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PT1030838E - Metodo de sintese de pirrolamidas - Google Patents

Metodo de sintese de pirrolamidas

Info

Publication number
PT1030838E
PT1030838E PT98946678T PT98946678T PT1030838E PT 1030838 E PT1030838 E PT 1030838E PT 98946678 T PT98946678 T PT 98946678T PT 98946678 T PT98946678 T PT 98946678T PT 1030838 E PT1030838 E PT 1030838E
Authority
PT
Portugal
Prior art keywords
reaction
pyrrolamides
synthesis
followed
cycloakane
Prior art date
Application number
PT98946678T
Other languages
English (en)
Inventor
Shane Allen Eisenbeis
John Anthony Ragan
Teresa Woodall Makowski
David Jon Am Ende
Pamela Jane Clifford
Gregory Randall Young
Alyson Kay Conrad
George Joseph Quallich
Douglas John Meldrum Allen
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PT1030838E publication Critical patent/PT1030838E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Tea And Coffee (AREA)
  • Fats And Perfumes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
PT98946678T 1997-11-13 1998-10-21 Metodo de sintese de pirrolamidas PT1030838E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6542297P 1997-11-13 1997-11-13
US7426698P 1998-02-10 1998-02-10

Publications (1)

Publication Number Publication Date
PT1030838E true PT1030838E (pt) 2003-03-31

Family

ID=26745584

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98946678T PT1030838E (pt) 1997-11-13 1998-10-21 Metodo de sintese de pirrolamidas

Country Status (35)

Country Link
US (1) US6262272B1 (pt)
EP (1) EP1030838B1 (pt)
JP (1) JP3497469B2 (pt)
KR (1) KR100386722B1 (pt)
CN (2) CN1508129A (pt)
AT (1) ATE231492T1 (pt)
AU (1) AU745788B2 (pt)
BG (1) BG64530B1 (pt)
BR (1) BR9814161A (pt)
CA (1) CA2310095A1 (pt)
CZ (1) CZ20001769A3 (pt)
DE (1) DE69810959T2 (pt)
DK (1) DK1030838T3 (pt)
DZ (1) DZ2651A1 (pt)
EA (1) EA002243B1 (pt)
ES (1) ES2186232T3 (pt)
HR (1) HRP20000298A2 (pt)
HU (1) HUP0100235A3 (pt)
ID (1) ID24135A (pt)
IL (1) IL135710A0 (pt)
IS (1) IS5469A (pt)
MA (1) MA24697A1 (pt)
NO (1) NO20002214L (pt)
NZ (1) NZ503916A (pt)
OA (1) OA11378A (pt)
PA (1) PA8462901A1 (pt)
PL (1) PL340554A1 (pt)
PT (1) PT1030838E (pt)
SK (1) SK6872000A3 (pt)
TN (1) TNSN98204A1 (pt)
TR (1) TR200001343T2 (pt)
TW (1) TW509675B (pt)
UY (1) UY25249A1 (pt)
WO (1) WO1999025684A1 (pt)
YU (1) YU27300A (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7092800A (en) 1999-08-31 2001-03-26 Neurogen Corporation Fused pyrrolecarboxamides: gaba brain receptor ligands
JP2004508359A (ja) * 2000-09-06 2004-03-18 ニューロゲン コーポレイション アリール置換テトラヒドロインダゾール、及び、gaba−a受容体に対するリガンドとしてのそれらの使用
CA2430841A1 (en) * 2000-12-04 2002-06-13 Pfizer Products Inc. Synthesis of fused pyrrolecarboxamides
US6852730B2 (en) 2002-02-07 2005-02-08 Neurogen Corporation Substituted fused pyrazolecarboxylic acid arylamides and related compounds
US20080153629A1 (en) * 2004-05-07 2008-06-26 Sullivan Michael J Thick Outer Cover Layer Golf Ball
CN102786458B (zh) * 2012-06-04 2014-02-12 天津渤海职业技术学院 吡咯甲酰胺衍生物、其制备方法和用途
EP3097095A1 (en) * 2014-01-24 2016-11-30 AbbVie Inc. Furo-3-carboxamide derivatives and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US5804686A (en) 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
WO1997034870A1 (en) * 1996-03-22 1997-09-25 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands

Also Published As

Publication number Publication date
EP1030838A1 (en) 2000-08-30
HRP20000298A2 (en) 2001-02-28
BG64530B1 (bg) 2005-06-30
ATE231492T1 (de) 2003-02-15
JP2001523660A (ja) 2001-11-27
NO20002214L (no) 2000-05-12
WO1999025684A1 (en) 1999-05-27
AU745788B2 (en) 2002-03-28
US6262272B1 (en) 2001-07-17
CN1280566A (zh) 2001-01-17
DK1030838T3 (da) 2003-02-24
KR20010032063A (ko) 2001-04-16
BG104413A (en) 2001-02-28
TR200001343T2 (tr) 2001-02-21
YU27300A (sh) 2002-10-18
UY25249A1 (es) 1999-07-19
IL135710A0 (en) 2001-05-20
ES2186232T3 (es) 2003-05-01
TNSN98204A1 (fr) 2005-03-15
ID24135A (id) 2000-07-06
KR100386722B1 (ko) 2003-06-09
JP3497469B2 (ja) 2004-02-16
AU9363998A (en) 1999-06-07
DE69810959D1 (de) 2003-02-27
CN1508129A (zh) 2004-06-30
IS5469A (is) 2000-04-26
BR9814161A (pt) 2000-09-26
TW509675B (en) 2002-11-11
OA11378A (en) 2004-01-27
HUP0100235A3 (en) 2002-04-29
MA24697A1 (fr) 1999-07-01
PL340554A1 (en) 2001-02-12
PA8462901A1 (es) 2000-05-24
HUP0100235A2 (hu) 2001-12-28
DE69810959T2 (de) 2003-06-05
NZ503916A (en) 2002-08-28
EP1030838B1 (en) 2003-01-22
CA2310095A1 (en) 1999-05-27
SK6872000A3 (en) 2002-02-05
NO20002214D0 (no) 2000-04-28
CZ20001769A3 (cs) 2001-09-12
EA200000413A1 (ru) 2000-12-25
EA002243B1 (ru) 2002-02-28
DZ2651A1 (fr) 2003-03-15

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