PT2164993T - Métodos para produção e usos de populações de células multipotentes, populações de células pluripotentes, populações de célula diferenciadas e populações de células resistentes a vih - Google Patents
Métodos para produção e usos de populações de células multipotentes, populações de células pluripotentes, populações de célula diferenciadas e populações de células resistentes a vihInfo
- Publication number
- PT2164993T PT2164993T PT87697611T PT08769761T PT2164993T PT 2164993 T PT2164993 T PT 2164993T PT 87697611 T PT87697611 T PT 87697611T PT 08769761 T PT08769761 T PT 08769761T PT 2164993 T PT2164993 T PT 2164993T
- Authority
- PT
- Portugal
- Prior art keywords
- cell populations
- hiv
- production
- methods
- multipotent
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93202007P | 2007-05-29 | 2007-05-29 | |
US93313307P | 2007-06-05 | 2007-06-05 | |
US93367007P | 2007-06-08 | 2007-06-08 | |
US644908P | 2008-01-14 | 2008-01-14 | |
US6476108P | 2008-03-25 | 2008-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2164993T true PT2164993T (pt) | 2017-01-12 |
Family
ID=40094346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT87697611T PT2164993T (pt) | 2007-05-29 | 2008-05-28 | Métodos para produção e usos de populações de células multipotentes, populações de células pluripotentes, populações de célula diferenciadas e populações de células resistentes a vih |
Country Status (15)
Country | Link |
---|---|
US (1) | US20110217274A1 (pt) |
EP (2) | EP2164993B1 (pt) |
JP (2) | JP2010528613A (pt) |
CN (2) | CN101772580B (pt) |
AU (1) | AU2008260187A1 (pt) |
BR (1) | BRPI0810949A2 (pt) |
CA (1) | CA2725953A1 (pt) |
ES (1) | ES2612538T3 (pt) |
HU (1) | HUE030872T2 (pt) |
IL (2) | IL202401A (pt) |
PL (1) | PL2164993T3 (pt) |
PT (1) | PT2164993T (pt) |
RU (2) | RU2535365C2 (pt) |
SG (2) | SG10201509679XA (pt) |
WO (1) | WO2008150814A2 (pt) |
Families Citing this family (45)
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MX2008007654A (es) | 2005-12-13 | 2008-09-26 | Univ Kyoto | Factor de reprogramacion nuclear. |
US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
CN101743306A (zh) | 2007-03-23 | 2010-06-16 | 威斯康星校友研究基金会 | 体细胞重编程 |
US11859168B2 (en) * | 2007-05-29 | 2024-01-02 | Christopher B. REID | Electroporation, developmentally-activated cells, pluripotent-like cells, cell reprogramming and regenerative medicine |
US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
JP5346925B2 (ja) | 2008-05-02 | 2013-11-20 | 国立大学法人京都大学 | 核初期化方法 |
DK2297307T3 (en) | 2008-06-04 | 2016-07-25 | Cellular Dynamics Int Inc | PROCEDURES FOR THE MANUFACTURE OF IPS CELLS USING NON-VIRAL METHODS |
EP3330371A1 (en) * | 2008-08-12 | 2018-06-06 | Cellular Dynamics International, Inc. | Methods for the production of ips cells |
JP2010148440A (ja) * | 2008-12-25 | 2010-07-08 | Japan Health Science Foundation | 組換えアデノウイルス迅速構築システム |
WO2010127166A2 (en) | 2009-04-30 | 2010-11-04 | The Regents Of The University Of California | Combination anti-hiv vectors, targeting vectors, and methods of use |
US9365866B2 (en) * | 2009-06-03 | 2016-06-14 | National Institute Of Advanced Industrial Science And Technology | Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same |
US9453205B2 (en) * | 2009-10-31 | 2016-09-27 | Genesis Technologies Limited | Methods for reprogramming cells and uses thereof |
