PL401469A1 - Pochodna azabicykliczna, sposób jej wytwarzania, jej zastosowanie w medycynie oraz zawierajaca pochodna kompozycja - Google Patents

Pochodna azabicykliczna, sposób jej wytwarzania, jej zastosowanie w medycynie oraz zawierajaca pochodna kompozycja

Info

Publication number: PL401469A1
Authority: PL; Poland
Prior art keywords: derivative; medicine; production; azabicyclic; composition
Prior art date: 2000-08-01

Application number

PL401469A

Other languages

English (en)

Other versions

PL234468B1 (pl

Inventor

Maxime Lampilas

Jozsef Aszodi

David Alan Rowlands

Claude Fromentin

Original Assignee

Novexel

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-01

Filing date

2001-07-24

Publication date

2013-02-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8853181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL401469(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-07-24 Application filed by Novexel filed Critical Novexel

2013-02-04 Publication of PL401469A1 publication Critical patent/PL401469A1/pl

2020-02-28 Publication of PL234468B1 publication Critical patent/PL234468B1/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PL401469A 2000-08-01 2001-07-24 Pochodna azabicykliczna, sposób jej wytwarzania, jej zastosowanie w medycynie oraz zawierająca tą pochodną kompozycja PL234468B1 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR00/10121		2000-08-01
FR0010121A FR2812635B1 (fr)	2000-08-01	2000-08-01	Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
PCT/FR2001/002418 WO2002010172A1 (fr)	2000-08-01	2001-07-24	Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens

Publications (2)

Publication Number	Publication Date
PL401469A1 true PL401469A1 (pl)	2013-02-04
PL234468B1 PL234468B1 (pl)	2020-02-28

Family

ID=8853181

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL365162A PL216028B1 (pl)	2000-08-01	2001-07-24	Pochodna azabicykliczna, jej zastosowanie jako lek oraz zawierajaca ja kompozycja
PL401469A PL234468B1 (pl)	2000-08-01	2001-07-24	Pochodna azabicykliczna, sposób jej wytwarzania, jej zastosowanie w medycynie oraz zawierająca tą pochodną kompozycja

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL365162A PL216028B1 (pl)	2000-08-01	2001-07-24	Pochodna azabicykliczna, jej zastosowanie jako lek oraz zawierajaca ja kompozycja

Country Status (42)

