US4673574A
(en)
*
|
1981-08-31 |
1987-06-16 |
Anderson Porter W |
Immunogenic conjugates
|
US5360897A
(en)
*
|
1981-08-31 |
1994-11-01 |
The University Of Rochester |
Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad
|
US5097020A
(en)
*
|
1983-07-05 |
1992-03-17 |
The University Of Rochester |
Immunogenic conjugates
|
US4902506A
(en)
*
|
1983-07-05 |
1990-02-20 |
The University Of Rochester |
Immunogenic conjugates
|
US4663160A
(en)
*
|
1983-03-14 |
1987-05-05 |
Miles Laboratories, Inc. |
Vaccines for gram-negative bacteria
|
US4761283A
(en)
*
|
1983-07-05 |
1988-08-02 |
The University Of Rochester |
Immunogenic conjugates
|
US4762713A
(en)
*
|
1983-07-05 |
1988-08-09 |
The University Of Rochester |
Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers
|
US4695624A
(en)
*
|
1984-05-10 |
1987-09-22 |
Merck & Co., Inc. |
Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
|
US4808700A
(en)
*
|
1984-07-09 |
1989-02-28 |
Praxis Biologics, Inc. |
Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
|
SE8405493D0
(sv)
*
|
1984-11-01 |
1984-11-01 |
Bror Morein |
Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
|
NZ214503A
(en)
*
|
1984-12-20 |
1990-02-26 |
Merck & Co Inc |
Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates
|
US6074650A
(en)
*
|
1985-06-24 |
2000-06-13 |
Hoechst Aktiengesellschaft |
Membrane anchor/active compound conjugate, its preparation and its uses
|
US6024964A
(en)
*
|
1985-06-24 |
2000-02-15 |
Hoechst Aktiengesellschaft |
Membrane anchor/active compound conjugate, its preparation and its uses
|
US4762822A
(en)
*
|
1985-08-08 |
1988-08-09 |
Ettinger Anna C |
Reduction of gastrointestinal disease-producing organisms with sialic acid and gangliosides
|
US4707543A
(en)
*
|
1985-09-17 |
1987-11-17 |
The United States Of America As Represented By The Secretary Of The Army |
Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines
|
US4681761A
(en)
*
|
1985-10-24 |
1987-07-21 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Major iron-regulated protein of Neisseria gonorrhoeae and its use as vaccine
|
AU619443B2
(en)
*
|
1986-04-21 |
1992-01-30 |
Bioenterprises Pty. Ltd. |
Immunopotentiation
|
CA1331355C
(en)
*
|
1986-04-21 |
1994-08-09 |
Bioenterprises Pty. Ltd |
Immunopotentation
|
US5374426A
(en)
*
|
1986-09-03 |
1994-12-20 |
University Of Saskatchewan |
Rotavirus nucleocapsid protein VP6 in vaccine compositions
|
US5300632A
(en)
*
|
1986-11-18 |
1994-04-05 |
Research Foundation Of State University Of New York |
Method for purifying an outer membrane protein of Haemophilus influenzae
|
NZ223009A
(en)
*
|
1986-12-31 |
1990-06-26 |
Nl Rivm Of Thoven |
Oligosaccharides containing d-ribose d-ribitol and phosphate units mimicing haemophilus influenzae type b antigens
|
US5976839A
(en)
*
|
1987-03-13 |
1999-11-02 |
Bioenterprises Pty Limited |
Immunopotentiation through covalent linkage between immunogen and immunopotentiating molecules
|
US5785973A
(en)
*
|
1988-02-01 |
1998-07-28 |
Praxis Biologics, Inc. |
Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines
|
US5204098A
(en)
*
|
1988-02-16 |
1993-04-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Polysaccharide-protein conjugates
|
US7118757B1
(en)
*
|
1988-12-19 |
2006-10-10 |
Wyeth Holdings Corporation |
Meningococcal class 1 outer-membrane protein vaccine
|
EP0407037B1
(en)
*
|
1989-06-12 |
1994-09-21 |
Merck & Co. Inc. |
