PT1261602E - Derivados imidazol-2-carboxamida como inibidores de cinase raf - Google Patents
Derivados imidazol-2-carboxamida como inibidores de cinase rafInfo
- Publication number
- PT1261602E PT1261602E PT01907980T PT01907980T PT1261602E PT 1261602 E PT1261602 E PT 1261602E PT 01907980 T PT01907980 T PT 01907980T PT 01907980 T PT01907980 T PT 01907980T PT 1261602 E PT1261602 E PT 1261602E
- Authority
- PT
- Portugal
- Prior art keywords
- sub
- sup
- alkyl
- hydrogen
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0005357.9A GB0005357D0 (en) | 2000-03-06 | 2000-03-06 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1261602E true PT1261602E (pt) | 2004-08-31 |
Family
ID=9887051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01907980T PT1261602E (pt) | 2000-03-06 | 2001-03-02 | Derivados imidazol-2-carboxamida como inibidores de cinase raf |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6987119B2 (pt) |
| EP (1) | EP1261602B1 (pt) |
| JP (1) | JP2003525937A (pt) |
| AT (1) | ATE266021T1 (pt) |
| AU (1) | AU2001235844A1 (pt) |
| DE (1) | DE60103133T2 (pt) |
| DK (1) | DK1261602T3 (pt) |
| ES (1) | ES2217118T3 (pt) |
| GB (1) | GB0005357D0 (pt) |
| PT (1) | PT1261602E (pt) |
| TR (1) | TR200401903T4 (pt) |
| WO (1) | WO2001066540A1 (pt) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2725000A (en) | 1999-01-13 | 2000-08-01 | Bayer Corporation | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ATE382044T1 (de) * | 1999-11-22 | 2008-01-15 | Smithkline Beecham Plc | Imidazol- derivate |
| ATE266022T1 (de) * | 2000-03-06 | 2004-05-15 | Smithkline Beecham Plc | Imidazol derivate als raf kinase inhibitoren |
| GB0112348D0 (en) * | 2001-05-19 | 2001-07-11 | Smithkline Beecham Plc | Compounds |
| GB0121494D0 (en) | 2001-09-05 | 2001-10-24 | Smithkline Beecham Plc | Compounds |
| GB0121488D0 (en) * | 2001-09-05 | 2001-10-24 | Smithkline Beecham Plc | Compounds |
| WO2003022837A1 (en) * | 2001-09-05 | 2003-03-20 | Smithkline Beecham P.L.C. | Heterocycle-carboxamide derivatives as raf kinase inhibitors |
| US7446106B2 (en) | 2001-09-05 | 2008-11-04 | Smithkline Beecham Plc | Pyridylfurans and pyrroles as Raf kinase inhibitors |
| DK1478358T3 (da) | 2002-02-11 | 2013-10-07 | Bayer Healthcare Llc | Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese |
| AR038966A1 (es) | 2002-03-18 | 2005-02-02 | Solvay Pharm Bv | Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial de cb1 |
| EP1539121A4 (en) | 2002-08-29 | 2008-08-13 | Scios Inc | METHOD OF REQUESTING OSTEOGENESIS |
| JP2007511203A (ja) | 2003-05-20 | 2007-05-10 | バイエル、ファーマシューテイカルズ、コーポレイション | キナーゼ阻害活性を有するジアリール尿素 |
| KR101139557B1 (ko) | 2003-07-23 | 2012-04-30 | 바이엘 파마슈티칼스 코포레이션 | 질환 및 상태의 치료 및 예방을 위한 플루오로 치환오메가-카르복시아릴 디페닐 우레아 |
| US7244441B2 (en) | 2003-09-25 | 2007-07-17 | Scios, Inc. | Stents and intra-luminal prostheses containing map kinase inhibitors |
| US20050282909A1 (en) * | 2003-11-14 | 2005-12-22 | Diks Sander H | Guanylhydrazones in methods of treatment or diagnosis as modulators of signal transduction |
| AU2005278959A1 (en) * | 2004-08-31 | 2006-03-09 | Astrazeneca Ab | Quinazolinone derivatives and their use as B-Raf inhibitors |
| KR20070055575A (ko) * | 2004-09-01 | 2007-05-30 | 아스트라제네카 아베 | 퀴나졸리논 유도체 및 이의 ｂ―ｒａｆ 억제제로서의 용도 |
| EP1676574A3 (en) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Methods for promoting survival of transplanted tissues and cells |
| NZ595182A (en) * | 2005-10-18 | 2012-12-21 | Janssen Pharmaceutica Nv | Pharmaceutical uses of 4-cyano-1H-imidazole-2-carboxylic acid { 2-cyclohex-1-enyl-4-[1-(2-dimethylamino-acetyl)-piperidin-4-yl]-phenyl} -amide |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| ES2566772T3 (es) | 2006-04-20 | 2016-04-15 | Janssen Pharmaceutica, N.V. | Inhibidores de la quinasa c-fms |
| TW200904816A (en) | 2007-06-05 | 2009-02-01 | Takeda Pharmaceutical | Fused heterocycle derivatives and use thereof |
| EP2170830B1 (en) | 2007-07-17 | 2014-10-15 | Plexxikon, Inc. | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS |
| US8324395B2 (en) | 2007-08-23 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| JP5350247B2 (ja) | 2007-08-29 | 2013-11-27 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| US8865732B2 (en) | 2008-03-21 | 2014-10-21 | Novartis Ag | Heterocyclic compounds and uses thereof |
| WO2009115572A2 (en) | 2008-03-21 | 2009-09-24 | Novartis Ag | Novel heterocyclic compounds and uses therof |
| EP2399921B1 (en) | 2008-12-01 | 2015-08-12 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| JO3101B1 (ar) | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