Country	Link
US (5)	US7112592B2 (pl)
EP (1)	EP1307457B1 (pl)
JP (2)	JP4515704B2 (pl)
KR (1)	KR100632906B1 (pl)
CN (1)	CN1289500C (pl)
AP (1)	AP1614A (pl)
AR (1)	AR031716A1 (pl)
AT (1)	ATE263768T1 (pl)
AU (2)	AU7990501A (pl)
BG (1)	BG66094B1 (pl)
BR (1)	BRPI0112986B8 (pl)
CA (1)	CA2417475C (pl)
CR (1)	CR6895A (pl)
CZ (1)	CZ294956B6 (pl)
DE (1)	DE60102702T2 (pl)
DK (1)	DK1307457T3 (pl)
DZ (1)	DZ3397A1 (pl)
EA (1)	EA004920B1 (pl)
EC (1)	ECSP034460A (pl)
EE (1)	EE05183B1 (pl)
ES (1)	ES2220793T3 (pl)
FR (1)	FR2812635B1 (pl)
HK (1)	HK1060356A1 (pl)
HR (1)	HRP20030034B1 (pl)
HU (1)	HU226889B1 (pl)
IL (2)	IL154187A0 (pl)
MA (1)	MA26938A1 (pl)
ME (2)	ME00060B (pl)
MX (1)	MXPA03000881A (pl)
NO (1)	NO324940B1 (pl)
NZ (1)	NZ523707A (pl)
OA (1)	OA12347A (pl)
PL (2)	PL216028B1 (pl)
PT (1)	PT1307457E (pl)
RS (1)	RS50214B (pl)
SI (1)	SI1307457T1 (pl)
SK (1)	SK287597B6 (pl)
TR (1)	TR200400859T4 (pl)
TW (1)	TWI292401B (pl)
UA (1)	UA73791C2 (pl)
WO (1)	WO2002010172A1 (pl)
ZA (1)	ZA200300676B (pl)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2812635B1 (fr) *	2000-08-01	2002-10-11	Aventis Pharma Sa	Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) *	2002-01-28	2006-10-20	Aventis Pharma Sa	Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2844273B1 (fr) *	2002-09-05	2008-04-04	Aventis Pharma Sa	Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2848210B1 (fr) *	2002-12-06	2007-10-19	Aventis Pharma Sa	Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en) *	2002-12-06	2008-10-21	Novexel	Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
EP2308874B1 (en)	2005-12-07	2013-01-23	Basilea Pharmaceutica AG	Bridged monobactams useful as beta-lactamase inhibitors
EA017448B1 (ru)	2006-07-13	2012-12-28	Ачиллион Фармасьютикалз, Инк.	4-амино-4-оксобутаноиловые пептиды как ингибиторы вирусной репликации
EP2040698A4 (en) *	2006-07-14	2011-08-10	Shionogi & Co	OXIM CONNECTIONS AND ITS USE
WO2008039420A2 (en) *	2006-09-27	2008-04-03	Merck & Co., Inc.	Novel inhibitors of beta-lactamase
CN101589047A (zh) *	2006-10-23	2009-11-25	Irm责任有限公司	组织蛋白酶类抑制剂
WO2008093737A1 (ja)	2007-01-31	2008-08-07	Dainippon Sumitomo Pharma Co., Ltd.	アミド誘導体
FR2914923B1 (fr) *	2007-04-12	2013-06-14	Novexel	Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
US8563732B2 (en)	2007-05-31	2013-10-22	Shionogi & Co., Ltd.	Oxyimino compounds and the use thereof
FR2921060B1 (fr) *	2007-09-14	2012-06-15	Novexel	Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires
PL2666774T3 (pl) *	2008-01-18	2015-06-30	Merck Sharp & Dohme	Inhibitory beta-laktamazy
ES2408159T3 (es)	2008-06-11	2013-06-18	Shionogi & Co., Ltd.	Compuestos de oxicarbamoilo y su utilización
EP3260551A1 (en)	2008-06-19	2017-12-27	Astra Zeneca Holding France	Use of (1r,2s,5r) 1,6-diazabicyclo [3.2.1] octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, monosodium salt as a diagnostic reagent for detecting serine beta-lactamases
FR2936798B1 (fr) *	2008-10-03	2012-09-28	Novexel	Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr)	2008-10-10	2012-11-23	Novexel	Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
WO2010126820A2 (en) *	2009-04-30	2010-11-04	Merck Sharp & Dohme Corp.	Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
TWI461422B (zh)	2009-06-24	2014-11-21	Sumitomo Dainippon Pharma Co Ltd	Ｎ－取代－環狀胺基衍生物
FR2951171A1 (fr) *	2009-10-09	2011-04-15	Novexel	Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
