PT2285786E - Derivados de quinoxalinediona - Google Patents

Derivados de quinoxalinediona Download PDF

Info

Publication number: PT2285786E
Authority: PT; Portugal
Prior art keywords: quinoxalinedione derivatives; quinoxalinedione; derivatives
Prior art date: 2008-06-16

Application number

PT97654891T

Other languages

English (en)

Inventor

Daniel Cravo

Sophie Hallakou-Bozec

Franck Lepifre

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-16

Filing date

2009-05-19

Publication date

2014-01-07

2009-05-19 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2014-01-07 Publication of PT2285786E publication Critical patent/PT2285786E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT97654891T 2008-06-16 2009-05-19 Derivados de quinoxalinediona PT2285786E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP08290564		2008-06-16

Publications (1)

Publication Number	Publication Date
PT2285786E true PT2285786E (pt)	2014-01-07

Family

ID=40823394

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97654891T PT2285786E (pt)	2008-06-16	2009-05-19	Derivados de quinoxalinediona

Country Status (25)

Country	Link
US (2)	US8329698B2 (pt)
EP (1)	EP2285786B1 (pt)
JP (1)	JP5596676B2 (pt)
KR (1)	KR101641391B1 (pt)
CN (1)	CN102066342B (pt)
AR (1)	AR072148A1 (pt)
AU (1)	AU2009259754B2 (pt)
BR (1)	BRPI0915064B8 (pt)
CA (1)	CA2728018C (pt)
CO (1)	CO6321252A2 (pt)
CY (1)	CY1114737T1 (pt)
DK (1)	DK2285786T3 (pt)
EA (1)	EA020236B1 (pt)
EC (1)	ECSP11010760A (pt)
ES (1)	ES2436195T3 (pt)
HK (1)	HK1157784A1 (pt)
HR (1)	HRP20131069T1 (pt)
IL (1)	IL209421A (pt)
MX (1)	MX2010013577A (pt)
MY (1)	MY155695A (pt)
NZ (1)	NZ590503A (pt)
PL (1)	PL2285786T3 (pt)
PT (1)	PT2285786E (pt)
SI (1)	SI2285786T1 (pt)
WO (1)	WO2009152909A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
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US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8889730B2 (en)	2012-04-10	2014-11-18	Pfizer Inc.	Indole and indazole compounds that activate AMPK
IN2014KN02601A (pt)	2012-04-24	2015-05-08	Vertex Pharma
PT2970218T (pt)	2013-03-12	2019-03-01	Vertex Pharma	Inibidores de adn-pk
US9394285B2 (en)	2013-03-15	2016-07-19	Pfizer Inc.	Indole and indazole compounds that activate AMPK
CN103435561B (zh) *	2013-08-19	2016-08-10	上海交通大学	一种新型d-氨基酸氧化酶抑制剂及其制备和应用
ES2802296T3 (es)	2013-10-17	2021-01-18	Vertex Pharma	Co-cristales de (S)-N-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propan-2-il)quinolin-4-carboxamida y derivados deuterados de la misma como inhibidores de DNA-PK
JP2019529475A (ja)	2016-09-27	2019-10-17	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	Ｄｎａ損傷剤とｄｎａ−ｐｋ阻害剤との組合せ物を使用する、がんを処置するための方法
WO2020190939A1 (en) *	2019-03-18	2020-09-24	University Of Washington	Methods of promoting cellular maturation with ampk activators
CN110642798B (zh) *	2019-11-10	2020-07-24	湖南科技学院	一种n-取代-1,4-二氢-2,3-喹喔啉二酮化合物的绿色合成方法
US11618751B1 (en)	2022-03-25	2023-04-04	Ventus Therapeutics U.S., Inc.	Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
KR20230012597A (ko)	2020-05-19	2023-01-26	칼리오페, 인크.	Ampk 활성화제
JP2023531726A (ja)	2020-06-26	2023-07-25	キャリーオペ，インク．	Ａｍｐｋアクチベーター
JP2023544026A (ja)	2020-09-30	2023-10-19	バイオベラティブセラピューティクスインコーポレイテッド	Ａｍｐｋ活性化因子及びその使用方法
US11767320B2 (en)	2020-10-02	2023-09-26	Incyte Corporation	Bicyclic dione compounds as inhibitors of KRAS
WO2022114812A1 (ko) *	2020-11-26	2022-06-02	주식회사 엘지화학	다이아실글리세롤 키나아제 저해제로서 헤테로사이클 화합물 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5631373A (en)	1993-11-05	1997-05-20	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon	Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
EP0963372A1 (en)	1997-02-18	1999-12-15	American Home Products Corporation	5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists
CA2445650A1 (en) *	2001-05-25	2002-12-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Combination of a dopamine d2-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways
KR20060130159A (ko) *	2004-01-06	2006-12-18	얀센 파마슈티카 엔.브이.	당뇨병 및 비만증 치료용 글리코겐 인산화효소억제제로서의(3-옥소-3,4-디하이드로-퀴녹살린-2-일-아미노)-벤즈아미드유도체 및 관련 화합물
MY139645A (en) *	2004-02-11	2009-10-30	Amgen Inc	Vanilloid receptor ligands and their use in treatments
WO2007136465A2 (en) *	2006-05-15	2007-11-29	Irm Llc	Compositions and methods for fgf receptor kinases inhibitors
FR2903695B1 (fr) *	2006-07-13	2008-10-24	Merck Sante Soc Par Actions Si	Utilisation de derives d'imidazole activateurs de l'ampk, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

