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PT100691A - Intermediarios de fosforos modificados para fornecer grupos funcionais na extremidade 5' dos oligonucleotidos - Google Patents

Intermediarios de fosforos modificados para fornecer grupos funcionais na extremidade 5' dos oligonucleotidos

Info

Publication number
PT100691A
PT100691A PT100691A PT10069192A PT100691A PT 100691 A PT100691 A PT 100691A PT 100691 A PT100691 A PT 100691A PT 10069192 A PT10069192 A PT 10069192A PT 100691 A PT100691 A PT 100691A
Authority
PT
Portugal
Prior art keywords
carbon atoms
group
oligonucleotide
atoms
oligonucleotidos
Prior art date
Application number
PT100691A
Other languages
English (en)
Other versions
PT100691B (pt
Inventor
Michael J Conrad
Douglas A Livingston
David S Jones
John P Hachmann
Stephen Coutts
Original Assignee
Jolla Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jolla Pharma filed Critical Jolla Pharma
Publication of PT100691A publication Critical patent/PT100691A/pt
Publication of PT100691B publication Critical patent/PT100691B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20Free hydroxyl or mercaptan
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2404Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
PT100691A 1991-07-15 1992-07-15 Intermediarios de fosforos modificados para fornecer grupos funcionais na extremidade 5' dos oligonucleotidos PT100691B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73105591A 1991-07-15 1991-07-15

Publications (2)

Publication Number Publication Date
PT100691A true PT100691A (pt) 1993-10-29
PT100691B PT100691B (pt) 1999-06-30

Family

ID=24937868

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100691A PT100691B (pt) 1991-07-15 1992-07-15 Intermediarios de fosforos modificados para fornecer grupos funcionais na extremidade 5' dos oligonucleotidos

Country Status (13)

Country Link
EP (1) EP0523978B1 (pt)
JP (3) JP2899111B2 (pt)
AT (1) ATE179982T1 (pt)
AU (3) AU664184B2 (pt)
CA (1) CA2073846C (pt)
DE (1) DE69229149T2 (pt)
DK (1) DK0523978T3 (pt)
ES (1) ES2131060T3 (pt)
GR (1) GR3030260T3 (pt)
HK (1) HK1014369A1 (pt)
IE (1) IE922292A1 (pt)
PT (1) PT100691B (pt)
WO (1) WO1993002093A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268454A (en) 1991-02-08 1993-12-07 La Jolla Pharmaceutical Company Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
KR100361933B1 (ko) 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
AU2003200284B2 (en) * 1998-03-27 2006-11-02 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
US6858210B1 (en) 1998-06-09 2005-02-22 La Jolla Pharmaceutical Co. Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
DE69928995T2 (de) * 1998-06-22 2006-09-07 Affymetrix, Inc., Santa Clara Reagenz und Verfahren zu fester Phase Synthese
US6399578B1 (en) 1998-12-09 2002-06-04 La Jolla Pharmaceutical Company Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
US6458953B1 (en) 1998-12-09 2002-10-01 La Jolla Pharmaceutical Company Valency platform molecules comprising carbamate linkages
CN101422614A (zh) 1999-11-28 2009-05-06 拉卓拉药物公司 基于抗体亲和力来治疗狼疮的方法及使用这种方法的筛选方法和组合物
DE10013600A1 (de) * 2000-03-18 2002-01-10 Aventis Res & Tech Gmbh & Co Reaktive Monomere für die Oligonucleotid- und Polynucleotidsynthese, modifizierte Oligonucleotide und Polynucleotiden und ein Verfahren zu deren Herstellung
US20030199466A1 (en) 2001-06-21 2003-10-23 Fearon Karen L. Chimeric immunomodulatory compounds and methods of using the same - ll
DE10163836A1 (de) * 2001-12-22 2003-07-10 Friz Biochem Gmbh Multifunktionales Reagenz zur Synthese von thiolmodifizierten Oligomeren
JP4495670B2 (ja) * 2005-12-27 2010-07-07 三井化学株式会社 メルカプトアルキルホスホニウム化合物の製造法
WO2011034605A2 (en) 2009-09-16 2011-03-24 Genentech, Inc. Coiled coil and/or tether containing protein complexes and uses thereof
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
CN103384681B (zh) 2010-12-23 2018-05-18 霍夫曼-拉罗奇有限公司 结合剂
CN103384825B (zh) 2010-12-23 2017-05-24 霍夫曼-拉罗奇有限公司 通过二价结合剂检测经翻译后修饰的多肽
RU2644341C2 (ru) 2012-02-10 2018-02-08 Дженентек, Инк. Одноцепочечные антитела и другие гетеромультимеры
FR2989089B1 (fr) * 2012-04-04 2020-02-07 Etablissement Francais Du Sang Oligonucleotides modifies comprenant des fonctions thiol et leur utilisation pour la detection d'acides nucleiques
FR2989086B1 (fr) * 2012-04-04 2017-03-24 Centre Nat De La Rech Scient (Cnrs) Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies
ES2597228T3 (es) 2012-06-27 2017-01-17 F. Hoffmann-La Roche Ag Procedimiento para la selección y la producción de entidades de objetivación, como dianas, altamente selectivas y multiespecíficas, personalizadas, las cuales contienen por lo menos dos entidades de unión diferentes, y utilización de éstas
EP2867254B1 (en) 2012-06-27 2017-10-25 F. Hoffmann-La Roche AG Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
CN104903307A (zh) 2012-12-06 2015-09-09 默沙东公司 二硫化物屏蔽的前体药物组合物和方法
PL3227332T3 (pl) 2014-12-03 2020-06-15 F. Hoffmann-La Roche Ag Wielospecyficzne przeciwciała
EP4499111A2 (en) * 2022-03-28 2025-02-05 Empirico Inc. Compositions and methods for the treatment of angiopoietin like 7 (angptl7) related diseases
KR20240163743A (ko) * 2022-03-28 2024-11-19 엠피리코 인크. 변형된 올리고뉴클레오티드

