PT1257276E - Derivados de azaindole antivirais - Google Patents

Derivados de azaindole antivirais

Info

Publication number: PT1257276E
Authority: PT; Portugal
Prior art keywords: azaindole; antiviral derivatives; antiviral; derivatives; azaindole antiviral
Prior art date: 2000-02-22

Application number

PT01904970T

Other languages

English (en)

Inventor

Wang Tao

Owen B Wallace

Zhang Zhongxing

Nicholas A Meanwell

John A Bender

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-22

Filing date

2001-01-19

Publication date

2006-05-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22675206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1257276(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-01-19 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2006-05-31 Publication of PT1257276E publication Critical patent/PT1257276E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT01904970T 2000-02-22 2001-01-19 Derivados de azaindole antivirais PT1257276E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US18400400P	2000-02-22	2000-02-22

Publications (1)

Publication Number	Publication Date
PT1257276E true PT1257276E (pt)	2006-05-31

Family

ID=22675206

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT01904970T PT1257276E (pt)	2000-02-22	2001-01-19	Derivados de azaindole antivirais

Country Status (32)

Country	Link
US (1)	US20020061892A1 (pt)
EP (1)	EP1257276B1 (pt)
JP (1)	JP3868814B2 (pt)
KR (1)	KR100496574B1 (pt)
CN (1)	CN1404392A (pt)
AR (1)	AR029469A1 (pt)
AT (1)	ATE314072T1 (pt)
AU (2)	AU2001232895B2 (pt)
BR (1)	BRPI0108485B1 (pt)
CA (1)	CA2400700C (pt)
CO (1)	CO5271657A1 (pt)
CY (1)	CY1107460T1 (pt)
DE (1)	DE60116260T2 (pt)
DK (1)	DK1257276T3 (pt)
EG (1)	EG24669A (pt)
ES (1)	ES2254367T3 (pt)
HK (1)	HK1052132A1 (pt)
HU (1)	HU229992B1 (pt)
IL (1)	IL150734A0 (pt)
MX (1)	MXPA02008113A (pt)
MY (1)	MY128458A (pt)
NO (1)	NO323564B1 (pt)
NZ (1)	NZ520317A (pt)
PE (1)	PE20020786A1 (pt)
PL (1)	PL357434A1 (pt)
PT (1)	PT1257276E (pt)
RU (1)	RU2259372C2 (pt)
TR (1)	TR200201961T2 (pt)
TW (1)	TWI293629B (pt)
UY (1)	UY26593A1 (pt)
WO (1)	WO2001062255A1 (pt)
ZA (1)	ZA200206073B (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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US20040110785A1 (en) *	2001-02-02	2004-06-10	Tao Wang	Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20030207910A1 (en) *	2001-02-02	2003-11-06	Tao Wang	Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
CZ303750B6 (cs) *	2001-02-02	2013-04-17	Bristol-Myers Squibb Company	Prostredky obsahující substituované deriváty azaindoloxoacetylpiperazinu a jejich antivirová aktivita
US6825201B2 (en) *	2001-04-25	2004-11-30	Bristol-Myers Squibb Company	Indole, azaindole and related heterocyclic amidopiperazine derivatives
US20030236277A1 (en)	2002-02-14	2003-12-25	Kadow John F.	Indole, azaindole and related heterocyclic pyrrolidine derivatives
WO2003072028A2 (en) *	2002-02-23	2003-09-04	Bristol-Myers Squibb Company	Method of treating hiv infection by preventing interaction of cd4 and gp120
US20040063744A1 (en) *	2002-05-28	2004-04-01	Tao Wang	Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
US20050075364A1 (en) *	2003-07-01	2005-04-07	Kap-Sun Yeung	Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
US7745625B2 (en) *	2004-03-15	2010-06-29	Bristol-Myers Squibb Company	Prodrugs of piperazine and substituted piperidine antiviral agents
CN1953985B (zh) *	2004-03-15	2010-06-09	布里斯托尔-迈尔斯斯奎布公司	哌嗪和取代的哌啶抗病毒药物的前药
US20050252408A1 (en) *	2004-05-17	2005-11-17	Richardson H W	Particulate wood preservative and method for producing same
DE602005010698D1 (de)	2004-06-09	2008-12-11	Glaxo Group Ltd	Pyrrolopyridinderivate
US7498342B2 (en)	2004-06-17	2009-03-03	Plexxikon, Inc.	Compounds modulating c-kit activity
US20060100209A1 (en) *	2004-11-09	2006-05-11	Chong-Hui Gu	Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) *	2004-11-09	2006-05-11	Matiskella John D	Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7183284B2 (en) *	2004-12-29	2007-02-27	Bristol-Myers Squibb Company	Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
US7601715B2 (en)	2005-06-22	2009-10-13	Bristol-Myers Squibb Company	Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
US20070026441A1 (en)	2005-07-22	2007-02-01	Olson William C	Methods for reducing viral load in HIV-1-infected patients
US7598380B2 (en)	2005-08-03	2009-10-06	Bristol-Myers Squibb Company	Method of preparation of azaindole derivatives
US7396830B2 (en) *	2005-10-04	2008-07-08	Bristol-Myers Squibb Company	Piperazine amidines as antiviral agents
US7851476B2 (en) *	2005-12-14	2010-12-14	Bristol-Myers Squibb Company	Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) *	2006-04-25	2010-10-05	Bristol-Myers Squibb Company	Diketo-piperazine and piperidine derivatives as antiviral agents
WO2008063888A2 (en)	2006-11-22	2008-05-29	Plexxikon, Inc.	Compounds modulating c-fms and/or c-kit activity and uses therefor
CN101679358B (zh) *	2007-06-18	2013-10-30	塞诺菲-安万特股份有限公司	作为p2y12拮抗剂的吡咯衍生物
EP2170830B1 (en)	2007-07-17	2014-10-15	Plexxikon, Inc.	2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS
WO2009011912A1 (en) *	2007-07-18	2009-01-22	Bristol-Myers Squibb Company	A composition for treating hiv comprising virus-like particles
CN101970437B (zh)	2008-01-31	2013-04-03	赛诺菲-安万特	环状氮杂吲哚-3-甲酰胺、其制备和其作为药物的用途
CA2735008C (en) *	2008-09-04	2016-11-29	Bristol-Myers Squibb Company	Extended release formulation for optimized delivery of an hiv attachment inhibitor
US9447089B2 (en)	2009-04-03	2016-09-20	Plexxikon Inc.	Compositions and uses thereof
EA201290210A1 (ru)	2009-11-06	2012-10-30	Плексксикон, Инк.	Соединения и способы модуляции киназы и показания для их применения
ES2585396T3 (es)	2010-12-02	2016-10-05	VIIV Healthcare UK (No.5) Limited	Alquilamidas como inhibidores de la unión del VIH
EA028821B9 (ru)	2011-02-07	2018-10-31	Плексксикон, Инк.	Соединения и способы для модуляции киназ, а также показания к их применению
AR085279A1 (es)	2011-02-21	2013-09-18	Plexxikon Inc	Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
EP2696937B1 (en)	2011-04-12	2017-05-17	VIIV Healthcare UK (No.5) Limited	Thioamide, amidoxime and amidrazone derivatives as hiv attachment inhibitors
EP2751118B1 (en)	2011-08-29	2016-10-12	Bristol-Myers Squibb Company	Spiro bicyclic diamine derivatives as hiv attachment inhibitors
EP2751119B1 (en)	2011-08-29	2016-11-23	VIIV Healthcare UK (No.5) Limited	Fused bicyclic diamine derivatives as hiv attachment inhibitors
US9193725B2 (en)	2012-03-14	2015-11-24	Bristol-Meyers Squibb Company	Cyclic hydrazine derivatives as HIV attachment inhibitors
US9150570B2 (en)	2012-05-31	2015-10-06	Plexxikon Inc.	Synthesis of heterocyclic compounds
CN102746295B (zh) *	2012-06-20	2014-10-15	上海阿达玛斯试剂有限公司	4位取代-7-氮杂吲哚的制备方法
EP2895471B1 (en)	2012-08-09	2016-11-23	VIIV Healthcare UK (No.5) Limited	Piperidine amide derivatives as hiv attachment inhibitors
EP2895472B1 (en)	2012-08-09	2016-11-23	VIIV Healthcare UK (No.5) Limited	Tricyclic alkene derivatives as HIV attachment inhibitors
CN109528749B (zh) *	2017-09-22	2023-04-28	上海交通大学医学院附属瑞金医院	长链非编码rna-h19在制备治疗垂体瘤药物中的用途
WO2022076975A1 (en)	2020-10-05	2022-04-14	Enliven Therapeutics, Inc.	5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases
CN118515629A (zh) *	2020-11-24	2024-08-20	中国人民解放军海军军医大学	一类取代苯甲酰哌嗪类化合物及其应用

