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PT2066399T - Dispositivos de eletroporação e métodos de usar os mesmos para eletroporação de células em mamíferos - Google Patents

Dispositivos de eletroporação e métodos de usar os mesmos para eletroporação de células em mamíferos

Info

Publication number
PT2066399T
PT2066399T PT07839621T PT07839621T PT2066399T PT 2066399 T PT2066399 T PT 2066399T PT 07839621 T PT07839621 T PT 07839621T PT 07839621 T PT07839621 T PT 07839621T PT 2066399 T PT2066399 T PT 2066399T
Authority
PT
Portugal
Prior art keywords
electroporation
mammals
cells
methods
same
Prior art date
Application number
PT07839621T
Other languages
English (en)
Inventor
Draghia-Akli Ruxandra
A Brown Patricia
S Khan Amir
A Pope Melissa
Original Assignee
Inovio Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inovio Pharmaceuticals Inc filed Critical Inovio Pharmaceuticals Inc
Publication of PT2066399T publication Critical patent/PT2066399T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0412Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0472Structure-related aspects
    • A61N1/0476Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Electrotherapy Devices (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
PT07839621T 2006-10-17 2007-10-17 Dispositivos de eletroporação e métodos de usar os mesmos para eletroporação de células em mamíferos PT2066399T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85214906P 2006-10-17 2006-10-17
US97898207P 2007-10-10 2007-10-10

Publications (1)

Publication Number Publication Date
PT2066399T true PT2066399T (pt) 2019-01-11

Family

ID=38935920

Family Applications (2)

Application Number Title Priority Date Filing Date
PT181983495T PT3524316T (pt) 2006-10-17 2007-10-17 Dispositivos de eletroporação para eletroporação de células em mamíferos
PT07839621T PT2066399T (pt) 2006-10-17 2007-10-17 Dispositivos de eletroporação e métodos de usar os mesmos para eletroporação de células em mamíferos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT181983495T PT3524316T (pt) 2006-10-17 2007-10-17 Dispositivos de eletroporação para eletroporação de células em mamíferos

Country Status (16)

