PL352827A1 - Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants - Google Patents

Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants

Info

Publication number: PL352827A1
Authority: PL; Poland
Prior art keywords: pyrymidinones; anticoagulants; heteroaryl; useful; polycyclic aryl
Prior art date: 1999-05-19

Application number

PL00352827A

Other languages

Polish (pl)

Inventor

Michael S. South

Ashton T.II Hamme

William Neumann

Darin E. Jones

Melvin L. Rueppel

Original Assignee

Pharmacia Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-19

Filing date

2000-05-17

Publication date

2003-09-08

2000-05-17 Application filed by Pharmacia Corporation filed Critical Pharmacia Corporation

2003-09-08 Publication of PL352827A1 publication Critical patent/PL352827A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

PL00352827A 1999-05-19 2000-05-17 Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants PL352827A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13479499P	1999-05-19	1999-05-19
PCT/US2000/009806 WO2000069832A1 (en)	1999-05-19	2000-05-17	Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants

Publications (1)

Publication Number	Publication Date
PL352827A1 true PL352827A1 (en)	2003-09-08

Family

ID=22465042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL00352827A PL352827A1 (en)	1999-05-19	2000-05-17	Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants

Country Status (22)

Country	Link
EP (1)	EP1178970A1 (en)
JP (1)	JP2002544262A (en)
KR (1)	KR20010114271A (en)
CN (1)	CN1157380C (en)
AR (1)	AR030021A1 (en)
AU (2)	AU771718B2 (en)
BR (1)	BR0010758A (en)
CA (1)	CA2373614A1 (en)
CZ (1)	CZ20014116A3 (en)
EA (1)	EA004867B1 (en)
HU (1)	HUP0201242A3 (en)
IL (1)	IL146243A0 (en)
MX (1)	MXPA01011804A (en)
NO (1)	NO20015604L (en)
NZ (1)	NZ514874A (en)
PE (1)	PE20010229A1 (en)
PL (1)	PL352827A1 (en)
SK (1)	SK15852001A3 (en)
TW (1)	TWI222445B (en)
UY (1)	UY26156A1 (en)
WO (1)	WO2000069832A1 (en)
ZA (2)	ZA200109339B (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6653316B1 (en)	1999-05-19	2003-11-25	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6750342B1 (en)	1999-05-19	2004-06-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en)	1999-05-19	2005-03-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
MXPA01011806A (en) *	1999-05-19	2003-09-04	Pharmacia Corp	Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents.
US7015230B1 (en)	1999-05-19	2006-03-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6664255B1 (en)	1999-05-19	2003-12-16	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en)	1999-05-19	2004-04-06	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6458952B1 (en)	1999-05-19	2002-10-01	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6852761B2 (en)	2000-03-13	2005-02-08	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
WO2001077079A2 (en)	2000-04-05	2001-10-18	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
AU2001249870A1 (en)	2000-04-05	2001-10-23	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
AU2001253363A1 (en)	2000-04-17	2001-10-30	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
WO2001087851A1 (en) *	2000-05-18	2001-11-22	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6710058B2 (en)	2000-11-06	2004-03-23	Bristol-Myers Squibb Pharma Company	Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
JP2004517074A (en)	2000-11-20	2004-06-10	ファルマシア・コーポレーション	Substituted polycyclic aryl and heteroaryl pyridines useful for selectively inhibiting the coagulation cascade
US7015223B1 (en)	2000-11-20	2006-03-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
US7119094B1 (en)	2000-11-20	2006-10-10	Warner-Lambert Company	Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
BR0213099A (en)	2001-10-03	2004-10-19	Pharmacia Corp	Substituted 5-membered polycyclic compounds useful for selective inhibition of coagulation cascade
MXPA04003167A (en) *	2001-10-03	2004-07-08	Pharmacia Corp	6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade.
MXPA04003163A (en)	2001-10-03	2004-07-08	Pharmacia Corp	6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade.
WO2003072107A1 (en) *	2002-02-22	2003-09-04	Pharmacia & Upjohn Company	Substituted pyrimidinones and pyrimidinthiones
TW200307667A (en)	2002-05-06	2003-12-16	Bristol Myers Squibb Co	Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
US7217794B2 (en)	2003-04-02	2007-05-15	Daiamed, Inc.	Compounds and methods for treatment of thrombosis
US7182738B2 (en)	2003-04-23	2007-02-27	Marctec, Llc	Patient monitoring apparatus and method for orthosis and other devices
WO2006133242A2 (en) *	2005-06-07	2006-12-14	Pharmacopeia, Inc.	Azinone and diazinone v3 inhibitors for depression and stress disorders
CN104311537B (en) *	2014-09-19	2016-08-24	广东东阳光药业有限公司	Containing pyrimidone acetyl substituents pyrazole compound and combinations thereof thing and purposes
CN115779953B (en) *	2022-12-19	2024-06-21	中南大学	Copper-loaded carbon-based monoatomic material, and preparation method and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5441960A (en) *	1992-04-16	1995-08-15	Zeneca Limited	1-pyrimidinylacetamide human leukocyte elastate inhibitors
US5948785A (en) *	1995-04-27	1999-09-07	The Green Cross Corporation	Heterocyclic amide compounds and pharmaceutical use of the same

