PT868526E - Processo para a preparacao de n-acetil-(l)-4-cianofenilalanina ac-(l)-phe(4-cn)-oh e n-acetil-(l)-p-amidinofenilalanina-ciclo-hexilglicina-beta-(3-n-metilpiridinio)-alanina ac-(l)-paph-chg-palme(3)-nh2 - Google Patents

Processo para a preparacao de n-acetil-(l)-4-cianofenilalanina ac-(l)-phe(4-cn)-oh e n-acetil-(l)-p-amidinofenilalanina-ciclo-hexilglicina-beta-(3-n-metilpiridinio)-alanina ac-(l)-paph-chg-palme(3)-nh2

Info

Publication number: PT868526E
Authority: PT; Portugal
Prior art keywords: cyclohexylglycin; amidinefenylalanine; paph; palme; methylpyridyl
Prior art date: 1995-12-20

Application number

PT96942085T

Other languages

English (en)

Inventor

Chi-Hsin R King

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-20

Filing date

1996-11-25

Publication date

2002-12-31

1996-11-25 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2002-12-31 Publication of PT868526E publication Critical patent/PT868526E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cosmetics (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PT96942085T 1995-12-20 1996-11-25 Processo para a preparacao de n-acetil-(l)-4-cianofenilalanina ac-(l)-phe(4-cn)-oh e n-acetil-(l)-p-amidinofenilalanina-ciclo-hexilglicina-beta-(3-n-metilpiridinio)-alanina ac-(l)-paph-chg-palme(3)-nh2 PT868526E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57556995A	1995-12-20	1995-12-20

Publications (1)

Publication Number	Publication Date
PT868526E true PT868526E (pt)	2002-12-31

Family

ID=24300839

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96942085T PT868526E (pt)	1995-12-20	1996-11-25	Processo para a preparacao de n-acetil-(l)-4-cianofenilalanina ac-(l)-phe(4-cn)-oh e n-acetil-(l)-p-amidinofenilalanina-ciclo-hexilglicina-beta-(3-n-metilpiridinio)-alanina ac-(l)-paph-chg-palme(3)-nh2

Country Status (27)

Country	Link
EP (1)	EP0868526B1 (pt)
JP (1)	JP4044614B2 (pt)
KR (1)	KR100438879B1 (pt)
CN (1)	CN1087349C (pt)
AR (1)	AR005119A1 (pt)
AT (1)	ATE222293T1 (pt)
AU (1)	AU717995B2 (pt)
BR (1)	BR9612059A (pt)
CA (1)	CA2241210C (pt)
CZ (1)	CZ295362B6 (pt)
DE (1)	DE69623038T2 (pt)
DK (1)	DK0868526T3 (pt)
EE (1)	EE03698B1 (pt)
ES (1)	ES2179957T3 (pt)
HK (1)	HK1017384A1 (pt)
IL (1)	IL125003A (pt)
MX (1)	MX9804997A (pt)
NO (1)	NO319678B1 (pt)
NZ (1)	NZ324159A (pt)
PL (1)	PL185541B1 (pt)
PT (1)	PT868526E (pt)
RU (1)	RU2170764C2 (pt)
SK (1)	SK281432B6 (pt)
TR (1)	TR199801107T2 (pt)
UA (1)	UA48993C2 (pt)
WO (1)	WO1997022712A1 (pt)
ZA (1)	ZA9610600B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2358578A1 (en) *	1999-01-02	2000-07-13	Aventis Pharma Deutschland Gmbh	Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor xa activity)
EP1016663A1 (en) *	1999-01-02	2000-07-05	Aventis Pharma Deutschland GmbH	Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity)
ATE325810T1 (de)	2000-01-28	2006-06-15	Sanofi Aventis Deutschland	Verfahren zur herstellung von acetylamidiniophenylalanyl-cyclohexylglycyl- pyridylalaninamiden
EP1127884A1 (en) *	2000-02-26	2001-08-29	Aventis Pharma Deutschland GmbH	Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them
EP2982668A3 (en)	2002-12-03	2016-04-13	Pharmacyclics LLC	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors for the treatment of thromboembolic disorders
GB0306267D0 (en)	2003-03-19	2003-04-23	Ineos Fluor Ltd	Process
JP2008260755A (ja) *	2007-03-20	2008-10-30	Sumitomo Chemical Co Ltd	Ｌ−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法
CN106946724B (zh) *	2017-04-07	2019-03-22	苏州汉德创宏生化科技有限公司	单胺基抑制剂类中间体2-乙酰氨基-2-苄基丙二酸单乙酯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4981799A (en) *	1987-08-21	1991-01-01	Takeda Chemical Industries, Ltd.	Acylamino acid racemase, production and use thereof
DE4115468A1 (de) *	1991-05-11	1992-11-12	Behringwerke Ag	Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DK0513675T3 (da) *	1991-05-13	1996-09-30	Fujisawa Pharmaceutical Co	Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf
DE69532754T2 (de) *	1994-04-26	2005-03-10	Aventis Pharmaceuticals, Inc.	Faktor xa inhibitoren

