[go: up one dir, main page]

PT1033975E - Processo para a preparacao de substancias biologicamente activas nao-cristalinas isentas de dissolventes - Google Patents

Processo para a preparacao de substancias biologicamente activas nao-cristalinas isentas de dissolventes

Info

Publication number
PT1033975E
PT1033975E PT98965661T PT98965661T PT1033975E PT 1033975 E PT1033975 E PT 1033975E PT 98965661 T PT98965661 T PT 98965661T PT 98965661 T PT98965661 T PT 98965661T PT 1033975 E PT1033975 E PT 1033975E
Authority
PT
Portugal
Prior art keywords
dissolvents
nao
preparation
biologically active
crystalline substances
Prior art date
Application number
PT98965661T
Other languages
English (en)
Inventor
Jorg Rosenberg
Jorg Breitenbach
Ulrich Reinhold
Jurgen Zeidler
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of PT1033975E publication Critical patent/PT1033975E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT98965661T 1997-11-28 1998-11-09 Processo para a preparacao de substancias biologicamente activas nao-cristalinas isentas de dissolventes PT1033975E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752895 1997-11-28

Publications (1)

Publication Number Publication Date
PT1033975E true PT1033975E (pt) 2002-07-31

Family

ID=7850166

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98965661T PT1033975E (pt) 1997-11-28 1998-11-09 Processo para a preparacao de substancias biologicamente activas nao-cristalinas isentas de dissolventes

Country Status (11)

Country Link
US (1) US6547997B1 (pt)
EP (1) EP1033975B1 (pt)
JP (1) JP2001524503A (pt)
CN (1) CN1150891C (pt)
AT (1) ATE214595T1 (pt)
CA (1) CA2310847C (pt)
DE (1) DE59803468D1 (pt)
DK (1) DK1033975T3 (pt)
ES (1) ES2174538T3 (pt)
PT (1) PT1033975E (pt)
WO (1) WO1999027891A2 (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5767429B2 (ja) * 1999-11-12 2015-08-19 アッヴィ・インコーポレイテッド 固体分散剤中の結晶化阻害剤
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10361596A1 (de) * 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032051A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US8075872B2 (en) * 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US20070048228A1 (en) * 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004020220A1 (de) * 2004-04-22 2005-11-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
ES2407143T3 (es) * 2003-08-06 2013-06-11 Grünenthal GmbH Forma de dosificación protegida contra un posible abuso
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
DE102004032103A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004032049A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
WO2009085828A2 (en) * 2007-12-20 2009-07-09 Mutual Pharmaceutical Company, Inc. Quinine sulfate polymorphs, processes of preparing, compositions and uses thereof
JP5774853B2 (ja) 2008-01-25 2015-09-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 医薬投薬形
EP2273983B1 (en) 2008-05-09 2016-07-20 Grünenthal GmbH Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
EP2997965B1 (en) 2009-07-22 2019-01-02 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive opioids
CA2765971C (en) 2009-07-22 2017-08-22 Gruenenthal Gmbh Hot-melt extruded controlled release dosage form
US9579285B2 (en) * 2010-02-03 2017-02-28 Gruenenthal Gmbh Preparation of a powdery pharmaceutical composition by means of an extruder
AR082862A1 (es) 2010-09-02 2013-01-16 Gruenenthal Gmbh Forma de dosificacion resistente a alteracion que comprende un polimero anionico
PE20131102A1 (es) 2010-09-02 2013-10-12 Gruenenthal Chemie Forma de dosificacion resistente a manipulacion que comprende una sal inorganica
AR087359A1 (es) 2011-07-29 2014-03-19 Gruenenthal Gmbh Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco
EA201400172A1 (ru) 2011-07-29 2014-06-30 Грюненталь Гмбх Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
EP2819656A1 (en) 2012-02-28 2015-01-07 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
AU2013248351B2 (en) 2012-04-18 2018-04-26 Grunenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AR096438A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
KR20160031526A (ko) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
BR112016010482B1 (pt) 2013-11-26 2022-11-16 Grünenthal GmbH Preparação de uma composição farmacêutica em pó por meio de criomoagem
AU2015261060A1 (en) 2014-05-12 2016-11-03 Grunenthal Gmbh Tamper resistant immediate release capsule formulation comprising Tapentadol
MX2016015417A (es) 2014-05-26 2017-02-22 Gruenenthal Gmbh Multiparticulas protegidas contra vertido de dosis etanolico.
WO2016170097A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
GB201801415D0 (en) * 2018-01-29 2018-03-14 Univ Limerick Method and apparatus