Country Link
US (1) US9452285B2 (pt)
EP (4) EP2409727B1 (pt)
JP (1) JP5439183B2 (pt)
KR (1) KR101421760B1 (pt)
CN (1) CN105457157B (pt)
AU (1) AU2007313203B2 (pt)
CA (1) CA2666501C (pt)
DK (2) DK2066399T3 (pt)
ES (2) ES2993941T3 (pt)
FI (1) FI3524316T3 (pt)
HU (1) HUE042044T2 (pt)
LT (1) LT3524316T (pt)
PL (2) PL2409727T3 (pt)
PT (2) PT3524316T (pt)
SG (1) SG175627A1 (pt)
WO (1) WO2008048632A1 (pt)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3845269A1 (en) * 2006-03-03 2021-07-07 OncoSec Medical Incorporated Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
US7687267B2 (en) * 2006-09-30 2010-03-30 Rational Biotechnology Inc. High-throughput cell transfection device and methods of using thereof
KR101255419B1 (ko) 2007-11-12 2013-04-17 이노비오 파마수티컬즈, 인크. 인플루엔자 바이러스의 다중 아형에 대한 신규 백신
JP2011504173A (ja) * 2007-11-14 2011-02-03 ブイジーエックス ファーマシューティカルズ,リミティド ライアビリティー カンパニー 電気穿孔により送達されるdnaワクチンにより誘導される抗体の産生
ES2588738T3 (es) * 2008-04-04 2016-11-04 The Trustees Of The University Of Pennsylvania Secuencias de consenso de proteínas del virus Chikungunya, moléculas de ácido nucleico que las codifican, y composiciones y métodos de uso de las mismas
JP5873717B2 (ja) 2008-04-04 2016-03-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Il−28及び組成物を用いたワクチン及び免疫治療薬並びにその使用方法
ITCO20080016A1 (it) * 2008-04-22 2009-10-23 Giuseppe Caccia Manipolo per elettroporazione di prodotti farmacologici e/o naturali e/o estetici su strati cutanei a spessore contenuto
US8921536B2 (en) 2008-10-29 2014-12-30 The Trustees Of The University Of Pennsylvania HCV vaccines and methods for using the same
AU2008363596B2 (en) 2008-10-29 2015-04-30 Inovio Pharmaceuticals, Inc Improved HCV vaccines and methods for using the same
CA3001374A1 (en) * 2008-11-17 2010-05-20 Vgx Pharmaceuticals, Llc Antigens that elicit immune response against flavivirus and methods of using same
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
CA2756276C (en) 2009-04-16 2018-09-25 Vgx Pharmaceuticals, Llc Contactless electropermeabilization electrode and method
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
WO2011050009A1 (en) * 2009-10-19 2011-04-28 Rational Biotechnology Inc. Method, device and apparatus for inducing self-adjusting cell electroporation
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
CA2789733A1 (en) * 2010-03-01 2011-09-09 Inovio Pharmaceuticals, Inc. Multiple tissue layer electroporation applicator and device
US9700368B2 (en) 2010-10-13 2017-07-11 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
EP2667805B1 (en) 2011-01-28 2023-04-05 The General Hospital Corporation Apparatus and method for tissue biopsy
CN106913371B (zh) 2011-01-28 2019-12-10 通用医疗公司 用于不连续皮肤磨削的方法和装置
CN103547226B (zh) 2011-01-28 2018-04-17 通用医疗公司 用于皮肤再表面化的装置
CA2826199A1 (en) 2011-01-31 2012-08-09 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof
US9320536B2 (en) * 2011-03-03 2016-04-26 Jongju Na Method, system, and apparatus for dermatological treatment
ITTO20110374A1 (it) * 2011-04-29 2012-10-30 Igea S P A Metodo di controllo di un dispositivo di elettro-porazione
CA2839196A1 (en) 2011-06-15 2012-12-20 Chrontech Pharma Ab Injection needle and device
KR102171142B1 (ko) * 2011-06-28 2020-10-28 이노비오 파마수티컬즈, 인크. 최소 침습 피부 전기천공 장치
AU2015203882C1 (en) * 2011-06-28 2017-09-21 Inovio Pharmaceuticals, Inc. A minimally invasive dermal electroporation device
DK2734249T3 (en) 2011-07-21 2018-12-10 Massachusetts Gen Hospital DEVICE FOR DESTRUCTION AND REMOVAL OF FAT
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
CN102680526B (zh) * 2012-05-16 2014-07-02 清华大学 单细胞阵列微芯片及其制造、电测量和电穿孔方法
KR101979746B1 (ko) * 2012-09-13 2019-05-17 (주)아모레퍼시픽 전기 천공 장치
US20140171957A1 (en) * 2012-12-19 2014-06-19 Alcon Research, Ltd. Control of Automated Intraocular Lens Injectors
EP2934667A1 (en) * 2012-12-24 2015-10-28 E-Motion Medical, Ltd. Gi tract stimulation devices and methods
BR112015019440A8 (pt) 2013-02-20 2019-11-12 Cytrellis Biosystems Inc curativo regulável, kit, uso e método para fortalecimento da pele
CA2920662A1 (en) 2013-08-09 2015-02-12 Cytrellis Biosystems, Inc. Methods and apparatuses for skin treatment using non-thermal tissue ablation
EP3082897A4 (en) 2013-12-19 2017-07-26 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
US11260137B2 (en) * 2014-04-06 2022-03-01 Emily Chen Tang Electroporation apparatuses and their method of use
US12114911B2 (en) * 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
KR20240090941A (ko) 2014-11-14 2024-06-21 사이트렐리스 바이오시스템즈, 인크. 피부 절제를 위한 디바이스 및 방법
WO2016161113A1 (en) 2015-03-31 2016-10-06 University Of South Florida System and method for electroporation controlled by electrical impedance measurements
CA2981474A1 (en) * 2015-03-31 2016-10-06 Oncosec Medical Incorporated Systems and methods for improved tissue-sensing based electroporation
WO2017117273A1 (en) 2015-12-28 2017-07-06 Inovio Pharmaceuticals, Inc. Intradermal jet injection electroporation device
ITUB20159819A1 (it) * 2015-12-31 2017-07-01 Biopulse S R L Elettroporatore teranostico ad onda bifasica per la diagnosi delle aree patologiche ed il trasferimento terapeutico di molecole e relativo procedimento
KR102742526B1 (ko) 2016-02-05 2024-12-18 이노비오 파마수티컬즈, 인크. 암 백신 및 이를 이용하는 치료 방법
KR102561605B1 (ko) 2016-03-29 2023-08-01 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
EP3443107A1 (en) 2016-04-13 2019-02-20 Synthetic Genomics, Inc. Recombinant arterivirus replicon systems and uses thereof
KR102515836B1 (ko) 2016-09-21 2023-03-31 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
BR112019007433A2 (pt) 2016-10-17 2019-07-02 Synthetic Genomics Inc sistemas de replicon de vírus recombinante e usos dos mesmos
JP7158820B2 (ja) * 2016-10-26 2022-10-24 ロレアル エレクトロポレーションデバイスおよびエレクトロポレーションデバイスを制御するための方法
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
CN110352247B (zh) 2016-12-05 2024-06-28 杨森制药公司 用于增强基因表达的组合物和方法
KR20180123312A (ko) * 2017-05-08 2018-11-16 (주)오스힐 미세전류 조절 수단을 구비한 스킨 부스터
JP6518971B2 (ja) * 2017-05-12 2019-05-29 株式会社ベックス エレクトロポレーター用電源
CN107126628A (zh) * 2017-06-14 2017-09-05 重庆百国智科技发展有限公司 一种人体电位差细胞补水及生物电信号修复的装置及其方法
DE102017116305A1 (de) * 2017-07-19 2019-01-24 Cinogy Gmbh Plasma-Behandlungsgerät
SE541651C2 (en) * 2017-07-28 2019-11-19 Scandinavian Chemotech Ab An electrode device and a needle electrode for use in delivery of electrical pulses to a desired tissue of a mammal
KR20240024366A (ko) 2017-12-13 2024-02-23 이노비오 파마수티컬즈, 인크. 메소텔린을 표적으로 하는 암 백신 및 이의 용도
CN111479585A (zh) 2017-12-13 2020-07-31 艾诺奥医药品有限公司 靶向boris的癌症疫苗和其用途
EA202091516A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv)
IL275427B2 (en) 2017-12-19 2024-04-01 Janssen Sciences Ireland Unlimited Co Hepatitis virus vaccines HBV) B) and their uses
EP3727446A1 (en) 2017-12-19 2020-10-28 Janssen Sciences Ireland Unlimited Company Methods and compositions for inducing an immune response against hepatitis b virus (hbv)
US11021692B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Hepatitis B virus (HBV) vaccines and uses thereof
EA202091517A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
JP7494117B2 (ja) 2018-01-19 2024-06-03 ヤンセン ファーマシューティカルズ,インコーポレーテッド 組換えレプリコン系を使用する免疫応答の誘導および増強
KR102132370B1 (ko) * 2018-03-13 2020-08-05 주식회사 지씨에스 피부관리장치, 피부관리장치의 구동방법 및 컴퓨터 판독가능 기록매체
WO2020028697A1 (en) * 2018-08-01 2020-02-06 Ohio State Innovation Foundation Compositions and methods for reprogramming skin into insulin producing tissue
EP3673846A1 (en) * 2018-12-27 2020-07-01 Bogdan Ionescu Device for an electrophysiology procedure
US11071860B2 (en) * 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
AU2020295012A1 (en) 2019-06-18 2022-02-17 Janssen Sciences Ireland Unlimited Company Combination of hepatitis B virus (HBV) vaccines and anti-PD-1 or anti-PD-L1 antibody
WO2020255022A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and aminopyridine derivatives as hpk1 inhibitors
WO2020255019A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and a quinazoline derivative
WO2020255035A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyrimidine derivatives
CA3141238A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Hepatitis b virus (hbv) vaccines and uses thereof
CA3140702A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
WO2020255039A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives
WO2020255009A2 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 antibody
US20250041386A1 (en) 2019-06-18 2025-02-06 Janssen Sciences Ireland Unlimited Company Recombinant Interleukin 12 Construct and Uses Thereof
CA3140588A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and small molecule pdl1 or pd1 inhibitor
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
US20220233684A1 (en) 2019-06-18 2022-07-28 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pd-l1 inhibitors
WO2020255008A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi
WO2020255010A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines
US20220305116A1 (en) 2019-06-18 2022-09-29 Janssen Sciences lreland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being sulfonamide derivatives
WO2020255038A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives
US20220305117A1 (en) 2019-06-18 2022-09-29 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai
WO2020255015A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
WO2020255013A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives
WO2020254876A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Virus-like particle delivery of hepatitis b virus (hbv) vaccines
WO2020255042A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and a pyrimidine derivative
US20220305118A1 (en) 2019-06-20 2022-09-29 Janssen Sciences Ireland Unlimited Company Carbohydrate nanocarrier delivery of hepatitis b virus (hbv) vaccines
WO2020255062A1 (en) 2019-06-20 2020-12-24 Janssen Sciences Ireland Unlimited Company Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines
WO2021041979A1 (en) * 2019-08-30 2021-03-04 Virginia Tech Intellectual Properties Inc. Method for intracellular delivery of compounds using cell force and shape with electric fields
PE20221815A1 (es) * 2020-03-20 2022-11-29 Inovio Pharmaceuticals Inc Dispositivos de electroporacion asistidos por vacio y sistemas y metodos relacionados
CN111581642A (zh) * 2020-05-03 2020-08-25 付贵龙 一种互联网安全防护系统
IL298874A (en) 2020-06-12 2023-02-01 Univ Rochester ENCODING AND EXPRESSION OF ACE-tRNAs
CA3188801A1 (en) 2020-07-08 2022-01-13 Janssen Sciences Ireland Unlimited Company Rna replicon vaccines against hbv
US12006507B2 (en) 2020-07-22 2024-06-11 Nantcell, Inc. Electroporation with active compensation
US12076071B2 (en) 2020-08-14 2024-09-03 Kardium Inc. Systems and methods for treating tissue with pulsed field ablation
US20220071692A1 (en) * 2020-09-08 2022-03-10 Biosense Webster (Israel) Ltd. Impedance based irreversible-electroporation (ire)
WO2022133230A1 (en) 2020-12-18 2022-06-23 Janssen Pharmaceuticals, Inc. Combination therapy for treating hepatitis b virus infection
WO2022146654A1 (en) 2020-12-28 2022-07-07 Janssen Pharmaceuticals, Inc. Transcription activator-like effector nucleases (talens) targeting hbv
IL314679A (en) 2022-02-07 2024-10-01 Univ Rochester Effective sequences for enhanced tRNA expression and/or enhanced stop mutation suppression
KR20240151223A (ko) * 2022-02-25 2024-10-17 이노비오 파마수티컬즈, 인크. 핸드헬드 전기천공 디바이스 및 관련 시스템 및 방법
WO2023215874A1 (en) * 2022-05-05 2023-11-09 Renbio, Inc. Device related to therapeutic dna delivery
WO2023233290A1 (en) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Rnai agents targeting pd-l1
WO2024129459A1 (en) 2022-12-16 2024-06-20 University Of Rochester Repairmen! of barrier dysfunction in esophagus