1996
- 1996-11-25 NZ NZ324159A patent/NZ324159A/xx not_active IP Right Cessation
- 1996-11-25 PT PT96942085T patent/PT868526E/pt unknown
- 1996-11-25 SK SK855-98A patent/SK281432B6/sk not_active IP Right Cessation
- 1996-11-25 AU AU11251/97A patent/AU717995B2/en not_active Ceased
- 1996-11-25 EE EE9800188A patent/EE03698B1/xx not_active IP Right Cessation
- 1996-11-25 EP EP96942085A patent/EP0868526B1/en not_active Expired - Lifetime
- 1996-11-25 IL IL12500396A patent/IL125003A/en not_active IP Right Cessation
- 1996-11-25 AT AT96942085T patent/ATE222293T1/de active
- 1996-11-25 PL PL96327314A patent/PL185541B1/pl not_active IP Right Cessation
- 1996-11-25 ES ES96942085T patent/ES2179957T3/es not_active Expired - Lifetime
- 1996-11-25 DK DK96942085T patent/DK0868526T3/da active
- 1996-11-25 WO PCT/US1996/019005 patent/WO1997022712A1/en active IP Right Grant
- 1996-11-25 TR TR1998/01107T patent/TR199801107T2/xx unknown
- 1996-11-25 CZ CZ19981956A patent/CZ295362B6/cs not_active IP Right Cessation
- 1996-11-25 CN CN96199198A patent/CN1087349C/zh not_active Expired - Fee Related
- 1996-11-25 RU RU98113301/04A patent/RU2170764C2/ru not_active IP Right Cessation
- 1996-11-25 JP JP52233697A patent/JP4044614B2/ja not_active Expired - Fee Related
- 1996-11-25 UA UA98062939A patent/UA48993C2/uk unknown
- 1996-11-25 KR KR10-1998-0704683A patent/KR100438879B1/ko not_active IP Right Cessation
- 1996-11-25 CA CA002241210A patent/CA2241210C/en not_active Expired - Fee Related
- 1996-11-25 DE DE69623038T patent/DE69623038T2/de not_active Expired - Lifetime
- 1996-11-25 BR BR9612059A patent/BR9612059A/pt not_active Application Discontinuation
- 1996-12-17 ZA ZA9610600A patent/ZA9610600B/xx unknown
- 1996-12-18 AR ARP960105740A patent/AR005119A1/es active IP Right Grant
1998
- 1998-06-19 MX MX9804997A patent/MX9804997A/es not_active IP Right Cessation
- 1998-06-19 NO NO19982868A patent/NO319678B1/no not_active IP Right Cessation
1999
- 1999-05-25 HK HK99102351A patent/HK1017384A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
UA48993C2 (uk)	2002-09-16
SK281432B6 (sk)	2001-03-12
KR100438879B1 (ko)	2004-07-16
JP2000501618A (ja)	2000-02-15
IL125003A (en)	2001-12-23
HK1017384A1 (en)	1999-11-19
DE69623038D1 (de)	2002-09-19
EP0868526B1 (en)	2002-08-14
NO982868D0 (no)	1998-06-19
MX9804997A (es)	1998-09-30
AR005119A1 (es)	1999-04-14
BR9612059A (pt)	1999-02-23
ATE222293T1 (de)	2002-08-15
JP4044614B2 (ja)	2008-02-06
CN1087349C (zh)	2002-07-10
CN1205742A (zh)	1999-01-20
TR199801107T2 (xx)	1998-10-21
KR20000064486A (ko)	2000-11-06
PL327314A1 (en)	1998-12-07
NO982868L (no)	1998-08-19
ZA9610600B (en)	1997-06-20
SK85598A3 (en)	1998-12-02
RU2170764C2 (ru)	2001-07-20
NO319678B1 (no)	2005-09-05
PL185541B1 (pl)	2003-05-30
AU717995B2 (en)	2000-04-06
EE03698B1 (et)	2002-04-15
CZ295362B6 (cs)	2005-07-13
IL125003A0 (en)	1999-01-26
CA2241210A1 (en)	1997-06-26
DK0868526T3 (da)	2002-12-02
WO1997022712A1 (en)	1997-06-26
ES2179957T3 (es)	2003-02-01
NZ324159A (en)	1999-07-29
CA2241210C (en)	2002-05-14
EP0868526A1 (en)	1998-10-07
EE9800188A (et)	1998-12-15
CZ195698A3 (cs)	1999-01-13
DE69623038T2 (de)	2002-12-12
AU1125197A (en)	1997-07-14

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PT868526E (pt)	2002-12-31	Processo para a preparacao de n-acetil-(l)-4-cianofenilalanina ac-(l)-phe(4-cn)-oh e n-acetil-(l)-p-amidinofenilalanina-ciclo-hexilglicina-beta-(3-n-metilpiridinio)-alanina ac-(l)-paph-chg-palme(3)-nh2
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