PT88173A - Processo para a preparacao de 1,4-di-hidropiridinas e sua aplicacao como medicamentos - Google Patents

Processo para a preparacao de 1,4-di-hidropiridinas e sua aplicacao como medicamentos

Info

Publication number: PT88173A
Authority: PT; Portugal
Prior art keywords: methyl; dihydro; hydropyridines; medicines; preparation
Prior art date: 1987-08-03

Application number

PT88173A

Other languages

English (en)

Other versions

PT88173B (pt

Original Assignee

Delagrange Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-03

Filing date

1988-08-02

Publication date

1989-06-30

1988-08-02 Application filed by Delagrange Lab filed Critical Delagrange Lab

1989-06-30 Publication of PT88173A publication Critical patent/PT88173A/pt

1995-03-01 Publication of PT88173B publication Critical patent/PT88173B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PT88173A 1987-08-03 1988-08-02 Processo para a preparacao de 1,4-di-hidropiridinas e sua aplicacao como medicamentos PT88173B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP87401799A EP0302980B1 (fr)	1987-08-03	1987-08-03	1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments

Publications (2)

Publication Number	Publication Date
PT88173A true PT88173A (pt)	1989-06-30
PT88173B PT88173B (pt)	1995-03-01

Family

ID=8198243

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT88173A PT88173B (pt)	1987-08-03	1988-08-02	Processo para a preparacao de 1,4-di-hidropiridinas e sua aplicacao como medicamentos

Country Status (34)

Country	Link
US (1)	US4952592A (pt)
EP (1)	EP0302980B1 (pt)
JP (1)	JPH0733383B2 (pt)
KR (1)	KR960001724B1 (pt)
CN (1)	CN1038587C (pt)
AT (1)	ATE61588T1 (pt)
BE (1)	BE1001055A4 (pt)
CA (2)	CA1306261C (pt)
CH (1)	CH675999A5 (pt)
CZ (1)	CZ282077B6 (pt)
DD (1)	DD282008A5 (pt)
DE (2)	DE3768658D1 (pt)
DK (1)	DK430288A (pt)
ES (1)	ES2007543A6 (pt)
FI (1)	FI91406C (pt)
GB (1)	GB2208861B (pt)
GR (2)	GR880100507A (pt)
HU (1)	HU204523B (pt)
IE (1)	IE60358B1 (pt)
IL (1)	IL87321A (pt)
IN (1)	IN167550B (pt)
IS (1)	IS1549B (pt)
IT (1)	IT1235013B (pt)
LU (1)	LU87297A1 (pt)
MA (1)	MA21344A1 (pt)
NO (1)	NO170934C (pt)
NZ (1)	NZ225661A (pt)
PH (1)	PH25645A (pt)
PT (1)	PT88173B (pt)
RU (1)	RU2036922C1 (pt)
SK (1)	SK541388A3 (pt)
TN (1)	TNSN88081A1 (pt)
YU (1)	YU46547B (pt)
ZA (1)	ZA885684B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5242933A (en) *	1990-07-10	1993-09-07	Adir Et Compagnie	Piperidine, tetrahydropyridine and pyrrolidine compounds
EP0854721B1 (en) *	1995-08-02	2001-10-24	Smithkline Beecham Corporation	Endothelin receptor antagonists
DE60128683T2 (de) *	2000-04-11	2008-01-24	Sankyo Co., Ltd.	Stabilisierte pharmazeutische zusammenstellungen die den calziumkanalblocker azelnidipine enthalten
OA12905A (en)	2002-08-19	2006-10-13	Pfizer Prod Inc	Combination therapy for hyperproliferative diseases.
MX2007000979A (es) *	2004-07-26	2007-07-11	Cotherix Inc	Tratamiento de la hipertension pulmonar por iloprost inhalado con una formulacion microparticulada.
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
WO2007050783A2 (en)	2005-10-26	2007-05-03	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (en)	2005-10-26	2012-08-22	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
TW200736245A (en) *	2005-11-29	2007-10-01	Sankyo Co	Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) *	2005-11-29	2008-02-01	Sankyo Co	Acid addition salts of dihydropyridine derivatives
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
WO2008070496A2 (en)	2006-12-01	2008-06-12	Bristol-Myers Squibb Company	N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2012037665A1 (en)	2010-09-24	2012-03-29	Oral Delivery Technology Ltd.	Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
RU2618628C1 (ru)	2013-04-17	2017-05-05	Пфайзер Инк.	Производные N-пиперидин-3-илбензамида для лечения сердечно-сосудистых заболеваний
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
CA3125765A1 (en)	2019-01-18	2020-07-23	Astrazeneca Ab	Pcsk9 inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3441648A (en) *	1967-02-07	1969-04-29	Smithkline Corp	Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US4031104A (en) *	1972-04-18	1977-06-21	Bayer Aktiengesellschaft	1,4-Dihydropyridine carboxylic acid esters
JPS5978186A (ja) *	1982-10-27	1984-05-04	Yoshitomi Pharmaceut Ind Ltd	１，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
ES8507495A1 (es) *	1984-03-27	1985-09-01	Inst Investigacion Desarrollo	Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
IE57810B1 (en) *	1984-03-27	1993-04-21	Delagrange Lab	1,4-dihydropyridine derivatives,their preparation and their use
JPH068294B2 (ja) *	1985-02-26	1994-02-02	富山化学工業株式会社	新規な１，４−ジヒドロピリジン誘導体およびその塩
EP0174131A3 (en) *	1984-09-01	1989-06-07	FISONS plc	Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
JPH01207267A (ja) *	1987-03-05	1989-08-21	Yamanouchi Pharmaceut Co Ltd	ピリジン誘導体及び該化合物を含有する肝疾患治療剤

