PL443474A1 - 7,4'-di-O-nonylnaringenin oxime and method of obtaining 7,4'-di-O-nonylnaringenin oxime - Google Patents
7,4'-di-O-nonylnaringenin oxime and method of obtaining 7,4'-di-O-nonylnaringenin oximeInfo
- Publication number
- PL443474A1 PL443474A1 PL443474A PL44347423A PL443474A1 PL 443474 A1 PL443474 A1 PL 443474A1 PL 443474 A PL443474 A PL 443474A PL 44347423 A PL44347423 A PL 44347423A PL 443474 A1 PL443474 A1 PL 443474A1
- Authority
- PL
- Poland
- Prior art keywords
- nonylnaringenin
- oxime
- obtaining
- formula
- mixture
- Prior art date
Links
- 150000002923 oximes Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 229940040526 anhydrous sodium acetate Drugs 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 239000005457 ice water Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Przedmiotem zgłoszenia jest oksym 7,4'-di-O-nonylonaringeniny o wzorze 2 oraz sposób otrzymywania oksymu 7,4'-di-O-nonylonaringeniny polegający na tym, że do substratu, którym jest 7,4'-di-O-nonylonaringenina o wzorze 1 dodaje się chlorowodorek hydroksyloaminy oraz bezwodny octan sodu w stosunku molowym co najmniej 1:3:3 oraz minimalną ilość alkoholu, co stanowi mieszaninę reakcyjną, którą pozostawia się w temperaturze od 30°C do 55°C na okres od 6 do 36 godzin przy ciągłym mieszaniu, po czym mieszaninę wylewa się do wody z lodem, wytrącony osad sączy się pod zmniejszonym ciśnieniem, a następnie otrzymany surowy produkt oczyszcza się.The subject of the application is 7,4'-di-O-nonylnaringenin oxime of formula 2 and a method for obtaining 7,4'-di-O-nonylnaringenin oxime by adding 7,4'-di-O- to the substrate, which is 7,4'-di-O- nonylnaringenin of formula 1, hydroxylamine hydrochloride and anhydrous sodium acetate are added in a molar ratio of at least 1:3:3 and a minimum amount of alcohol, which constitutes the reaction mixture, which is left at a temperature from 30°C to 55°C for a period of 6 to 36 hours with constant stirring, then the mixture is poured into ice water, the precipitate is filtered under reduced pressure, and then the crude product obtained is purified.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL443474A PL443474A1 (en) | 2023-01-13 | 2023-01-13 | 7,4'-di-O-nonylnaringenin oxime and method of obtaining 7,4'-di-O-nonylnaringenin oxime |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL443474A PL443474A1 (en) | 2023-01-13 | 2023-01-13 | 7,4'-di-O-nonylnaringenin oxime and method of obtaining 7,4'-di-O-nonylnaringenin oxime |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL443474A1 true PL443474A1 (en) | 2024-07-15 |
Family
ID=91899603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL443474A PL443474A1 (en) | 2023-01-13 | 2023-01-13 | 7,4'-di-O-nonylnaringenin oxime and method of obtaining 7,4'-di-O-nonylnaringenin oxime |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL443474A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL421047A1 (en) * | 2017-03-29 | 2018-10-08 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-didodecanoxy-naringenin-oxime and method for obtaining 7,4'-didodecanoxy-naringenin-oxime |
| PL422935A1 (en) * | 2017-09-21 | 2019-03-25 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-didecanoxy-naringenin oxime and method for obtaining 7,4'-didecanoxy-naringenin oxime |
| PL434616A1 (en) * | 2020-07-10 | 2022-01-17 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-di-O-hexylnaringenin oxime and method of its preparation |
-
2023
- 2023-01-13 PL PL443474A patent/PL443474A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL421047A1 (en) * | 2017-03-29 | 2018-10-08 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-didodecanoxy-naringenin-oxime and method for obtaining 7,4'-didodecanoxy-naringenin-oxime |
| PL422935A1 (en) * | 2017-09-21 | 2019-03-25 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-didecanoxy-naringenin oxime and method for obtaining 7,4'-didecanoxy-naringenin oxime |
| PL434616A1 (en) * | 2020-07-10 | 2022-01-17 | Uniwersytet Przyrodniczy we Wrocławiu | 7,4'-di-O-hexylnaringenin oxime and method of its preparation |
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