| KR20140011780A (ko) | 2012-07-19 | 2014-01-29 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 이소퀴놀린-5-카복스아미드 유도체 |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| WO2015041534A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk in combination with raf/erk/mek |
| US9629851B2 (en) | 2013-09-20 | 2017-04-25 | Stitching Het Nederlands Kanker Institut—Antoni Van Leeuwenhoek Ziekenhuis | ROCK in combination with MAPK pathway |
| US20170027940A1 (en) | 2014-04-10 | 2017-02-02 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
| WO2015178770A1 (en) | 2014-05-19 | 2015-11-26 | Stichting Het Nederlands Kanker Instituut | Compositions for cancer treatment |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| BR112019005046A2 (pt) | 2016-09-19 | 2019-06-18 | Novartis Ag | combinações terapêuticas compreendendo um inibidor de raf e um inibidor de erk |
| KR102641827B1 (ko) | 2017-05-02 | 2024-03-04 | 노파르티스 아게 | 병용 요법 |
| EP3969449B1 (en) | 2019-05-13 | 2025-02-12 | Novartis AG | New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD201677A5 (de) | 1980-07-25 | 1983-08-03 | Ciba Geigy | Verfahren zur herstellung von trisubstituierten imidazolderivaten |
| US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5620999A (en) | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
| US5514505A (en) * | 1995-05-15 | 1996-05-07 | Xerox Corporation | Method for obtaining improved image contrast in migration imaging members |
| CA2224563A1 (en) | 1995-06-12 | 1996-12-27 | G.D. Searle & Co. | Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations |
| WO1997012876A1 (en) | 1995-10-06 | 1997-04-10 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
| US5717100A (en) * | 1995-10-06 | 1998-02-10 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
| GB2306108A (en) | 1995-10-13 | 1997-04-30 | Merck & Co Inc | Treatment of Raf-mediated cancers with imidazole derivatives |
| AU727939B2 (en) | 1996-04-03 | 2001-01-04 | Merck & Co., Inc. | A method of treating cancer |
| DE69733135T2 (de) | 1996-06-10 | 2006-03-02 | Merck & Co., Inc. | Substituierte imidazole mit cytokinin-inhibirender wirkung |
| EP0932402B1 (en) | 1996-10-15 | 2004-07-21 | G.D. Searle LLC | Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia |
| EP0994858A1 (en) | 1997-06-30 | 2000-04-26 | Ortho-McNeil Pharmaceutical, Inc. | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
| WO1999021555A2 (en) | 1997-10-27 | 1999-05-06 | Takeda Chemical Industries, Ltd. | Adenosine a3 receptor antagonists |
| TR200002616T2 (tr) | 1997-12-22 | 2000-11-21 | Bayer Corporation | Simetrik ve simetrik olmayan sübstitüe edilmiş difenil üreler kullanılarak raf kinazın inhibe edilmesi |
| KR20010025087A (ko) | 1998-05-22 | 2001-03-26 | 스튜어트 알. 수터 | 신규한 2-알킬 치환된 이미다졸 화합물 |
| ATE382044T1 (de) | 1999-11-22 | 2008-01-15 | Smithkline Beecham Plc | Imidazol- derivate |
| AU2002236476A1 (en) | 2000-11-20 | 2002-05-27 | Smith Kline Beecham Corporation | Novel compounds |
-
2000
- 2000-03-06 GB GBGB0005357.9A patent/GB0005357D0/en not_active Ceased
-
2001
- 2001-03-02 AT AT01907980T patent/ATE266021T1/de not_active IP Right Cessation
- 2001-03-02 PT PT01907980T patent/PT1261602E/pt unknown
- 2001-03-02 DE DE60103133T patent/DE60103133T2/de not_active Expired - Fee Related
- 2001-03-02 US US10/220,675 patent/US6987119B2/en not_active Expired - Fee Related
- 2001-03-02 EP EP01907980A patent/EP1261602B1/en not_active Expired - Lifetime
- 2001-03-02 WO PCT/GB2001/000916 patent/WO2001066540A1/en active IP Right Grant
- 2001-03-02 AU AU2001235844A patent/AU2001235844A1/en not_active Abandoned
- 2001-03-02 ES ES01907980T patent/ES2217118T3/es not_active Expired - Lifetime
- 2001-03-02 TR TR2004/01903T patent/TR200401903T4/xx unknown
- 2001-03-02 DK DK01907980T patent/DK1261602T3/da active
- 2001-03-02 JP JP2001565356A patent/JP2003525937A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ATE266021T1 (de) | 2004-05-15 |
| GB0005357D0 (en) | 2000-04-26 |
| TR200401903T4 (tr) | 2004-09-21 |
| WO2001066540A1 (en) | 2001-09-13 |
| JP2003525937A (ja) | 2003-09-02 |
| DE60103133T2 (de) | 2004-10-14 |
| DE60103133D1 (de) | 2004-06-09 |
| DK1261602T3 (da) | 2004-08-30 |
| US20030134837A1 (en) | 2003-07-17 |
| US6987119B2 (en) | 2006-01-17 |
| ES2217118T3 (es) | 2004-11-01 |
| EP1261602B1 (en) | 2004-05-06 |
| AU2001235844A1 (en) | 2001-09-17 |
| EP1261602A1 (en) | 2002-12-04 |
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