Process for removing bacterial endotoxin from gram-negative polysaccharides
|
CU22302A1
(es)
*
|
1990-09-07 |
1995-01-31 |
Cigb |
Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales
|
IL98838A0
(en)
*
|
1990-07-19 |
1992-07-15 |
Merck & Co Inc |
Protein of the outer membrane of neisseria meningitidis having immunologic carrier and enhancement properties
|
EP0467714A1
(en)
*
|
1990-07-19 |
1992-01-22 |
Merck & Co. Inc. |
The class II protein of the outer membrane of neisseria meningitidis
|
CA2059692C
(en)
*
|
1991-01-28 |
2004-11-16 |
Peter J. Kniskern |
Pneumoccoccal polysaccharide conjugate vaccine
|
CA2059693C
(en)
*
|
1991-01-28 |
2003-08-19 |
Peter J. Kniskern |
Polysaccharide antigens from streptococcus pneumoniae
|
CZ28294A3
(en)
*
|
1991-08-13 |
1994-05-18 |
Biotech Australia Pty Ltd |
Immunostimulation
|
US5314811A
(en)
*
|
1992-07-13 |
1994-05-24 |
Merck & Co., Inc. |
Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide
|
US5736146A
(en)
*
|
1992-07-30 |
1998-04-07 |
Yeda Research And Development Co. Ltd. |
Conjugates of poorly immunogenic antigens and synthetic peptide carriers and vaccines comprising them
|
US6153406A
(en)
*
|
1993-07-23 |
2000-11-28 |
North American Vaccine, Inc. |
Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
|
GB9422096D0
(en)
*
|
1994-11-02 |
1994-12-21 |
Biocine Spa |
Combined meningitis vaccine
|
US6309646B1
(en)
|
1996-05-09 |
2001-10-30 |
The Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates
|
AU771330B2
(en)
*
|
1998-08-19 |
2004-03-18 |
Baxter Healthcare Sa |
Immunogenic beta-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an N-acryloylated polysaccharide
|
US6146902A
(en)
*
|
1998-12-29 |
2000-11-14 |
Aventis Pasteur, Inc. |
Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
|
IL153506A0
(en)
*
|
2000-06-29 |
2003-07-06 |
Glaxosmithkline Biolog Sa |
Multivalent vaccine composition
|
GB0115176D0
(en)
*
|
2001-06-20 |
2001-08-15 |
Chiron Spa |
Capular polysaccharide solubilisation and combination vaccines
|
CA2501812C
(en)
|
2002-10-11 |
2012-07-10 |
Mariagrazia Pizza |
Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages
|
GB0227346D0
(en)
|
2002-11-22 |
2002-12-31 |
Chiron Spa |
741
|
US10272147B2
(en)
|
2003-01-30 |
2019-04-30 |
Glaxosmithkline Biologicals S.A. |
Injectable vaccines against multiple meningococcal serogroups
|
GB0323103D0
(en)
|
2003-10-02 |
2003-11-05 |
Chiron Srl |
De-acetylated saccharides
|
SI1961426T1
(sl)
|
2003-10-02 |
2011-10-28 |
Novartis Ag |
Kombinirana cepiva proti meningitisu
|
GB0406013D0
(en)
|
2004-03-17 |
2004-04-21 |
Chiron Srl |
Analysis of saccharide vaccines without interference
|
GB0408977D0
(en)
|
2004-04-22 |
2004-05-26 |
Chiron Srl |
Immunising against meningococcal serogroup Y using proteins
|
GB0500787D0
(en)
|
2005-01-14 |
2005-02-23 |
Chiron Srl |
Integration of meningococcal conjugate vaccination
|
GB0409745D0
(en)
|
2004-04-30 |
2004-06-09 |
Chiron Srl |
Compositions including unconjugated carrier proteins
|
PT1740217E
(pt)
|
2004-04-30 |
2011-08-02 |
Novartis Ag |
Vacinação meningocócica conjugada
|
GB0411387D0
(en)
|
2004-05-21 |
2004-06-23 |
Chiron Srl |
Analysis of saccharide length
|
GB0413868D0
(en)
|
2004-06-21 |
2004-07-21 |
Chiron Srl |
Dimensional anlaysis of saccharide conjugates
|
MX2007016237A
(es)
|
2005-06-27 |
2008-03-07 |
Glaxosmithkline Biolog Sa |
Composicion inmunogenica.
