PT714444E - Atenuacao de um epitopo imunodominante de um antigenio para utilizacao em vacinas e imunoterapias para plantas, animais e homens - Google Patents

Atenuacao de um epitopo imunodominante de um antigenio para utilizacao em vacinas e imunoterapias para plantas, animais e homens

Info

Publication number: PT714444E
Authority: PT; Portugal
Prior art keywords: immunodominant; antigen; epitopo; atenuation; immunotherapies
Prior art date: 1993-08-20

Application number

PT94925937T

Other languages

English (en)

Inventor

Robert R Garrity

Peter L Nara

Jaap Goudsmit

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-20

Filing date

1994-08-19

Publication date

2002-07-31

1994-08-19 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2002-07-31 Publication of PT714444E publication Critical patent/PT714444E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pulmonology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT94925937T 1993-08-20 1994-08-19 Atenuacao de um epitopo imunodominante de um antigenio para utilizacao em vacinas e imunoterapias para plantas, animais e homens PT714444E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/109,934 US5585250A (en)	1993-08-20	1993-08-20	Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies

Publications (1)

Publication Number	Publication Date
PT714444E true PT714444E (pt)	2002-07-31

Family

ID=22330363

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT94925937T PT714444E (pt)	1993-08-20	1994-08-19	Atenuacao de um epitopo imunodominante de um antigenio para utilizacao em vacinas e imunoterapias para plantas, animais e homens

Country Status (11)

Country	Link
US (2)	US5585250A (pt)
EP (1)	EP0714444B1 (pt)
JP (2)	JP3851938B2 (pt)
AT (1)	ATE211767T1 (pt)
AU (1)	AU700786B2 (pt)
CA (2)	CA2169764C (pt)
DE (1)	DE69429625T2 (pt)
DK (1)	DK0714444T3 (pt)
ES (1)	ES2170771T3 (pt)
PT (1)	PT714444E (pt)
WO (1)	WO1995006124A1 (pt)

Families Citing this family (42)

