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PT867436E - Derivados de n-aril-piperidina e sua utilizacao como ligandos do receptor 5-ht1b - Google Patents

Derivados de n-aril-piperidina e sua utilizacao como ligandos do receptor 5-ht1b

Info

Publication number
PT867436E
PT867436E PT98400711T PT98400711T PT867436E PT 867436 E PT867436 E PT 867436E PT 98400711 T PT98400711 T PT 98400711T PT 98400711 T PT98400711 T PT 98400711T PT 867436 E PT867436 E PT 867436E
Authority
PT
Portugal
Prior art keywords
aryl
piperidine derivatives
receptor ligands
ht1b receptor
alkyl
Prior art date
Application number
PT98400711T
Other languages
English (en)
Inventor
Jean-Louis Peglion
Mark Millan
Valerie Audinot
Alain Gobert
Bertrand Goument
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PT867436E publication Critical patent/PT867436E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT98400711T 1997-03-27 1998-03-26 Derivados de n-aril-piperidina e sua utilizacao como ligandos do receptor 5-ht1b PT867436E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9703760A FR2761358B1 (fr) 1997-03-27 1997-03-27 Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
PT867436E true PT867436E (pt) 2004-09-30

Family

ID=9505236

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98400711T PT867436E (pt) 1997-03-27 1998-03-26 Derivados de n-aril-piperidina e sua utilizacao como ligandos do receptor 5-ht1b

Country Status (18)

Country Link
US (1) US5965575A (pt)
EP (1) EP0867436B1 (pt)
JP (1) JPH10279578A (pt)
CN (1) CN1090628C (pt)
AT (1) ATE268767T1 (pt)
AU (1) AU731018B2 (pt)
BR (1) BR9803295A (pt)
CA (1) CA2232116C (pt)
DE (1) DE69824332T2 (pt)
DK (1) DK0867436T3 (pt)
ES (1) ES2223110T3 (pt)
FR (1) FR2761358B1 (pt)
HK (1) HK1014954A1 (pt)
NO (1) NO314628B1 (pt)
NZ (1) NZ330041A (pt)
PL (1) PL194118B1 (pt)
PT (1) PT867436E (pt)
ZA (1) ZA982607B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2782515B1 (fr) * 1998-08-21 2000-09-22 Adir NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
US6225324B1 (en) * 1999-01-28 2001-05-01 Bristol-Myers Squibb Company Antidepressant heterocyclic compounds
EP1189900B1 (en) * 1999-06-30 2004-01-14 Bristol-Myers Squibb Company Heterocyclic aminopyrrolidine derivatives as melatonergic agents
GB0013737D0 (en) 2000-06-07 2000-07-26 Astrazeneca Ab Novel compounds
NZ526697A (en) * 2001-01-16 2005-05-27 Astrazeneca Ab Therapeutic heterocyclic compounds
SE0103646D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic chroman compounds
IL156601A0 (en) * 2001-01-16 2004-01-04 Astrazeneca Ab Therapeutic chroman compounds
SE0103650D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic heterocyclic compounds
US6713479B2 (en) * 2001-03-02 2004-03-30 Sepracor Inc. Piperidine-piperazine ligands for neurotransmitter receptors
SE0103836D0 (sv) * 2001-11-16 2001-11-16 Astrazeneca Ab Novel compounds
JP2005343790A (ja) * 2002-05-31 2005-12-15 Ajinomoto Co Inc カルシウムチャネル拮抗薬を含有する医薬組成物
SE0300480D0 (sv) 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
GB0312609D0 (en) 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
US20070105840A1 (en) * 2003-06-30 2007-05-10 Altana Pharma Ag Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
CA2530317A1 (en) * 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolodihydroisoquinolines useful in the treatment of cancer
EP1661894A4 (en) * 2003-07-14 2007-02-28 Ube Industries METHOD FOR PRODUCING 4-AMINOTETRAHYDROPYRANES AND THEIR SALTS WITH ACIDS, INTERMEDIATE PRODUCTS FOR THE METHOD AND METHOD FOR THE PRODUCTION THEREOF
AR045258A1 (es) * 2003-08-21 2005-10-19 Altana Pharma Ag Un producto farmaceutico para inyeccion
US20060085924A1 (en) * 2004-10-13 2006-04-27 Gaelle Brun Coloring composition comprising at least one pigment and at least one electrophilic cyanoacrylate monomer
EP1838708A2 (en) * 2005-01-12 2007-10-03 Nycomed GmbH Pyrrolodihydroisoquinolines as antiproliferative agents
CA2593750A1 (en) * 2005-01-12 2006-08-31 Altana Pharma Ag Novel pyrrolodihydroisoquinolines as pde10 inhibitors
US8599822B2 (en) * 2005-03-23 2013-12-03 Cisco Technology, Inc. Slot-based transmission synchronization mechanism in wireless mesh networks
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY29892A1 (es) * 2005-11-04 2007-06-29 Astrazeneca Ab Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
US8604031B2 (en) 2006-05-18 2013-12-10 Mannkind Corporation Intracellular kinase inhibitors
WO2008114002A1 (en) 2007-03-22 2008-09-25 Astrazeneca Ab Quinoline derivatives for the treatment of inflammatory diseases
PE20091036A1 (es) 2007-11-30 2009-08-15 Astrazeneca Ab Derivado de quinolina como antagonista del receptor p2x7
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
FR2734819B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
PL194118B1 (pl) 2007-04-30
CA2232116C (fr) 2003-09-16
AU731018B2 (en) 2001-03-22
ES2223110T3 (es) 2005-02-16
AU5967798A (en) 1998-10-01
HK1014954A1 (en) 1999-10-08
DK0867436T3 (da) 2004-10-04
DE69824332T2 (de) 2005-06-16
CA2232116A1 (fr) 1998-09-27
NZ330041A (en) 1999-01-28
FR2761358B1 (fr) 1999-05-07
EP0867436A1 (fr) 1998-09-30
EP0867436B1 (fr) 2004-06-09
PL325575A1 (en) 1998-09-28
NO314628B1 (no) 2003-04-22
NO981415L (no) 1998-09-28
FR2761358A1 (fr) 1998-10-02
ATE268767T1 (de) 2004-06-15
CN1090628C (zh) 2002-09-11
BR9803295A (pt) 2000-03-21
CN1197072A (zh) 1998-10-28
ZA982607B (en) 1998-09-30
US5965575A (en) 1999-10-12
DE69824332D1 (de) 2004-07-15
JPH10279578A (ja) 1998-10-20
NO981415D0 (no) 1998-03-27

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