PT1353923E - Processo melhorado para a sintese de carbapenems - Google Patents

Processo melhorado para a sintese de carbapenems

Info

Publication number: PT1353923E
Authority: PT; Portugal
Prior art keywords: carbapenems; improved; synthetic process; synthetic; improved carbapenems
Prior art date: 2001-01-16

Application number

PT02701042T

Other languages

English (en)

Inventor

John M Williams

Skerlj Renato

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-16

Filing date

2002-01-11

Publication date

2005-01-31

2002-01-11 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2005-01-31 Publication of PT1353923E publication Critical patent/PT1353923E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT02701042T 2001-01-16 2002-01-11 Processo melhorado para a sintese de carbapenems PT1353923E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26193301P	2001-01-16	2001-01-16
US29344001P	2001-05-24	2001-05-24

Publications (1)

Publication Number	Publication Date
PT1353923E true PT1353923E (pt)	2005-01-31

Family

ID=26948925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT02701042T PT1353923E (pt)	2001-01-16	2002-01-11	Processo melhorado para a sintese de carbapenems

Country Status (29)

Country	Link
US (1)	US7071330B2 (pt)
EP (1)	EP1353923B1 (pt)
JP (1)	JP4098626B2 (pt)
KR (1)	KR100827562B1 (pt)
CN (1)	CN1249065C (pt)
AR (1)	AR035728A1 (pt)
AT (1)	ATE278691T1 (pt)
AU (1)	AU2002234240B2 (pt)
BR (1)	BR0206372A (pt)
CA (1)	CA2433874C (pt)
CZ (1)	CZ301440B6 (pt)
DE (1)	DE60201498T2 (pt)
DK (1)	DK1353923T3 (pt)
EA (1)	EA006098B1 (pt)
EG (1)	EG23993A (pt)
ES (1)	ES2227423T3 (pt)
HR (1)	HRP20030566B1 (pt)
HU (1)	HUP0302764A3 (pt)
IL (2)	IL156507A0 (pt)
MX (1)	MXPA03006322A (pt)
NZ (1)	NZ527191A (pt)
PL (1)	PL362912A1 (pt)
PT (1)	PT1353923E (pt)
RS (1)	RS50494B (pt)
SI (1)	SI1353923T1 (pt)
SK (1)	SK287350B6 (pt)
TW (1)	TWI318627B (pt)
UA (1)	UA74870C2 (pt)
WO (1)	WO2002057266A1 (pt)

Families Citing this family (19)

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Publication number	Priority date	Publication date	Assignee	Title
EP1426376A4 (en) *	2001-08-13	2004-12-22	Eisai Co Ltd	PROCESS FOR THE PREPARATION OF CARBAPENEM-BASED ANTIBIOTICS
CA2457642C (en) *	2001-09-26	2009-01-06	Merck & Co., Inc.	Crystalline forms of ertapenem sodium
ATE518864T1 (de) *	2001-09-26	2011-08-15	Merck Sharp & Dohme	Verfahren zur herstellung von carbapenemverbindungen
WO2003042215A1 (en) *	2001-11-16	2003-05-22	Ranbaxy Laboratories Limited	Process for the preparation of crystalline imipenem
AU2003284545A1 (en) *	2002-11-13	2004-06-03	Kaneka Corporation	Novel intermediate for carbapenem compound for oral administration and process for producing the same
DE102005025899A1 (de) *	2005-06-06	2006-12-07	Basf Ag	Verfahren zur Aufbereitung eines Alkoxycarbonylaminotriazin enthaltenden Reaktionsgemisches
US8148520B2 (en) *	2005-09-15	2012-04-03	Orchid Chemicals And Pharmaceuticals Limited	Process for the preparation of beta-lactam antibiotic meropenem trihydrate
CN101410398B (zh) *	2006-03-28	2013-01-23	株式会社钟化	碳青霉素烯化合物的改良制备方法
US8293894B2 (en)	2006-11-20	2012-10-23	Orchid Chemicals & Pharmaceuticals Limited	Process for the preparation of carbapenem antibiotic
CN101357920B (zh) *	2007-06-22	2011-01-12	山东轩竹医药科技有限公司	含有巯基吡咯烷甲酰胺基三嗪的培南化合物
CN101367807B (zh) *	2007-06-28	2011-01-12	山东轩竹医药科技有限公司	被巯基吡咯烷甲酰胺基吡啶取代的培南衍生物
WO2010124531A1 (zh)	2009-04-30	2010-11-04	石药集团中奇制药技术（石家庄）有限公司	一种厄他培南中间体、含其的组合物及其制备方法
US20130079322A1 (en) *	2010-05-21	2013-03-28	Xuanzhu Pharama Co., Ltd.	Crystalline of carbapenem derivative or its hydrate, preparation methods and uses thereof
WO2011150679A1 (zh) *	2010-06-03	2011-12-08	山东轩竹医药科技有限公司	碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途
WO2012038979A2 (en) *	2010-09-24	2012-03-29	Sequent Anti Biotics Private Limited	A process for preparation of ertapenem
CN102558182B (zh)	2010-12-31	2015-02-11	石药集团中奇制药技术（石家庄）有限公司	一种厄他培南钠晶型及其制备方法
WO2013121279A2 (en) *	2012-02-14	2013-08-22	Aurobindo Pharma Limited	Process to prepare ertapenem
WO2014097221A1 (en) *	2012-12-21	2014-06-26	Ranbaxy Laboratories Limited	Process for the purification of biapenem
EP3122749B1 (en) *	2014-03-27	2019-03-13	Johnson Matthey Public Limited Company	Process for preparing a carbapenem antibiotic