2009
- 2009-05-19 PT PT97654891T patent/PT2285786E/pt unknown
- 2009-05-19 US US12/997,641 patent/US8329698B2/en not_active Expired - Fee Related
- 2009-05-19 AU AU2009259754A patent/AU2009259754B2/en not_active Ceased
- 2009-05-19 CA CA2728018A patent/CA2728018C/en active Active
- 2009-05-19 MX MX2010013577A patent/MX2010013577A/es active IP Right Grant
- 2009-05-19 KR KR1020117000992A patent/KR101641391B1/ko active IP Right Grant
- 2009-05-19 EP EP09765489.1A patent/EP2285786B1/en active Active
- 2009-05-19 PL PL09765489T patent/PL2285786T3/pl unknown
- 2009-05-19 ES ES09765489T patent/ES2436195T3/es active Active
- 2009-05-19 SI SI200930812T patent/SI2285786T1/sl unknown
- 2009-05-19 MY MYPI2010005917A patent/MY155695A/en unknown
- 2009-05-19 DK DK09765489.1T patent/DK2285786T3/da active
- 2009-05-19 JP JP2011513895A patent/JP5596676B2/ja active Active
- 2009-05-19 WO PCT/EP2009/003538 patent/WO2009152909A1/en active Application Filing
- 2009-05-19 CN CN2009801227397A patent/CN102066342B/zh active Active
- 2009-05-19 BR BRPI0915064A patent/BRPI0915064B8/pt active IP Right Grant
- 2009-05-19 EA EA201100007A patent/EA020236B1/ru not_active IP Right Cessation
- 2009-05-19 NZ NZ590503A patent/NZ590503A/xx not_active IP Right Cessation
- 2009-06-16 AR ARP090102166A patent/AR072148A1/es active IP Right Grant
2010
- 2010-11-18 IL IL209421A patent/IL209421A/en active IP Right Grant
- 2010-12-14 CO CO10156748A patent/CO6321252A2/es active IP Right Grant
2011
- 2011-01-14 EC EC2011010760A patent/ECSP11010760A/es unknown
- 2011-11-16 HK HK11112373.9A patent/HK1157784A1/xx not_active IP Right Cessation
2012
- 2012-08-24 US US13/593,722 patent/US8674097B2/en active Active
2013
- 2013-11-08 HR HRP20131069AT patent/HRP20131069T1/hr unknown
- 2013-12-27 CY CY20131101166T patent/CY1114737T1/el unknown

Also Published As

Publication number	Publication date
CY1114737T1 (el)	2016-12-14
IL209421A0 (en)	2011-01-31
BRPI0915064B8 (pt)	2021-05-25
CN102066342B (zh)	2013-09-04
CO6321252A2 (es)	2011-09-20
CN102066342A (zh)	2011-05-18
AR072148A1 (es)	2010-08-11
EP2285786B1 (en)	2013-10-09
ECSP11010760A (es)	2011-02-28
US20120322806A1 (en)	2012-12-20
US20110130404A1 (en)	2011-06-02
US8329698B2 (en)	2012-12-11
EA201100007A1 (ru)	2011-08-30
AU2009259754A1 (en)	2009-12-23
KR20110017455A (ko)	2011-02-21
HRP20131069T1 (hr)	2013-12-20
US8674097B2 (en)	2014-03-18
BRPI0915064B1 (pt)	2019-10-08
PL2285786T3 (pl)	2014-01-31
BRPI0915064A2 (pt)	2015-10-27
WO2009152909A1 (en)	2009-12-23
AU2009259754B2 (en)	2014-10-02
EP2285786A1 (en)	2011-02-23
MY155695A (en)	2015-11-13
KR101641391B1 (ko)	2016-07-20
CA2728018C (en)	2016-10-11
ES2436195T3 (es)	2013-12-27
DK2285786T3 (da)	2013-11-04
EA020236B1 (ru)	2014-09-30
SI2285786T1 (sl)	2014-02-28
HK1157784A1 (en)	2012-07-06
JP2011524384A (ja)	2011-09-01
MX2010013577A (es)	2010-12-21
JP5596676B2 (ja)	2014-09-24
NZ590503A (en)	2012-08-31
CA2728018A1 (en)	2009-12-23
IL209421A (en)	2015-06-30

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