US20130097717A1 (en) * | 2010-06-23 | 2013-04-18 | Vivoscript, Inc. | Compositions and methods for re-programming cells without genetic modification for treatment of cardiovascular diseases |
AU2011311344B2 (en) | 2010-10-08 | 2016-09-08 | Mina Therapeutics Limited | Short RNA molecules |
WO2012061075A2 (en) * | 2010-10-25 | 2012-05-10 | The Regents Of The University Of California | Hiv resistant and functional hematopoietic stem/progenitor cells and macrophages from induced pluripotent stem cells |
JP6073795B2 (ja) * | 2010-10-27 | 2017-02-01 | カッパーアールエヌエー,インコーポレイテッド | インターフェロン関連発生制御因子1(ifrd1)への天然アンチセンス転写物の阻害によるifrd1関連疾患の治療 |
KR102196339B1 (ko) * | 2011-12-05 | 2020-12-29 | 팩터 바이오사이언스 인크. | 세포를 형질감염시키는 방법들 및 생성물들 |
CN102659951A (zh) * | 2012-05-29 | 2012-09-12 | 西安医学院 | 一种TAT结构域修饰的neurogenin2融合蛋白制备方法和用途 |
WO2014035433A1 (en) * | 2012-08-31 | 2014-03-06 | Jan Nolta | Genetically modified msc and therapeutic methods |
US20140065110A1 (en) | 2012-08-31 | 2014-03-06 | The Regents Of The University Of California | Genetically modified msc and therapeutic methods |
US9663564B2 (en) | 2013-03-15 | 2017-05-30 | The Regents Of The University Of California | Vectors and methods to treat ischemia |
US20140271923A1 (en) | 2013-03-14 | 2014-09-18 | Christopher Brian Reid | Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions |
CA2930973A1 (en) | 2013-11-22 | 2015-05-28 | Pal SAERTROM | C/ebp alpha short activating rna compositions and methods of use |
LT3268480T (lt) * | 2015-03-09 | 2021-07-26 | Sinai Health System | Priemonės ir būdai, skirti panaudoti ląstelių dalijimosi lokusus ląstelių proliferacijos kontroliavimui |
MA42312A (fr) | 2015-07-02 | 2018-05-09 | Medigen Inc | Particules de type virus recombinantes utilisant la protéine gag du virus de l'immunodéficience bovine |
JP6890831B2 (ja) * | 2015-07-08 | 2021-06-18 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Hiv予備免疫化および免疫療法 |
JP6841609B2 (ja) | 2015-07-10 | 2021-03-10 | 3スキャン インコーポレイテッド | 組織学的染色の空間的多重化 |
TWI808934B (zh) | 2015-12-31 | 2023-07-21 | 美商伯克利之光生命科技公司 | 經工程化以表現促發炎多肽之腫瘤浸潤細胞 |
WO2017160991A1 (en) | 2016-03-16 | 2017-09-21 | Lavieu Gregory G | Methods, systems and devices for selection and generation of genome edited clones |
CA3066107A1 (en) * | 2016-06-03 | 2017-12-07 | Hough Ear Institute | Combination therapies for inner ear sensory hair cell regeneration/replacement |
CN106086075B (zh) * | 2016-06-23 | 2019-08-06 | 福建医科大学 | CXCR4RNAi慢病毒载体的构建方法 |
KR20230074294A (ko) * | 2016-07-19 | 2023-05-26 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | Stat3를 타겟으로 하는 종양용해성 바이러스 |
CN106497882A (zh) * | 2016-10-29 | 2017-03-15 | 复旦大学 | 同时过表达R‑spondin1和Noggin的细胞株及其构建方法和应用 |
CA3048645A1 (en) | 2016-12-30 | 2018-07-05 | The Regents Of The University Of California | Methods for selection and generation of genome edited t cells |
CN108977463A (zh) * | 2017-05-31 | 2018-12-11 | 伯仕利生物科技发展(盐城)有限公司 | 一种用于抑制生产用干细胞分化的技术方法 |
WO2019156216A1 (ja) * | 2018-02-09 | 2019-08-15 | 国立大学法人京都大学 | 心筋細胞増殖促進剤及びその利用 |
US20210095258A1 (en) * | 2018-02-22 | 2021-04-01 | Celularity Inc. | Post partum tissue-derived induced pluripotent stem cells and uses thereof |
CN108715868A (zh) * | 2018-05-31 | 2018-10-30 | 深圳市免疫基因治疗研究院 | 一种Gaucher慢病毒载体、慢病毒及其制备方法和应用 |
CN111484977B (zh) * | 2019-01-25 | 2023-05-16 | 中国科学院脑科学与智能技术卓越创新中心 | 重编程产生功能性去甲肾上腺素能神经元的方法 |