US8772490B2 (en)	2010-12-22	2014-07-08	Meiji Seika Pharma Co., Ltd.	Optically active diazabicyclooctane derivatives and process for preparing the same
RU2591701C2 (ru) *	2010-12-22	2016-07-20	Мейдзи Сейка Фарма Ко., Лтд.	Оптически активное производное диазабициклооктана и способ его получения
CN103649051B (zh) *	2011-06-17	2016-04-13	阿斯利康(瑞典)有限公司	制备包括反-7-氧代-6-(磺基氧基)-1,6-二氮杂二环[3,2,1]辛烷-2-甲酰胺的杂环化合物及其盐的方法
AU2012303691B2 (en) *	2011-08-27	2014-06-19	Wockhardt Limited	1,6- diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
EP2872510B1 (en) *	2011-08-30	2016-11-23	Wockhardt Limited	1,6-diazabicyclo[3,2,1]octan-7-one derivatives and their use in the treatment of bacterial infections
US8969567B2 (en)	2011-09-13	2015-03-03	Wockhardt Ltd.	Nitrogen containing compounds and their use
CN103781787B (zh) *	2011-09-13	2015-09-23	沃克哈特有限公司	含氮化合物及其用途
US9505761B2 (en)	2011-12-02	2016-11-29	Fedora Pharmaceuticals Inc.	Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors
US8796257B2 (en)	2011-12-02	2014-08-05	Naeja Pharmaceutical Inc.	Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
MX2014011825A (es)	2012-03-30	2015-02-20	Cubist Pharm Inc	INHIBIDORES DE ISOXAZOL ß-LACTAMASA.
US8969570B2 (en)	2012-03-30	2015-03-03	Cubist Pharmaceuticals, Inc.	Beta-lactamase inhibitors
US8916709B2 (en)	2012-03-30	2014-12-23	Cubist Pharmaceuticals, Inc.	1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors
TW201343645A (zh)	2012-03-30	2013-11-01	Cubist Pharm Inc	１，３，４－□二唑及１，３，４－噻二唑β－內醯胺酶抑制劑
AR090539A1 (es) *	2012-04-02	2014-11-19	Astrazeneca Ab	COMPUESTOS INHIBIDORES DE b LACTAMASA
JP6265892B2 (ja)	2012-05-30	2018-01-24	ＭｅｉｊｉＳｅｉｋａファルマ株式会社	新規β−ラクタマーゼ阻害剤とその製造法
AU2013308127B2 (en) *	2012-08-25	2015-08-13	Wockhardt Limited	1,6- Diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections
WO2014069351A1 (ja)	2012-11-01	2014-05-08	株式会社カネカ	光学活性二環式ウレア化合物の製造方法
UA111925C2 (uk)	2012-12-11	2016-06-24	Федора Фармасьютікалз Інк.	БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ
US9512452B2 (en)	2013-02-19	2016-12-06	Api Corporation	L-lysine hydroxylase and production method for hydroxy-L-lysine and hydroxy-L-pipecolic acid using same
RU2632192C2 (ru) *	2013-03-08	2017-10-03	Вокхардт Лимитед	Способ получения натриевой соли (2s,5r)-2-карбоксамидо-7-оксо-6-сульфоокси-1,6-диазабицикло[3.2.1]октана
AU2013380572B2 (en) *	2013-03-08	2016-07-21	Wockhardt Limited	Sodium salt of (2S, 5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1 ] octane-2-carboxylic acid and its preparation
WO2014152996A1 (en)	2013-03-14	2014-09-25	Cubist Pharmaceuticals, Inc.	Crystalline form of a beta-lactamase inhibitor
MX362348B (es) *	2013-06-10	2019-01-11	Merck Sharp & Dohme	Preparacion de 4-((1r,2s,5r)-6-(benciloxi)-7-oxo-1,6-diazabiciclo[ 3.2.1]octano-2-carboxamido)piperidin-1-carboxilato de ter-butilo.
BR112016006246B8 (pt)	2013-09-24	2021-10-05	Meiji Seika Pharma Co Ltd	Processos de produção de derivados de diazabiciclo-octano e compostos intermediários dos mesmos
US9120796B2 (en)	2013-10-02	2015-09-01	Cubist Pharmaceuticals, Inc.	B-lactamase inhibitor picoline salt
DK3067355T3 (da)	2013-10-08	2021-01-04	Meiji Seika Pharma Co Ltd	Krystaller af diazabicyclooctanderivat og fremgangsmåde til fremstilling af krystaller af diazabicyclooctanderivat
MX2016004509A (es)	2013-10-11	2016-10-28	Wockhardt Ltd	Compuestos que contienen nitrogeno y su uso.
WO2015112441A1 (en)	2014-01-22	2015-07-30	Merck Sharp & Dohme Corp.	Metallo-beta-lactamase inhibitors
EP3139918B1 (en)	2014-05-09	2019-12-25	Merck Sharp & Dohme Corp.	Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