1987
- 1987-08-03 AT AT87401799T patent/ATE61588T1/de active
- 1987-08-03 DE DE8787401799T patent/DE3768658D1/de not_active Expired - Lifetime
- 1987-08-03 EP EP87401799A patent/EP0302980B1/fr not_active Expired - Lifetime
1988
- 1988-07-27 LU LU87297A patent/LU87297A1/fr unknown
- 1988-07-29 CA CA000573422A patent/CA1306261C/fr not_active Expired - Lifetime
- 1988-07-29 YU YU147088A patent/YU46547B/sh unknown
- 1988-07-29 DE DE3825962A patent/DE3825962A1/de not_active Withdrawn
- 1988-08-01 FI FI883603A patent/FI91406C/fi not_active IP Right Cessation
- 1988-08-01 NO NO883406A patent/NO170934C/no unknown
- 1988-08-01 DD DD88318537A patent/DD282008A5/de not_active IP Right Cessation
- 1988-08-01 JP JP63192591A patent/JPH0733383B2/ja not_active Expired - Lifetime
- 1988-08-01 MA MA21587A patent/MA21344A1/fr unknown
- 1988-08-02 PT PT88173A patent/PT88173B/pt not_active IP Right Cessation
- 1988-08-02 SK SK5413-88A patent/SK541388A3/sk unknown
- 1988-08-02 NZ NZ225661A patent/NZ225661A/xx unknown
- 1988-08-02 DK DK430288A patent/DK430288A/da not_active Application Discontinuation
- 1988-08-02 IL IL87321A patent/IL87321A/xx not_active IP Right Cessation
- 1988-08-02 CH CH2922/88A patent/CH675999A5/fr not_active IP Right Cessation
- 1988-08-02 IT IT8848259A patent/IT1235013B/it active
- 1988-08-02 BE BE8800893A patent/BE1001055A4/fr not_active IP Right Cessation
- 1988-08-02 GR GR880100507A patent/GR880100507A/el unknown
- 1988-08-02 US US07/227,373 patent/US4952592A/en not_active Expired - Fee Related
- 1988-08-02 KR KR1019880009867A patent/KR960001724B1/ko not_active IP Right Cessation
- 1988-08-02 HU HU884065A patent/HU204523B/hu not_active IP Right Cessation
- 1988-08-02 ES ES8802413A patent/ES2007543A6/es not_active Expired
- 1988-08-02 IS IS3378A patent/IS1549B/is unknown
- 1988-08-02 CZ CS885413A patent/CZ282077B6/cs not_active IP Right Cessation
- 1988-08-02 GB GB8818356A patent/GB2208861B/en not_active Expired - Lifetime
- 1988-08-02 IE IE236488A patent/IE60358B1/en not_active IP Right Cessation
- 1988-08-02 CN CN88106537A patent/CN1038587C/zh not_active Expired - Fee Related
- 1988-08-02 TN TNTNSN88081A patent/TNSN88081A1/fr unknown
- 1988-08-03 PH PH37337A patent/PH25645A/en unknown
- 1988-08-03 IN IN556/MAS/88A patent/IN167550B/en unknown
- 1988-08-03 ZA ZA885684A patent/ZA885684B/xx unknown
1990
- 1990-08-28 CA CA000615848A patent/CA1306262C/fr not_active Expired - Lifetime
1991
- 1991-05-22 GR GR91400660T patent/GR3001984T3/el unknown
1992
- 1992-03-31 RU SU925011204A patent/RU2036922C1/ru active