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3225063A (en) * 1962-05-21 1965-12-21 Scott Paper Co Organic cyclic carbonates
US4191668A (en) * 1977-02-03 1980-03-04 Scripps Clinic And Research Foundation Induction of immunological tolerance
US4220565A (en) * 1979-01-18 1980-09-02 Scripps Clinic & Research Foundation Immunochemical conjugates: method and composition
US4650675A (en) * 1983-08-18 1987-03-17 The Children's Medical Center Corporation Oligonucleotide conjugates
DK160818C (da) * 1983-12-30 1991-10-07 Hoffmann La Roche N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse
US4575558A (en) * 1984-02-15 1986-03-11 American Hospital Supply Corporation Preparation of optically active 1,3-dioxolane-4-methanol compounds
US4751181A (en) * 1984-12-31 1988-06-14 Duke University Methods and compositions useful in the diagnosis and treatment of autoimmune diseases
WO1987002777A1 (en) * 1985-10-24 1987-05-07 Research Corporation Limited Biochemical reagent
DE3811005A1 (de) * 1988-03-31 1989-10-19 Bayer Ag Thionophosphor(phosphon)saeureamidester
EP0354323A3 (en) * 1988-08-12 1990-06-13 American Cyanamid Company Antidiabetic phosphates
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
JP2849471B2 (ja) * 1989-06-22 1999-01-20 アライアンス ファーマシューティカル コーポレイション 界面活性剤の性質を有するフッ素およびリン含有両親媒性分子
DE3937116A1 (de) * 1989-11-03 1991-05-08 Dainippon Ink & Chemicals Verfahren zur herstellung cyclocarbonathaltiger ester

Also Published As

Publication number Publication date
AU664184B2 (en) 1995-11-09
CA2073846A1 (en) 1993-01-16
JP2001302684A (ja) 2001-10-31
JP3188243B2 (ja) 2001-07-16
DE69229149T2 (de) 1999-12-09
JPH07500576A (ja) 1995-01-19
AU703715B2 (en) 1999-04-01
DK0523978T3 (da) 1999-11-01
ES2131060T3 (es) 1999-07-16
AU4058095A (en) 1996-03-14
DE69229149D1 (de) 1999-06-17
AU4520297A (en) 1998-02-19
HK1014369A1 (en) 1999-09-24
JPH11228592A (ja) 1999-08-24
AU686911B2 (en) 1998-02-12
JP2899111B2 (ja) 1999-06-02
IE922292A1 (en) 1993-01-27
PT100691B (pt) 1999-06-30
WO1993002093A1 (en) 1993-02-04
GR3030260T3 (en) 1999-08-31
AU1968592A (en) 1993-01-21
EP0523978A1 (en) 1993-01-20
EP0523978B1 (en) 1999-05-12
JP3488435B2 (ja) 2004-01-19
CA2073846C (en) 2007-09-18
ATE179982T1 (de) 1999-05-15

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Legal Events

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BB1A Laying open of patent application

Effective date: 19930421

FG3A Patent granted, date of granting

Effective date: 19990316

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20100916