PL376475A1 - Pochodne N-podstawionej 2-oksodihydropirydyny - Google Patents

Pochodne N-podstawionej 2-oksodihydropirydyny

Info

Publication number: PL376475A1
Authority: PL; Poland
Prior art keywords: oxodihydropyridine; derivatives; substituted; oxodihydropyridine derivatives
Prior art date: 2002-09-30

Application number

PL03376475A

Other languages

English (en)

Inventor

Nagaaki Sato

Makoto Ando

Shiho Ishikawa

Tsuyoshi Nagase

Keita Nagai

Akio Kanatani

Original Assignee

Banyu Pharmaceutical Co, Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-30

Filing date

2003-09-25

Publication date

2005-12-27

2003-09-25 Application filed by Banyu Pharmaceutical Co, Ltd. filed Critical Banyu Pharmaceutical Co, Ltd.

2005-12-27 Publication of PL376475A1 publication Critical patent/PL376475A1/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL03376475A 2002-09-30 2003-09-25 Pochodne N-podstawionej 2-oksodihydropirydyny PL376475A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2002287015		2002-09-30
JP2002353202		2002-12-05

Publications (1)

Publication Number	Publication Date
PL376475A1 true PL376475A1 (pl)	2005-12-27

Family

ID=32072466

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL03376475A PL376475A1 (pl)	2002-09-30	2003-09-25	Pochodne N-podstawionej 2-oksodihydropirydyny

Country Status (17)

Country	Link
US (2)	US6869966B2 (pl)
EP (1)	EP1546133B1 (pl)
KR (1)	KR20050059217A (pl)
CN (1)	CN100528864C (pl)
AR (1)	AR041374A1 (pl)
AT (1)	ATE461191T1 (pl)
AU (1)	AU2003273522B2 (pl)
BR (1)	BR0314965A (pl)
CA (2)	CA2497237C (pl)
DE (1)	DE60331751D1 (pl)
MX (1)	MXPA05003293A (pl)
NO (1)	NO20052106L (pl)
PE (1)	PE20050087A1 (pl)
PL (1)	PL376475A1 (pl)
RU (1)	RU2005113310A (pl)
TW (1)	TW200407138A (pl)
WO (1)	WO2004031175A2 (pl)

Families Citing this family (39)

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US20040242566A1 (en) *	2003-03-25	2004-12-02	Syrrx, Inc.	Dipeptidyl peptidase inhibitors
RU2006107553A (ru) *	2003-08-13	2007-09-20	Такеда Фармасьютикал Компани Лимитед (Jp)	Производные 4-пиримидона и их применение в качестве ингибиторов пептидилпептидаз
US7169926B1 (en)	2003-08-13	2007-01-30	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
US7678909B1 (en)	2003-08-13	2010-03-16	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
EP1699777B1 (en) *	2003-09-08	2012-12-12	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
WO2005030751A2 (en) *	2003-09-08	2005-04-07	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
FR2861302A1 (fr) *	2003-10-24	2005-04-29	Sanofi Synthelabo	Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique.
FR2861303A1 (fr) *	2003-10-24	2005-04-29	Sanofi Synthelabo	Utilisation d'un derive de pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique
FR2861301B1 (fr) *	2003-10-24	2008-07-11	Sanofi Synthelabo	Utilisation du derive du pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique.
FR2861300B1 (fr) *	2003-10-24	2008-07-11	Sanofi Synthelabo	Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique
US7732446B1 (en)	2004-03-11	2010-06-08	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
EA013427B1 (ru) *	2004-03-15	2010-04-30	Такеда Фармасьютикал Компани Лимитед	Ингибиторы дипептидилпептидазы
US7838552B2 (en)	2004-06-04	2010-11-23	Forest Laboratories Holdings Limited	Compositions comprising nebivolol
US7803838B2 (en)	2004-06-04	2010-09-28	Forest Laboratories Holdings Limited	Compositions comprising nebivolol
EP1753730A1 (en) *	2004-06-04	2007-02-21	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
JP4675586B2 (ja) *	2004-06-23	2011-04-27	壽製薬株式会社	高血圧症及び血清高尿酸血症の重複発症の治療のための薬剤
WO2006019965A2 (en)	2004-07-16	2006-02-23	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
EP1828192B1 (en) *	2004-12-21	2014-12-03	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
EP1942898B2 (en) *	2005-09-14	2014-05-14	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors for treating diabetes
HRP20140091T4 (hr) *	2005-09-14	2021-12-24	Takeda Pharmaceutical Company Limited	Davanje inhibitora dipeptidil peptidaze
TW200745079A (en) *	2005-09-16	2007-12-16	Takeda Pharmaceuticals Co	Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
CN101360723A (zh) *	2005-09-16	2009-02-04	武田药品工业株式会社	制备嘧啶二酮衍生物的方法
TW200745080A (en) *	2005-09-16	2007-12-16	Takeda Pharmaceuticals Co	Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
EP1940842B1 (en)	2005-09-29	2012-05-30	Merck Sharp & Dohme Corp.	Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
JP2009531456A (ja) *	2006-03-28	2009-09-03	武田薬品工業株式会社	（ｒ）−３−アミノピペリジン二塩酸塩の調製
WO2007112347A1 (en)	2006-03-28	2007-10-04	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
WO2007115967A1 (en) *	2006-04-12	2007-10-18	F. Hoffmann-La Roche Ag	Crystalline isopropanol solvate of glucokinase activator
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
EP2083831B1 (en)	2006-09-22	2013-12-25	Merck Sharp & Dohme Corp.	Method of treatment using fatty acid synthesis inhibitors
TW200838536A (en) *	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
AU2008233662B2 (en)	2007-04-02	2012-08-23	Msd K.K.	Indoledione derivative
CN102272103B (zh)	2008-10-30	2015-10-21	默沙东公司	异烟酰胺食欲素受体拮抗剂
AR088352A1 (es)	2011-10-19	2014-05-28	Merck Sharp & Dohme	Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
TWI762806B (zh) *	2014-04-09	2022-05-01	美商建南德克公司	作為ｅｒｋ抑制劑之化合物
CN112047889A (zh) *	2018-11-30	2020-12-08	华南农业大学	一种n-二氟甲基杂芳烃并咪唑硫脲衍生物的制备方法
TW202045476A (zh)	2019-02-13	2020-12-16	美商默沙東藥廠	5-烷基吡咯啶食慾素受體促效劑
WO2021026047A1 (en)	2019-08-08	2021-02-11	Merck Sharp & Dohme Corp.	Heteroaryl pyrrolidine and piperidine orexin receptor agonists
CA3189908A1 (en)	2020-08-18	2022-02-24	Stephane L. Bogen	Bicycloheptane pyrrolidine orexin receptor agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH234887A (de) *	1942-12-11	1944-10-31	Ag J R Geigy	Verfahren zur Herstellung von N-Cyclohexyl-6-pyridon-3-carbonsäurediäthylamid.
CZ403592A3 (en) *	1992-02-20	1993-12-15	Hoechst Ag	Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use
AU757290B2 (en)	1998-03-25	2003-02-13	Bristol-Myers Squibb Company	Imidazolone anorectic agents: II. phenyl derivatives
WO2001062738A1 (fr)	2000-02-22	2001-08-30	Banyu Pharmaceutical Co., Ltd.	Composes a base d'imidazoline