2001
- 2001-01-18 US US09/765,189 patent/US20020061892A1/en not_active Abandoned
- 2001-01-19 WO PCT/US2001/002009 patent/WO2001062255A1/en active IP Right Grant
- 2001-01-19 AU AU2001232895A patent/AU2001232895B2/en not_active Ceased
- 2001-01-19 DK DK01904970T patent/DK1257276T3/da active
- 2001-01-19 HU HU0301508A patent/HU229992B1/hu not_active IP Right Cessation
- 2001-01-19 CA CA2400700A patent/CA2400700C/en not_active Expired - Fee Related
- 2001-01-19 DE DE60116260T patent/DE60116260T2/de not_active Expired - Lifetime
- 2001-01-19 MX MXPA02008113A patent/MXPA02008113A/es active IP Right Grant
- 2001-01-19 PL PL01357434A patent/PL357434A1/xx not_active Application Discontinuation
- 2001-01-19 KR KR10-2002-7010888A patent/KR100496574B1/ko not_active IP Right Cessation
- 2001-01-19 NZ NZ520317A patent/NZ520317A/en not_active IP Right Cessation
- 2001-01-19 PT PT01904970T patent/PT1257276E/pt unknown
- 2001-01-19 CN CN01805504A patent/CN1404392A/zh active Pending
- 2001-01-19 TR TR2002/01961T patent/TR200201961T2/xx unknown
- 2001-01-19 BR BRPI0108485A patent/BRPI0108485B1/pt not_active IP Right Cessation
- 2001-01-19 IL IL15073401A patent/IL150734A0/xx unknown
- 2001-01-19 EP EP01904970A patent/EP1257276B1/en not_active Expired - Lifetime
- 2001-01-19 RU RU2002125494/04A patent/RU2259372C2/ru not_active IP Right Cessation
- 2001-01-19 AU AU3289501A patent/AU3289501A/xx active Pending
- 2001-01-19 ES ES01904970T patent/ES2254367T3/es not_active Expired - Lifetime
- 2001-01-19 JP JP2001561320A patent/JP3868814B2/ja not_active Expired - Fee Related
- 2001-01-19 AT AT01904970T patent/ATE314072T1/de active
- 2001-02-06 MY MYPI20010516A patent/MY128458A/en unknown
- 2001-02-07 TW TW090102639A patent/TWI293629B/zh not_active IP Right Cessation
- 2001-02-19 EG EG20010152A patent/EG24669A/xx active
- 2001-02-19 AR ARP010100742A patent/AR029469A1/es active IP Right Grant
- 2001-02-20 CO CO01013156A patent/CO5271657A1/es not_active Application Discontinuation
- 2001-02-21 UY UY26593A patent/UY26593A1/es not_active IP Right Cessation
- 2001-02-22 PE PE2001000190A patent/PE20020786A1/es not_active Application Discontinuation
2002
- 2002-07-30 ZA ZA200206073A patent/ZA200206073B/en unknown
- 2002-08-21 NO NO20023981A patent/NO323564B1/no not_active IP Right Cessation
2003
- 2003-04-23 HK HK03102905A patent/HK1052132A1/xx not_active IP Right Cessation
2006
- 2006-03-27 CY CY20061100420T patent/CY1107460T1/el unknown