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US5585250A (en) *	1993-08-20	1996-12-17	The United States Of America As Represented By The Department Of Health & Human Services	Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies
ES2233980T3 (es) *	1995-11-03	2005-06-16	The Binding Site Limited	Produccion de anticuerpos.
US6642011B2 (en) *	1998-04-15	2003-11-04	Genencor International, Inc.	Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
US6835550B1 (en) *	1998-04-15	2004-12-28	Genencor International, Inc.	Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6936249B1 (en) *	1998-04-15	2005-08-30	Genencor International, Inc.	Proteins producing an altered immunogenic response and methods of making and using the same
US20020182180A1 (en) *	1998-05-29	2002-12-05	Yutaro Kaneko	Method for inducing immunity to viruses
ES2289824T3 (es) *	1998-10-30	2008-02-01	Novozymes A/S	Proteinas glicosiladas con alergenicidad reducida.
US6759216B1 (en) *	1998-11-06	2004-07-06	Emory University	Glycosylated, low antigenicity low immunogenicity factor VIII
US7078043B2 (en)	1999-04-20	2006-07-18	Medical Research Council	Malaria vaccine
DE10055786A1 (de) *	2000-11-10	2002-05-29	Henkel Kgaa	Haftungsverstärker für monomerfreie reaktive Polyurethane
EP1237971B1 (de)	1999-11-29	2010-08-04	Henkel AG & Co. KGaA	Haftungsverstärker für monomerfreie reaktive polyurethane
US6673580B2 (en)	2000-10-27	2004-01-06	Genentech, Inc.	Identification and modification of immunodominant epitopes in polypeptides
WO2004053100A2 (en) *	2002-12-11	2004-06-24	The Scripps Research Institute	Immunogenic mutant human immunodeficiency virus gp120 polypeptides, and methods of using same
US7790405B2 (en) *	2004-04-26	2010-09-07	Centocor, Inc.	Solution phase biopanning method using engineered decoy proteins
US7514539B2 (en) *	2004-04-26	2009-04-07	Centocor, Inc.	Epitope directed selection of antibodies to murine tissue factor
CA2573313A1 (en) *	2004-07-10	2006-02-16	Alexion Pharmaceuticals, Inc.	Antibodies against cancer produced using masked cancer cells as immunogen
US7597884B2 (en)	2004-08-09	2009-10-06	Alios Biopharma, Inc.	Hyperglycosylated polypeptide variants and methods of use
US20100092505A1 (en) *	2005-04-05	2010-04-15	Elisabetta Bianchi	Method for Shielding Functional Sites or Epitopes on Proteins
US20090162383A1 (en) *	2006-12-26	2009-06-25	Padlan Eduardo A	Method for designing vaccines against constantly mutating pathogens
US20110177121A1 (en) *	2008-02-21	2011-07-21	Biological Mimetics, Inc.	Immunogenic Influenza Composition
US9782472B2 (en) *	2008-10-04	2017-10-10	The Regents Of The University Of California	Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity
CN102281884B (zh) *	2008-12-02	2015-09-30	国家科学和技术研究委员会(Conicet)	表达至少两种可变表面蛋白(vsp)的修饰原生动物,其疫苗及纯化方法、应用和免疫方法
WO2010077643A1 (en) *	2008-12-08	2010-07-08	Tegopharm Corporation	Masking ligands for reversible inhibition of multivalent compounds
WO2011028963A2 (en) *	2009-09-03	2011-03-10	Biological Mimetics, Inc.	Immunogenic hiv composition
EP2525818A4 (en) *	2010-01-24	2013-10-02	Biolog Mimetics Inc	IMMUNOGENEOUS INFLUENZA COMPOSITION
ES2625406T3 (es)	2010-03-25	2017-07-19	Oregon Health & Science University	Glicoproteínas de CMV y vectores recombinantes
AU2011344126B2 (en)	2010-12-13	2016-11-10	The University Of Utah Research Foundation	Vaccine antigens that direct immunity to conserved epitopes
RS57397B8 (sr)	2011-06-10	2020-01-31	Univ Oregon Health & Science	Cmv glikoproteini i rekombinantni vektori
CA2789539A1 (en)	2011-09-12	2013-03-12	International Aids Vaccine Initiative	Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US20140286983A1 (en)	2011-10-20	2014-09-25	The Government of the USA as represented by the Secretaryof the Dept. of Health and Human Services	Dengue virus e-glycoprotein polypeptides containing mutations that eliminate immunodominant cross-reactive epitopes
US9402894B2 (en)	2011-10-27	2016-08-02	International Aids Vaccine Initiative	Viral particles derived from an enveloped virus
ES2631608T3 (es)	2012-06-27	2017-09-01	International Aids Vaccine Initiative	Variante de la glicoproteína Env del VIH-1
PT2874656T (pt)	2012-07-17	2018-03-09	Merial Inc	Vacinas atenuadas contra a gripe suína e métodos de fabricação e uso das mesmas
US20150065381A1 (en)	2013-09-05	2015-03-05	International Aids Vaccine Initiative	Methods of identifying novel hiv-1 immunogens
EP2873423B1 (en)	2013-10-07	2017-05-31	International Aids Vaccine Initiative	Soluble hiv-1 envelope glycoprotein trimers
EP3107567A4 (en) *	2014-02-19	2017-10-25	Cangene Corporation	Methods of modulating an immune response
ZA201608812B (en)	2014-06-26	2019-08-28	Janssen Vaccines & Prevention Bv	Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
NZ727024A (en)	2014-06-26	2022-02-25	Janssen Vaccines & Prevention Bv	Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
EP3069730A3 (en)	2015-03-20	2017-03-15	International Aids Vaccine Initiative	Soluble hiv-1 envelope glycoprotein trimers
US9931394B2 (en)	2015-03-23	2018-04-03	International Aids Vaccine Initiative	Soluble HIV-1 envelope glycoprotein trimers
CN112512564A (zh)	2018-04-03	2021-03-16	赛诺菲	铁蛋白蛋白
BR112020019938A2 (pt) *	2018-04-03	2021-01-26	Sanofi	polipeptídeos antigênicos de vírus sincicial respiratório

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5041376A (en) *	1988-12-09	1991-08-20	The Board Of Regents Of The University Of Texas System	Method for identifying or shielding functional sites or epitopes of proteins that enter the exocytotic pathway of eukaryotic cells, the mutant proteins so produced and genes encoding said mutant proteins
US5585250A (en) *	1993-08-20	1996-12-17	The United States Of America As Represented By The Department Of Health & Human Services	Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies

1993
- 1993-08-20 US US08/109,934 patent/US5585250A/en not_active Expired - Lifetime
1994
- 1994-08-19 EP EP94925937A patent/EP0714444B1/en not_active Expired - Lifetime
- 1994-08-19 ES ES94925937T patent/ES2170771T3/es not_active Expired - Lifetime
- 1994-08-19 DK DK94925937T patent/DK0714444T3/da active
- 1994-08-19 DE DE69429625T patent/DE69429625T2/de not_active Expired - Lifetime
- 1994-08-19 WO PCT/US1994/009336 patent/WO1995006124A1/en active IP Right Grant
- 1994-08-19 CA CA002169764A patent/CA2169764C/en not_active Expired - Lifetime
- 1994-08-19 PT PT94925937T patent/PT714444E/pt unknown
- 1994-08-19 CA CA002623540A patent/CA2623540A1/en not_active Abandoned
- 1994-08-19 JP JP50766695A patent/JP3851938B2/ja not_active Expired - Lifetime
- 1994-08-19 AT AT94925937T patent/ATE211767T1/de active
- 1994-08-19 AU AU75692/94A patent/AU700786B2/en not_active Expired
1996
- 1996-12-13 US US08/764,575 patent/US5853724A/en not_active Expired - Lifetime
2005
- 2005-12-21 JP JP2005367769A patent/JP2006104216A/ja active Pending

Also Published As

Publication number	Publication date
CA2623540A1 (en)	1995-03-02
ES2170771T3 (es)	2002-08-16
US5853724A (en)	1998-12-29
DE69429625D1 (de)	2002-02-14
US5585250A (en)	1996-12-17
DE69429625T2 (de)	2002-09-12
DK0714444T3 (da)	2002-04-29
JPH09501933A (ja)	1997-02-25
EP0714444A1 (en)	1996-06-05
JP3851938B2 (ja)	2006-11-29
CA2169764C (en)	2008-04-15
JP2006104216A (ja)	2006-04-20
EP0714444B1 (en)	2002-01-09
WO1995006124A1 (en)	1995-03-02
AU7569294A (en)	1995-03-21
CA2169764A1 (en)	1995-03-02
ATE211767T1 (de)	2002-01-15
AU700786B2 (en)	1999-01-14

Publication	Publication Date	Title
PT714444E (pt)	2002-07-31	Atenuacao de um epitopo imunodominante de um antigenio para utilizacao em vacinas e imunoterapias para plantas, animais e homens
RU2434638C2 (ru)	2011-11-27	Вакцина альфа токсоида с.perfringens
ATE390933T1 (de)	2008-04-15	Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8
ES2152421T3 (es)	2001-02-01	Vacunas de conjugados polisacarido neumococcico-neumolisina recombinante para la inmunizacion contra las infecciones neumococcicas.
EA199700272A1 (ru)	1998-04-30	Вакцины, содержащие сапонин и стерин
ES2184769T3 (es)	2003-04-16	Metodos y composiciones para microencapsulacion de antigenos para utilizar como vacunas.
AP2003002937A0 (en)	2003-12-31	One dose vaccination with mycoplasma hyopneumoniae
NL940017I1 (nl)	1994-10-17	Vaccin-preparaat
YU48250B (sh)	1997-09-30	Postupak za pripremanje aktivne vakcine protiv lajmske bolesti
ATE255419T1 (de)	2003-12-15	Für den vogelembryo geeignete multivalente impfstoffe
BG95337A (bg)	1993-12-24	Ваксиниране и методи срещу заболявания,резултат от патогенни отговори на т-клетъчно специфични популации
EA199800946A1 (ru)	1999-06-24	Концентрированный препарат антител
MX9400166A (es)	1994-07-29	Microesferas de proteina vegetal, hidrolizada, modificada y metodos para su preparacion y su uso.
ES2176232T3 (es)	2002-12-01	Vacuna adecuada para ser utilizada en la prevencion y tratamiento de la infeccion por helicobacter.
ES2109929T3 (es)	1998-02-01	Procedimiento para preparar un glucano de levadura
SE7512828L (sv)	1976-05-24	Calicivirusvaccin
HUP9701586A2 (hu)	1998-07-28	Javított inaktivált vakcinák
ATE78403T1 (de)	1992-08-15	Impfstoff gegen mastitis.
ES2079851T3 (es)	1996-01-16	Uso de il-4 para mejorar la respuesta inmunitaria frente a inmunogenos en vacunas.
ES2166763T3 (es)	2002-05-01	Inmunizacion parenteral contra rotavirus.
ATE88350T1 (de)	1993-05-15	Arzneimittel.
ES2158857T3 (es)	2001-09-16	Vacunas a base de estreptoquinasa.
FR2385401A1 (fr)	1978-10-27	Vaccin a virus respiratoire syncytial
ES2102836T3 (es)	1997-08-01	El empleo de vacunas antihelminticas en el control de la enfermedad parasitaria asociada con la perdida de la inmunidad natural.
PT1194450E (pt)	2005-03-31	Vacina inactivada contra a calicivirose felina