2003
- 2003-08-15 US US10/641,017 patent/US6869966B2/en not_active Expired - Fee Related
- 2003-09-17 TW TW092125570A patent/TW200407138A/zh unknown
- 2003-09-22 PE PE2003000968A patent/PE20050087A1/es not_active Application Discontinuation
- 2003-09-24 AR ARP030103473A patent/AR041374A1/es unknown
- 2003-09-25 AT AT03755682T patent/ATE461191T1/de not_active IP Right Cessation
- 2003-09-25 CA CA2497237A patent/CA2497237C/en not_active Expired - Fee Related
- 2003-09-25 KR KR1020057005511A patent/KR20050059217A/ko not_active Application Discontinuation
- 2003-09-25 CN CNB038233398A patent/CN100528864C/zh not_active Expired - Fee Related
- 2003-09-25 BR BR0314965-0A patent/BR0314965A/pt not_active Application Discontinuation
- 2003-09-25 PL PL03376475A patent/PL376475A1/pl not_active Application Discontinuation
- 2003-09-25 MX MXPA05003293A patent/MXPA05003293A/es unknown
- 2003-09-25 EP EP03755682A patent/EP1546133B1/en not_active Expired - Lifetime
- 2003-09-25 CA CA2726754A patent/CA2726754C/en not_active Expired - Fee Related
- 2003-09-25 DE DE60331751T patent/DE60331751D1/de not_active Expired - Lifetime
- 2003-09-25 RU RU2005113310/04A patent/RU2005113310A/ru not_active Application Discontinuation
- 2003-09-25 WO PCT/JP2003/012290 patent/WO2004031175A2/en active Application Filing
- 2003-09-25 AU AU2003273522A patent/AU2003273522B2/en not_active Ceased
2004
- 2004-07-27 US US10/899,162 patent/US7138525B2/en not_active Expired - Fee Related
2005
- 2005-04-29 NO NO20052106A patent/NO20052106L/no unknown

Also Published As

Publication number	Publication date
WO2004031175A2 (en)	2004-04-15
PE20050087A1 (es)	2005-02-22
CN1684954A (zh)	2005-10-19
US20050009879A1 (en)	2005-01-13
BR0314965A (pt)	2005-08-02
US20040072874A1 (en)	2004-04-15
US6869966B2 (en)	2005-03-22
AU2003273522B2 (en)	2009-05-21
EP1546133A2 (en)	2005-06-29
ATE461191T1 (de)	2010-04-15
CA2726754A1 (en)	2004-04-15
MXPA05003293A (es)	2005-10-18
NO20052106L (no)	2005-04-29
KR20050059217A (ko)	2005-06-17
AU2003273522A1 (en)	2004-04-23
RU2005113310A (ru)	2005-11-10
WO2004031175A3 (en)	2005-02-24
US7138525B2 (en)	2006-11-21
CA2726754C (en)	2013-04-02
AR041374A1 (es)	2005-05-11
CA2497237A1 (en)	2004-04-15
CN100528864C (zh)	2009-08-19
CA2497237C (en)	2011-03-29
TW200407138A (en)	2004-05-16
EP1546133B1 (en)	2010-03-17
DE60331751D1 (de)	2010-04-29

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Legal Events

Date	Code	Title	Description
2012-04-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)