PT2665728E - Método de preparação de um intermediário de sitagliptina - Google Patents
Método de preparação de um intermediário de sitagliptina Download PDFInfo
- Publication number
- PT2665728E PT2665728E PT127371714T PT12737171T PT2665728E PT 2665728 E PT2665728 E PT 2665728E PT 127371714 T PT127371714 T PT 127371714T PT 12737171 T PT12737171 T PT 12737171T PT 2665728 E PT2665728 E PT 2665728E
- Authority
- PT
- Portugal
- Prior art keywords
- sitagliptin
- preparation
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- MFFMDFFZMYYVKS-SECBINFHSA-N sitagliptin Chemical compound C([C@H](CC(=O)N1CC=2N(C(=NN=2)C(F)(F)F)CC1)N)C1=CC(F)=C(F)C=C1F MFFMDFFZMYYVKS-SECBINFHSA-N 0.000 title 1
- 229960004034 sitagliptin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020110006081A KR101290029B1 (ko) | 2011-01-20 | 2011-01-20 | 시타글립틴의 중간체 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2665728E true PT2665728E (pt) | 2015-11-03 |
Family
ID=46516222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127371714T PT2665728E (pt) | 2011-01-20 | 2012-01-18 | Método de preparação de um intermediário de sitagliptina |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9006436B2 (pt) |
| EP (1) | EP2665728B1 (pt) |
| JP (1) | JP5735659B2 (pt) |
| KR (1) | KR101290029B1 (pt) |
| CN (1) | CN103403008B (pt) |
| ES (1) | ES2550342T3 (pt) |
| PT (1) | PT2665728E (pt) |
| WO (1) | WO2012099381A2 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8536201A1 (es) | 2000-12-29 | 2002-08-29 | Kenneth S Warren Inst Inc | Protección y mejoramiento de células, tejidos y órganos que responden a la eritropoyetina |
| AU2005282731B2 (en) | 2004-09-02 | 2010-04-01 | Yale University | Regulation of oncogenes by microRNAs |
| MX2013005242A (es) * | 2010-11-11 | 2013-06-12 | Redx Pharma Ltd | Derivados de farmacos. |
| EP2646107A2 (en) | 2010-12-01 | 2013-10-09 | Spinal Modulation Inc. | Agent delivery systems for selective neuromodulation |
| CZ306115B6 (cs) * | 2012-12-04 | 2016-08-10 | Zentiva, K.S. | Způsob přípravy derivátů kyseliny 3-amino-4-(2,4,5-trifluorfenyl)-butanové |
| WO2015145333A1 (en) | 2014-03-26 | 2015-10-01 | Sun Pharmaceutical Industries Limited | Process for the preparation of sitagliptin and its intermediate |
| JP6841753B2 (ja) | 2014-09-15 | 2021-03-10 | ザ チルドレンズ メディカル センター コーポレーション | ヒストンｈ３−リジントリメチル化を除去することによって体細胞核移入（ｓｃｎｔ）効率を増加させるための方法および組成物 |
| KR101772898B1 (ko) | 2015-06-11 | 2017-08-31 | 동방에프티엘(주) | 시타글립틴의 개선된 제조방법 |
| CN105330664B (zh) * | 2015-10-15 | 2018-06-19 | 合肥华方医药科技有限公司 | 一种西格列汀杂质的合成方法 |
| CN106124667B (zh) * | 2016-08-29 | 2018-07-31 | 上海应用技术学院 | 一种分离测定西格列汀有关物质的方法 |
| KR20210057603A (ko) | 2019-11-12 | 2021-05-21 | 제이투에이치바이오텍 (주) | 시타글립틴의 제조방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3834184B2 (ja) | 2000-04-24 | 2006-10-18 | 株式会社トクヤマ | 縮合剤およびその保存方法 |
| JP4065652B2 (ja) | 2000-08-11 | 2008-03-26 | 株式会社トクヤマ | 四級アンモニウム塩の保存方法 |
| UA74912C2 (en) * | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| JP5046002B2 (ja) | 2007-03-02 | 2012-10-10 | 公益財団法人新産業創造研究機構 | 塩化トリアジン誘導体、その製造方法およびその使用 |
| AU2008241692B2 (en) | 2007-04-19 | 2011-02-10 | Dong-A Pharm. Co., Ltd. | DPP-IV inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating a diabetes or an obesity |
| CN100569740C (zh) | 2007-06-16 | 2009-12-16 | 中国科学院昆明植物研究所 | N-or酰胺类化合物,其制备方法和其应用 |
| JP2009062290A (ja) | 2007-09-04 | 2009-03-26 | Takeda Chem Ind Ltd | シクロプロパン化合物 |
| US8334385B2 (en) | 2007-11-02 | 2012-12-18 | Glenmark Generics Limited | Process for the preparation of R-sitagliptin and its pharmaceutically acceptable salts thereof |
| US20090192326A1 (en) * | 2007-11-13 | 2009-07-30 | Nurit Perlman | Preparation of sitagliptin intermediate |
| TW200948788A (en) * | 2008-04-22 | 2009-12-01 | Daiichi Sankyo Co Ltd | 5-hydroxypyrimidine-4-carboxamide compounds |
| JP2010202575A (ja) * | 2009-03-03 | 2010-09-16 | Takeda Chem Ind Ltd | 複素環化合物 |
| JP5212183B2 (ja) | 2009-03-03 | 2013-06-19 | 株式会社リコー | 樹脂組成物及びこれを用いた成形品 |
| MX344498B (es) | 2009-03-30 | 2016-12-19 | Dong A St Co Ltd | Procedimiento mejorado para preparar inhibidor de dipeptidil peptidasa-iv e intermediario. |
| CN101624379B (zh) * | 2009-07-29 | 2011-04-27 | 苏州永拓医药科技有限公司 | 一种2-氯-4,6-二甲氧基-1,3,5-三嗪的制备方法 |
-
2011
- 2011-01-20 KR KR1020110006081A patent/KR101290029B1/ko active IP Right Grant
-
2012
- 2012-01-18 JP JP2013550394A patent/JP5735659B2/ja not_active Expired - Fee Related
- 2012-01-18 US US13/977,919 patent/US9006436B2/en not_active Expired - Fee Related
- 2012-01-18 CN CN201280006060.3A patent/CN103403008B/zh not_active Expired - Fee Related
- 2012-01-18 EP EP12737171.4A patent/EP2665728B1/en not_active Not-in-force
- 2012-01-18 WO PCT/KR2012/000408 patent/WO2012099381A2/en active Application Filing
- 2012-01-18 ES ES12737171.4T patent/ES2550342T3/es active Active
- 2012-01-18 PT PT127371714T patent/PT2665728E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014507415A (ja) | 2014-03-27 |
| EP2665728A2 (en) | 2013-11-27 |
| KR101290029B1 (ko) | 2013-07-30 |
| JP5735659B2 (ja) | 2015-06-17 |
| US20140005394A1 (en) | 2014-01-02 |
| WO2012099381A3 (en) | 2012-12-06 |
| KR20120084622A (ko) | 2012-07-30 |
| EP2665728A4 (en) | 2014-08-06 |
| CN103403008A (zh) | 2013-11-20 |
| WO2012099381A2 (en) | 2012-07-26 |
| EP2665728B1 (en) | 2015-07-22 |
| US9006436B2 (en) | 2015-04-14 |
| ES2550342T3 (es) | 2015-11-06 |
| CN103403008B (zh) | 2015-09-30 |
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