WO2016081452A1 (en) *	2014-11-17	2016-05-26	Entasis Therapeutics Limited	Combination therapy for treatment of resistant bacterial infections
WO2016089718A1 (en)	2014-12-02	2016-06-09	Merck Sharp & Dohme Corp.	Process for the preparation of tert-butyl 4-((2s,5r)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate and analogs thereof
AU2015355970B2 (en)	2014-12-05	2020-05-21	Meiji Seika Pharma Co., Ltd.	Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation
US10667737B2 (en)	2015-03-23	2020-06-02	International Business Machines Corporation	Monitoring a person for indications of a brain injury
WO2016177862A1 (en) *	2015-05-07	2016-11-10	Mutabilis	Heterocyclic compounds and their use in preventing or treating bacterial infections
EP3091018A1 (en) *	2015-05-07	2016-11-09	Mutabilis	Heterocyclic compounds and their use in preventing or treating bacterial infections
WO2016206101A1 (en)	2015-06-26	2016-12-29	Merck Sharp & Dohme Corp.	Metallo-beta-lactamase inhibitors
WO2017002089A1 (en)	2015-07-02	2017-01-05	Wockhardt Limited	Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002086A1 (en)	2015-07-02	2017-01-05	Wockhardt Limited	Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002087A1 (en)	2015-07-02	2017-01-05	Wockhardtlimited	Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002083A1 (en)	2015-07-02	2017-01-05	Wockhardt Limited	Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
ES2781458T3 (es) *	2015-08-10	2020-09-02	Sandoz Ag	Forma C de avibactam sódico
WO2017037607A1 (en)	2015-09-01	2017-03-09	Wockhardt Limited	(aminomethylidene)amino-substituted (2s,5r)-6-(sulfonyl)-7-oxo-1,6-diazabicyclo[3.2.1 ]octane-2-carboxamide derivatives with antibacterial activity
CN107531709B (zh)	2015-09-16	2020-10-23	吉林四环制药有限公司	β-内酰胺酶抑制剂及其用途
CA3000087A1 (en)	2015-10-02	2017-04-06	Legochem Biosciences, Inc.	Compositions and methods for inhibiting beta-lactamase
WO2017057730A1 (ja)	2015-10-02	2017-04-06	株式会社エーピーアイコーポレーション	ヒドロキシ－ｌ－ピペコリン酸の製造方法
WO2017081615A1 (en)	2015-11-09	2017-05-18	Wockhardt Limited	7-oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections
CN106749242B (zh) *	2015-11-23	2021-04-02	上海医药工业研究院	阿维巴坦中间体的制备方法
WO2017136254A1 (en)	2016-02-04	2017-08-10	Merck Sharp & Dohme Corp.	Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents
CN105753867B (zh) *	2016-03-24	2018-03-27	齐鲁制药有限公司	一种改进的阿维巴坦钠中间体化合物的制备方法
EP3156400B1 (en)	2016-05-27	2019-05-15	Valoralia I Más D, SL	Dihydrooxadiazine compounds for treating infections and cancer
CN106279163A (zh) *	2016-08-12	2017-01-04	上海龙翔生物医药开发有限公司	一种合成阿维巴坦及其中间体光学异构体的方法
KR102482826B1 (ko) *	2016-08-26	2022-12-28	산도즈 아게	아비박탐 유리 산
WO2018053215A1 (en)	2016-09-16	2018-03-22	Entasis Therapeutics Limited	Beta-lactamase inhibitor compounds
JOP20190061A1 (ar)	2016-09-28	2019-03-26	Novartis Ag	مثبطات بيتا-لاكتاماز
EP3301094A1 (en) *	2016-09-30	2018-04-04	Mutabilis	Heterocyclic compounds and their use in preventing or treating bacterial infections
CN106699756B (zh) *	2016-12-30	2019-10-29	淄博鑫泉医药技术服务有限公司	β内酰胺酶抑制剂阿维巴坦的合成方法
AU2018216243A1 (en) *	2017-02-06	2019-08-22	Mutabilis	Novel heterocyclic compounds and their use in preventing or treating bacterial infections
EP3630111B1 (en)	2017-05-08	2021-11-24	Entasis Therapeutics, Inc.	Compounds and methods for treating bacterial infections
US10085999B1 (en)	2017-05-10	2018-10-02	Arixa Pharmaceuticals, Inc.	Beta-lactamase inhibitors and uses thereof
