PT2970123T - Sal de omecamtiv mecarbil e método de preparação de sal - Google Patents

Sal de omecamtiv mecarbil e método de preparação de sal

Info

Publication number: PT2970123T
Authority: PT; Portugal
Prior art keywords: salt; preparing; omecamtiv mecarbil; mecarbil; omecamtiv
Prior art date: 2013-03-14

Application number

PT147203699T

Other languages

English (en)

Inventor

Muci Alex

Cui Sheng

Morrison Henry

Nagapudi Karthik

Walker Shawn

Bernard Charles

Hansen Karl Bennett

Fred Langille Neil

Martin Allgeier Alan

Mennen Steven

Woo Jacqueline

Paul Morgan Bradley

Original Assignee

Cytokinetics Inc

Amgen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-14

Filing date

2014-03-14

Publication date

2019-10-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50549466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2970123(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-03-14 Application filed by Cytokinetics Inc, Amgen Inc filed Critical Cytokinetics Inc

2019-10-28 Publication of PT2970123T publication Critical patent/PT2970123T/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Inorganic Chemistry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

PT147203699T 2013-03-14 2014-03-14 Sal de omecamtiv mecarbil e método de preparação de sal PT2970123T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201361785763P	2013-03-14	2013-03-14

Publications (1)

Publication Number	Publication Date
PT2970123T true PT2970123T (pt)	2019-10-28

Family

ID=50549466

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT147194724T PT2968173T (pt)	2013-03-14	2014-03-14	Compostos heterocíclicos e as suas utilizações
PT147203699T PT2970123T (pt)	2013-03-14	2014-03-14	Sal de omecamtiv mecarbil e método de preparação de sal

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT147194724T PT2968173T (pt)	2013-03-14	2014-03-14	Compostos heterocíclicos e as suas utilizações

Country Status (42)

Country	Link
US (16)	US9988354B2 (pt)
EP (3)	EP3821882A1 (pt)
JP (5)	JP6783138B2 (pt)
KR (2)	KR102374159B1 (pt)
CN (3)	CN105120844A (pt)
AP (1)	AP2015008789A0 (pt)
AR (2)	AR095542A1 (pt)
AU (2)	AU2014239995B2 (pt)
BR (2)	BR112015023417B1 (pt)
CA (2)	CA2902646C (pt)
CL (1)	CL2015002708A1 (pt)
CR (1)	CR20150549A (pt)
CY (2)	CY1122695T1 (pt)
DK (2)	DK2968173T3 (pt)
EA (1)	EA031185B1 (pt)
ES (2)	ES2837038T3 (pt)
HK (1)	HK1218080A1 (pt)
HR (2)	HRP20191728T1 (pt)
HU (2)	HUE046285T2 (pt)
IL (2)	IL240788B (pt)
JO (1)	JOP20140114B1 (pt)
LT (2)	LT2968173T (pt)
MA (2)	MA44637B1 (pt)
ME (1)	ME03566B (pt)
MX (3)	MX363347B (pt)
MY (2)	MY204971A (pt)
NZ (1)	NZ711225A (pt)
PE (1)	PE20151786A1 (pt)
PH (2)	PH12019500176B1 (pt)
PL (2)	PL2970123T3 (pt)
PT (2)	PT2968173T (pt)
RS (2)	RS61215B1 (pt)
RU (1)	RU2663663C2 (pt)
SA (1)	SA515361088B1 (pt)
SG (2)	SG10201706656RA (pt)
SI (2)	SI2970123T1 (pt)
SM (2)	SMT201900563T1 (pt)
TN (1)	TN2015000380A1 (pt)
TW (1)	TWI667026B (pt)
UA (1)	UA117011C2 (pt)
UY (1)	UY35449A (pt)
WO (2)	WO2014152236A1 (pt)

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WO2020131574A1 (en)	2018-12-18	2020-06-25	Amgen Inc.	Method of reducing aromatic nitro compounds
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WO2021070123A1 (en) *	2019-10-09	2021-04-15	Dr. Reddy’S Laboratories Limited	Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof
US20230090391A1 (en)	2020-02-10	2023-03-23	Amgen Inc.	Omecamtiv mecarbil tablet
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KR20230107282A (ko)	2020-11-12	2023-07-14	암젠 인크	오메캄티브 메카빌을 투여하여 심부전을 치료하는 방법
WO2022177927A1 (en)	2021-02-16	2022-08-25	Assia Chemical Industries Ltd	Unhydrous crystalline form of omecamtiv mecarbil dihydrobromide salt
BR112023018095A2 (pt)	2021-03-10	2023-12-12	Amgen Inc	Processos para sintetizar 2-fluoro-3-nitrotolueno, 1-(bromometil)-2-fluoro-3-nitrobenzeno e para preparar omecamtiv mecarbil ou um sal do mesmo, um hidrato do mesmo ou um hidrato de sal do mesmo
WO2024081611A1 (en)	2022-10-11	2024-04-18	Cytokinetics, Incorporated	Methods for treating heart failure by administering cardiac sarcomere activators
US11986474B1 (en)	2023-06-27	2024-05-21	Cytokinetics, Incorporated	Methods for treating heart failure by administering cardiac sarcomere activators