|
GB0524066D0
(en)
|
2005-11-25 |
2006-01-04 |
Chiron Srl |
741 ii
|
GB0607088D0
(en)
|
2006-04-07 |
2006-05-17 |
Glaxosmithkline Biolog Sa |
Vaccine
|
TW201350129A
(zh)
|
2005-12-22 |
2013-12-16 |
Glaxosmithkline Biolog Sa |
包含莢膜醣結合物之肺炎鏈球菌免疫原組合物、包含其之疫苗及套組及其用途
|
GB0605757D0
(en)
|
2006-03-22 |
2006-05-03 |
Chiron Srl |
Separation of conjugated and unconjugated components
|
PT2004225E
(pt)
|
2006-03-22 |
2012-05-30 |
Novartis Ag |
Regimes para imunização com conjugados meningocócicos
|
GB0612854D0
(en)
|
2006-06-28 |
2006-08-09 |
Novartis Ag |
Saccharide analysis
|
MX2009002560A
(es)
|
2006-09-07 |
2009-03-20 |
Glaxosmithkline Biolog Sa |
Vacuna.
|
GB0700562D0
(en)
|
2007-01-11 |
2007-02-21 |
Novartis Vaccines & Diagnostic |
Modified Saccharides
|
AU2008248640A1
(en)
|
2007-05-02 |
2008-11-13 |
Glaxosmithkline Biologicals S.A. |
Vaccine
|
BRPI0813307C1
(pt)
|
2007-06-26 |
2021-05-25 |
Glaxosmithkline Biologicals Sa |
composição imunogênica, vacina, e, processo para fabricar a vacina
|
FR2918671B1
(fr)
*
|
2007-07-10 |
2010-10-15 |
Sanofi Pasteur |
Milieu de culture d'haemophilus influenzae type b.
|
GB0713880D0
(en)
*
|
2007-07-17 |
2007-08-29 |
Novartis Ag |
Conjugate purification
|
GB0714963D0
(en)
|
2007-08-01 |
2007-09-12 |
Novartis Ag |
Compositions comprising antigens
|
SI2200642T1
(sl)
|
2007-10-19 |
2012-06-29 |
Novartis Ag |
Formulacije meningokoknega cepiva
|
GB0818453D0
(en)
|
2008-10-08 |
2008-11-12 |
Novartis Ag |
Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
|
EP2886551A3
(en)
|
2008-02-21 |
2015-09-23 |
Novartis AG |
Meningococcal fhbp polypeptides
|
WO2010049806A1
(en)
|
2008-10-27 |
2010-05-06 |
Novartis Ag |
Purification method
|
GB0822633D0
(en)
|
2008-12-11 |
2009-01-21 |
Novartis Ag |
Formulation
|
GB0822634D0
(en)
|
2008-12-11 |
2009-01-21 |
Novartis Ag |
Meningitis vaccines
|
MX2011006648A
(es)
|
2008-12-17 |
2011-10-14 |
Novartis Ag |
Vacunas meningococales que incluyen receptor de hemoglobina.
|
ES2797504T3
(es)
|
2009-03-24 |
2020-12-02 |
Glaxosmithkline Biologicals Sa |
Proteína de enlace del factor H meningocócico utilizada como adyuvante
|
AU2010227220B2
(en)
|
2009-03-24 |
2014-11-13 |
Glaxosmithkline Biologicals S.A. |
Combinations of meningococcal factor H binding protein and pneumococcal saccharide conjugates
|
KR20120034612A
(ko)
|
2009-04-14 |
2012-04-12 |
노파르티스 아게 |
황색 포도상구균에 대한 면역화를 위한 조성물
|
EP2437779B1
(en)
*
|
2009-06-01 |
2016-10-26 |
Her Majesty The Queen In Right of Canada as represented by The Minister of Health |
Reagents and methods for detecting influenza virus proteins
|
WO2010141312A2
(en)
|
2009-06-01 |
2010-12-09 |
Wake Forest University Health Sciences |
Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same
|
CA2772104A1
(en)
|
2009-08-27 |
2011-03-03 |
Novartis Ag |
Hybrid polypeptides including meningococcal fhbp sequences
|
KR20120081587A
(ko)
|
2009-09-10 |
2012-07-19 |
노파르티스 아게 |
기도 질병에 대한 조합 백신
|
AU2010302344A1
(en)
|
2009-09-30 |
2012-04-26 |
Novartis Ag |
Expression of meningococcal fhbp polypeptides
|
US20130022633A1
(en)
|
2009-10-27 |
2013-01-24 |
University Of Florence |
MENINGOCOCCAL fHBP POLYPEPTIDES
|
GB0919690D0
(en)
|
2009-11-10 |
2009-12-23 |
Guy S And St Thomas S Nhs Foun |
compositions for immunising against staphylococcus aureus
|
US9173954B2
(en)
|
2009-12-30 |
2015-11-03 |
Glaxosmithkline Biologicals Sa |
Polysaccharide immunogens conjugated to E. coli carrier proteins
|
GB201003333D0
(en)
|
2010-02-26 |
2010-04-14 |
Novartis Ag |
Immunogenic proteins and compositions
|
GB201003924D0
(en)
|
2010-03-09 |
2010-04-21 |
Glaxosmithkline Biolog Sa |
Immunogenic composition
|
GB201003922D0
(en)
|
2010-03-09 |
2010-04-21 |
Glaxosmithkline Biolog Sa |
Conjugation process
|
GB201005625D0
(en)
|
2010-04-01 |
2010-05-19 |
Novartis Ag |
Immunogenic proteins and compositions
|
WO2011148382A1
(en)
*
|
2010-05-28 |
2011-12-01 |
Biological E Limited |
An improved process for the purification of capsular polysaccharides of haemophilus influenza - b, neisseria meningitis such as serotypes a, c, y and w-135, and other similar related capsular polysaccharides produced from both gram negative and gram positive microorganisms using aluminium phosphate with alcohol.
