PT100691A - Intermediarios de fosforos modificados para fornecer grupos funcionais na extremidade 5' dos oligonucleotidos - Google Patents
Intermediarios de fosforos modificados para fornecer grupos funcionais na extremidade 5' dos oligonucleotidosInfo
- Publication number
- PT100691A PT100691A PT100691A PT10069192A PT100691A PT 100691 A PT100691 A PT 100691A PT 100691 A PT100691 A PT 100691A PT 10069192 A PT10069192 A PT 10069192A PT 100691 A PT100691 A PT 100691A
- Authority
- PT
- Portugal
- Prior art keywords
- carbon atoms
- group
- oligonucleotide
- atoms
- oligonucleotidos
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73105591A | 1991-07-15 | 1991-07-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT100691A true PT100691A (pt) | 1993-10-29 |
PT100691B PT100691B (pt) | 1999-06-30 |
Family
ID=24937868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT100691A PT100691B (pt) | 1991-07-15 | 1992-07-15 | Intermediarios de fosforos modificados para fornecer grupos funcionais na extremidade 5' dos oligonucleotidos |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0523978B1 (pt) |
JP (3) | JP2899111B2 (pt) |
AT (1) | ATE179982T1 (pt) |
AU (3) | AU664184B2 (pt) |
CA (1) | CA2073846C (pt) |
DE (1) | DE69229149T2 (pt) |
DK (1) | DK0523978T3 (pt) |
ES (1) | ES2131060T3 (pt) |
GR (1) | GR3030260T3 (pt) |
HK (1) | HK1014369A1 (pt) |
IE (1) | IE922292A1 (pt) |
PT (1) | PT100691B (pt) |
WO (1) | WO1993002093A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5268454A (en) | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
AU2003200284B2 (en) * | 1998-03-27 | 2006-11-02 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
US6344330B1 (en) * | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
DE69928995T2 (de) * | 1998-06-22 | 2006-09-07 | Affymetrix, Inc., Santa Clara | Reagenz und Verfahren zu fester Phase Synthese |
US6399578B1 (en) | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
US6458953B1 (en) | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
CN101422614A (zh) | 1999-11-28 | 2009-05-06 | 拉卓拉药物公司 | 基于抗体亲和力来治疗狼疮的方法及使用这种方法的筛选方法和组合物 |
DE10013600A1 (de) * | 2000-03-18 | 2002-01-10 | Aventis Res & Tech Gmbh & Co | Reaktive Monomere für die Oligonucleotid- und Polynucleotidsynthese, modifizierte Oligonucleotide und Polynucleotiden und ein Verfahren zu deren Herstellung |
US20030199466A1 (en) | 2001-06-21 | 2003-10-23 | Fearon Karen L. | Chimeric immunomodulatory compounds and methods of using the same - ll |
DE10163836A1 (de) * | 2001-12-22 | 2003-07-10 | Friz Biochem Gmbh | Multifunktionales Reagenz zur Synthese von thiolmodifizierten Oligomeren |
JP4495670B2 (ja) * | 2005-12-27 | 2010-07-07 | 三井化学株式会社 | メルカプトアルキルホスホニウム化合物の製造法 |
WO2011034605A2 (en) | 2009-09-16 | 2011-03-24 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
CN103384681B (zh) | 2010-12-23 | 2018-05-18 | 霍夫曼-拉罗奇有限公司 | 结合剂 |
CN103384825B (zh) | 2010-12-23 | 2017-05-24 | 霍夫曼-拉罗奇有限公司 | 通过二价结合剂检测经翻译后修饰的多肽 |
RU2644341C2 (ru) | 2012-02-10 | 2018-02-08 | Дженентек, Инк. | Одноцепочечные антитела и другие гетеромультимеры |
FR2989089B1 (fr) * | 2012-04-04 | 2020-02-07 | Etablissement Francais Du Sang | Oligonucleotides modifies comprenant des fonctions thiol et leur utilisation pour la detection d'acides nucleiques |
FR2989086B1 (fr) * | 2012-04-04 | 2017-03-24 | Centre Nat De La Rech Scient (Cnrs) | Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies |
ES2597228T3 (es) | 2012-06-27 | 2017-01-17 | F. Hoffmann-La Roche Ag | Procedimiento para la selección y la producción de entidades de objetivación, como dianas, altamente selectivas y multiespecíficas, personalizadas, las cuales contienen por lo menos dos entidades de unión diferentes, y utilización de éstas |
EP2867254B1 (en) | 2012-06-27 | 2017-10-25 | F. Hoffmann-La Roche AG | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
CN104903307A (zh) | 2012-12-06 | 2015-09-09 | 默沙东公司 | 二硫化物屏蔽的前体药物组合物和方法 |
PL3227332T3 (pl) | 2014-12-03 | 2020-06-15 | F. Hoffmann-La Roche Ag | Wielospecyficzne przeciwciała |
EP4499111A2 (en) * | 2022-03-28 | 2025-02-05 | Empirico Inc. | Compositions and methods for the treatment of angiopoietin like 7 (angptl7) related diseases |