Also Published As

Publication number	Publication date
EP1257276B1 (en)	2005-12-28
CA2400700C (en)	2010-10-26
HUP0301508A2 (hu)	2003-09-29
JP3868814B2 (ja)	2007-01-17
AU2001232895B2 (en)	2005-03-17
ES2254367T3 (es)	2006-06-16
RU2002125494A (ru)	2004-03-20
EP1257276A1 (en)	2002-11-20
CA2400700A1 (en)	2001-08-30
EG24669A (en)	2010-04-11
BRPI0108485B1 (pt)	2016-08-23
AR029469A1 (es)	2003-07-02
NO323564B1 (no)	2007-06-11
DE60116260D1 (de)	2006-02-02
US20020061892A1 (en)	2002-05-23
UY26593A1 (es)	2001-09-28
NO20023981L (no)	2002-10-17
NZ520317A (en)	2004-05-28
HUP0301508A3 (en)	2004-08-30
IL150734A0 (en)	2003-02-12
CN1404392A (zh)	2003-03-19
MXPA02008113A (es)	2003-01-28
JP2003523392A (ja)	2003-08-05
MY128458A (en)	2007-02-28
HK1052132A1 (en)	2003-09-05
CO5271657A1 (es)	2003-04-30
EP1257276A4 (en)	2004-10-27
ATE314072T1 (de)	2006-01-15
PL357434A1 (en)	2004-07-26
CY1107460T1 (el)	2012-12-19
HU229992B1 (en)	2015-04-28
WO2001062255A1 (en)	2001-08-30
NO20023981D0 (no)	2002-08-21
ZA200206073B (en)	2003-10-30
AU3289501A (en)	2001-09-03
KR20020073598A (ko)	2002-09-27
RU2259372C2 (ru)	2005-08-27
DK1257276T3 (da)	2006-04-10
KR100496574B1 (ko)	2005-06-22
DE60116260T2 (de)	2006-08-31
TR200201961T2 (tr)	2002-12-23
BR0108485A (pt)	2003-04-22
PE20020786A1 (es)	2002-09-06
TWI293629B (pt)	2008-02-21

Publication	Publication Date	Title
PT1257276E (pt)	2006-05-31	Derivados de azaindole antivirais
NO20010743D0 (no)	2001-02-14	Antivirale indoloksoacetyl-piperazin-derivater
DE60119492D1 (de)	2006-06-14	Purinderivate
DK1296996T3 (da)	2004-08-16	Purinderivater
ATE321065T1 (de)	2006-04-15	Purin-derivate
ATE238336T1 (de)	2003-05-15	Purin-derivate
IS6196A (is)	2001-12-11	Púrín afleiður
NO20032453L (no)	2003-07-16	Substituerte imidazopyridiner
PT1303521E (pt)	2005-05-31	Derivados de tetra-hidro-heterocicloazepinil-pirimidina
AR028602A1 (es)	2003-05-14	Derivados de pirrol
AR028282A1 (es)	2003-04-30	Derivados de aminofenil pirimidona
PT1246791E (pt)	2005-03-31	Derivados de aminometilfenilciclo-hexanona
DE50104434D1 (de)	2004-12-09	Lactam-substituierte pyrazolopyridinderivate