|
EP2585106A1
(en)
|
2010-06-25 |
2013-05-01 |
Novartis AG |
Combinations of meningococcal factor h binding proteins
|
WO2012072769A1
(en)
|
2010-12-01 |
2012-06-07 |
Novartis Ag |
Pneumococcal rrgb epitopes and clade combinations
|
WO2012085668A2
(en)
|
2010-12-24 |
2012-06-28 |
Novartis Ag |
Compounds
|
AU2012222883A1
(en)
|
2011-03-02 |
2013-10-17 |
Novartis Ag |
Combination vaccines with lower doses of antigen and/or adjuvant
|
GB201103836D0
(en)
|
2011-03-07 |
2011-04-20 |
Glaxosmithkline Biolog Sa |
Conjugation process
|
GB201114923D0
(en)
|
2011-08-30 |
2011-10-12 |
Novartis Ag |
Immunogenic proteins and compositions
|
CA2854934A1
(en)
|
2011-11-07 |
2013-05-16 |
Novartis Ag |
Carrier molecule comprising a spr0096 and a spr2021 antigen
|
EP4400115A3
(en)
|
2011-12-06 |
2024-10-23 |
Valneva Austria GmbH |
Aluminium compounds for use in therapeutics and vaccines
|
GB201121301D0
(en)
|
2011-12-12 |
2012-01-25 |
Novartis Ag |
Method
|
AU2011384634A1
(en)
|
2011-12-29 |
2014-06-19 |
Novartis Ag |
Adjuvanted combinations of meningococcal factor H binding proteins
|
CN104519910B
(zh)
|
2012-03-07 |
2017-05-03 |
诺华股份有限公司 |
肺炎链球菌抗原的含佐剂制剂
|
CN104159603A
(zh)
|
2012-03-08 |
2014-11-19 |
诺华股份有限公司 |
带有tlr4激动剂的联合疫苗
|
SA115360586B1
(ar)
|
2012-03-09 |
2017-04-12 |
فايزر انك |
تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
|
JP6324961B2
(ja)
|
2012-09-06 |
2018-05-16 |
ノバルティス アーゲー |
血清群b髄膜炎菌とd/t/pとの組み合わせワクチン
|
WO2014053521A2
(en)
|
2012-10-02 |
2014-04-10 |
Novartis Ag |
Nonlinear saccharide conjugates
|
EP2906239A1
(en)
|
2012-10-12 |
2015-08-19 |
GlaxoSmithKline Biologicals SA |
Non-cross-linked acellular pertussis antigens for use in combination vaccines
|
RU2018137673A
(ru)
|
2012-11-30 |
2019-03-22 |
Глаксосмитклайн Байолоджикалс Са |
Антигены и комбинации антигенов pseudomonas
|
US9827190B2
(en)
|
2013-02-01 |
2017-11-28 |
Glaxosmithkline Biologicals Sa |
Intradermal delivery of immunological compositions comprising toll-like receptor 7 agonists
|
CA2923129C
(en)
|
2013-09-08 |
2020-06-09 |
Pfizer Inc. |
Neisseria meningitidis compositions and methods thereof
|
US10392424B2
(en)
|
2014-02-28 |
2019-08-27 |
Glaxosmithkline Biologicals Sa |
Modified meningococcal fHbp polypeptides
|
EP3034516A1
(en)
|
2014-12-19 |
2016-06-22 |
Novartis AG |
Purification of streptococcal capsular polysaccharide
|
GB201518684D0
(en)
|
2015-10-21 |
2015-12-02 |
Glaxosmithkline Biolog Sa |
Vaccine
|
US12161707B2
(en)
|
2016-09-02 |
2024-12-10 |
Glaxosmithkline Biologicals Sa |
Vaccines for Neisseria gonorrhoeae
|
EP3530285B1
(en)
|
2016-10-20 |
2023-08-09 |
KM Biologics Co., Ltd. |
