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PT2588480T - Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)dicarboxamida, sua preparação e sua utilização terapêutica - Google Patents

Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)dicarboxamida, sua preparação e sua utilização terapêutica

Info

Publication number
PT2588480T
PT2588480T PT117815902T PT11781590T PT2588480T PT 2588480 T PT2588480 T PT 2588480T PT 117815902 T PT117815902 T PT 117815902T PT 11781590 T PT11781590 T PT 11781590T PT 2588480 T PT2588480 T PT 2588480T
Authority
PT
Portugal
Prior art keywords
dihydropyrrolo
pyrazine
preparation
therapeutic use
dicarboxamide derivatives
Prior art date
Application number
PT117815902T
Other languages
English (en)
Inventor
Cote-Des-Combes Sylvain
Froissant Jacques
Gibert Jean-François
Marguet Frank
Pacaud Christophe
Puech Frédéric
Ravet Antoine
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42697541&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2588480(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PT2588480T publication Critical patent/PT2588480T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT117815902T 2010-06-03 2011-06-01 Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)dicarboxamida, sua preparação e sua utilização terapêutica PT2588480T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1054372A FR2960876B1 (fr) 2010-06-03 2010-06-03 Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
PT2588480T true PT2588480T (pt) 2016-11-21

Family

ID=42697541

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117815902T PT2588480T (pt) 2010-06-03 2011-06-01 Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)dicarboxamida, sua preparação e sua utilização terapêutica

Country Status (39)