KR20240163743A (ko) * | 2022-03-28 | 2024-11-19 | 엠피리코 인크. | 변형된 올리고뉴클레오티드 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3225063A (en) * | 1962-05-21 | 1965-12-21 | Scott Paper Co | Organic cyclic carbonates |
US4191668A (en) * | 1977-02-03 | 1980-03-04 | Scripps Clinic And Research Foundation | Induction of immunological tolerance |
US4220565A (en) * | 1979-01-18 | 1980-09-02 | Scripps Clinic & Research Foundation | Immunochemical conjugates: method and composition |
US4650675A (en) * | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
DK160818C (da) * | 1983-12-30 | 1991-10-07 | Hoffmann La Roche | N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse |
US4575558A (en) * | 1984-02-15 | 1986-03-11 | American Hospital Supply Corporation | Preparation of optically active 1,3-dioxolane-4-methanol compounds |
US4751181A (en) * | 1984-12-31 | 1988-06-14 | Duke University | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases |
WO1987002777A1 (en) * | 1985-10-24 | 1987-05-07 | Research Corporation Limited | Biochemical reagent |
DE3811005A1 (de) * | 1988-03-31 | 1989-10-19 | Bayer Ag | Thionophosphor(phosphon)saeureamidester |
EP0354323A3 (en) * | 1988-08-12 | 1990-06-13 | American Cyanamid Company | Antidiabetic phosphates |
DE3916871A1 (de) * | 1989-05-24 | 1990-11-29 | Boehringer Mannheim Gmbh | Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren |
JP2849471B2 (ja) * | 1989-06-22 | 1999-01-20 | アライアンス ファーマシューティカル コーポレイション | 界面活性剤の性質を有するフッ素およびリン含有両親媒性分子 |
DE3937116A1 (de) * | 1989-11-03 | 1991-05-08 | Dainippon Ink & Chemicals | Verfahren zur herstellung cyclocarbonathaltiger ester |
-
1992
- 1992-07-14 JP JP5502916A patent/JP2899111B2/ja not_active Expired - Fee Related
- 1992-07-14 CA CA002073846A patent/CA2073846C/en not_active Expired - Fee Related
- 1992-07-14 IE IE229292A patent/IE922292A1/en not_active IP Right Cessation
- 1992-07-14 WO PCT/US1992/005897 patent/WO1993002093A1/en active Search and Examination
- 1992-07-14 AU AU19685/92A patent/AU664184B2/en not_active Ceased
- 1992-07-15 DE DE69229149T patent/DE69229149T2/de not_active Expired - Fee Related
- 1992-07-15 AT AT92306477T patent/ATE179982T1/de not_active IP Right Cessation
- 1992-07-15 EP EP92306477A patent/EP0523978B1/en not_active Expired - Lifetime
- 1992-07-15 PT PT100691A patent/PT100691B/pt not_active IP Right Cessation
- 1992-07-15 DK DK92306477T patent/DK0523978T3/da active
- 1992-07-15 ES ES92306477T patent/ES2131060T3/es not_active Expired - Lifetime
-
1995
- 1995-12-20 AU AU40580/95A patent/AU686911B2/en not_active Ceased
-
1997
- 1997-11-12 AU AU45202/97A patent/AU703715B2/en not_active Ceased
-
1998
- 1998-12-02 JP JP34324698A patent/JP3188243B2/ja not_active Expired - Fee Related
- 1998-12-24 HK HK98115739A patent/HK1014369A1/xx not_active IP Right Cessation
-
1999
- 1999-05-19 GR GR990401353T patent/GR3030260T3/el unknown
-
2001
- 2001-03-08 JP JP2001065808A patent/JP3488435B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU664184B2 (en) | 1995-11-09 |
CA2073846A1 (en) | 1993-01-16 |
JP2001302684A (ja) | 2001-10-31 |
JP3188243B2 (ja) | 2001-07-16 |
DE69229149T2 (de) | 1999-12-09 |
JPH07500576A (ja) | 1995-01-19 |
AU703715B2 (en) | 1999-04-01 |
DK0523978T3 (da) | 1999-11-01 |
ES2131060T3 (es) | 1999-07-16 |
AU4058095A (en) | 1996-03-14 |
DE69229149D1 (de) | 1999-06-17 |
AU4520297A (en) | 1998-02-19 |
HK1014369A1 (en) | 1999-09-24 |
JPH11228592A (ja) | 1999-08-24 |
AU686911B2 (en) | 1998-02-12 |
JP2899111B2 (ja) | 1999-06-02 |
IE922292A1 (en) | 1993-01-27 |
PT100691B (pt) | 1999-06-30 |
WO1993002093A1 (en) | 1993-02-04 |
GR3030260T3 (en) | 1999-08-31 |
AU1968592A (en) | 1993-01-21 |
EP0523978A1 (en) | 1993-01-20 |
EP0523978B1 (en) | 1999-05-12 |
JP3488435B2 (ja) | 2004-01-19 |
CA2073846C (en) | 2007-09-18 |
ATE179982T1 (de) | 1999-05-15 |
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Legal Events
Date | Code | Title | Description |
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BB1A | Laying open of patent application |
Effective date: 19930421 |
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FG3A | Patent granted, date of granting |
Effective date: 19990316 |
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MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20100916 |