METHOD FOR PRODUCING HIB CONJUGATE VACCINE USING PRP WITH
LOWERED MOLECULAR WEIGHT
|
JP7165468B2
(ja)
|
2016-11-25 |
2022-11-04 |
グラクソスミスクライン バイオロジカルズ ソシエテ アノニム |
nOMV-抗原コンジュゲート及びその使用
|
BR112019010227A2
(pt)
|
2016-11-25 |
2019-10-08 |
Glaxosmithkline Biologicals Sa |
conjugado imunogênico, processo para preparação de conjugado imunogênico, composição imunogênica, vacina, e, uso de nomv
|
WO2018104889A1
(en)
|
2016-12-06 |
2018-06-14 |
Glaxosmithkline Biologicals Sa |
Purification process for capsular polysaccharide
|
KR102567845B1
(ko)
|
2017-01-31 |
2023-08-17 |
화이자 인코포레이티드 |
네이세리아 메닌기티디스 조성물 및 그의 방법
|
US11246918B2
(en)
|
2017-02-03 |
2022-02-15 |
Eva Barbara Schadeck |
Haemophilus influenzae saccharide-carrier conjugate compositions and uses thereof
|
EP3607967A1
(en)
|
2018-08-09 |
2020-02-12 |
GlaxoSmithKline Biologicals S.A. |
Modified meningococcal fhbp polypeptides
|
WO2020165711A1
(en)
|
2019-02-11 |
2020-08-20 |
Pfizer Inc. |
Neisseria meningitidiscompositions and methods thereof
|
JP7239509B6
(ja)
|
2019-02-22 |
2023-03-28 |
ファイザー・インク |
細菌多糖類を精製するための方法
|
JOP20200214A1
(ar)
|
2019-09-03 |
2021-03-03 |
Serum Institute Of India Pvt Ltd |
تركيبات مولدة للمناعة ضد الأمراض المعوية وطرق لتحضيرها
|
MX2022003682A
(es)
|
2019-09-27 |
2022-04-25 |
Pfizer |
Composiciones de neisseria meningitidis y metodos de las mismas.
|
EP3799884A1
(en)
|
2019-10-01 |
2021-04-07 |
GlaxoSmithKline Biologicals S.A. |
Immunogenic compositions
|
JP2021132644A
(ja)
|
2020-02-21 |
2021-09-13 |
ファイザー・インク |
糖の精製
|
GB202013262D0
(en)
|
2020-08-25 |
2020-10-07 |
Glaxosmithkline Biologicals Sa |
Vaccine Composition
|
US20230383324A1
(en)
|
2020-10-22 |
2023-11-30 |
Pfizer Inc. |
Methods for purifying bacterial polysaccharides
|
CA3201450A1
(en)
|
2020-11-13 |
2022-05-19 |
Glaxosmithkline Biologicals Sa |
Bacterial protein carriers and conjugation methods
|
GB202208093D0
(en)
|
2022-06-01 |
2022-07-13 |
Glaxosmithkline Biologicals Sa |
Immunogenic composition
|
GB202208089D0
(en)
|
2022-06-01 |
2022-07-13 |
Glaxosmithkline Biologicals Sa |
Immunogenic composition
|
GB202215414D0
(en)
|
2022-10-18 |
2022-11-30 |
Glaxosmithkline Biologicals Sa |
Vaccine
|
WO2024201324A2
(en)
|
2023-03-30 |
2024-10-03 |
Pfizer Inc. |
Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
|
WO2024214016A1
(en)
|
2023-04-14 |
2024-10-17 |
Pfizer Inc. |
Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
|
WO2024224266A1
(en)
|
2023-04-24 |
2024-10-31 |
Pfizer Inc. |
Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
|
WO2025021710A1
(en)
|
2023-07-21 |
2025-01-30 |
Glaxosmithkline Biologicals Sa |
Immunogenic composition
|