Country Link
US (2) US8791119B2 (pt)
EP (1) EP2588480B1 (pt)
JP (1) JP5995841B2 (pt)
KR (1) KR20130113928A (pt)
CN (1) CN103168041B (pt)
AR (1) AR081832A1 (pt)
AU (1) AU2011268651B2 (pt)
BR (1) BR112012030697A2 (pt)
CA (1) CA2801154C (pt)
CL (1) CL2012003360A1 (pt)
CO (1) CO6602113A2 (pt)
CR (1) CR20120595A (pt)
CY (1) CY1118512T1 (pt)
DK (1) DK2588480T3 (pt)
DO (1) DOP2012000296A (pt)
EA (1) EA201291364A1 (pt)
EC (1) ECSP12012322A (pt)
ES (1) ES2603420T3 (pt)
FR (1) FR2960876B1 (pt)
GT (1) GT201200319A (pt)
HR (1) HRP20161494T1 (pt)
HU (1) HUE030650T2 (pt)
IL (1) IL223364A (pt)
LT (1) LT2588480T (pt)
MA (1) MA34360B1 (pt)
MX (1) MX2012014084A (pt)
NI (1) NI201200176A (pt)
NZ (1) NZ603947A (pt)
PE (1) PE20130259A1 (pt)
PH (1) PH12012502353A1 (pt)
PL (1) PL2588480T3 (pt)
PT (1) PT2588480T (pt)
SG (1) SG186143A1 (pt)
SI (1) SI2588480T1 (pt)
TN (1) TN2012000520A1 (pt)
TW (1) TWI487707B (pt)
UY (1) UY33428A (pt)
WO (1) WO2011161537A2 (pt)
ZA (1) ZA201209071B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2960876B1 (fr) * 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
AR098414A1 (es) 2013-11-14 2016-05-26 Bristol Myers Squibb Co PIPERAZINAS DE PIRAZOLO SUSTITUIDO COMO INHIBIDORES DE CASEÍNA QUINASA 1 d/e
JP6307989B2 (ja) * 2014-04-02 2018-04-11 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
CN110709523B (zh) * 2017-04-12 2023-07-11 豪夫迈·罗氏有限公司 使用经pictet spengler反应获得的加标签的核苷的测序反应方法
US11247998B2 (en) * 2017-07-27 2022-02-15 Jiangsu Hengrui Medicine Co., Ltd. Piperazine heteroaryl derivative, preparation method therefor and use of same in medicine
CN119451964A (zh) * 2022-06-29 2025-02-14 英矽智能科技知识产权有限公司 Fgfr2和fgfr3抑制剂及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU778870B2 (en) 1999-02-01 2004-12-23 University Of Virginia Patent Foundation Compositions for treating inflammatory response
PL369530A1 (en) * 2001-09-19 2005-05-02 Aventis Pharma S.A. Chemical compounds
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
CN100439367C (zh) 2003-12-11 2008-12-03 安万特药物公司 作为酪蛋白激酶Iε抑制剂的取代的1H-吡咯并[3,2-b、3,2-c和2,3-c]吡啶-2-甲酰胺以及相关类似物
GB0328900D0 (en) 2003-12-12 2004-01-14 Glaxo Group Ltd Novel compounds
US8304408B2 (en) * 2007-05-24 2012-11-06 The Regents Of The University Of California Wnt signaling inhibitors, and methods for making and using them
BRPI0813094A2 (pt) * 2007-07-27 2014-12-23 Sanofi Aventis Derivados de 1,2,3,4-tetra-hidro pirrolo (1,2-a) pirazina-6-carboxamidas e de 2,3,4,5-tetra hidro pirrolo (1,2-a) (1,4)-diazepina-7-carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica.
JP2011509961A (ja) * 2008-01-17 2011-03-31 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換スルホンアミド誘導体
WO2009097515A2 (en) * 2008-01-30 2009-08-06 Wyeth [a]-fused indole compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
FR2960876B1 (fr) * 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
HUE030650T2 (en) 2017-05-29
US20140336189A1 (en) 2014-11-13
MA34360B1 (fr) 2013-07-03
NZ603947A (en) 2014-12-24
PL2588480T3 (pl) 2017-08-31
US8791119B2 (en) 2014-07-29
DK2588480T3 (en) 2016-12-12
TN2012000520A1 (en) 2014-04-01
PE20130259A1 (es) 2013-03-22
BR112012030697A2 (pt) 2019-09-24
EP2588480A2 (en) 2013-05-08
EP2588480B1 (en) 2016-08-17
TWI487707B (zh) 2015-06-11
US20130090340A1 (en) 2013-04-11
PH12012502353A1 (en) 2014-10-22
JP5995841B2 (ja) 2016-09-21
KR20130113928A (ko) 2013-10-16
AU2011268651A1 (en) 2012-12-20
CO6602113A2 (es) 2013-01-18
FR2960876A1 (fr) 2011-12-09
GT201200319A (es) 2014-01-17
DOP2012000296A (es) 2013-02-28
CR20120595A (es) 2013-01-03
ES2603420T3 (es) 2017-02-27
HRP20161494T1 (hr) 2016-12-16
EA201291364A1 (ru) 2013-05-30
AU2011268651B2 (en) 2016-09-01
AR081832A1 (es) 2012-10-24
TW201202248A (en) 2012-01-16
FR2960876B1 (fr) 2012-07-27
LT2588480T (lt) 2016-12-12
US9233965B2 (en) 2016-01-12
SI2588480T1 (sl) 2016-12-30
SG186143A1 (en) 2013-01-30
MX2012014084A (es) 2013-01-29
ECSP12012322A (es) 2013-03-28
WO2011161537A3 (en) 2012-03-01
UY33428A (es) 2011-12-30
CY1118512T1 (el) 2017-07-12
CL2012003360A1 (es) 2013-04-01
CA2801154C (en) 2018-01-09
WO2011161537A2 (en) 2011-12-29
JP2013527226A (ja) 2013-06-27
NI201200176A (es) 2013-02-06
IL223364A (en) 2015-06-30
ZA201209071B (en) 2014-02-26
CN103168041B (zh) 2015-08-26
CN103168041A (zh) 2013-06-19
CA2801154A1 (en) 2011-12-29

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