WO2018234962A1 (en)	2017-06-20	2018-12-27	Wockhardt Limited	PROCESS FOR O-SULFONATION OF 1,6-DIAZABICYCLO [3.2.1] OCTANE COMPOUNDS
EP3654968B1 (en)	2017-07-17	2023-08-16	Merck Sharp & Dohme LLC	Metallo-beta-lactamase inhibitors and methods of use thereof
WO2019070595A1 (en)	2017-10-02	2019-04-11	Arixa Pharmaceuticals, Inc.	AZTREONAM DERIVATIVES AND USES THEREOF
CN109678856B (zh) *	2017-10-18	2020-09-25	新发药业有限公司	一种阿维巴坦中间体的制备方法
CN111373033A (zh)	2017-11-23	2020-07-03	豪夫迈·罗氏有限公司	脯氨酸羟化酶及其相关用途、方法和产品
CN109956941B (zh) *	2017-12-25	2020-08-04	新发药业有限公司	一种阿维巴坦的简便制备方法
US11905286B2 (en)	2018-08-09	2024-02-20	Antabio Sas	Diazabicyclooctanones as inhibitors of serine beta-lactamases
CA3114618C (en)	2018-10-01	2023-09-05	Arixa Pharmaceuticals, Inc.	Derivatives of relebactam and uses thereof
CN111072660B (zh) *	2018-10-22	2021-05-18	新发药业有限公司	一种瑞来巴坦的简便制备方法
JP2022524118A (ja)	2019-03-12	2022-04-27	アリクサファーマシューティカルズ、インコーポレイテッド	アビバクタム誘導体の結晶形
WO2020219258A1 (en)	2019-04-25	2020-10-29	Arixa Pharmaceuticals, Inc.	Methods of synthesizing aztreonam derivatives
CN110078728B (zh) *	2019-05-23	2020-10-23	江西富祥药业股份有限公司	一种阿维巴坦中间体、制备方法及其应用
WO2021106864A1 (en) *	2019-11-25	2021-06-03	Eisai R&D Management Co., Ltd.	Process for the preparation of producing pyrazolo[1,5-a] pyrimidine derivatives
US11814385B2 (en)	2021-06-25	2023-11-14	University Of South Florida	Small molecule inhibitors targeting Clostridioides difficile sporulation
WO2025027521A1 (en)	2023-08-01	2025-02-06	Fresenius Kabi Oncology Ltd.	An improved process for the preparation of avibactam and intermediate thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4939678B1 (pl) *	1968-05-06	1974-10-28
US4024147A (en) *	1972-06-30	1977-05-17	John Wyeth & Brother Limited	Heterocyclic compounds
US4049821A (en) *	1976-05-12	1977-09-20	A. H. Robins Company, Inc.	Method of treating allergy
JPS63119471A (ja) *	1986-09-02	1988-05-24	ザ・ユニバーシテイ・オブ・メルボルン	２−オキソ−４−カルボキシ−ピリミジン
EP0260057A3 (en) *	1986-09-02	1989-02-01	The University Of Melbourne	2-oxo-4-carboxy-pyrimidines
EP0737194B1 (en) *	1993-12-29	1999-03-03	Pfizer Inc.	Diazabicyclic neurokinin antagonists
TW358097B (en) *	1996-05-24	1999-05-11	Hoffmann La Roche	Beta-lactams and their process and pharmaceutical compositions
HUP0001741A3 (en) *	1996-08-02	2000-11-28	Smithkline Beecham Plc	Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
PL335161A1 (en) *	1997-02-10	2000-04-10	Pfizer Prod Inc	2-amino-6-(2-substituted-4-phenoxy)-substituted pyridines
US6060585A (en) *	1997-03-04	2000-05-09	Wisconsin Alumni Research Foundation	β-polypeptide foldamers of well-defined secondary structure
KR100207096B1 (ko) *	1997-07-08	1999-07-15	이명환	시사프라이드의 제조 방법
IL138969A0 (en) *	1998-04-20	2001-11-25	Fujisawa Pharmaceutical Co	Anthranilic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
GB9817029D0 (en) *	1998-08-05	1998-09-30	Smithkline Beecham Plc	Novel compounds
FR2784682B1 (fr) *	1998-10-15	2002-12-06	Hoechst Marion Roussel Inc	Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments
JP2002533454A (ja) *	1998-12-23	2002-10-08	イーライ・リリー・アンド・カンパニー	芳香族アミド類
CZ20012379A3 (cs) *	1999-01-02	2001-09-12	Aventis Pharma Deutschland Gmbh	Nové deriváty malonové kyseliny, způsoby jejich přípravy, použití a farmaceutické přípravky obsahující tyto deriváty (inhibitory aktivity faktoru Xa)
FR2812635B1 (fr) *	2000-08-01	2002-10-11	Aventis Pharma Sa	Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) *	2002-01-28	2006-10-20	Aventis Pharma Sa	Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases