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3310676A1 (de) 1983-03-24 1984-09-27 Basf Ag, 6700 Ludwigshafen Verfahren und vorrichtung zum entfernen von fluechtigen anteilen aus polymerenschmelzen oder paste
ES2145063T3 (es) * 1992-10-14 2000-07-01 Nippon Shinyaku Co Ltd Procedimiento de dislocacion del estado cristalino.
US5811547A (en) 1992-10-14 1998-09-22 Nippon Shinyaju Co., Ltd. Method for inducing crystalline state transition in medicinal substance
US5466865A (en) 1993-07-02 1995-11-14 Ibah, Inc. Neomorphic ibuprofen and methods of using same
WO1995027710A1 (fr) * 1994-04-11 1995-10-19 Chugai Seiyaku Kabushiki Kaisha DERIVE DE 4,6-DI-t-BUTYL-2,3-DIHIDROBENZOTHIOPHENE
DE4418837A1 (de) * 1994-05-30 1995-12-07 Bayer Ag Thermisches Granulierverfahren
NZ322907A (en) * 1995-11-23 1998-12-23 Janssen Pharmaceutica Nv Solid mixtures of cyclodextrins prepared via melt-extrusion
DE19624607A1 (de) 1996-06-20 1998-01-02 Basf Ag Verfahren zur Herstellung von Salzen von Säuregruppen tragenden pharmazeutischen Wirkstoffen
DE19801073A1 (de) * 1998-01-14 1999-07-15 Bayer Ag Mischvorrichtung

Also Published As

Publication number Publication date
ES2174538T3 (es) 2002-11-01
EP1033975A2 (de) 2000-09-13
US6547997B1 (en) 2003-04-15
CN1150891C (zh) 2004-05-26
WO1999027891A3 (de) 1999-08-12
DE59803468D1 (de) 2002-04-25
EP1033975B1 (de) 2002-03-20
CA2310847C (en) 2007-03-13
ATE214595T1 (de) 2002-04-15
WO1999027891A2 (de) 1999-06-10
CN1280491A (zh) 2001-01-17
CA2310847A1 (en) 1999-06-10
DK1033975T3 (da) 2002-05-27
JP2001524503A (ja) 2001-12-04

Similar Documents

Publication Publication Date Title
PT1033975E (pt) Processo para a preparacao de substancias biologicamente activas nao-cristalinas isentas de dissolventes
AU7259196A (en) Moldable, hand-shapable biodegradable implant material
AU4757496A (en) Biodegradable implant for fracture nonunions
BR0107942A (pt) Polìmeros de proteìna de liberação lenta
AU2018801A (en) Cellular matrix
AU5106996A (en) Process for producing active agent preparations in the form of a solid solution of the active agent in a polymer matrix and active agent preparations obtained thereby
AU3203800A (en) A method for the preparation of uhmwpe doped with an antioxidant and an implant made thereof
ES2138271T3 (es) Compuestos de 6-dimetil-amino-metil-1-fenil-ciclohexano como principio activo farmaceutico.
AU2339997A (en) Diode laser irradiation system for biological tissue stimulation
FI956014A0 (fi) Nona- ja dekapeptidien käyttö lääkkeen valmistamiseksi AIDS-sairauden hoitoon
AR004357A1 (es) Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, y procedimiento de preparacion para dichos compuestos.
BR9506305A (pt) Aparelho e processo para preparação de formas sólidas com desprendimento controlado do ingrediente ativo
AU7169996A (en) Iontophoretic drug delivery system, including disposable patch
AU697005B2 (en) Implantable molded articles for the administration of active substances to plants
HK1019404A1 (en) Injection formulations of avermectins or milbemycins based on castor oil, their preparation, and use of castor for preparing the same
AU8148494A (en) Bandages
ITMI962385A0 (it) Diaril-ciclometilenpirazoli farmacologicamente attivi procedimento per prepararli e composizioni farmaceutiche che li contengono
AU4428597A (en) Iontophoretic drug delivery system, including method for activating same
ES2162929T3 (es) Procedimiento para la preparacion de 2-(1-azabiciclo(2.2.2)oct-3-il)-2,4,5,6-tetrahidro-1h-benz(de)isoquinolin-1-ona y producto intermediario.
AU7236394A (en) Optically active 1-(4-nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5h -2,3-benzodiazepine and process for preparing same
AU7552098A (en) Physiologically active substances tkr2449, process for producing the same, and microorganism
PT1017681E (pt) Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios
AU6700996A (en) Somatostatin-analogous cyclic peptides with inhibitory activity on growth hormone
IT1290910B1 (it) 2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive
AU1411200A (en) Novel physiologically active substance, process for producing the same and utilization thereof