[go: up one dir, main page]

PL3330370T3 - Sposób hodowania komórek cho - Google Patents

Sposób hodowania komórek cho

Info

Publication number
PL3330370T3
PL3330370T3 PL17199357T PL17199357T PL3330370T3 PL 3330370 T3 PL3330370 T3 PL 3330370T3 PL 17199357 T PL17199357 T PL 17199357T PL 17199357 T PL17199357 T PL 17199357T PL 3330370 T3 PL3330370 T3 PL 3330370T3
Authority
PL
Poland
Prior art keywords
cultivation
cho cells
cho
cells
Prior art date
Application number
PL17199357T
Other languages
English (en)
Inventor
Christoph E. Joosten
Christian Leist
Jörg Schmidt
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44041460&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3330370(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL3330370T3 publication Critical patent/PL3330370T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/60Buffer, e.g. pH regulation, osmotic pressure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00Culture process characterised by temperature

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
PL17199357T 2010-04-26 2011-04-25 Sposób hodowania komórek cho PL3330370T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32784610P 2010-04-26 2010-04-26
PCT/EP2011/056507 WO2011134919A2 (en) 2010-04-26 2011-04-25 Improved cell cultivation process
EP17199357.9A EP3330370B1 (en) 2010-04-26 2011-04-25 Process for cultivation of cho cells
EP11715933.5A EP2563906B1 (en) 2010-04-26 2011-04-25 Process for cultivation of cho cells

Publications (1)

Publication Number Publication Date
PL3330370T3 true PL3330370T3 (pl) 2021-09-20

Family

ID=44041460

Family Applications (2)

Application Number Title Priority Date Filing Date
PL11715933T PL2563906T3 (pl) 2010-04-26 2011-04-25 Sposób hodowli komórek cho
PL17199357T PL3330370T3 (pl) 2010-04-26 2011-04-25 Sposób hodowania komórek cho

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL11715933T PL2563906T3 (pl) 2010-04-26 2011-04-25 Sposób hodowli komórek cho

Country Status (18)

Country Link
US (1) US8765413B2 (pl)
EP (3) EP3862423A1 (pl)
JP (2) JP5980772B2 (pl)
KR (1) KR101828624B1 (pl)
CN (2) CN107254499B (pl)
AU (1) AU2011246502B2 (pl)
BR (1) BR112012027430B1 (pl)
CA (1) CA2795461C (pl)
DK (2) DK2563906T3 (pl)
ES (2) ES2870469T3 (pl)
IL (1) IL222454B (pl)
LT (2) LT2563906T (pl)
MX (1) MX2012012528A (pl)
PL (2) PL2563906T3 (pl)
PT (2) PT3330370T (pl)
RU (1) RU2577972C2 (pl)
SG (1) SG185014A1 (pl)
WO (1) WO2011134919A2 (pl)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX345141B (es) 2006-09-13 2017-01-18 Abbvie Inc * Mejoras de cultivos celulares.
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
WO2010141039A1 (en) 2008-10-20 2010-12-09 Abbott Laboratories Isolation and purification of antibodies using protein a affinity chromatography
CN102257005A (zh) 2008-10-20 2011-11-23 雅培制药有限公司 在抗体纯化过程中的病毒灭活
CN107254499B (zh) 2010-04-26 2021-09-17 诺华股份有限公司 改进的细胞培养方法
CN105331659B (zh) 2010-04-26 2019-07-16 诺华股份有限公司 改进的细胞培养基
KR101507254B1 (ko) * 2010-12-07 2015-03-30 에프. 호프만-라 로슈 아게 공급물 혼합 장치 및 그 용도
US9133493B2 (en) 2011-04-21 2015-09-15 Amgen Inc. Method for culturing mammalian cells to improve recombinant protein production
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US10059770B2 (en) 2012-01-30 2018-08-28 Dr. Reddy's Laboratories Limited Process of modulating man5 and/or afucosylation content of a glycoprotein composition
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
CA2883272A1 (en) 2012-09-02 2014-03-06 Abbvie Inc. Methods to control protein heterogeneity
EP2906683B1 (en) 2012-10-15 2017-05-31 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
WO2014143205A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
CN110951670A (zh) 2013-03-15 2020-04-03 豪夫迈·罗氏有限公司 具有抗氧化剂的细胞培养组合物和多肽生产方法
KR101439195B1 (ko) 2013-04-18 2014-09-12 동아대학교 산학협력단 에셰리키아 콜리 a-53 균주를 이용하여 섬유소 분해효소의 생산성을 향상시키는 공정
AR096839A1 (es) * 2013-07-06 2016-02-03 Cadila Healthcare Ltd Proceso mejorado para la producción de anticuerpos monoclonales
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
SG11201606856SA (en) 2014-02-27 2016-09-29 Hoffmann La Roche Modulation of cell growth and glycosylation in recombinant glycoprotein production
CN106661557B (zh) * 2014-08-11 2022-01-18 豪夫迈·罗氏有限公司 用于增加真核细胞的比生产率的方法
KR20160049390A (ko) 2014-10-27 2016-05-09 삼성전자주식회사 산알 배양용 조성물 및 이를 이용한 산알 배양 방법
CA2986625A1 (en) 2015-05-22 2016-12-01 Csl Behring Recombinant Facility Ag Methods for preparing modified von willebrand factor
HU231463B1 (hu) * 2015-08-04 2024-01-28 Richter Gedeon Nyrt. Módszer rekombináns proteinek galaktóz tartalmának növelésére
KR101936049B1 (ko) * 2015-10-15 2019-01-08 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 생산방법
WO2017065559A1 (ko) 2015-10-15 2017-04-20 (주)알테오젠 Igg fc 도메인을 가지는 융합 단백질의 생산방법
WO2018018613A1 (zh) 2016-07-29 2018-02-01 广东东阳光药业有限公司 一种提高抗体纯度的细胞培养基和培养方法
CN109952370B (zh) * 2016-10-19 2023-09-08 豪夫迈·罗氏有限公司 用于产生免疫缀合物的方法
GB201708655D0 (en) 2017-05-31 2017-07-12 Ucb Biopharma Sprl Cell culture methods
CN111406112A (zh) 2017-11-30 2020-07-10 豪夫迈·罗氏有限公司 用于培养哺乳动物细胞的工艺
EP3492582A1 (en) 2017-12-01 2019-06-05 UCB Biopharma SPRL Cell culture methods
CN109517738A (zh) * 2018-12-14 2019-03-26 杭州奕安济世生物药业有限公司 一种调控生物反应器中二氧化碳含量的方法
EP4196597A2 (en) * 2020-08-14 2023-06-21 Bristol-Myers Squibb Company Manufacturing process for protein
GB202012991D0 (en) 2020-08-20 2020-10-07 Ucb Biopharma Sprl Cell culture processes
GB202105424D0 (en) 2021-04-16 2021-06-02 UCB Biopharma SRL Cell culture processes
WO2024099551A1 (en) * 2022-11-09 2024-05-16 Infors Ag Incubator avoiding condensation

