PT90816A - Processo para a preparacao de composicoes farmaceuticas contendo analogos de 2',5'-oligoadenilato - Google Patents

Processo para a preparacao de composicoes farmaceuticas contendo analogos de 2',5'-oligoadenilato

Info

Publication number: PT90816A
Authority: PT; Portugal
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; analogs; oligoadenylate
Prior art date: 1988-06-09

Application number

PT90816A

Other languages

English (en)

Other versions

PT90816B (pt

Inventor

Wolfgang Pfleiderer

Robert J Suhadolnik

Original Assignee

Univ Temple

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-09

Filing date

1989-06-09

Publication date

1989-12-29

1989-06-09 Application filed by Univ Temple filed Critical Univ Temple

1989-12-29 Publication of PT90816A publication Critical patent/PT90816A/pt

1994-11-30 Publication of PT90816B publication Critical patent/PT90816B/pt

Links

SIIZPVYVXNXXQG-KGXOGWRBSA-N [(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-4-[[(3s,4r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methyl [(2r,4r,5r)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(phosphonooxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class C1=NC2=C(N)N=CN=C2N1[C@@H]1O[C@H](COP(O)(=O)OC2[C@@H](O[C@H](COP(O)(O)=O)[C@H]2O)N2C3=NC=NC(N)=C3N=C2)[C@@H](O)[C@H]1OP(O)(=O)OCC([C@@H](O)[C@H]1O)OC1N1C(N=CN=C2N)=C2N=C1 SIIZPVYVXNXXQG-KGXOGWRBSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000824 D-ribofuranosyl group Chemical group [H]OC([H])([H])[C@@]1([H])OC([H])(*)[C@]([H])(O[H])[C@]1([H])O[H] 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
208000037357 HIV infectious disease Diseases 0.000 abstract 1
230000007547 defect Effects 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
150000003833 nucleoside derivatives Chemical group 0.000 abstract 1
230000037361 pathway Effects 0.000 abstract 1
DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical group N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Botany (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

PT90816A 1988-06-09 1989-06-09 Processo para a preparacao de composicoes farmaceuticas contendo analogos de 2',5'-oligoadenilato PT90816B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US20465988A	1988-06-09	1988-06-09

Publications (2)

Publication Number	Publication Date
PT90816A true PT90816A (pt)	1989-12-29
PT90816B PT90816B (pt)	1994-11-30

Family

ID=22758878

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT90816A PT90816B (pt)	1988-06-09	1989-06-09	Processo para a preparacao de composicoes farmaceuticas contendo analogos de 2',5'-oligoadenilato

Country Status (14)

Country	Link
EP (2)	EP0420872B1 (pt)
JP (1)	JP2947580B2 (pt)
KR (1)	KR0141684B1 (pt)
CN (1)	CN1107508C (pt)
AT (2)	ATE141796T1 (pt)
AU (1)	AU637975B2 (pt)
CA (1)	CA1335356C (pt)
DE (2)	DE68927055T2 (pt)
DK (1)	DK174025B1 (pt)
ES (1)	ES2016464A6 (pt)
IL (1)	IL90499A (pt)
NZ (1)	NZ229422A (pt)
PT (1)	PT90816B (pt)
WO (1)	WO1989012380A2 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5550111A (en) *	1984-07-11	1996-08-27	Temple University-Of The Commonwealth System Of Higher Education	Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
IE882585L (en) *	1988-08-25	1990-02-25	Prendergast Patrick T	Viral treatment system
PH30703A (en) *	1990-06-21	1997-09-16	Patrick T Prendergast	Administering particular compounds against variousparasites, mycoplasmas, other indications and otheer indications and other infections.
US5594121A (en) *	1991-11-07	1997-01-14	Gilead Sciences, Inc.	Enhanced triple-helix and double-helix formation with oligomers containing modified purines
WO1994024144A2 (en) *	1993-04-19	1994-10-27	Gilead Sciences, Inc.	Enhanced triple-helix and double-helix formation with oligomers containing modified purines
AU7710398A (en)	1997-06-12	1998-12-30	Temple University - Of The Commonwealth System Of Higher Education	Aminoaklanoyl-linked conjugates of 2',5'-oligoadenylate and antiviral uses thereof
AU7804798A (en)	1997-06-12	1998-12-30	Temple University - Of The Commonwealth System Of Higher Education	Base-modified derivatives of 2',5'-oligoadenylate and antiviral uses thereof
AU5429000A (en) *	1999-06-25	2001-01-31	Sankyo Company Limited	Novel bicyclonucleoside derivatives
TWI347948B (en)	2002-11-19	2011-09-01	Sankyo Co	Novel 2',5'-oligoadenylic acid compositions
GB201019043D0 (en)	2010-11-10	2010-12-22	Protea Biopharma N V	Use of 2',5'-oligoadenylate derivative compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4210746A (en) *	1978-08-10	1980-07-01	National Research Development Corporation	Nucleotide inhibitor of protein synthesis
US4464359A (en) *	1981-04-10	1984-08-07	Research Corporation	(2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof
US4539313A (en)	1981-04-10	1985-09-03	Research Corporation	(2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof
US4824941A (en) *	1983-03-10	1989-04-25	Julian Gordon	Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
US4859768A (en) *	1984-07-11	1989-08-22	Temple University Of The Commonwealth System Of Higher Education	Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof
US4654326A (en) *	1984-07-12	1987-03-31	Yair Devash	Inhibition of plant viruses with oligonucleotides