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Also Published As

Publication number	Publication date
US8178554B2 (en)	2012-05-15
KR100632906B1 (ko)	2006-10-13
PT1307457E (pt)	2004-08-31
NO20030494D0 (no)	2003-01-31
NO20030494L (no)	2003-03-28
PL216028B1 (pl)	2014-02-28
MEP17108A (en)	2010-06-10
BRPI0112986B8 (pt)	2021-05-25
BR0112986B1 (pt)	2014-04-01
PL234468B1 (pl)	2020-02-28
NZ523707A (en)	2005-02-25
US20060046995A1 (en)	2006-03-02
CR6895A (es)	2007-07-12
EP1307457A1 (fr)	2003-05-07
JP2010138206A (ja)	2010-06-24
EE200300046A (et)	2004-10-15
TWI292401B (en)	2008-01-11
US7638529B2 (en)	2009-12-29
ATE263768T1 (de)	2004-04-15
ECSP034460A (es)	2003-03-10
MA26938A1 (fr)	2004-12-20
JP4515704B2 (ja)	2010-08-04
CN1289500C (zh)	2006-12-13
US7732610B2 (en)	2010-06-08
OA12347A (fr)	2006-05-15
WO2002010172A1 (fr)	2002-02-07
AU7990501A (en)	2002-02-13
ES2220793T3 (es)	2004-12-16
HK1060356A1 (en)	2004-08-06
DZ3397A1 (fr)	2002-02-07
IL154187A (en)	2009-02-11
BG66094B1 (bg)	2011-04-29
HU226889B1 (en)	2010-01-28
HRP20030034A2 (en)	2004-02-29
BG107497A (bg)	2003-09-30
AU2001279905B2 (en)	2005-12-08
CA2417475A1 (fr)	2002-02-07
US20030199541A1 (en)	2003-10-23
JP2004505088A (ja)	2004-02-19
IL154187A0 (en)	2003-07-31
RS50214B (sr)	2009-07-15
BR0112986A (pt)	2003-07-08
EP1307457B1 (fr)	2004-04-07
HUP0302943A3 (en)	2007-08-28
EA004920B1 (ru)	2004-10-28
YU6303A (sh)	2006-03-03
EE05183B1 (et)	2009-06-15
US20110021772A1 (en)	2011-01-27
SI1307457T1 (en)	2004-08-31
US20060189652A1 (en)	2006-08-24
CN1468242A (zh)	2004-01-14
TR200400859T4 (tr)	2004-06-21
KR20030019642A (ko)	2003-03-06
HRP20030034B1 (en)	2011-03-31
ME00060B (me)	2010-06-10
DK1307457T3 (da)	2004-08-09
US20110213147A1 (en)	2011-09-01
MXPA03000881A (es)	2003-06-06
CA2417475C (en)	2010-04-20
ZA200300676B (en)	2004-05-10
SK287597B6 (sk)	2011-03-04
HUP0302943A2 (hu)	2003-12-29
CZ2003223A3 (cs)	2003-08-13
SK1052003A3 (en)	2003-11-04
FR2812635B1 (fr)	2002-10-11
PL365162A1 (pl)	2004-12-27
CZ294956B6 (cs)	2005-04-13
FR2812635A1 (fr)	2002-02-08
AP2003002726A0 (en)	2003-06-30
AP1614A (en)	2006-05-21
AR031716A1 (es)	2003-10-01
UA73791C2 (uk)	2005-09-15
EA200300211A1 (ru)	2003-06-26
DE60102702D1 (de)	2004-05-13
US7112592B2 (en)	2006-09-26
DE60102702T2 (de)	2005-04-07
NO324940B1 (no)	2008-01-07

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DE60134371D1 (de)	2008-07-24	Spiralkontaktor und dessen Herstellungsmethode
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CY2013011I1 (el)	2015-08-05	Μεθοδος χορηγησης διφωσφονικων
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EE200200470A (et)	2003-12-15	Uued ühendid, meetod nende valmistamiseks ning nende kasutamine
DE60139930D1 (de)	2009-10-29	Desinfizieruns- und desodorierungsverfahren
EE05149B1 (et)	2009-04-15	Biarlkarboksamiidid, meetod nende valmistamiseks, neid sisaldav ravimkoostis ning nende kasutamine ravis
DE60225385D1 (de)	2008-04-17	Autentisches Document und dessen Herstellungsverfahren
EE200300103A (et)	2005-02-15	Kontratseptsioonimeetod ja kontratseptiivi manustatav vorm
NO20025227L (no)	2002-10-31	Tropanderivater nyttige i terapi
ID28997A (id)	2001-07-26	Kedok sekali pakai, dan proses pembuatannya
DE60023103D1 (de)	2006-02-23	Lüfter und dessen Herstellungverfahren
EE04490B1 (et)	2005-06-15	Ühend, selle valmistamise meetod ning kasutamine meditsiinis
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EE200200697A (et)	2004-08-16	Uued ühendid, meetod nende valmistamiseks ning nende kasutamine
NO20030156D0 (no)	2003-01-13	Farmasöytiske sammensetninger og fremgangsmåter for anvendelse derav
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FI20000194A0 (fi)	2000-01-31	Menetelmä kaupankäynnissä
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