CN110055224B (zh) * | 2019-04-03 | 2023-06-30 | 深圳市体内生物医药科技有限公司 | 一种基因修饰的免疫细胞及其制备方法和应用 |
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US7763722B2 (en) * | 2003-01-17 | 2010-07-27 | University Of Florida Research Foundation, Inc. | Small interference RNA gene therapy |
KR101376013B1 (ko) | 2005-08-26 | 2014-03-19 | 리전츠 오브 더 유니버스티 오브 미네소타 | 기관 및 조직의 세포제거 및 재세포화 |
MX2008007654A (es) * | 2005-12-13 | 2008-09-26 | Univ Kyoto | Factor de reprogramacion nuclear. |
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2008
- 2008-05-28 PT PT87697611T patent/PT2164993T/pt unknown
- 2008-05-28 SG SG10201509679XA patent/SG10201509679XA/en unknown
- 2008-05-28 PL PL08769761T patent/PL2164993T3/pl unknown
- 2008-05-28 HU HUE08769761A patent/HUE030872T2/en unknown
- 2008-05-28 BR BRPI0810949A patent/BRPI0810949A2/pt not_active Application Discontinuation
- 2008-05-28 CA CA2725953A patent/CA2725953A1/en not_active Abandoned
- 2008-05-28 EP EP08769761.1A patent/EP2164993B1/en active Active
- 2008-05-28 US US12/601,819 patent/US20110217274A1/en not_active Abandoned
- 2008-05-28 CN CN200880101094.4A patent/CN101772580B/zh active Active
- 2008-05-28 SG SG10201903161XA patent/SG10201903161XA/en unknown
- 2008-05-28 JP JP2010510472A patent/JP2010528613A/ja active Pending
- 2008-05-28 EP EP16189709.5A patent/EP3128015A3/en not_active Withdrawn
- 2008-05-28 RU RU2009148666/10A patent/RU2535365C2/ru active
- 2008-05-28 WO PCT/US2008/065007 patent/WO2008150814A2/en active Application Filing
- 2008-05-28 AU AU2008260187A patent/AU2008260187A1/en not_active Abandoned
- 2008-05-28 ES ES08769761.1T patent/ES2612538T3/es active Active
- 2008-05-28 CN CN201510680523.XA patent/CN105586358B/zh active Active
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2009
- 2009-11-29 IL IL202401A patent/IL202401A/en active IP Right Grant
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2014
- 2014-10-02 RU RU2014139904A patent/RU2718536C2/ru active
- 2014-11-10 JP JP2014227688A patent/JP2015077132A/ja active Pending
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Also Published As
Publication number | Publication date |
---|---|
SG10201903161XA (en) | 2019-05-30 |
RU2535365C2 (ru) | 2014-12-10 |
WO2008150814A3 (en) | 2009-02-05 |
CN105586358A (zh) | 2016-05-18 |
RU2009148666A (ru) | 2011-07-10 |
WO2008150814A2 (en) | 2008-12-11 |
EP2164993A2 (en) | 2010-03-24 |
US20110217274A1 (en) | 2011-09-08 |
EP2164993B1 (en) | 2016-09-21 |
JP2015077132A (ja) | 2015-04-23 |
RU2718536C2 (ru) | 2020-04-08 |
IL202401A (en) | 2015-10-29 |
IL241906B (en) | 2021-07-29 |
IL202401A0 (en) | 2011-08-01 |
AU2008260187A1 (en) | 2008-12-11 |
CN105586358B (zh) | 2020-08-25 |
PL2164993T4 (pl) | 2017-08-31 |
EP3128015A2 (en) | 2017-02-08 |
ES2612538T3 (es) | 2017-05-17 |
EP3128015A3 (en) | 2017-05-03 |
CA2725953A1 (en) | 2008-12-11 |
EP2164993A4 (en) | 2011-04-13 |
PL2164993T3 (pl) | 2017-08-31 |
JP2010528613A (ja) | 2010-08-26 |
CN101772580B (zh) | 2015-11-25 |
CN101772580A (zh) | 2010-07-07 |
BRPI0810949A2 (pt) | 2015-10-27 |
WO2008150814A8 (en) | 2009-07-30 |
RU2014139904A3 (pt) | 2018-06-28 |
SG10201509679XA (en) | 2015-12-30 |
RU2014139904A (ru) | 2016-04-20 |
IL241906A0 (en) | 2015-11-30 |
HUE030872T2 (en) | 2017-06-28 |
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