Also Published As

Publication number	Publication date
MA21344A1 (fr)	1989-04-01
KR960001724B1 (ko)	1996-02-03
DE3825962A1 (de)	1989-02-16
TNSN88081A1 (fr)	1990-07-10
IE882364L (en)	1989-02-03
US4952592A (en)	1990-08-28
HUT54142A (en)	1991-01-28
IS1549B (is)	1994-06-08
DE3768658D1 (de)	1991-04-18
LU87297A1 (fr)	1989-02-02
NO170934B (no)	1992-09-21
SK278775B6 (sk)	1998-02-04
SK541388A3 (en)	1998-02-04
ATE61588T1 (de)	1991-03-15
FI91406C (fi)	1994-06-27
NZ225661A (en)	1990-08-28
IL87321A0 (en)	1989-01-31
HU204523B (en)	1992-01-28
RU2036922C1 (ru)	1995-06-09
IS3378A7 (is)	1989-02-04
CZ541388A3 (en)	1997-01-15
IE60358B1 (en)	1994-06-29
JPH0733383B2 (ja)	1995-04-12
EP0302980B1 (fr)	1991-03-13
NO883406L (no)	1989-02-06
AU2033088A (en)	1989-02-09
CN1031531A (zh)	1989-03-08
DK430288D0 (da)	1988-08-02
PT88173B (pt)	1995-03-01
PH25645A (en)	1991-08-21
FI883603A0 (fi)	1988-08-01
IT1235013B (it)	1992-06-16
FI883603A (fi)	1989-02-04
JPH01294675A (ja)	1989-11-28
FI91406B (fi)	1994-03-15
GR3001984T3 (en)	1992-11-23
CZ282077B6 (cs)	1997-05-14
YU147088A (en)	1990-04-30
KR890003743A (ko)	1989-04-17
CA1306261C (fr)	1992-08-11
IT8848259A0 (it)	1988-08-02
BE1001055A4 (fr)	1989-06-20
CN1038587C (zh)	1998-06-03
AU606441B2 (en)	1991-02-07
CH675999A5 (en)	1990-11-30
YU46547B (sh)	1993-11-16
NO170934C (no)	1992-12-30
ES2007543A6 (es)	1989-06-16
DK430288A (da)	1989-02-03
NO883406D0 (no)	1988-08-01
GR880100507A (el)	1989-05-25
IL87321A (en)	1993-04-04
GB8818356D0 (en)	1988-09-07
IN167550B (pt)	1990-11-10
DD282008A5 (de)	1990-08-29
ZA885684B (en)	1989-04-26
CA1306262C (fr)	1992-08-11
EP0302980A1 (fr)	1989-02-15
GB2208861A (en)	1989-04-19
GB2208861B (en)	1991-07-17

Publication	Publication Date	Title
PT88173A (pt)	1989-06-30	Processo para a preparacao de 1,4-di-hidropiridinas e sua aplicacao como medicamentos
FI875229A0 (fi)	1987-11-27	Menetelmä uusien farmakologisesti aktiivisten katekolijohdoksien valmistamiseksi
NO901657L (no)	1990-10-18	Fuktende baeremiddel for topisk administrering av vitamin a syre.
ATE53376T1 (de)	1990-06-15	Entzuendungshemmende agentien.
SE9300758L (sv)	1993-09-11	Förfarande för framställning av kavulansyrasalter
FI900145A (fi)	1990-01-11	Menetelmä farmaseuttisesti käyttökelpoisten 1,1-diokso-kefem-4-karbotiolihappojohdannaisten valmistamiseksi
IT8621112A0 (it)	1986-07-14	Derivati dell'acido tiazolidin-4-carbossilico adattivita' farmaceutica.
FI99013B (fi)	1997-06-13	Analogiamenetelmä terapeuttisesti käyttökelpoisten bentsimidatsolijohdannaisten valmistamiseksi
ES541215A0 (es)	1986-04-16	Un metodo para preparar un cianoimidazol-nucleosido
FI93725B (fi)	1995-02-15	Menetelmä optisesti aktiivisten, oikealle kiertävien okso-isoindolinyylijohdannaisten valmistamiseksi
SE8605255D0 (sv)	1986-12-08	4h-benzo(4,5)cyclohepta(1,2-b)thiophene derivatives
FI93008B (fi)	1994-10-31	Menetelmä bakteerien vastaisten 6-fluori-1,4-dihydrokinol-4-oni-3-karboksyylihappojohdannaisten valmistamiseksi
DE3764457D1 (de)	1990-09-27	Empfaengnisverhuetende, waessrig-saure zusammensetzung und verfahren zu ihrer herstellung.
IT8019354A0 (it)	1980-01-22	Derivati dell'acido nicotinico adattivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche.
IT8722079A0 (it)	1987-09-30	Derivati dell'acido 2-osso-1-azetidin solfonico dotati di attivita' antibatterica, procedimento per la loro preparazione e relative formulazioni farmaceutiche.

Legal Events

Date	Code	Title	Description
1995-03-01	FG3A	Patent granted, date of granting	Effective date: 19940822
1996-06-28	PC3A	Transfer or assignment	Free format text: 960403 PRODESFARMA S.A. ES
1998-04-30	PC3A	Transfer or assignment	Free format text: 980202 ALMIRALL-PRODESFARMA, SOCIEDAD ANONIMA ES
2001-06-29	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20010228