PT88340A - Processo para a preparacao de novos derivados de aristeromicina/adenosina - Google Patents

Processo para a preparacao de novos derivados de aristeromicina/adenosina

Info

Publication number: PT88340A
Authority: PT; Portugal
Prior art keywords: arysteromycin; preparation; new; adenosin; derivatives
Prior art date: 1987-08-26

Application number

PT88340A

Other languages

English (en)

Other versions

PT88340B (pt

Inventor

Esa Tero Jarvi

Nellikunja J Parakash

James R Maccarthy

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-26

Filing date

1988-08-25

Publication date

1989-06-30

1988-08-25 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-06-30 Publication of PT88340A publication Critical patent/PT88340A/pt

1995-05-04 Publication of PT88340B publication Critical patent/PT88340B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT88340A 1987-08-26 1988-08-25 Processo para a preparacao de novos derivados de aristeromicina/adenosina PT88340B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US8969387A	1987-08-26	1987-08-26

Publications (2)

Publication Number	Publication Date
PT88340A true PT88340A (pt)	1989-06-30
PT88340B PT88340B (pt)	1995-05-04

Family

ID=22219090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT88340A PT88340B (pt)	1987-08-26	1988-08-25	Processo para a preparacao de novos derivados de aristeromicina/adenosina

Country Status (22)

Country	Link
US (1)	US4997924B1 (pt)
EP (1)	EP0304889B1 (pt)
JP (1)	JP2722215B2 (pt)
KR (1)	KR970002660B1 (pt)
CN (1)	CN1023561C (pt)
AR (1)	AR244229A1 (pt)
AT (1)	ATE141282T1 (pt)
AU (1)	AU613660B2 (pt)
CA (1)	CA1315779C (pt)
DE (1)	DE3855470T2 (pt)
DK (1)	DK166355C (pt)
ES (1)	ES2092981T3 (pt)
FI (1)	FI90876C (pt)
GR (1)	GR3020849T3 (pt)
HU (1)	HU199153B (pt)
IE (1)	IE81117B1 (pt)
IL (1)	IL87532A (pt)
NO (1)	NO168361C (pt)
NZ (1)	NZ225906A (pt)
PH (1)	PH25533A (pt)
PT (1)	PT88340B (pt)
ZA (1)	ZA886216B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4996308A (en) *	1988-03-25	1991-02-26	Merrell Dow Pharmaceuticals Inc.	Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
HU204843B (en) *	1988-09-27	1992-02-28	Merrell Dow Pharma	Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
JPH02215781A (ja) *	1989-02-14	1990-08-28	Toyo Jozo Co Ltd	６’―デオキシ―６’―ハロゲノネプラノシンａおよびその製造法
US5100896A (en) *	1989-07-24	1992-03-31	Glaxo Group Limited	Carbocyclic analogues of 7H-1,2,3-triazolo [4,5-d]pyrimidine furanosides
ZA908001B (en) *	1989-10-11	1991-08-28	Merrell Dow Pharma	Inosine/guanosine derivatives as immunosuppressive agents
ZA907994B (en) *	1989-10-11	1991-07-31	Merrell Dow Pharma	Novel inosine/guanosine derivatives
ZA907998B (en) *	1989-10-11	1991-07-31	Merrell Dow Pharma	Inosine/guanosine derivatives as antineoplastic agents
DE4005275A1 (de) *	1990-02-20	1991-08-22	Grundmann Ewald	Verwendung von s-adenosylmethionin als mittel gegen virale infektionen durch retroviren
JPH0421682A (ja) *	1990-05-11	1992-01-24	Asahi Chem Ind Co Ltd	２―フルオロネプラノシンａおよびその製造法
US5618704A (en) *	1990-07-27	1997-04-08	Isis Pharmacueticals, Inc.	Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
ZA916350B (en) *	1990-08-16	1992-05-27	Merrell Dow Pharma	5'-vinylhalo-aristeromycin/adenosine analogs as immunosuppressants
US5514688A (en) *	1990-09-14	1996-05-07	Merrell Dow Pharmaceuticals Inc.	Carbocyclic adenosine analogs useful as immunosuppressants
US5244896A (en) *	1990-09-14	1993-09-14	Marion Merrell Dow Inc.	Carbocyclic adenosine analogs useful as immunosuppressants
US5206244A (en) *	1990-10-18	1993-04-27	E. R. Squibb & Sons, Inc.	Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
CA2158462A1 (en) *	1993-03-18	1994-09-29	Akira Matsuda	Novel 2'-methylidenenucleotide compounds, methods for production thereof and pharmaceutical use thereof
EP0630897A3 (en) *	1993-06-25	1995-03-01	Bristol Myers Squibb Co	3-hydroxy-4-hydroxymethyl-2-methylene-cyclopentyl purines and pyrimidines.
US6579857B1 (en) *	1999-06-11	2003-06-17	Evanston Northwestern Healthcare Research Institute	Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3928319A (en) *	1971-06-16	1975-12-23	Syntex Inc	4 -Fluoro nucleosides, novel intermediates and methods of preparing same
US3910885A (en) *	1974-03-12	1975-10-07	Syntex Inc	4-Alkoxy nucleosides and intermediates therefore
JPS5651414A (en) *	1979-10-02	1981-05-09	Toyo Jozo Co Ltd	Antibiotic substance neplanocin preparation
US4543255A (en) *	1984-05-10	1985-09-24	Southern Research Institute	Carbocyclic analogs of purine 2'-deoxyribofuranosides