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68925030T2 (de) * 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5545130A (en) 1992-04-08 1996-08-13 Genetronics, Inc. Flow through electroporation method
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5869326A (en) 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6120493A (en) 1998-01-27 2000-09-19 Genetronics, Inc. Method for the introduction of therapeutic agents utilizing an electroporation apparatus
US6208893B1 (en) * 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
CA2337129A1 (en) 1998-07-13 2000-01-20 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
US6972013B1 (en) * 1998-07-13 2005-12-06 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
CA2337652C (en) * 1998-07-13 2013-03-26 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6192270B1 (en) * 1998-08-14 2001-02-20 Genetronics, Inc. Apparatus and method for the delivery of drugs and genes into tissue
US6150148A (en) 1998-10-21 2000-11-21 Genetronics, Inc. Electroporation apparatus for control of temperature during the process
US6148232A (en) * 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
EP1292359A4 (en) * 2000-05-22 2005-03-30 Merck & Co Inc SYSTEM AND METHOD FOR EVALUATING THE EFFICACY OF A PHARMACEUTICAL AGENT DELIVERY DEVICE
CN1345610A (zh) * 2000-09-30 2002-04-24 杭州泰士生物科技有限公司 一种活体组织电穿孔用的波形及波形发生器
JP3543326B2 (ja) 2001-08-30 2004-07-14 ソニー株式会社 情報処理装置および方法、情報処理システム、情報配信装置、記録媒体、並びにプログラム
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7245963B2 (en) 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US20080269153A1 (en) * 2002-05-28 2008-10-30 Ruxandra Draghia-Akli Increased stability of a dna formulation by including poly-l-glutamate
US7328064B2 (en) * 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US20050070841A1 (en) 2002-07-04 2005-03-31 Inovio As Electroporation device and injection apparatus
US7238522B2 (en) 2003-05-30 2007-07-03 Advisys, Inc. Devices and methods for biomaterial production

