PT2343380T - Permuta de cassetes da região variável de imunoglobulina - Google Patents
Permuta de cassetes da região variável de imunoglobulinaInfo
- Publication number
- PT2343380T PT2343380T PT10014128T PT10014128T PT2343380T PT 2343380 T PT2343380 T PT 2343380T PT 10014128 T PT10014128 T PT 10014128T PT 10014128 T PT10014128 T PT 10014128T PT 2343380 T PT2343380 T PT 2343380T
- Authority
- PT
- Portugal
- Prior art keywords
- variable region
- immunoglobulin variable
- cassette exchange
- region cassette
- exchange
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62858104P | 2004-11-16 | 2004-11-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2343380T true PT2343380T (pt) | 2019-09-18 |
Family
ID=36407771
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT10014128T PT2343380T (pt) | 2004-11-16 | 2005-11-16 | Permuta de cassetes da região variável de imunoglobulina |
PT191691351T PT3540062T (pt) | 2004-11-16 | 2005-11-16 | Permuta de cassete de região variável de imunoglobulina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT191691351T PT3540062T (pt) | 2004-11-16 | 2005-11-16 | Permuta de cassete de região variável de imunoglobulina |
Country Status (10)
Country | Link |
---|---|
US (2) | US20060134098A1 (pt) |
EP (3) | EP2343380B1 (pt) |
JP (1) | JP2008520586A (pt) |
AU (1) | AU2005306502B2 (pt) |
CA (1) | CA2587158C (pt) |
DK (2) | DK2343380T3 (pt) |
ES (3) | ES2881353T3 (pt) |
PL (2) | PL2343380T3 (pt) |
PT (2) | PT2343380T (pt) |
WO (1) | WO2006055778A2 (pt) |
Families Citing this family (61)
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DK1713503T3 (da) * | 2004-02-10 | 2013-11-04 | Univ Colorado Regents | Hæmning af faktor b, den alternative komplemenpathway og dertil relaterede fremgangsmåde |
PL2343380T3 (pl) | 2004-11-16 | 2020-03-31 | Humanigen, Inc. | Wymiana kasety dla regionu zmiennego immunoglobuliny |
CN103505728A (zh) * | 2005-05-26 | 2014-01-15 | 科罗拉多大学评议会法人机构 | 用于治疗外伤性脑损伤、脊髓损伤及相关病症的补体旁路抑制 |
EP2035448A4 (en) | 2006-06-01 | 2010-11-03 | Elan Pharm Inc | NEUROACTIVE FRAGMENTS OF APP |
WO2008063898A2 (en) * | 2006-11-08 | 2008-05-29 | Kalobios Pharmaceuticals, Inc. | Methods of treating idiopathic thrombocytopenia purpura using a gm-csf antagonist |
US8398972B2 (en) * | 2006-11-21 | 2013-03-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a GM-CSF antagonist |
CN101605547A (zh) | 2006-11-21 | 2009-12-16 | 卡罗拜奥斯制药公司 | 使用gm-csf拮抗剂治疗慢性炎症疾病的方法 |
WO2008103475A1 (en) | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Somatic hypermutation systems |
PT3199180T (pt) * | 2007-03-08 | 2022-04-01 | Univ Monash | Anticorpos epha3 para o tratamento de tumores sólidos |
EP2236518B1 (en) * | 2007-03-14 | 2014-08-06 | Alexion Cambridge Corporation | Humaneered anti-factor B antibody |
BRPI0813833A2 (pt) * | 2007-07-17 | 2015-01-06 | Irm Llc | Anticorpos antagonistas de receptor-1 ativado por protease (par1) |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
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WO2009114815A1 (en) * | 2008-03-13 | 2009-09-17 | Dyax Corp | Libraries of genetic packages comprising novel hc cdr3 designs |
US9388510B2 (en) | 2008-04-24 | 2016-07-12 | Dyax Corp. | Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs |
MX2010011761A (es) | 2008-04-28 | 2010-11-30 | Kalobios Pharmaceuticals Inc | Anticuerpos para el factor que estimula la colonia del granulocito-macrofago. |
JP2012516897A (ja) | 2009-02-04 | 2012-07-26 | カロバイオス ファーマシューティカルズ インコーポレイティッド | シュードモナス・エルギノーサ(PseudomonasAeruginosa)感染の治療のための抗生物質と抗体療法との組み合わせ |
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WO2010093814A1 (en) | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
AU2010221159B2 (en) | 2009-03-06 | 2015-11-26 | Humanigen, Inc. | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to EphA3 |
EP2432878B2 (en) * | 2009-05-20 | 2018-05-16 | Novimmune SA | Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants |
CA2767105A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
CN102666589B (zh) | 2009-10-14 | 2014-08-20 | 卡罗拜奥斯制药公司 | EphA3抗体 |
AR079336A1 (es) * | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
US9150641B2 (en) * | 2009-12-22 | 2015-10-06 | Hoffmann—La Roche Inc. | Sequence dependent aggregation |
RU2565539C2 (ru) | 2010-02-18 | 2015-10-20 | Те Риджентс Оф Те Юниверсити Оф Калифорния | АНТИТЕЛА, НЕЙТРАЛИЗУЮЩИЕ ИНТЕГРИН ανβ8 |
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JP2014511378A (ja) | 2011-02-11 | 2014-05-15 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Pcsk9アンタゴニスト |
WO2012125733A2 (en) | 2011-03-15 | 2012-09-20 | X-Body, Inc. | Antibody screening methods |
WO2012170607A2 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Use of pcsk9 antagonists |
WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
US20130109586A1 (en) * | 2011-10-05 | 2013-05-02 | Kalobios Pharmaceuticals, Inc. | Generation of antibodies to an epitope of interest that contains a phosphomimetic amino acid |
AU2012328819B2 (en) | 2011-10-26 | 2017-08-03 | Elanco Tiergesundheit Ag | Monoclonal antibodies and methods of use |
WO2013177035A2 (en) | 2012-05-24 | 2013-11-28 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor b antibody |
WO2014084859A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Molecules and methods for modulating tmem16a activities |
AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
HUE047283T2 (hu) | 2013-12-09 | 2020-04-28 | Allakos Inc | Anti-SIGLEC-8 antitestek és eljárások az alkalmazásukra |
EP3110446B1 (en) | 2014-02-28 | 2021-12-01 | Allakos Inc. | Methods and compositions for treating siglec-8 associated diseases |
EP3157951B1 (en) * | 2014-06-17 | 2020-05-13 | Academia Sinica | Humanized anti-ige antibodies that crosslink cd23 on b lymphocytes but do not sensitize mast cells |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
EP3310385A4 (en) | 2015-06-17 | 2018-12-19 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
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US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
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WO2018081649A1 (en) | 2016-10-28 | 2018-05-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin c-terminal hydrolase l1 (uch-l1) and glial fibrillary acidic protein (gfap) and related methods |
WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
AU2018261887A1 (en) | 2017-05-05 | 2019-12-05 | Allakos Inc. | Methods and compositions for treating allergic ocular diseases |
JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
WO2018215938A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use |
AU2018274216A1 (en) | 2017-05-24 | 2019-12-12 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer |
WO2018215937A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
EP3691663A4 (en) | 2017-10-02 | 2021-08-18 | Humanigen, Inc. | METHODS OF TREATMENT OF TOXICITY ASSOCIATED WITH IMMUNOTHERAPIES USING A GM-CSF ANTAGONIST |
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CA3209364A1 (en) | 2021-03-01 | 2022-09-09 | Jennifer O'neil | Combination of masked ctla4 and pd1/pdl1 antibodies for treating cancer |
TW202317612A (zh) | 2021-03-01 | 2023-05-01 | 美商艾希利歐發展股份有限公司 | 用於治療癌症的ctla4及pd1/pdl1抗體之組合 |
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-
2005
- 2005-11-16 PL PL10014128T patent/PL2343380T3/pl unknown
- 2005-11-16 EP EP10014128.2A patent/EP2343380B1/en active Active
- 2005-11-16 EP EP19169135.1A patent/EP3540062B1/en active Active
- 2005-11-16 PT PT10014128T patent/PT2343380T/pt unknown
- 2005-11-16 ES ES19169135T patent/ES2881353T3/es active Active
- 2005-11-16 JP JP2007541495A patent/JP2008520586A/ja active Pending
- 2005-11-16 PL PL19169135T patent/PL3540062T3/pl unknown
- 2005-11-16 EP EP05851809.3A patent/EP1824987B1/en not_active Revoked
- 2005-11-16 CA CA2587158A patent/CA2587158C/en active Active
- 2005-11-16 DK DK10014128.2T patent/DK2343380T3/da active
- 2005-11-16 US US11/282,107 patent/US20060134098A1/en not_active Abandoned
- 2005-11-16 ES ES05851809T patent/ES2429541T3/es active Active
- 2005-11-16 ES ES10014128T patent/ES2744149T3/es active Active
- 2005-11-16 PT PT191691351T patent/PT3540062T/pt unknown
- 2005-11-16 AU AU2005306502A patent/AU2005306502B2/en not_active Ceased
- 2005-11-16 WO PCT/US2005/041825 patent/WO2006055778A2/en active Application Filing
- 2005-11-16 DK DK19169135.1T patent/DK3540062T3/da active
-
2015
- 2015-12-14 US US14/968,709 patent/US10919983B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
DK3540062T3 (da) | 2021-06-28 |
US20060134098A1 (en) | 2006-06-22 |
AU2005306502A1 (en) | 2006-05-26 |
US20160102152A1 (en) | 2016-04-14 |
EP3540062A1 (en) | 2019-09-18 |
ES2429541T3 (es) | 2013-11-15 |
WO2006055778A2 (en) | 2006-05-26 |
EP3540062B1 (en) | 2021-05-12 |
EP1824987A2 (en) | 2007-08-29 |
EP2343380B1 (en) | 2019-06-12 |
EP1824987A4 (en) | 2008-03-19 |
CA2587158A1 (en) | 2006-05-26 |
EP1824987B1 (en) | 2013-08-21 |
ES2744149T3 (es) | 2020-02-21 |
US10919983B2 (en) | 2021-02-16 |
CA2587158C (en) | 2016-01-12 |
WO2006055778A3 (en) | 2006-11-23 |
DK2343380T3 (da) | 2019-09-09 |
PL3540062T3 (pl) | 2021-12-27 |
JP2008520586A (ja) | 2008-06-19 |
PT3540062T (pt) | 2021-07-06 |
AU2005306502B2 (en) | 2012-11-15 |
EP2343380A1 (en) | 2011-07-13 |
ES2881353T3 (es) | 2021-11-29 |
PL2343380T3 (pl) | 2020-03-31 |
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