PT2049480E - Derivados de 2-arilindole como inibidores da mpges-i - Google Patents

Derivados de 2-arilindole como inibidores da mpges-i

Info

Publication number: PT2049480E
Authority: PT; Portugal
Prior art keywords: mpges; inhibitors; arylindole; arylindole derivatives; derivatives
Prior art date: 2006-07-14

Application number

PT77867406T

Other languages

English (en)

Inventor

Angelo Guglielmotti

Lorenzo Polenzani

Nicola Cazzolla

Guido Furlotti

Maria Alessandra Alisi

Giorgina Mangano

Isabella Coletta

Caterina Maugeri

Barbara Garofalo

Beatrice Garrone

Rosella Ombrato

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-14

Filing date

2007-06-14

Publication date

2013-12-16

2007-06-14 Application filed by Acraf filed Critical Acraf

2013-12-16 Publication of PT2049480E publication Critical patent/PT2049480E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT77867406T 2006-07-14 2007-06-14 Derivados de 2-arilindole como inibidores da mpges-i PT2049480E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT001368A ITMI20061368A1 (it)	2006-07-14	2006-07-14	Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo

Publications (1)

Publication Number	Publication Date
PT2049480E true PT2049480E (pt)	2013-12-16

Family

ID=37895798

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT77867406T PT2049480E (pt)	2006-07-14	2007-06-14	Derivados de 2-arilindole como inibidores da mpges-i

Country Status (22)

Country	Link
US (1)	US8017644B2 (pt)
EP (1)	EP2049480B1 (pt)
JP (1)	JP5302191B2 (pt)
KR (2)	KR20140091569A (pt)
CN (1)	CN101490000B (pt)
AR (1)	AR061973A1 (pt)
AU (1)	AU2007271865B2 (pt)
BR (1)	BRPI0712889A8 (pt)
CA (1)	CA2655750C (pt)
DK (1)	DK2049480T3 (pt)
EA (1)	EA015689B1 (pt)
ES (1)	ES2441594T3 (pt)
GE (1)	GEP20115166B (pt)
HK (1)	HK1124068A1 (pt)
IL (1)	IL196000A (pt)
IT (1)	ITMI20061368A1 (pt)
MX (1)	MX2009000492A (pt)
PL (1)	PL2049480T3 (pt)
PT (1)	PT2049480E (pt)
SI (1)	SI2049480T1 (pt)
UA (1)	UA96759C2 (pt)
WO (1)	WO2008006663A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2078711A1 (en) *	2007-12-28	2009-07-15	AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.	(Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor
AU2010232729A1 (en)	2009-03-31	2011-10-20	Arqule, Inc.	Substituted indolo-pyridinone compounds
WO2011077313A1 (en)	2009-12-22	2011-06-30	Pfizer Inc.	Piperidinecarboxamides as mpges - 1 inhibitors
UA108950C2 (uk) *	2011-08-18	2015-06-25		Гетероциклічна похідна і фармацевтичний засіб
WO2013038308A1 (en) *	2011-09-15	2013-03-21	Glenmark Pharmaceuticals S.A.	SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS
CN105636951B (zh)	2014-04-14	2018-05-15	上海恒瑞医药有限公司	酰胺类衍生物及其可药用盐、其制备方法及其在医药上的应用
CN107001267A (zh) *	2014-08-08	2017-08-01	马合伙人株式会社	稠合杂环化合物
CN112074505B (zh)	2018-03-08	2024-04-05	因赛特公司	作为PI3K-γ抑制剂的氨基吡嗪二醇化合物
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors
US20230000821A1 (en) *	2019-08-26	2023-01-05	Kukje Pharma Co., Ltd.	Indole carboxamide derivative and pharmaceutical composition containing same
KR20230010236A (ko)	2020-05-12	2023-01-18	피엠브이 파마슈티컬스 인코포레이티드	돌연변이 p53 기능을 회복시키기 위한 방법 및 화합물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003270426A1 (en) *	2002-09-12	2004-04-30	Avanir Pharmaceuticals	PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
PL378119A1 (pl) *	2003-02-07	2006-03-06	Ono Pharmaceutical Co., Ltd.	Kwasy karboksylowe
OA13247A (en)	2003-09-03	2007-01-31	Pfizer	Phenyl or pyridyl amide coumpounds as prostaglandin E2 antagonists.
ITTO20040125A1 (it) *	2004-03-01	2004-06-01	Rotta Research Lab	Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
GB0410121D0 (en)	2004-05-06	2004-06-09	Glaxo Group Ltd	Compounds