1989
- 1989-05-24 AT AT89906575T patent/ATE141796T1/de not_active IP Right Cessation
- 1989-05-24 AU AU37403/89A patent/AU637975B2/en not_active Ceased
- 1989-05-24 DE DE68927055T patent/DE68927055T2/de not_active Expired - Fee Related
- 1989-05-24 EP EP89906575A patent/EP0420872B1/en not_active Expired - Lifetime
- 1989-05-24 KR KR1019900700257A patent/KR0141684B1/ko not_active IP Right Cessation
- 1989-05-24 DE DE68929321T patent/DE68929321T2/de not_active Expired - Fee Related
- 1989-05-24 EP EP96101815A patent/EP0716856B1/en not_active Expired - Lifetime
- 1989-05-24 JP JP1506395A patent/JP2947580B2/ja not_active Expired - Fee Related
- 1989-05-24 AT AT96101815T patent/ATE204752T1/de not_active IP Right Cessation
- 1989-05-24 WO PCT/US1989/002284 patent/WO1989012380A2/en active IP Right Grant
- 1989-06-01 IL IL9049989A patent/IL90499A/en not_active IP Right Cessation
- 1989-06-08 ES ES8901996A patent/ES2016464A6/es not_active Expired - Lifetime
- 1989-06-09 CA CA000602302A patent/CA1335356C/en not_active Expired - Fee Related
- 1989-06-09 PT PT90816A patent/PT90816B/pt not_active IP Right Cessation
- 1989-06-09 CN CN89106235A patent/CN1107508C/zh not_active Expired - Fee Related
- 1989-10-06 NZ NZ229422A patent/NZ229422A/xx unknown
1990
- 1990-12-07 DK DK199002913A patent/DK174025B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE204752T1 (de)	2001-09-15
ES2016464A6 (es)	1990-11-01
EP0716856A2 (en)	1996-06-19
EP0420872A1 (en)	1991-04-10
CN1107508C (zh)	2003-05-07
EP0420872B1 (en)	1996-08-28
JP2947580B2 (ja)	1999-09-13
IL90499A (en)	1994-05-30
AU3740389A (en)	1990-01-12
DE68927055D1 (de)	1996-10-02
DE68927055T2 (de)	1997-04-10
DK291390D0 (da)	1990-12-07
IL90499A0 (en)	1990-01-18
DK174025B1 (da)	2002-04-29
EP0716856A3 (en)	1996-10-30
WO1989012380A3 (en)	1990-06-28
DE68929321D1 (de)	2001-10-04
CA1335356C (en)	1995-04-25
DK291390A (da)	1990-12-07
ATE141796T1 (de)	1996-09-15
CN1040321A (zh)	1990-03-14
DE68929321T2 (de)	2002-05-08
EP0420872A4 (en)	1992-10-21
KR0141684B1 (ko)	1998-06-01
NZ229422A (en)	1992-12-23
JPH03504970A (ja)	1991-10-31
KR900701279A (ko)	1990-12-01
WO1989012380A2 (en)	1989-12-28
AU637975B2 (en)	1993-06-17
EP0716856B1 (en)	2001-08-29
PT90816B (pt)	1994-11-30

