PT87927A - Processo para a preparacao de acidos 3,5-dihidroxi-hepta-6-enoicos substituidos por 7-{1h-pirrol-3-ilo}, das suas correspondentes delta-lactonas e sais, e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de acidos 3,5-dihidroxi-hepta-6-enoicos substituidos por 7-{1h-pirrol-3-ilo}, das suas correspondentes delta-lactonas e sais, e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT87927A PT87927A PT87927A PT8792788A PT87927A PT 87927 A PT87927 A PT 87927A PT 87927 A PT87927 A PT 87927A PT 8792788 A PT8792788 A PT 8792788A PT 87927 A PT87927 A PT 87927A
- Authority
- PT
- Portugal
- Prior art keywords
- pyrrol
- lactones
- salts
- contain
- acid
- Prior art date
Links
- -1 1H-PYRROL-3-YL Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000422 delta-lactone group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873722806 DE3722806A1 (de) | 1987-07-10 | 1987-07-10 | 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
Publications (2)
Publication Number | Publication Date |
---|---|
PT87927A true PT87927A (pt) | 1989-06-30 |
PT87927B PT87927B (pt) | 1995-03-01 |
Family
ID=6331291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT87927A PT87927B (pt) | 1987-07-10 | 1988-07-07 | Processo para a preparacao de acidos 3,5-dihidroxi-hepta-6-enoicos substituidos por 7-(1h-pirrol-3-ilo), das suas correspondentes delta-lactonas e sais, e de composicoes farmaceuticas que os contem |
Country Status (19)
Country | Link |
---|---|
US (1) | US5055484A (pt) |
EP (1) | EP0300249B1 (pt) |
JP (1) | JPS6434959A (pt) |
KR (1) | KR890002135A (pt) |
AT (1) | ATE85324T1 (pt) |
AU (1) | AU1888088A (pt) |
DE (2) | DE3722806A1 (pt) |
DK (1) | DK384288A (pt) |
ES (1) | ES2043736T3 (pt) |
FI (1) | FI883247A (pt) |
GR (1) | GR3007611T3 (pt) |
HU (1) | HU208672B (pt) |
IE (1) | IE63205B1 (pt) |
IL (1) | IL87036A0 (pt) |
NO (1) | NO883072L (pt) |
NZ (1) | NZ225342A (pt) |
PH (1) | PH26375A (pt) |
PT (1) | PT87927B (pt) |
ZA (1) | ZA884918B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3826814A1 (de) * | 1988-08-06 | 1990-02-08 | Hoechst Ag | Neue 6-fluor-3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
IT1237793B (it) * | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
US5128366A (en) * | 1990-07-05 | 1992-07-07 | Shinogi & Co., Ltd. | Pyrrole derivatives |
DE4243279A1 (de) * | 1992-12-21 | 1994-06-23 | Bayer Ag | Substituierte Triole |
US7250444B2 (en) * | 2003-08-11 | 2007-07-31 | Pfizer Inc. | Pyrrole-based HMG-CoA reductase inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3928380A (en) * | 1973-03-29 | 1975-12-23 | Sterling Drug Inc | 1,1{40 -Spirobis(cyclopenta-{8 4,5-c{9 pyrroles) |
US4647576A (en) * | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
US4851427A (en) * | 1985-10-25 | 1989-07-25 | Sandoz Pharm. Corp. | Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use |
KR900001212B1 (ko) * | 1985-10-25 | 1990-02-28 | 산도즈 파마슈티칼스 코오포레이숀 | 메바로노락톤 및 그것의 유도체의 헤테로사이클릭 유사체 및 그것의 생산방법 및 약학적인 그것의 용도 |
US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
NO881411L (no) * | 1987-04-14 | 1988-10-17 | Bayer Ag | Substituerte pyrroler. |
-
1987
- 1987-07-10 DE DE19873722806 patent/DE3722806A1/de not_active Withdrawn
-
1988
- 1988-07-01 EP EP88110533A patent/EP0300249B1/de not_active Expired - Lifetime
- 1988-07-01 ES ES88110533T patent/ES2043736T3/es not_active Expired - Lifetime
- 1988-07-01 AT AT88110533T patent/ATE85324T1/de not_active IP Right Cessation
- 1988-07-01 DE DE8888110533T patent/DE3878067D1/de not_active Expired - Fee Related
- 1988-07-07 PT PT87927A patent/PT87927B/pt not_active IP Right Cessation
- 1988-07-07 FI FI883247A patent/FI883247A/fi not_active Application Discontinuation
- 1988-07-08 AU AU18880/88A patent/AU1888088A/en not_active Abandoned
- 1988-07-08 NZ NZ225342A patent/NZ225342A/en unknown
- 1988-07-08 ZA ZA884918A patent/ZA884918B/xx unknown
- 1988-07-08 NO NO88883072A patent/NO883072L/no unknown
- 1988-07-08 DK DK384288A patent/DK384288A/da not_active Application Discontinuation
- 1988-07-08 US US07/216,423 patent/US5055484A/en not_active Expired - Fee Related