2000
- 2000-05-17 HU HU0201242A patent/HUP0201242A3/en unknown
- 2000-05-17 CZ CZ20014116A patent/CZ20014116A3/en unknown
- 2000-05-17 EP EP00931928A patent/EP1178970A1/en not_active Withdrawn
- 2000-05-17 SK SK1585-2001A patent/SK15852001A3/en unknown
- 2000-05-17 MX MXPA01011804A patent/MXPA01011804A/en unknown
- 2000-05-17 IL IL14624300A patent/IL146243A0/en unknown
- 2000-05-17 JP JP2000618249A patent/JP2002544262A/en active Pending
- 2000-05-17 KR KR1020017014753A patent/KR20010114271A/en not_active Application Discontinuation
- 2000-05-17 EA EA200101214A patent/EA004867B1/en not_active IP Right Cessation
- 2000-05-17 PL PL00352827A patent/PL352827A1/en not_active Application Discontinuation
- 2000-05-17 AU AU49734/00A patent/AU771718B2/en not_active Ceased
- 2000-05-17 CA CA002373614A patent/CA2373614A1/en not_active Abandoned
- 2000-05-17 NZ NZ514874A patent/NZ514874A/en unknown
- 2000-05-17 WO PCT/US2000/009806 patent/WO2000069832A1/en not_active Application Discontinuation
- 2000-05-17 CN CNB008077479A patent/CN1157380C/en not_active Expired - Fee Related
- 2000-05-17 BR BR0010758-1A patent/BR0010758A/en not_active IP Right Cessation
- 2000-05-19 AR ARP000102446A patent/AR030021A1/en unknown
- 2000-05-19 UY UY26156A patent/UY26156A1/en not_active Application Discontinuation
- 2000-06-09 PE PE2000000575A patent/PE20010229A1/en not_active Application Discontinuation
- 2000-07-25 TW TW089109595A patent/TWI222445B/en not_active IP Right Cessation
2001
- 2001-11-13 ZA ZA200109339A patent/ZA200109339B/en unknown
- 2001-11-16 NO NO20015604A patent/NO20015604L/en not_active Application Discontinuation
2004
- 2004-01-21 ZA ZA200400448A patent/ZA200400448B/en unknown
- 2004-05-31 AU AU2004202375A patent/AU2004202375A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ZA200109339B (en)	2004-05-26
NO20015604L (en)	2002-01-11
BR0010758A (en)	2003-06-10
EA004867B1 (en)	2004-08-26
NZ514874A (en)	2004-11-26
JP2002544262A (en)	2002-12-24
IL146243A0 (en)	2002-07-25
AR030021A1 (en)	2003-08-13
EP1178970A1 (en)	2002-02-13
AU771718B2 (en)	2004-04-01
SK15852001A3 (en)	2003-06-03
TWI222445B (en)	2004-10-21
AU2004202375A1 (en)	2004-06-24
ZA200400448B (en)	2004-09-29
NO20015604D0 (en)	2001-11-16
PE20010229A1 (en)	2001-03-07
MXPA01011804A (en)	2003-09-04
HUP0201242A2 (en)	2002-12-28
HUP0201242A3 (en)	2003-02-28
WO2000069832A1 (en)	2000-11-23
CN1157380C (en)	2004-07-14
EA200101214A1 (en)	2002-06-27
CN1351593A (en)	2002-05-29
KR20010114271A (en)	2001-12-31
UY26156A1 (en)	2000-12-29
CA2373614A1 (en)	2000-11-23
CZ20014116A3 (en)	2002-06-12
AU4973400A (en)	2000-12-05

Publication	Publication Date	Title
IL146243A0 (en)	2002-07-25	Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants
IL131195A0 (en)	2001-01-28	Remote laboratory
AU4145200A (en)	2000-11-21	Cyclic compounds and uses thereof
GB9923894D0 (en)	1999-12-08	Accelerometer
EP1223932A4 (en)	2003-01-15	Compounds and methods
EP1146790A4 (en)	2004-03-17	Compounds and methods
ZA200109338B (en)	2004-05-26	Substituted polycyclic aryl and heteroaryl uracils as anti-coagulative agents.
HK1045312A1 (en)	2002-11-22	Cyclic compound
GB0000276D0 (en)	2000-03-01	Capacitor
PL353372A1 (en)	2003-11-17	Substituted heterocyclyl-2h-chromenes
IL150200A0 (en)	2002-12-01	Substituted pyrroles
GB9922942D0 (en)	1999-12-01	Catch
GB9911456D0 (en)	1999-07-14	Oligohydroxyl substituted 3-urea-benzofurane-and-pyridofurane-derivatives
GB9922530D0 (en)	1999-11-24	Distractor
PL352101A1 (en)	2003-07-28	Substituted phenylcyclohexanocarboxyamides
GB9929107D0 (en)	2000-02-02	Window component etc
GB9921851D0 (en)	1999-11-17	Structural elements
GB9929433D0 (en)	2000-02-09	Cyclic compound
GB2357543B (en)	2003-12-31	Structural members
HU0000970D0 (en)	2000-05-28	Rapid fastening set
GB9905450D0 (en)	1999-05-05	Crane
AU139821S (en)	2000-02-18	Height chart
PL332520A1 (en)	2000-10-23	Organomineral sorbent
GB9927083D0 (en)	2000-01-12	Rodenticides
GB9929538D0 (en)	2000-02-09	Rodenticides

Legal Events

Date	Code	Title	Description
2007-11-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)