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BE794554A (fr) *	1972-01-31	1973-07-26	Lilly Co Eli	Nouveaux derives de penicilline et de cephalusporine
US3925372A (en) *	1973-02-23	1975-12-09	Lilly Co Eli	Alpha-aminoacyl-3-halo cephalosporins
US3897424A (en) *	1973-07-23	1975-07-29	Lilly Co Eli	Process for 7-{62 -amino-7-{60 -methoxy-cephalosporanic acid esters and related compounds
AR207327A1 (es) *	1974-02-06	1976-09-30	Lilly Co Eli	Un procedimiento para preparar acidos 3-cefem 3-sulfonatos y sus esteres
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US4369187A (en) *	1980-02-06	1983-01-18	Merck & Co., Inc.	3-Substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
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US4501741A (en) *	1983-04-12	1985-02-26	Eli Lilly And Company	Cephalosporin antibiotics
US4783453A (en) *	1985-06-10	1988-11-08	Merck & Co., Inc.	2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
JPS6475488A (en) *	1987-09-17	1989-03-22	Sumitomo Pharma	Production of beta-lactam compound
US5034384A (en) *	1990-08-01	1991-07-23	Merck & Co., Inc.	2-(9-fluorenonyl)-carbapenem antibacterial agents
GB9202298D0 (en) *	1992-02-04	1992-03-18	Ici Plc	Antibiotic compounds
CA2091309A1 (en) *	1992-03-26	1993-09-27	Frederic H. Jung	Antibiotic compounds
HRP970281B1 (en)	1996-05-28	2002-04-30	Merck & Co Inc	Carbapenem antibiotic, composition and method of preparation
UA62920C2 (en) *	1996-05-28	2004-01-15	Merck & Co Inc	Carbapeneme antibiotic, a composition and a method for the preparation
US6180783B1 (en)	1997-06-16	2001-01-30	Merck & Co., Inc.	Stabilized carbapenem intermediates and improved process for carbapenem synthesis
US6063931A (en) *	1997-07-09	2000-05-16	Merck & Co., Inc.	Process for synthesizing carbapenem side chain intermediates
US5872250A (en) *	1997-07-30	1999-02-16	Merck & Co., Inc.	Process for synthesizing carbapenem antibiotics
JP3953274B2 (ja) *	1998-03-02	2007-08-08	メルクエンドカムパニーインコーポレーテッド	カルバペネム抗生物質の合成方法

