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PT2318365E - Formas polimórficas inovadoras de (l)-arginina de perindopril e processo para a preparação dos mesmos - Google Patents

Formas polimórficas inovadoras de (l)-arginina de perindopril e processo para a preparação dos mesmos Download PDF

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Publication number
PT2318365E
PT2318365E PT97698104T PT09769810T PT2318365E PT 2318365 E PT2318365 E PT 2318365E PT 97698104 T PT97698104 T PT 97698104T PT 09769810 T PT09769810 T PT 09769810T PT 2318365 E PT2318365 E PT 2318365E
Authority
PT
Portugal
Prior art keywords
perindopril
arginine
preparation
polymorphic forms
novel polymorphic
Prior art date
Application number
PT97698104T
Other languages
English (en)
Inventor
Jetti Ramakoteswara Rao
Ramakoteswara Rao Jetti
Chetan Kanaiyalal Raval
Ramireddy Bommareddy Aggi
Debashish Datta
Original Assignee
Mylan Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41203736&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2318365(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mylan Lab Ltd filed Critical Mylan Lab Ltd
Publication of PT2318365E publication Critical patent/PT2318365E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT97698104T 2008-06-24 2009-06-22 Formas polimórficas inovadoras de (l)-arginina de perindopril e processo para a preparação dos mesmos PT2318365E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1535CH2008 2008-06-24

Publications (1)

Publication Number Publication Date
PT2318365E true PT2318365E (pt) 2015-11-25

Family

ID=41203736

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97698104T PT2318365E (pt) 2008-06-24 2009-06-22 Formas polimórficas inovadoras de (l)-arginina de perindopril e processo para a preparação dos mesmos

Country Status (13)

Country Link
US (3) US8686161B2 (pt)
EP (2) EP2318365B1 (pt)
AU (1) AU2009263737B2 (pt)
CA (2) CA2729604C (pt)
CY (1) CY1116930T1 (pt)
DK (1) DK2318365T3 (pt)
ES (1) ES2552653T3 (pt)
HR (1) HRP20151208T1 (pt)
HU (1) HUE025982T2 (pt)
PL (1) PL2318365T3 (pt)
PT (1) PT2318365E (pt)
SI (1) SI2318365T1 (pt)
WO (1) WO2009157018A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2897866B1 (fr) 2006-02-28 2008-04-18 Servier Lab Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
DK2318365T3 (en) 2008-06-24 2015-11-23 Mylan Lab Ltd NOVEL polymorphic forms of perindopril (L) -arginine AND PROCESS FOR PREPARATION THEREOF
AU2009212902A1 (en) * 2008-09-03 2010-03-18 Apotex Pharmachem Inc. Amorphous form of an L-arginine salt of perindopril and processes of preparation thereof
FR2985512B1 (fr) * 2012-01-05 2014-06-20 Servier Lab Procede de preparation du sel de l-arginine du perindopril
FR2985511B1 (fr) * 2012-01-05 2014-01-03 Servier Lab Forme cristalline delta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN103172696B (zh) * 2012-12-19 2014-12-17 宁波美诺华药业股份有限公司 一种γ晶型的培哚普利精氨酸盐的制备方法
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN109725022A (zh) * 2018-12-27 2019-05-07 湖南科技大学 一种结合水含量的快速测量方法
EP3842035A1 (en) 2019-12-23 2021-06-30 KRKA, d.d., Novo mesto Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules
CN112047999B (zh) * 2020-09-18 2022-12-02 天津力生制药股份有限公司 一种γ晶型的精氨酸培哚普利盐的制备方法
SI26268A (sl) * 2021-11-18 2023-05-31 Zupet Rok Postopek za pripravo hidratirane oblike perindopril l-arginina
CN114149357B (zh) * 2021-12-29 2024-06-25 江苏嘉逸医药有限公司 一种γ晶型培哚普利精氨酸盐的制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4616031A (en) * 1979-12-07 1986-10-07 Adir Perhydroindole-2-carboxylic acids as antihypertensives
US4508729A (en) 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4616030A (en) * 1979-12-07 1986-10-07 Adir Perhydroindole-2-carboxylic acids as antihypertensives
US5162362A (en) * 1980-08-30 1992-11-10 Hoechst Aktiengesellschaft Octahydroindole-2-carboxylic acids
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
FR2620709B1 (fr) 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
GB9101443D0 (en) 1991-01-23 1991-03-06 Plessey Telecomm Coin mechanisms
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2838648B1 (fr) 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
CA2517205C (en) * 2003-02-28 2010-08-24 Lupin Limited Process for preparation of perindopril and salts thereof
DE60302287T2 (de) * 2003-08-29 2006-08-10 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
PT1420029E (pt) * 2003-12-10 2008-04-14 Servier Lab Processo de síntese do perindopril e dos seus sais farmaceuticamente aceitáveis
US7615571B2 (en) * 2004-05-31 2009-11-10 Ipca Laboratories Ltd. Process for manufacture of pure (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl]amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid and its tert. butyl amine salt
CA2614099A1 (en) * 2005-07-05 2007-01-11 Cipla Limited Process for the synthesis of the ace inhibitor
FR2897866B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2897865B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EP1864973A1 (en) 2006-06-09 2007-12-12 Sochinaz SA Process for the preparation of perindopril and salts thereof
DK2318365T3 (en) 2008-06-24 2015-11-23 Mylan Lab Ltd NOVEL polymorphic forms of perindopril (L) -arginine AND PROCESS FOR PREPARATION THEREOF
AU2009212902A1 (en) 2008-09-03 2010-03-18 Apotex Pharmachem Inc. Amorphous form of an L-arginine salt of perindopril and processes of preparation thereof
AU2013328352A1 (en) * 2012-10-10 2015-05-14 Piramal Enterprises Limited An improved process for preparation of Perindopril intermediate

Also Published As

Publication number Publication date
WO2009157018A2 (en) 2009-12-30
CA2919564A1 (en) 2009-12-30
CA2729604A1 (en) 2009-12-30
US20140135504A1 (en) 2014-05-15
WO2009157018A3 (en) 2010-07-29
EP2318365B1 (en) 2015-08-12
EP2682388B1 (en) 2018-01-10
SI2318365T1 (sl) 2016-01-29
HRP20151208T1 (hr) 2015-12-18
AU2009263737A1 (en) 2009-12-30
CY1116930T1 (el) 2017-04-05
DK2318365T3 (en) 2015-11-23
EP2318365A2 (en) 2011-05-11
US20150336890A1 (en) 2015-11-26
EP2682388A1 (en) 2014-01-08
CA2729604C (en) 2017-12-05
WO2009157018A9 (en) 2010-06-10
PL2318365T3 (pl) 2016-02-29
US9725412B2 (en) 2017-08-08
US20110301357A1 (en) 2011-12-08
AU2009263737B2 (en) 2013-10-24
HUE025982T2 (en) 2016-05-30
US8686161B2 (en) 2014-04-01
ES2552653T3 (es) 2015-12-01

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