[go: up one dir, main page]

PT92603A - Processo de producao de factor de crescimento transformante, quimerico,beta - Google Patents

Processo de producao de factor de crescimento transformante, quimerico,beta

Info

Publication number
PT92603A
PT92603A PT92603A PT9260389A PT92603A PT 92603 A PT92603 A PT 92603A PT 92603 A PT92603 A PT 92603A PT 9260389 A PT9260389 A PT 9260389A PT 92603 A PT92603 A PT 92603A
Authority
PT
Portugal
Prior art keywords
beta
production
growth factor
quimerico
transformante
Prior art date
Application number
PT92603A
Other languages
English (en)
Other versions
PT92603B (pt
Inventor
Anthony F Purchio
Linda Madisen
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen filed Critical Oncogen
Publication of PT92603A publication Critical patent/PT92603A/pt
Publication of PT92603B publication Critical patent/PT92603B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Jellies, Jams, And Syrups (AREA)
PT92603A 1988-12-15 1989-12-15 Processo de producao de factor de crescimento transformante, quimerico,beta PT92603B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28497288A 1988-12-15 1988-12-15

Publications (2)

Publication Number Publication Date
PT92603A true PT92603A (pt) 1990-06-29
PT92603B PT92603B (pt) 1995-09-12

Family

ID=23092228

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92603A PT92603B (pt) 1988-12-15 1989-12-15 Processo de producao de factor de crescimento transformante, quimerico,beta

Country Status (18)

Country Link
US (1) US5244793A (pt)
EP (1) EP0374044B1 (pt)
JP (1) JPH0335794A (pt)
KR (1) KR900009983A (pt)
CN (1) CN1045994A (pt)
AT (1) ATE111520T1 (pt)
AU (1) AU634733B2 (pt)
CA (1) CA2005120A1 (pt)
DE (1) DE68918248T2 (pt)
DK (1) DK633389A (pt)
ES (1) ES2063834T3 (pt)
FI (1) FI97299C (pt)
HU (1) HUT52550A (pt)
IE (1) IE66571B1 (pt)
IL (1) IL92669A (pt)
NO (1) NO300464B1 (pt)
PT (1) PT92603B (pt)
ZA (1) ZA899517B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304541A (en) * 1988-12-15 1994-04-19 Bristol-Myers Squibb Company Methods using novel chimeric transforming growth factor-β1/β2
CA2003886A1 (en) * 1988-12-16 1990-06-16 Anthony F. Purchio Cloning and expression of simian transforming growth factor-beta 1
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
GB9106678D0 (en) * 1991-03-28 1991-05-15 Ferguson Mark W J Wound healing
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
AU2738392A (en) * 1991-11-11 1993-05-13 Ciba-Geigy Ag Novel hybrid transforming growth factors
IT1259042B (it) * 1992-01-27 1996-03-11 Mini Ricerca Scient Tecnolog Preparazione di vettori di espressione per la sintesi del polipeptide chiamato fattore osteogenetico op-1 in cellule eucariotiche di spodoptera frugiperda via infezione con baculovirus ricombinante
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US5420243A (en) * 1993-01-26 1995-05-30 Celtrix Pharmaceuticals, Inc. Biologically active TGF-β2 peptides
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2162586C (en) * 1993-05-13 2006-01-03 David J. Grainger Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US6117911A (en) 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
KR100688871B1 (ko) * 2002-03-12 2007-03-02 티슈진, 인코포레이티드 연골세포 및 ＴＧＦ-β를 사용한 연골 재생

Also Published As

Publication number Publication date
EP0374044B1 (en) 1994-09-14
EP0374044A3 (en) 1991-07-31
PT92603B (pt) 1995-09-12
HUT52550A (en) 1990-07-28
DE68918248T2 (de) 1995-05-04
IL92669A0 (en) 1990-08-31
JPH0335794A (ja) 1991-02-15
NO300464B1 (no) 1997-06-02
NO895028D0 (no) 1989-12-14
DK633389A (da) 1990-06-16
FI895935A0 (fi) 1989-12-12
HU896613D0 (en) 1990-02-28
ZA899517B (en) 1990-09-26
ATE111520T1 (de) 1994-09-15
IE893984L (en) 1990-06-15
IL92669A (en) 1997-02-18
DK633389D0 (da) 1989-12-14
AU4683489A (en) 1990-06-21
NO895028L (no) 1990-06-18
EP0374044A2 (en) 1990-06-20
DE68918248D1 (de) 1994-10-20
CA2005120A1 (en) 1990-06-15
FI97299B (fi) 1996-08-15
CN1045994A (zh) 1990-10-10
IE66571B1 (en) 1996-01-24
US5244793A (en) 1993-09-14
ES2063834T3 (es) 1995-01-16
AU634733B2 (en) 1993-03-04
KR900009983A (ko) 1990-07-06
FI97299C (fi) 1996-11-25

Similar Documents

Publication Publication Date Title
PT92603A (pt) Processo de producao de factor de crescimento transformante, quimerico,beta
DE68929510D1 (de) Nukleotidsequenzen, die für ein Protein mit Ureaseaktivität kodieren
DE69521752D1 (de) Verfahren für die Herstellung von Proteinen
EP0174367A4 (en) HOSTS AND METHODS FOR PRODUCING RECOMBINANT PRODUCTS IN LARGE QUANTITIES.
HUT43630A (en) Mammalian interleukine-4 and process for producing it
FI101381B1 (fi) Nukleotidisekvenssi ja menetelmä polypeptidin HSA(1-387) tuottamiseksi
PT92278A (pt) Processo para a preparacao de proteinas de ligacao de factor de crescimento semelhante a insulina
ATE90944T1 (de) Fuer ein hirudinaehnliches protein kodierende dns- sequenz und verfahren zur herstellung eines solchen proteins.
DE3586773D1 (de) Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.
EP0562508A3 (en) Protein with bone formation ability and process for its production
FI890127A (fi) Menetelmä terapeuttisesti käyttökelpoisen hirudiinijohdannaisen valmistamiseksi
EP0317627A4 (en) Oncogene-encoded polypeptide having growth factor activity and methods of production and use thereof
DE59409964D1 (de) Rekombinante D-Hydantoinase, Verfahren zur Herstellung und Verwendung
ATE109827T1 (de) Verfahren zur herstellung von peptiden, dazu zu verwendendes rekombinantes plasmid und mit diesem plasmid transformierte myelomzellen.
ATE113986T1 (de) Verfahren zur herstellung von aprotinin und aprotinin-homologen in hefe.
DE3781832D1 (de) C-terminal-alpha-amidierendes enzym und verfahren zu dessen herstellung und verwendung.
BR9000445A (pt) Processo para a producao de glucagon,sequencia de dna codificando glucagon,vetor de expressao,transformante e glucagon purificado
DK0828004T3 (da) Proteindisulfidisomerase-gen afledt af stamme af methylotrof gær
GR3001086T3 (en) Substituted dioxanones, method for preparing same and use thereof
DK210288D0 (da) Overproduktion af exocelllulaere proteiner

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19950502

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991130