PT1511710E - Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson - Google Patents
Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson Download PDFInfo
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- PT1511710E PT1511710E PT37563434T PT03756343T PT1511710E PT 1511710 E PT1511710 E PT 1511710E PT 37563434 T PT37563434 T PT 37563434T PT 03756343 T PT03756343 T PT 03756343T PT 1511710 E PT1511710 E PT 1511710E
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- C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
- C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
- C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
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- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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US7601876B2 (en) * | 2002-05-31 | 2009-10-13 | Proteotech, Inc. | Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis |
US20130137775A1 (en) * | 2002-05-31 | 2013-05-30 | Alan D. Snow | Compositions and methods for the treatment of systemic aa amyloid diseases |
US20070276034A1 (en) * | 2002-05-31 | 2007-11-29 | Luke Esposito | Compounds, compositions and methods for the treatment of synucleinopathies |
US20140005240A1 (en) * | 2002-05-31 | 2014-01-02 | Alan D. Snow | Compounds and compositions for use as modulators of tau aggregation and alleviation of tauopathies |
PT1511710E (pt) * | 2002-05-31 | 2014-02-26 | Proteotech Inc | Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson |
US8829198B2 (en) * | 2007-10-31 | 2014-09-09 | Proteotech Inc | Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies |
US20110104055A1 (en) * | 2002-05-31 | 2011-05-05 | Alan Snow | Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies |
US8227643B2 (en) * | 2002-05-31 | 2012-07-24 | Proteotech, Inc. | Sirtuin 1 and the treatment of neurodegenerative diseases |
EP1539675B1 (en) * | 2002-08-29 | 2013-11-06 | Temple University - Of The Commonwealth System of Higher Education | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof |
JP4630267B2 (ja) * | 2002-12-25 | 2011-02-09 | 第一三共株式会社 | ジアミン誘導体 |
AU2003292828B9 (en) | 2002-12-25 | 2009-10-01 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
US20100331380A1 (en) * | 2009-06-29 | 2010-12-30 | Esposito Luke A | Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies |
US8916598B2 (en) | 2003-05-30 | 2014-12-23 | Proteotech Inc | Compounds, compositions, and methods for the treatment of β-amyloid diseases and synucleinopathies |
KR101168451B1 (ko) * | 2004-05-12 | 2012-07-25 | 프로테오테크, 인크. | 아밀로이드 병 및 시뉴클레인 병의 치료를 위한 치환된 n-아릴 벤즈아미드 및 관련 화합물 |
RU2361872C2 (ru) | 2004-05-26 | 2009-07-20 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Циннамидное соединение |
GB0415181D0 (en) | 2004-07-06 | 2004-08-11 | School Of Pharmacy The Univers | Compounds for use in the treatment of infection |
DE102004041496A1 (de) * | 2004-08-27 | 2006-03-02 | Symrise Gmbh & Co. Kg | Hydroxybenzoesäureamide und deren Verwendung zur Maskierung von bitterem Geschmack |
NZ584773A (en) * | 2004-09-17 | 2012-07-27 | Whitehead Biomedical Inst | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity |
ATE458729T1 (de) * | 2004-10-26 | 2010-03-15 | Eisai R&D Man Co Ltd | Amorphe form einer zimtsäureamidverbindung |
FR2892923B1 (fr) | 2005-11-08 | 2009-01-16 | Engelhard Lyon Sa | Utilisatiion des derives de l'acide para-coumarique ou para- hydroxycinnamique dans des compositions cosmetiques ou dermatologiques. |
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- 2003-05-30 EP EP03756343.4A patent/EP1511710B1/en not_active Expired - Lifetime
- 2003-05-30 SI SI200332337T patent/SI1511710T1/sl unknown
- 2003-05-30 DK DK03756343.4T patent/DK1511710T3/en active
- 2003-05-30 PT PT121663702T patent/PT2527315E/pt unknown
- 2003-05-30 WO PCT/US2003/017288 patent/WO2003101927A1/en active Application Filing
- 2003-05-30 EP EP12166370.2A patent/EP2527315B1/en not_active Expired - Lifetime
- 2003-05-30 AU AU2003249678A patent/AU2003249678B2/en not_active Ceased
- 2003-05-30 JP JP2004509622A patent/JP4568603B2/ja not_active Expired - Fee Related
- 2003-05-30 DK DK12166370.2T patent/DK2527315T3/da active
- 2003-05-30 CA CA2486869A patent/CA2486869C/en not_active Expired - Fee Related
- 2003-05-30 ES ES03756343.4T patent/ES2447417T3/es not_active Expired - Lifetime
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2008
- 2008-11-04 US US12/264,858 patent/US7763747B2/en not_active Expired - Fee Related
- 2008-11-11 US US12/269,017 patent/US20090197965A1/en not_active Abandoned
- 2008-12-08 US US12/329,811 patent/US7714170B2/en not_active Expired - Fee Related
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2009
- 2009-05-21 AU AU2009202023A patent/AU2009202023B2/en not_active Ceased
- 2009-05-21 AU AU2009202022A patent/AU2009202022B2/en not_active Ceased
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2010
- 2010-03-11 JP JP2010053970A patent/JP5179533B2/ja not_active Expired - Fee Related
- 2010-07-16 US US12/837,721 patent/US8163957B2/en not_active Expired - Fee Related
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2012
- 2012-03-06 US US13/413,417 patent/US8586585B2/en not_active Expired - Fee Related
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2013
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- 2013-10-01 US US14/042,891 patent/US8895554B2/en not_active Expired - Fee Related
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2014
- 2014-06-18 CY CY20141100440T patent/CY1115484T1/el unknown
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