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WO2020131574A1 (en)	2018-12-18	2020-06-25	Amgen Inc.	Method of reducing aromatic nitro compounds
WO2021053175A1 (en)	2019-09-19	2021-03-25	Synthon B.V.	Salts of omecamtiv mecarbil and solid forms thereof
WO2021053189A1 (en)	2019-09-19	2021-03-25	Synthon B.V.	Salts of omecamtiv mecarbil and solid forms thereof
WO2021070123A1 (en)	2019-10-09	2021-04-15	Dr. Reddy’S Laboratories Limited	Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof
WO2021070124A1 (en)	2019-10-09	2021-04-15	Dr. Reddy’S Laboratories Limited	Alternate processes for the preparation of omecamtiv mecarbil
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KR20230107282A (ko)	2020-11-12	2023-07-14	암젠 인크	오메캄티브 메카빌을 투여하여 심부전을 치료하는 방법
WO2022177927A1 (en)	2021-02-16	2022-08-25	Assia Chemical Industries Ltd	Unhydrous crystalline form of omecamtiv mecarbil dihydrobromide salt
BR112023018095A2 (pt)	2021-03-10	2023-12-12	Amgen Inc	Processos para sintetizar 2-fluoro-3-nitrotolueno, 1-(bromometil)-2-fluoro-3-nitrobenzeno e para preparar omecamtiv mecarbil ou um sal do mesmo, um hidrato do mesmo ou um hidrato de sal do mesmo
US11986474B1 (en)	2023-06-27	2024-05-21	Cytokinetics, Incorporated	Methods for treating heart failure by administering cardiac sarcomere activators

2014
- 2014-03-14 EA EA201591728A patent/EA031185B1/ru unknown
- 2014-03-14 US US14/773,436 patent/US9988354B2/en active Active
- 2014-03-14 UA UAA201509685A patent/UA117011C2/uk unknown
- 2014-03-14 PH PH1/2019/500176A patent/PH12019500176B1/en unknown
- 2014-03-14 HR HRP20191728 patent/HRP20191728T1/hr unknown
- 2014-03-14 CN CN201480014897.1A patent/CN105120844A/zh active Pending
- 2014-03-14 AP AP2015008789A patent/AP2015008789A0/xx unknown
- 2014-03-14 EP EP20201011.2A patent/EP3821882A1/en active Pending
- 2014-03-14 PE PE2015002000A patent/PE20151786A1/es unknown
- 2014-03-14 HU HUE14720369A patent/HUE046285T2/hu unknown
- 2014-03-14 PL PL14720369T patent/PL2970123T3/pl unknown
- 2014-03-14 BR BR112015023417-8A patent/BR112015023417B1/pt active IP Right Grant
- 2014-03-14 AR ARP140101155A patent/AR095542A1/es not_active Application Discontinuation
- 2014-03-14 RU RU2015143643A patent/RU2663663C2/ru active
- 2014-03-14 MX MX2015012414A patent/MX363347B/es unknown
- 2014-03-14 PT PT147194724T patent/PT2968173T/pt unknown
- 2014-03-14 WO PCT/US2014/027104 patent/WO2014152236A1/en not_active Ceased
- 2014-03-14 NZ NZ711225A patent/NZ711225A/en unknown
- 2014-03-14 UY UY0001035449A patent/UY35449A/es active IP Right Grant
- 2014-03-14 KR KR1020157025283A patent/KR102374159B1/ko active Active
- 2014-03-14 SG SG10201706656RA patent/SG10201706656RA/en unknown
- 2014-03-14 EP EP14719472.4A patent/EP2968173B1/en active Active
- 2014-03-14 ES ES14719472T patent/ES2837038T3/es active Active
- 2014-03-14 SG SG11201507258PA patent/SG11201507258PA/en unknown
- 2014-03-14 KR KR1020227007907A patent/KR102474467B1/ko active Active
- 2014-03-14 SI SI201431358T patent/SI2970123T1/sl unknown
- 2014-03-14 AU AU2014239995A patent/AU2014239995B2/en active Active
- 2014-03-14 RS RS20201513A patent/RS61215B1/sr unknown
- 2014-03-14 BR BR112015022857-7A patent/BR112015022857B1/pt active IP Right Grant
- 2014-03-14 JP JP2016502348A patent/JP6783138B2/ja active Active
- 2014-03-14 AU AU2014240049A patent/AU2014240049C1/en active Active
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WO2014152270A1 (en)	2014-09-25
IL241089B (en)	2019-10-31
CY1122695T1 (el)	2021-03-12
US20200399221A1 (en)	2020-12-24
CN105209437B (zh)	2018-09-18
UA117011C2 (uk)	2018-06-11
US20220153700A1 (en)	2022-05-19
CA2902646A1 (en)	2014-09-25
AP2015008789A0 (en)	2015-10-31
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JP2020125307A (ja)	2020-08-20
JP6783138B2 (ja)	2020-11-11
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PL2970123T3 (pl)	2020-03-31
BR112015023417A2 (pt)	2017-07-18
CA3147180C (en)	2024-04-23
HK1218080A1 (zh)	2017-02-03
AR129504A2 (es)	2024-09-04
JP6689942B2 (ja)	2020-04-28
JP6966590B2 (ja)	2021-11-17
LT2970123T (lt)	2019-11-11
MA44637B1 (fr)	2021-04-30
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PH12015501998A1 (en)	2016-01-11
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PE20151786A1 (es)	2015-12-11
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AU2014239995A1 (en)	2015-09-10
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EP3821882A1 (en)	2021-05-19
US20200079736A1 (en)	2020-03-12

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