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EP3524316B1 (en) 2024-08-07
US9452285B2 (en) 2016-09-27
SG175627A1 (en) 2011-11-28
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EP4477254A2 (en) 2024-12-18
EP4477254A3 (en) 2025-02-19
DK3524316T3 (da) 2024-11-11
WO2008048632A8 (en) 2008-10-02
AU2007313203B2 (en) 2012-08-16
JP5439183B2 (ja) 2014-03-12
LT3524316T (lt) 2024-11-25
EP3524316A1 (en) 2019-08-14
WO2008048632A1 (en) 2008-04-24
EP2066399A1 (en) 2009-06-10
CA2666501A1 (en) 2008-04-24
ES2993941T3 (en) 2025-01-14
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CA2666501C (en) 2017-03-21
EP2409727B1 (en) 2018-10-03
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FI3524316T3 (fi) 2024-11-08
PL2409727T3 (pl) 2019-03-29
KR101421760B1 (ko) 2014-07-22
CN105457157A (zh) 2016-04-06
AU2007313203A1 (en) 2008-04-24
KR20090107014A (ko) 2009-10-12
DK2066399T3 (en) 2019-01-21
ES2703744T3 (es) 2019-03-12
EP2409727A1 (en) 2012-01-25
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EP2066399B1 (en) 2018-10-03
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