1987
- 1987-08-23 NZ NZ225906A patent/NZ225906A/xx unknown
1988
- 1988-08-22 ZA ZA886216A patent/ZA886216B/xx unknown
- 1988-08-22 CA CA000575389A patent/CA1315779C/en not_active Expired - Fee Related
- 1988-08-23 AU AU21438/88A patent/AU613660B2/en not_active Ceased
- 1988-08-23 FI FI883889A patent/FI90876C/fi not_active IP Right Cessation
- 1988-08-23 IL IL87532A patent/IL87532A/xx not_active IP Right Cessation
- 1988-08-23 AR AR88311731A patent/AR244229A1/es active
- 1988-08-24 EP EP88113788A patent/EP0304889B1/en not_active Expired - Lifetime
- 1988-08-24 DE DE3855470T patent/DE3855470T2/de not_active Expired - Fee Related
- 1988-08-24 ES ES88113788T patent/ES2092981T3/es not_active Expired - Lifetime
- 1988-08-24 AT AT88113788T patent/ATE141282T1/de not_active IP Right Cessation
- 1988-08-25 IE IE259388A patent/IE81117B1/en not_active IP Right Cessation
- 1988-08-25 CN CN88106240A patent/CN1023561C/zh not_active Expired - Fee Related
- 1988-08-25 KR KR88010802A patent/KR970002660B1/ko not_active IP Right Cessation
- 1988-08-25 PT PT88340A patent/PT88340B/pt not_active IP Right Cessation
- 1988-08-25 NO NO883793A patent/NO168361C/no unknown
- 1988-08-25 DK DK475488A patent/DK166355C/da not_active IP Right Cessation
- 1988-08-25 HU HU884455A patent/HU199153B/hu not_active IP Right Cessation
- 1988-08-26 PH PH37465A patent/PH25533A/en unknown
- 1988-08-26 JP JP63210913A patent/JP2722215B2/ja not_active Expired - Fee Related
1989
- 1989-11-29 US US07445892 patent/US4997924B1/en not_active Expired - Lifetime
1996
- 1996-08-22 GR GR960402206T patent/GR3020849T3/el unknown