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US5672502A (en) * 1985-06-28 1997-09-30 Celltech Therapeutics Limited Animal cell culture
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
GB9118664D0 (en) 1991-08-30 1991-10-16 Celltech Ltd Cell culture
USH1532H (en) 1993-11-03 1996-05-07 Genetics Institute, Inc. Adaption of mammalian cell lines to high cell densities
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US6656466B1 (en) 1995-06-06 2003-12-02 Genetech, Inc. Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
JP4306813B2 (ja) 1995-09-19 2009-08-05 アスビオファーマ株式会社 動物細胞の新規培養方法
EP2243827B2 (en) 1996-08-30 2017-11-22 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
US20020012991A1 (en) 1997-04-07 2002-01-31 Florence Chua Nee Ho Kit Fong Cell culture media for enhanced protein production
TR200504220T2 (tr) 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
RU2215748C2 (ru) * 1999-04-09 2003-11-10 Сентро Де Инмунология Молекулар Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция
EP1757700A3 (en) 1999-04-26 2009-03-11 Genentech, Inc. Cell culture process for glycoproteins
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
AU2002256005A1 (en) 2001-03-27 2002-10-08 Smithkline Beecham Corporation Control of glycoforms in igg
JP2004532642A (ja) 2001-06-13 2004-10-28 ジェネンテック・インコーポレーテッド 動物細胞の培養方法と動物細胞でのポリペプチド産生
CN1158388C (zh) * 2001-09-29 2004-07-21 陈志南 连续灌流式培养杂交瘤细胞制备抗体的方法
HUP0402226A2 (hu) * 2001-11-28 2005-02-28 Sandoz Ag. Eljárás sejttenyésztésre
US20030190710A1 (en) 2002-03-28 2003-10-09 Devries Ruth L. Control of glycoforms in IgG
US6924124B1 (en) 2002-08-23 2005-08-02 Immunex Corporation Feeding strategies for cell culture
CN101857851A (zh) 2002-12-23 2010-10-13 布里斯托尔-迈尔斯斯奎布公司 用于蛋白质生产的哺乳动物细胞培养方法
AU2003303394B2 (en) 2002-12-23 2009-02-19 Bristol-Myers Squibb Company Product quality enhancement in mammalian cell culture processes for protein production
US7335491B2 (en) 2004-08-27 2008-02-26 Wyeth Research Ireland Limited Production of anti-abeta
TWI364458B (en) 2004-08-27 2012-05-21 Wyeth Res Ireland Ltd Production of tnfr-lg
TWI384069B (zh) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
PL2495307T3 (pl) 2006-07-13 2018-07-31 Wyeth Llc Wytwarzanie czynnika krzepliwości krwi IX o polepszonym wzorze glikozylacji
WO2008013809A1 (en) 2006-07-24 2008-01-31 Amgen Inc. Cell culture methods
MX345141B (es) * 2006-09-13 2017-01-18 Abbvie Inc * Mejoras de cultivos celulares.
CA2666317C (en) 2006-11-03 2013-08-06 Wyeth Glycolysis-inhibiting substances in cell culture
WO2008063892A2 (en) 2006-11-08 2008-05-29 Wyeth Rationally designed media for cell culture
AU2008232903B9 (en) 2007-03-30 2013-09-05 Medimmune Llc Antibodies with decreased deamidation profiles
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
JP5576115B2 (ja) * 2007-04-26 2014-08-20 中外製薬株式会社 高濃度アミノ酸含有培地を用いた細胞の培養方法
ES2392701T3 (es) 2007-05-11 2012-12-13 Amgen Inc. Medios de alimentación mejorados
CN107254499B (zh) 2010-04-26 2021-09-17 诺华股份有限公司 改进的细胞培养方法