2002
- 2002-01-09 AR ARP020100062A patent/AR035728A1/es active IP Right Grant
- 2002-01-11 ES ES02701042T patent/ES2227423T3/es not_active Expired - Lifetime
- 2002-01-11 SK SK897-2003A patent/SK287350B6/sk not_active IP Right Cessation
- 2002-01-11 CA CA002433874A patent/CA2433874C/en not_active Expired - Fee Related
- 2002-01-11 PT PT02701042T patent/PT1353923E/pt unknown
- 2002-01-11 SI SI200230039T patent/SI1353923T1/xx unknown
- 2002-01-11 US US10/466,876 patent/US7071330B2/en not_active Expired - Fee Related
- 2002-01-11 IL IL15650702A patent/IL156507A0/xx unknown
- 2002-01-11 KR KR1020037009510A patent/KR100827562B1/ko not_active IP Right Cessation
- 2002-01-11 CN CNB028037421A patent/CN1249065C/zh not_active Expired - Fee Related
- 2002-01-11 NZ NZ527191A patent/NZ527191A/en not_active IP Right Cessation
- 2002-01-11 CZ CZ20031911A patent/CZ301440B6/cs not_active IP Right Cessation
- 2002-01-11 HU HU0302764A patent/HUP0302764A3/hu unknown
- 2002-01-11 RS YUP-550/03A patent/RS50494B/sr unknown
- 2002-01-11 BR BR0206372-7A patent/BR0206372A/pt active Search and Examination
- 2002-01-11 EA EA200300804A patent/EA006098B1/ru not_active IP Right Cessation
- 2002-01-11 AT AT02701042T patent/ATE278691T1/de active
- 2002-01-11 DK DK02701042T patent/DK1353923T3/da active
- 2002-01-11 PL PL02362912A patent/PL362912A1/xx not_active Application Discontinuation
- 2002-01-11 WO PCT/US2002/000821 patent/WO2002057266A1/en active IP Right Grant
- 2002-01-11 DE DE60201498T patent/DE60201498T2/de not_active Expired - Lifetime
- 2002-01-11 MX MXPA03006322A patent/MXPA03006322A/es active IP Right Grant
- 2002-01-11 EP EP02701042A patent/EP1353923B1/en not_active Expired - Lifetime
- 2002-01-11 JP JP2002557943A patent/JP4098626B2/ja not_active Expired - Lifetime
- 2002-01-11 AU AU2002234240A patent/AU2002234240B2/en not_active Ceased
- 2002-01-12 EG EG20020034A patent/EG23993A/xx active
- 2002-01-15 TW TW091100466A patent/TWI318627B/zh not_active IP Right Cessation
- 2002-11-01 UA UA2003087771A patent/UA74870C2/uk unknown
2003
- 2003-06-18 IL IL156507A patent/IL156507A/en not_active IP Right Cessation
- 2003-07-11 HR HR20030566A patent/HRP20030566B1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK1353923T3 (da)	2005-01-31
AU2002234240B2 (en)	2006-04-27
NZ527191A (en)	2004-04-30
IL156507A (en)	2010-06-30
SK287350B6 (sk)	2010-08-09
US20040063931A1 (en)	2004-04-01
PL362912A1 (en)	2004-11-02
CZ20031911A3 (cs)	2003-10-15
DE60201498D1 (de)	2004-11-11
WO2002057266A1 (en)	2002-07-25
IL156507A0 (en)	2004-01-04
EA006098B1 (ru)	2005-08-25
EP1353923B1 (en)	2004-10-06
ATE278691T1 (de)	2004-10-15
CN1249065C (zh)	2006-04-05
KR20040007438A (ko)	2004-01-24
DE60201498T2 (de)	2005-11-17
CA2433874C (en)	2009-08-11
RS50494B (sr)	2010-03-02
MXPA03006322A (es)	2003-10-06
YU55003A (sh)	2006-05-25
UA74870C2 (en)	2006-02-15
CN1486318A (zh)	2004-03-31
CA2433874A1 (en)	2002-07-25
AR035728A1 (es)	2004-07-07
HUP0302764A3 (en)	2005-11-28
JP2004518672A (ja)	2004-06-24
KR100827562B1 (ko)	2008-05-07
TWI318627B (en)	2009-12-21
HRP20030566A2 (en)	2005-06-30
JP4098626B2 (ja)	2008-06-11
HUP0302764A2 (hu)	2003-11-28
ES2227423T3 (es)	2005-04-01
CZ301440B6 (cs)	2010-03-03
EA200300804A1 (ru)	2003-12-25
EG23993A (en)	2008-03-10
SI1353923T1 (en)	2005-02-28
HRP20030566B1 (en)	2011-08-31
BR0206372A (pt)	2003-12-23
US7071330B2 (en)	2006-07-04
SK8972003A3 (en)	2003-10-07
EP1353923A1 (en)	2003-10-22

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