Also Published As

Publication number	Publication date
CN1023561C (zh)	1994-01-19
AU613660B2 (en)	1991-08-08
AR244229A1 (es)	1993-10-29
NZ225906A (en)	1990-10-26
ATE141282T1 (de)	1996-08-15
DE3855470D1 (de)	1996-09-19
NO168361C (no)	1992-02-12
NO883793L (no)	1989-02-27
PH25533A (en)	1991-07-24
FI90876C (fi)	1994-04-11
DK475488D0 (da)	1988-08-25
DK166355B (da)	1993-04-13
KR890003796A (ko)	1989-04-18
ZA886216B (en)	1989-04-26
IE882593L (en)	1989-02-26
DK475488A (da)	1989-02-27
US4997924A (en)	1991-03-05
AU2143888A (en)	1989-03-02
GR3020849T3 (en)	1996-11-30
IE81117B1 (en)	2000-03-22
EP0304889A3 (en)	1990-01-24
HUT47954A (en)	1989-04-28
EP0304889B1 (en)	1996-08-14
DE3855470T2 (de)	1997-03-13
HU199153B (en)	1990-01-29
KR970002660B1 (en)	1997-03-07
ES2092981T3 (es)	1996-12-16
NO168361B (no)	1991-11-04
CA1315779C (en)	1993-04-06
CN1033632A (zh)	1989-07-05
EP0304889A2 (en)	1989-03-01
JPH01308267A (ja)	1989-12-12
FI883889A (fi)	1989-02-27
NO883793D0 (no)	1988-08-25
IL87532A0 (en)	1989-01-31
US4997924B1 (en)	1995-11-14
JP2722215B2 (ja)	1998-03-04
FI883889A0 (fi)	1988-08-23
DK166355C (da)	1993-09-06
PT88340B (pt)	1995-05-04
IL87532A (en)	1993-05-13
FI90876B (fi)	1993-12-31

Publication	Publication Date	Title
PT81859B (pt)	1988-05-27	Processo para a preparacao de derivados de tiazolidinodionas
PT87933A (pt)	1989-06-30	Processo para a preparacao de di-hidrato de azitromicina
BR8802484A (pt)	1988-12-20	Processo para a preparacao de isocianatos
PT90119A (pt)	1989-11-10	Processo para a preparacao de um adocante
PT81463B (pt)	1988-03-03	Processo para a preparacao de novos derivados 5-amino-4-hidroxivalerilo
PT84561B (pt)	1989-11-10	Processo aperfeicoado para a preparacao de derivados macrolidos
PT89205A (pt)	1989-12-29	Processo para a preparacao de derivados de indano
PT89482A (pt)	1989-10-04	Processo para a preparacao de derivados de nucleosidos disesoxi-didesidro-carboxilico
PT88340A (pt)	1989-06-30	Processo para a preparacao de novos derivados de aristeromicina/adenosina
PT88180A (pt)	1989-06-30	Processo para a preparacao de derivados alquilaminoalcoxifenilo
BR8702112A (pt)	1988-02-09	Processo para a preparacao de um derivado de pirazol pirimidina
PT89039A (pt)	1988-12-01	Processo para a preparacao de l-ramnose
PT92365A (pt)	1990-05-31	Processo para a preparacao de (s)-alfa-etil-2-oxo-1-pirrolidinoacetamida
PT89775A (pt)	1989-10-04	Processo para a preparacao de derivados de isoquinolina
PT91027A (pt)	1990-02-08	Processo para a preparacao de derivados peptidicos
PT92539A (pt)	1990-06-29	Processo para a preparacao de derivados de anfotericina b
BR8803678A (pt)	1989-02-14	Processo para a preparacao de polieteramidas
PT80264B (pt)	1987-10-20	Processo para a preparacao de derivados de hidroxi-4-2h-1-benzotiopiran-2-onas
PT94008A (pt)	1991-01-08	Processo para a preparacao de novos derivados de tieno-triazolo-diazepina
PT82245B (pt)	1988-02-17	Processo para a preparacao de 2-amino-6-cloropurina
BR8806351A (pt)	1989-08-22	Processo para a preparacao de fenil-ureias
PT88990A (pt)	1989-11-30	Processo para a preparacao de novos acidos aza-cicloalquil-alcano-difosfonicos
PT85608A (pt)	1988-08-17	Processo para a preparacao de derivados de fenil-etanolamina
BR8700457A (pt)	1987-12-08	Processo para a preparacao de um derivado de alquileno-diamina
PT89778A (pt)	1989-10-04	Processo para a preparacao de um derivado de hirudina

Legal Events

Date	Code	Title	Description
1995-05-04	FG3A	Patent granted, date of granting	Effective date: 19941021
2005-06-30	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20050421

Date

Code

Title

Description

1995-05-04

FG3A

Patent granted, date of granting

Effective date: 19941021

2005-06-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20050421