Publication	Publication Date	Title
PT82580B (pt)	1989-01-17	Processo para a preparacao de 2',3'- didesoxinucleosidos e de composicoes farmaceuticas que os contem
ZA928170B (en)	1993-11-15	Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid
FI941245A (fi)	1994-03-16	Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi
FI903153A0 (fi)	1990-06-21	11b-aryl-4-estrener, foerfarande foer deras framstaellning samt deras anvaendning som laekemedel.
NL960024I1 (nl)	1996-12-02	Farmaceutisch preparaat omvattend 3'-deoxythymidine-2'-een (3'-deoxy-2',3'-didehydrothymidine) voor de behandeling van met retrovirus gesmette patiënten.
PT90816A (pt)	1989-12-29	Processo para a preparacao de composicoes farmaceuticas contendo analogos de 2',5'-oligoadenilato
PT84404B (pt)	1989-10-04	Processo para a preparacao de 2-alcoxi-n-(1-azabiciclo {2.2.2} octil-3)-benzamidas e tiobenzamidas apropriadas para aliviar a emese provocada por drogas anti-cancro sem platina
DE3875769D1 (de)	1992-12-17	Therapeutische nukleoside.
PT95212A (pt)	1991-05-22	Processo para a preparacao de uma composicao para uso topico para o tratamento da fragilidade capilar, contendo defibrotide
DE3887068D1 (de)	1994-02-24	2,2-Dimethylchromenderivate, Verfahren zur Herstellung und diese enthaltende pharmazeutische Zusammenstellungen.
ES2039267T3 (es)	1993-09-16	Dihidropiridinamidas, procedimiento para su preparacion y su empleo en medicamentos.
NO902400D0 (no)	1990-05-30	Dibenzo(1,5)-dioxocin-5-on-derivater, deres anvendelse i legemidler og deres fremstilling.
OA07270A (fr)	1984-04-30	Dérivés N-(vinblastinoyl-23) d'acide aminés, leur préparation et leur application thérapeutique.
PT84405B (pt)	1989-10-04	Processo para a preparacao de composicoes farmaceuticas contendo 2-alcoxi-n-(1-azabiciclo {2.2.2} octil-3-benzamida-n-oxidos apropriadas para controlar a emese provocada por drogas anti-cancro
PT90169A (pt)	1989-11-10	Processo para a preparacao de composicoes farmaceuticas contendo timopentina para o tratamento de pacientes sofrendo de viremias provocadas por hiv
BR9302809A (pt)	1994-03-15	Composto,processo para sua preparacao,processo de purificacao dos compostos,medicmanto,emprego e processo para a preparacao de um agente anti-tumoral
PT87563A (pt)	1989-05-31	Process for the preparation of vinylcephalosporins useful as medicaments
NO903291D0 (no)	1990-07-24	Renin-hemmende aminooligohydroksy-derivater.
PT89582B (pt)	1994-01-31	Processo para a preparacao de antibioticos beta-lactamicos uteis como medicamentos
ATE106874T1 (de)	1994-06-15	Kynurensäurederivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
FI894813A0 (fi)	1989-10-11	Menetelmä terapeuttisesti aktiivisten 2-metoksikarbonyylisubstituoitujen N,N'-di(trimetoksibentsoyyli)piperatsiinijohdannaisten valmistamiseksi
FR2710062B1 (fr)	1995-12-01	Dérivés d'acide 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur préparation et les médicaments les contenant.
MA21325A1 (fr)	1989-04-01	Procede de preparation des cis-n-(3 methoxy-4-pipiridinyl) benzamides.
FR2646850B1 (fr)	1991-07-12	Derives d'acide dibenzo(b,e)thiepinne-3-acetique, leur preparation et leur application en therapeutique

Legal Events

Date	Code	Title	Description
1994-11-30	FG3A	Patent granted, date of granting	Effective date: 19940511
2005-01-31	MM3A	Annulment or lapse	Effective date: 20041111