PT1512679E - Novos derivados de adamantano com actividades neuroprotectoras, anti-depressivas e anti-isquémicas e processo para os preparar - Google Patents
Novos derivados de adamantano com actividades neuroprotectoras, anti-depressivas e anti-isquémicas e processo para os preparar Download PDFInfo
- Publication number
- PT1512679E PT1512679E PT04020517T PT04020517T PT1512679E PT 1512679 E PT1512679 E PT 1512679E PT 04020517 T PT04020517 T PT 04020517T PT 04020517 T PT04020517 T PT 04020517T PT 1512679 E PT1512679 E PT 1512679E
- Authority
- PT
- Portugal
- Prior art keywords
- ischaemic
- neuroprotective
- antidepressant
- activities
- preparing
- Prior art date
Links
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical class C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 title 1
- 230000001430 anti-depressive effect Effects 0.000 title 1
- 230000002253 anti-ischaemic effect Effects 0.000 title 1
- 239000000935 antidepressant agent Substances 0.000 title 1
- 229940005513 antidepressants Drugs 0.000 title 1
- 229940052761 dopaminergic adamantane derivative Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000000324 neuroprotective effect Effects 0.000 title 1
- 125000003277 amino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 208000027232 peripheral nervous system disease Diseases 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
- C07C279/32—N-nitroguanidines
- C07C279/36—Substituted N-nitroguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000668A ITTO20030668A1 (it) | 2003-09-02 | 2003-09-02 | Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1512679E true PT1512679E (pt) | 2011-08-03 |
Family
ID=34131246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04020517T PT1512679E (pt) | 2003-09-02 | 2004-08-30 | Novos derivados de adamantano com actividades neuroprotectoras, anti-depressivas e anti-isquémicas e processo para os preparar |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7145037B2 (pt) |
| EP (1) | EP1512679B1 (pt) |
| JP (1) | JP5116207B2 (pt) |
| AT (1) | ATE517079T1 (pt) |
| AU (1) | AU2004206990A1 (pt) |
| CA (1) | CA2479613A1 (pt) |
| ES (1) | ES2369888T3 (pt) |
| IT (1) | ITTO20030668A1 (pt) |
| PT (1) | PT1512679E (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7982070B2 (en) | 2006-03-21 | 2011-07-19 | Wisconsin Alumni Research Foundation | Ionizable isotopic labeling reagents for relative quantification by mass spectrometry |
| WO2007117544A2 (en) * | 2006-04-07 | 2007-10-18 | Ssv Therapeutics, Inc. | Carnitine conjugates of adamantanamines and neramexane derivatives as duel prodrugs for various uses |
| WO2008103421A1 (en) * | 2007-02-21 | 2008-08-28 | Ssv Therapeutics, Inc. | Adamantanamines and neramexane salts of thiomolybdic and thiotungstic acids |
| DE102007022007A1 (de) * | 2007-05-08 | 2008-11-13 | Schebo Biotech Ag | Neuartike Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Prophylaxe und Therapie von ZNS-Erkrankungen und Diabetes |
| US20110236881A1 (en) * | 2008-08-12 | 2011-09-29 | Degrado William F | Modulation of influenza virus |
| US9464075B2 (en) | 2008-09-16 | 2016-10-11 | The Trustees Of The University Of Pennsylvania | Influenza A virus inhibition |
| US8592216B2 (en) | 2009-04-15 | 2013-11-26 | Wisconsin Alumni Research Foundation | Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis |
| US9301950B2 (en) * | 2009-08-21 | 2016-04-05 | The Trustees Of The University Of Pennsylvania | Adamantane analogs |
| US8440720B2 (en) * | 2009-09-11 | 2013-05-14 | Influmedix, Inc. | Methods of use of antiviral compounds |
| US20110065762A1 (en) * | 2009-09-11 | 2011-03-17 | Jizhou Wang | Methods of use of antiviral compounds |
| JP5562716B2 (ja) * | 2010-05-12 | 2014-07-30 | 花王株式会社 | 電位依存性カチオンチャネル抑制剤 |
| US9884832B2 (en) | 2011-12-06 | 2018-02-06 | The Trustees Of The University Of Pennsylvania | Inhibitors targeting drug-resistant influenza A |
| JP7543136B2 (ja) | 2017-11-22 | 2024-09-02 | パノラマ リサーチ，インコーポレイティド | Ｃｎｓ疾患を治療するためのアミノアダマンチルナイトレート化合物およびそれらの使用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US28836A (en) * | 1860-06-26 | Improvement in plows | ||
| GB1274652A (en) | 1968-08-27 | 1972-05-17 | Lilly Industries Ltd | Adamantanyl-alkylamine derivatives and their preparation |
| US4007181A (en) * | 1974-02-11 | 1977-02-08 | The Upjohn Company | Adamantyl containing guanidines |
| ES2059602T3 (es) | 1989-04-14 | 1994-11-16 | Merz & Co Gmbh & Co | Uso de derivados de adamantano para la prevencion y tratamiento de isquemia cerebral. |
| EP0532642A1 (en) | 1990-05-25 | 1993-03-24 | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON | Substituted guanidines having high binding to the sigma receptor and the use thereof |
| EP1032556B1 (en) | 1997-10-21 | 2007-12-19 | Wyeth a Corporation of the State of Delaware | Pharmaceutically active compounds and methods of use |
| GB9726388D0 (en) * | 1997-12-12 | 1998-02-11 | Cerebrus Ltd | Chemical compounds |
| GB9802225D0 (en) * | 1998-02-02 | 1998-04-01 | Cerebrus Ltd | Chemical compounds |
| GB9803536D0 (en) | 1998-02-19 | 1998-04-15 | Black James Foundation | Histamine H,receptor ligands |
| US6645968B2 (en) | 1999-08-03 | 2003-11-11 | Abbott Laboratories | Potassium channel openers |
| ITTO20010110A1 (it) * | 2001-02-08 | 2002-08-08 | Rotta Research Lab | Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. |
| US6974869B2 (en) | 2001-09-18 | 2005-12-13 | Bristol-Myers Squibb Pharma Company | Piperizinones as modulators of chemokine receptor activity |
-
2003
- 2003-09-02 IT IT000668A patent/ITTO20030668A1/it unknown
-
2004
- 2004-08-30 PT PT04020517T patent/PT1512679E/pt unknown
- 2004-08-30 AT AT04020517T patent/ATE517079T1/de active
- 2004-08-30 EP EP04020517A patent/EP1512679B1/en not_active Expired - Lifetime
- 2004-08-30 ES ES04020517T patent/ES2369888T3/es not_active Expired - Lifetime
- 2004-08-31 CA CA002479613A patent/CA2479613A1/en not_active Abandoned
- 2004-09-01 AU AU2004206990A patent/AU2004206990A1/en not_active Abandoned
- 2004-09-01 US US10/931,245 patent/US7145037B2/en not_active Expired - Fee Related
- 2004-09-01 JP JP2004254373A patent/JP5116207B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005075832A (ja) | 2005-03-24 |
| JP5116207B2 (ja) | 2013-01-09 |
| ITTO20030668A1 (it) | 2005-03-03 |
| ATE517079T1 (de) | 2011-08-15 |
| EP1512679B1 (en) | 2011-07-20 |
| EP1512679A1 (en) | 2005-03-09 |
| CA2479613A1 (en) | 2005-03-02 |
| AU2004206990A1 (en) | 2005-03-17 |
| US20050049312A1 (en) | 2005-03-03 |
| US7145037B2 (en) | 2006-12-05 |
| ES2369888T3 (es) | 2011-12-07 |
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