Also Published As

Publication number Publication date
EP2563906B1 (en) 2017-11-08
CN102858954A (zh) 2013-01-02
LT2563906T (lt) 2018-02-26
MX2012012528A (es) 2012-11-23
AU2011246502B2 (en) 2014-08-28
CA2795461C (en) 2018-04-24
ES2659117T3 (es) 2018-03-13
CN107254499B (zh) 2021-09-17
RU2577972C2 (ru) 2016-03-20
CA2795461A1 (en) 2011-11-03
IL222454B (en) 2018-11-29
BR112012027430A2 (pt) 2015-09-22
JP2013524824A (ja) 2013-06-20
WO2011134919A3 (en) 2013-01-24
RU2012150283A (ru) 2014-06-10
EP3330370A1 (en) 2018-06-06
PT3330370T (pt) 2021-05-11
LT3330370T (lt) 2021-06-10
US8765413B2 (en) 2014-07-01
WO2011134919A2 (en) 2011-11-03
CN107254499A (zh) 2017-10-17
US20130130316A1 (en) 2013-05-23
EP2563906A2 (en) 2013-03-06
ES2870469T3 (es) 2021-10-27
PT2563906T (pt) 2018-02-16
PL2563906T3 (pl) 2018-04-30
EP3330370B1 (en) 2021-02-24
EP3862423A1 (en) 2021-08-11
JP5980772B2 (ja) 2016-08-31
KR20130094723A (ko) 2013-08-26
IL222454A0 (en) 2012-12-31
KR101828624B1 (ko) 2018-02-12
DK2563906T3 (en) 2018-02-05
SG185014A1 (en) 2012-11-29
BR112012027430B1 (pt) 2020-04-07
DK3330370T3 (da) 2021-05-10
JP2016214254A (ja) 2016-12-22

Similar Documents

Publication Publication Date Title
LT3330370T (lt) Cho ląstelių auginimo būdas
HK1212731A1 (zh) 單個 細胞培養方法
TWI563079B (en) Process for fermentation of syngas
EP2729561A4 (en) CELL CULTURE METHOD
IL224321B (en) Methods for detecting diseases or conditions using phagocytic cells
EP2609120A4 (en) IMPROVED PROCESS FOR PREPARING SUGAMMADEX
EP2545178A4 (en) ACIDIFICATION BY FERMENTATION
EP2666370A4 (en) PROCESS FOR PREPARING A VEGETABLE FERMENTATION SOLUTION
GB201110042D0 (en) Growth of cells
HK1248242A1 (zh) 動物細胞的培養方法
EP2600413A4 (en) Process for production of solar cell
EP2571346A4 (en) MICROALGUE CULTURE POND DESIGN
IL223663A (en) Method for collecting algae
EP2650375A4 (en) PROCESS FOR THE PRODUCTION OF CHEMICALS BY CONTINUOUS FERMENTATION
IL228546A0 (en) fermentation process
ZA201304024B (en) Fermentation process involving adjusting specific co-uptake
EP2636730A4 (en) METHOD FOR OPEN CULTIVATION OF SILKETS
ZA201402773B (en) Use of phenylpyrazolin-3-carboxylates for improving plant yield
ZA201401439B (en) Use of 5-phenyl-or 5-benzyl-2isoxazoline-3carboxylates for improving plant yield
GB2481212B (en) Apparatus for biogas production
DK2591119T3 (da) Fermenteringsprocess
PL2571600T3 (pl) Proces otrzymywania alkoholu
PL2760978T3 (pl) Sposób wytwarzania biogazu
EP2554659A4 (en) PROCESS FOR PREPARING ES CELLS
IT1402269B1 (it) Impianto perfezionato per la produzione di biogas