- 1988-07-08 HU HU883600A patent/HU208672B/hu not_active IP Right Cessation
- 1988-07-08 IL IL87036A patent/IL87036A0/xx unknown
- 1988-07-08 IE IE209788A patent/IE63205B1/en not_active IP Right Cessation
- 1988-07-08 JP JP63169159A patent/JPS6434959A/ja active Pending
- 1988-07-08 PH PH37199A patent/PH26375A/en unknown
- 1988-07-09 KR KR1019880008546A patent/KR890002135A/ko not_active Application Discontinuation
-
1993
- 1993-04-09 GR GR930400426T patent/GR3007611T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU1888088A (en) | 1989-01-12 |
NO883072D0 (no) | 1988-07-08 |
DK384288A (da) | 1989-01-11 |
IL87036A0 (en) | 1988-12-30 |
FI883247A0 (fi) | 1988-07-07 |
US5055484A (en) | 1991-10-08 |
IE63205B1 (en) | 1995-04-05 |
KR890002135A (ko) | 1989-04-08 |
EP0300249A1 (de) | 1989-01-25 |
FI883247A (fi) | 1989-01-11 |
DE3722806A1 (de) | 1989-01-19 |
EP0300249B1 (de) | 1993-02-03 |
ES2043736T3 (es) | 1994-01-01 |
ZA884918B (en) | 1989-01-18 |
JPS6434959A (en) | 1989-02-06 |
PH26375A (en) | 1992-06-01 |
IE882097L (en) | 1989-01-10 |
HU208672B (en) | 1993-12-28 |
ATE85324T1 (de) | 1993-02-15 |
NZ225342A (en) | 1991-03-26 |
GR3007611T3 (pt) | 1993-08-31 |
NO883072L (no) | 1989-01-11 |
DE3878067D1 (de) | 1993-03-18 |
HUT48580A (en) | 1989-06-28 |
PT87927B (pt) | 1995-03-01 |
DK384288D0 (da) | 1988-07-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK383688D0 (da) | 3-desmethyl-mevalonsyrederivater, deres fremstilling og anvendelse samt mellemprodukter ved fremstilling | |
PT91766A (pt) | Processo para a preparacao de derivados do acido 3,5-dihidroxihept-6-ina-carboxilico substituidos na posicao, de seus compostos intermedios e de composicoes farmaceuticas que os contem | |
NO174392C (no) | Analogifremgangsmåte for fremstilling av acyldeoksyribonukleosidderivater | |
PT87927A (pt) | Processo para a preparacao de acidos 3,5-dihidroxi-hepta-6-enoicos substituidos por 7-{1h-pirrol-3-ilo}, das suas correspondentes delta-lactonas e sais, e de composicoes farmaceuticas que os contem | |
PT87930A (pt) | Processo para a preparacao de derivados de acido 3-desmetil-4-fluor-mevalonico e de composicoes farmaceuticas que os contem | |
DK330585D0 (da) | Kombinationspraeparat af pyrimido-pyrimidiner og 0-acetylsalicylsyre og deres farmaceutisk acceptable salte | |
PT81860B (pt) | Processo para a preparacao de piridopirimidinas uteis como medicamentos | |
IE880628L (en) | Substituted pyridine-2,4-dicarboxylic acid derivatives,¹processes for their preparation, the use thereof and¹medicaments based on these compounds | |
PT91362A (pt) | Processo para a preparacao de novos acidos 6-fluor-3,5-di-hidroxi-carboxilicos e seus derivados, e de composicoes farmaceuticas que os contem e de produtos intermediarios | |
SE8306225L (sv) | 2-piperazinyl-kinazolinderivat, deras framstellning och farmaceutiska kompositioner innehallande desamma | |
PT91873A (pt) | Processo para a preparacao de composicoes farmaceuticas contendo acidos oxapenem-3-carboxilicos estaveis uteis como inibidores de beta-lactamase | |
ES2039211T3 (es) | Nuevos n-glicosilamidoderivados, procedimientos para su obtencion y su empleo como medicamentos. | |
SE8500822L (sv) | Diazepinoindoler, deras framstellning samt farmaceutiska kompositioner innehallande desamma | |
PT88073A (pt) | Processo para a preparacao de antagonistas de leucotrieno e de composicoes farmaceuticas que os contem | |
ES2037116T3 (es) | Procedimiento para la obtencion de bencilaminoarildihidropiridinlactonas. | |
FI873483A0 (fi) | Oxiranpseudooligosackarider, foerfarande foer deras framstaellning, deras anvaendning och farmaceutiska preparat. | |
PT93597A (pt) | Processo para a preparacao de derivados cefalosporanicos polares e de composicoes farmaceuticas que os contem | |
PT93581A (pt) | Processo para a preparacao de derivados cefalosporanicos e de composicoes farmaceuticas que os contem | |
ES1006093Y (es) | Juego de composicion para la formacion de cuadros. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19940812 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19970228 |