PL373400A1 - Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) - Google Patents

Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr)

Info

Publication number: PL373400A1
Authority: PL; Poland
Prior art keywords: gpcr; ligands; protein coupled; coupled receptors; tetrahydrocarbozole
Prior art date: 2001-12-14

Application number

PL02373400A

Other languages

Polish (pl)

Inventor

Marcus Koppitz

Hans Peter Muhn

Ken Shaw

Holger Hess-Stumpp

Klaus Paulini

Original Assignee

Zentaris Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-14

Filing date

2002-12-16

Publication date

2005-08-22

2001-12-14 Priority claimed from DE10164564A external-priority patent/DE10164564B4/en

2002-12-16 Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh

2005-08-22 Publication of PL373400A1 publication Critical patent/PL373400A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Crystallography & Structural Chemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pregnancy & Childbirth (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL02373400A 2001-12-14 2002-12-16 Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) PL373400A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10164564A DE10164564B4 (en)	2001-12-14	2001-12-14	Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCR)
US34187801P	2001-12-21	2001-12-21

Publications (1)

Publication Number	Publication Date
PL373400A1 true PL373400A1 (en)	2005-08-22

Family

ID=26010882

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL02373400A PL373400A1 (en)	2001-12-14	2002-12-16	Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr)

Country Status (17)

Country	Link
EP (1)	EP1453803A2 (en)
JP (1)	JP2005518375A (en)
CN (1)	CN100500654C (en)
AR (1)	AR037863A1 (en)
AU (1)	AU2002361430B2 (en)
BR (1)	BR0214958A (en)
CA (1)	CA2468880A1 (en)
HR (1)	HRP20040609A2 (en)
HU (1)	HUP0500014A3 (en)
IL (2)	IL161626A0 (en)
MX (1)	MXPA04005768A (en)
NO (1)	NO326692B1 (en)
NZ (1)	NZ533430A (en)
PL (1)	PL373400A1 (en)
RU (1)	RU2319692C2 (en)
TW (1)	TWI246423B (en)
WO (1)	WO2003051837A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1638551T1 (en) *	2003-05-19	2012-04-30	Irm Llc	Immunosuppressant compounds and compositions
DE602004017326D1 (en) *	2003-06-10	2008-12-04	Smithkline Beecham Corp	TETRAHYDROCARBAZOL DERIVATIVES AND THEIR PHARMACEUTICAL USE
ES2530972T3 (en) *	2003-09-12	2015-03-09	Elixir Pharmaceuticals Inc	Methods of treatment of disorders
US20060074124A1 (en) *	2003-09-12	2006-04-06	Andrew Napper	Methods of treating a disorder
DE102004033902A1 (en) *	2004-07-14	2006-02-16	Zentaris Gmbh	New tetrahydrocarbazole compounds are neurokinin-1 receptor antagonists useful to treat or prevent e.g. pubertas praecox, hirsutism, polycystic ovary syndrome, hormone dependent neoplastic diseases and Alzheimer's disease
PT1833791E (en) *	2004-12-27	2011-10-19	Actelion Pharmaceuticals Ltd	2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists
EP1902026B1 (en) *	2005-06-24	2010-02-17	Eli Lilly And Company	Tetrahydrocarbazole derivatives useful as androgen receptor modulators (sarm)
SI2051962T1 (en) *	2006-08-07	2012-02-29	Actelion Pharmaceuticals Ltd	(3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
EP1967202A1 (en) *	2007-03-05	2008-09-10	AEterna Zentaris GmbH	Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity
EP1988098A1 (en)	2007-04-27	2008-11-05	AEterna Zentaris GmbH	Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
EP2095818A1 (en)	2008-02-29	2009-09-02	AEterna Zentaris GmbH	Use of LHRH antagonists at non-castrating doses
CN102791689B (en)	2010-03-22	2014-10-29	埃科特莱茵药品有限公司	3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin D2 receptor modulators
SG193902A1 (en)	2011-04-14	2013-11-29	Actelion Pharmaceuticals Ltd	7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators
MY179356A (en)	2014-03-17	2020-11-05	Idorsia Pharmaceuticals Ltd	Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
WO2015140701A1 (en)	2014-03-18	2015-09-24	Actelion Pharmaceuticals Ltd	Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
CA2993893A1 (en)	2015-09-15	2017-03-23	Idorsia Pharmaceuticals Ltd	Crystalline forms

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1418703A (en) *	1973-06-02	1975-12-24	Pfizer Ltd	3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles
EP0239306B1 (en) *	1986-03-27	1993-06-02	Merck Frosst Canada Inc.	Tetrahydrocarbazole esters
US5607939A (en) *	1994-04-28	1997-03-04	Takeda Chemical Industries, Ltd.	Condensed heterocyclic compounds, their production and use
AU728988B2 (en) *	1997-06-05	2001-01-25	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone

2002
- 2002-12-16 CN CNB028241487A patent/CN100500654C/en not_active Expired - Fee Related
- 2002-12-16 TW TW091136440A patent/TWI246423B/en not_active IP Right Cessation
- 2002-12-16 JP JP2003552724A patent/JP2005518375A/en active Pending
- 2002-12-16 EP EP02796648A patent/EP1453803A2/en not_active Withdrawn
- 2002-12-16 NZ NZ533430A patent/NZ533430A/en unknown
- 2002-12-16 CA CA002468880A patent/CA2468880A1/en not_active Abandoned
- 2002-12-16 PL PL02373400A patent/PL373400A1/en not_active Application Discontinuation
- 2002-12-16 MX MXPA04005768A patent/MXPA04005768A/en active IP Right Grant
- 2002-12-16 HU HU0500014A patent/HUP0500014A3/en unknown
- 2002-12-16 IL IL16162602A patent/IL161626A0/en unknown
- 2002-12-16 WO PCT/EP2002/014344 patent/WO2003051837A2/en active Application Filing
- 2002-12-16 AU AU2002361430A patent/AU2002361430B2/en not_active Ceased
- 2002-12-16 BR BR0214958-3A patent/BR0214958A/en not_active IP Right Cessation
- 2002-12-16 RU RU2004121776/04A patent/RU2319692C2/en not_active IP Right Cessation
- 2002-12-17 AR ARP020104893A patent/AR037863A1/en unknown
2004
- 2004-05-26 NO NO20042198A patent/NO326692B1/en not_active IP Right Cessation
- 2004-07-05 HR HR20040609A patent/HRP20040609A2/en not_active Application Discontinuation
2008
- 2008-07-23 IL IL192991A patent/IL192991A0/en unknown

Also Published As

Publication number	Publication date
WO2003051837A8 (en)	2004-05-06
CN100500654C (en)	2009-06-17
IL161626A0 (en)	2004-09-27
HUP0500014A3 (en)	2010-06-28
HRP20040609A2 (en)	2005-06-30
MXPA04005768A (en)	2004-09-10
EP1453803A2 (en)	2004-09-08
BR0214958A (en)	2004-12-28
NO326692B1 (en)	2009-02-02
AU2002361430A1 (en)	2003-06-30
AR037863A1 (en)	2004-12-09
HUP0500014A2 (en)	2005-04-28
TW200305405A (en)	2003-11-01
JP2005518375A (en)	2005-06-23
WO2003051837A2 (en)	2003-06-26
RU2319692C2 (en)	2008-03-20
TWI246423B (en)	2006-01-01
CA2468880A1 (en)	2003-06-26
WO2003051837A3 (en)	2004-02-26
NO20042198L (en)	2004-07-09
AU2002361430B2 (en)	2007-09-13
RU2004121776A (en)	2005-05-10
NZ533430A (en)	2005-12-23
CN1599720A (en)	2005-03-23
IL192991A0 (en)	2011-08-01

Publication	Publication Date	Title
IL161626A0 (en)	2004-09-27	Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr)
AU2001268471A1 (en)	2002-01-02	G-protein coupled receptors
AU2003227909A1 (en)	2003-11-17	Imidazo-triazine derivatives as ligands for gaba receptors
AU2001234766A1 (en)	2001-08-14	G-protein coupled receptors
AU2001280785A1 (en)	2002-02-13	G-protein coupled receptors
DE10164564B4 (en)	2007-05-16	Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCR)
AU4439801A (en)	2001-10-23	Pyrazolo-triazine derivatives as ligands for gaba receptors
AU2001238178A1 (en)	2001-08-20	Seven-transmembrane proteins/g-protein coupled receptors
AU2001240097A1 (en)	2001-09-17	G protein-coupled receptors
AU2001251175A1 (en)	2001-10-08	G-protein coupled receptors
AU2001296444A1 (en)	2002-04-08	G-protein coupled receptors
AU2001261814A1 (en)	2001-12-03	G-protein coupled receptors
AU2001249922A1 (en)	2001-10-23	G protein-coupled receptors
AU2002235543A1 (en)	2002-03-04	Imidazolophthalazine derivatives as ligands for gabaa receptors
AU2002327615A1 (en)	2003-03-24	G-protein coupled receptors
AU2002254466A1 (en)	2002-10-15	G-protein coupled receptors
AU2001259322A1 (en)	2001-11-12	G protein-coupled receptors
AU2002316366A1 (en)	2003-01-08	G-protein coupled receptors
AU2002308498A8 (en)	2006-11-02	G-protein coupled receptors
AU2003229884A1 (en)	2003-10-27	Imidazo-pyridine derivatives as ligands for gaba receptors
AU2003259974A8 (en)	2004-03-11	G-protein coupled receptors
AU2002307903A1 (en)	2002-11-11	G-protein coupled receptor
AU2003219312A1 (en)	2003-10-27	Imidazo-pyridine derivatives as ligands for gaba receptors
EP1463941A4 (en)	2006-04-26	Novel g-protein coupled receptors
GB0223399D0 (en)	2002-11-13	Receptors

Legal Events

Date	Code	Title	Description
2010-08-31	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)