en active IP Right Grant
- 1997-08-04 JP JP51465898A patent/JP3962091B2/ja not_active Expired - Fee Related
- 1997-08-04 EP EP97935308A patent/EP0928291B1/en not_active Expired - Lifetime
- 1997-09-13 TW TW086113339A patent/TW445262B/zh not_active IP Right Cessation
- 1997-09-15 ZA ZA9708307A patent/ZA978307B/xx unknown
- 1997-09-17 AR ARP970104242A patent/AR009363A1/es active IP Right Grant
1999
- 1999-03-17 IL IL129035A patent/IL129035A/en not_active IP Right Cessation
- 1999-03-18 NO NO991316A patent/NO991316L/no not_active Application Discontinuation
- 1999-12-21 HK HK99105993A patent/HK1020741A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AR009363A1 (es)	2000-04-12
AU718055B2 (en)	2000-04-06
NO991316L (no)	1999-05-18
EP0928291A1 (en)	1999-07-14
WO1998012211A1 (en)	1998-03-26
BR9713207A (pt)	2000-04-04
ES2184126T3 (es)	2003-04-01
CA2266759C (en)	2004-10-26
CA2266759A1 (en)	1998-03-26
HUP9904165A2 (hu)	2000-03-28
IL129035A0 (en)	2000-02-17
HK1020741A1 (en)	2000-05-19
AU3827897A (en)	1998-04-14
JP2001501926A (ja)	2001-02-13
KR100545460B1 (ko)	2006-01-24
CN1234039A (zh)	1999-11-03
KR20000036246A (ko)	2000-06-26
HUP9904165A3 (en)	2002-01-28
NO991316D0 (no)	1999-03-18
DE69717647D1 (de)	2003-01-16
DK0928291T3 (da)	2003-03-17
JP3962091B2 (ja)	2007-08-22
IL129035A (en)	2006-12-10
DE69717647T2 (de)	2003-09-25
ATE229034T1 (de)	2002-12-15
CN1150205C (zh)	2004-05-19
TW445262B (en)	2001-07-11
ZA978307B (en)	1998-03-19
NZ334490A (en)	2000-08-25
EP0928291B1 (en)	2002-12-04

Publication	Publication Date	Title
PT1147095E (pt)	2004-12-31	Acidos 2,3,4,5-tetra-1h-[1,4] benzodiazepino-3-hidroxamicos como inibidores de metaloproteinases de matriz
PT1114033E (pt)	2004-12-31	4-carboxiamino-2-metil-1,2,3,4-tetra-hidroquinolinas como inibidores de cetp
PT946512E (pt)	2004-01-30	Derivados de 6-fenilpiridil-2-amina uteis como inibidores de nos
CU23063A3 (es)	2005-07-19	Imidazotriazinonas 2-fenil sustituidas como inhibidores de fosfodiesterasas
PT1185529E (pt)	2005-02-28	Pirazolobenzodiazepinas como inibidores de cdk2
PT818448E (pt)	2004-04-30	Cicloalcano-piridinas como inibidores da cetp
CU23082A3 (es)	2005-08-17	4-carboxiamino-2-subsituidos-1,2,3,4- tetrahidroquinolas como inhibidores cetp
PT1140840E (pt)	2006-05-31	Difenilureias substituidas com (.)-carboxiarilo como inibidores de raf-quinase
NO995967D0 (no)	1999-12-03	Mykningsmiddelbehandlet, absorberende interlabial gjenstand
PT928291E (pt)	2003-03-31	Derivados de 3-mercaptoacetilamino-1,5-substituido-2-oxo-azepano uteis como inibidores de metaloproteinases matriciais
PT901474E (pt)	2006-07-31	Derivados de aril-pirimidina.
NL1016815A1 (nl)	2001-06-18	Oximester-fotoinitiatoren.
NO983764D0 (no)	1998-08-17	Knekt, sµrlig for bµrekanaler
DE69725473D1 (de)	2003-11-13	Dünner, absorbierender gegenstand
IT1306971B1 (it)	2001-10-11	Distributore idraulico.
PT942901E (pt)	2003-07-31	Iminas ciclicas utilizadas como pesticidas
PT858452E (pt)	2002-07-31	Derivado tiazol como inibidor da proteina-quinase c
PT1100792E (pt)	2004-08-31	Sulfonamidas triciclicas e seus derivados como inibidores de metaloproteinases da matriz
ID22228A (id)	1999-09-23	Turunan-turunan 16-hidroksi-11-(disubstitusifenil)-estra-4,9-diena
PT922050E (pt)	2003-12-31	Derivados de 3-descladinose-2,3-anidroeritromicina
PT1189907E (pt)	2005-05-31	Tienopirimidinas como inibidores da fosfodiesterase
PT1047665E (pt)	2004-01-30	Inibidores de metaloproteases de matriz
PT1153015E (pt)	2004-12-31	Pirimidina-2,4,6-trionas uteis como inibidores de metaloproteinases matriciais
BR9706239B1 (pt)	2010-10-19	3-(1-hidroxifenil-1-alcoxiiminometil) dioxazinas bem como processos de preparação dos mesmos.
PT1121349E (pt)	2004-08-31	Tiadiazolsulfonamidas substituidas como inibidores de interleucina-1-beta