2006
- 2006-07-14 IT IT001368A patent/ITMI20061368A1/it unknown
2007
- 2007-06-14 SI SI200731381T patent/SI2049480T1/sl unknown
- 2007-06-14 US US12/306,426 patent/US8017644B2/en not_active Expired - Fee Related
- 2007-06-14 BR BRPI0712889A patent/BRPI0712889A8/pt not_active IP Right Cessation
- 2007-06-14 EA EA200970124A patent/EA015689B1/ru not_active IP Right Cessation
- 2007-06-14 PT PT77867406T patent/PT2049480E/pt unknown
- 2007-06-14 DK DK07786740.6T patent/DK2049480T3/da active
- 2007-06-14 KR KR1020147014551A patent/KR20140091569A/ko not_active Application Discontinuation
- 2007-06-14 PL PL07786740T patent/PL2049480T3/pl unknown
- 2007-06-14 ES ES07786740.6T patent/ES2441594T3/es active Active
- 2007-06-14 EP EP07786740.6A patent/EP2049480B1/en active Active
- 2007-06-14 CN CN200780026647XA patent/CN101490000B/zh not_active Expired - Fee Related
- 2007-06-14 KR KR1020097003017A patent/KR101440015B1/ko not_active IP Right Cessation
- 2007-06-14 AU AU2007271865A patent/AU2007271865B2/en not_active Ceased
- 2007-06-14 UA UAA200814463A patent/UA96759C2/ru unknown
- 2007-06-14 CA CA2655750A patent/CA2655750C/en not_active Expired - Fee Related
- 2007-06-14 WO PCT/EP2007/055901 patent/WO2008006663A1/en active Application Filing
- 2007-06-14 GE GEAP200711112A patent/GEP20115166B/en unknown
- 2007-06-14 MX MX2009000492A patent/MX2009000492A/es active IP Right Grant
- 2007-06-14 JP JP2009518814A patent/JP5302191B2/ja not_active Expired - Fee Related
- 2007-07-12 AR ARP070103095A patent/AR061973A1/es not_active Application Discontinuation
2008
- 2008-12-17 IL IL196000A patent/IL196000A/en active IP Right Grant
2009
- 2009-05-06 HK HK09104184.9A patent/HK1124068A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK2049480T3 (da)	2014-01-20
PL2049480T3 (pl)	2014-03-31
JP5302191B2 (ja)	2013-10-02
EA015689B1 (ru)	2011-10-31
EA200970124A1 (ru)	2009-06-30
SI2049480T1 (sl)	2014-02-28
AU2007271865B2 (en)	2013-02-21
MX2009000492A (es)	2009-01-27
KR20140091569A (ko)	2014-07-21
GEP20115166B (en)	2011-02-25
ITMI20061368A1 (it)	2008-01-15
IL196000A0 (en)	2009-09-01
JP2009543766A (ja)	2009-12-10
IL196000A (en)	2013-10-31
EP2049480A1 (en)	2009-04-22
US8017644B2 (en)	2011-09-13
AR061973A1 (es)	2008-08-10
CN101490000B (zh)	2012-10-03
CN101490000A (zh)	2009-07-22
BRPI0712889A8 (pt)	2018-01-02
ES2441594T3 (es)	2014-02-05
KR101440015B1 (ko)	2014-09-12
HK1124068A1 (en)	2009-08-07
WO2008006663A1 (en)	2008-01-17
BRPI0712889A2 (pt)	2012-10-09
CA2655750A1 (en)	2008-01-17
EP2049480B1 (en)	2013-10-30
AU2007271865A1 (en)	2008-01-17
CA2655750C (en)	2014-09-09
KR20090054962A (ko)	2009-06-01
US20090186922A1 (en)	2009-07-23
UA96759C2 (en)	2011-12-12

Publication	Publication Date	Title
PT2049480E (pt)	2013-12-16	Derivados de 2-arilindole como inibidores da mpges-i
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WO2006116733A3 (en)	2006-12-14	Protein kinase inhibitors
SE0400284D0 (sv)	2004-02-10	Novel compounds
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TW200639156A (en)	2006-11-16	New compounds
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WO2009105969A8 (zh)	2010-10-07	埃坡霉素类似物、其药物组合物、用途及其制备方法
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DE602004008959D1 (de)	2007-10-25	Benzoäbüä1,4üdioxepinderivate
MX2009006334A (es)	2009-06-23	Derivados de heteroaril-pirrolidinil- y -piperidinil-cetona.