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PL3290414T3 - Sposób otrzymywania n-[5-(3,5-difluorobenzylo)-1h-indazol-3-ilo]-4-(4-metylopiperazyn-1-ylo)-2-(tetrahydropiran-4-yloamino)benzamidu - Google Patents

Sposób otrzymywania n-[5-(3,5-difluorobenzylo)-1h-indazol-3-ilo]-4-(4-metylopiperazyn-1-ylo)-2-(tetrahydropiran-4-yloamino)benzamidu

Info

Publication number
PL3290414T3
PL3290414T3 PL17192138T PL17192138T PL3290414T3 PL 3290414 T3 PL3290414 T3 PL 3290414T3 PL 17192138 T PL17192138 T PL 17192138T PL 17192138 T PL17192138 T PL 17192138T PL 3290414 T3 PL3290414 T3 PL 3290414T3
Authority
PL
Poland
Prior art keywords
indazol
ylamino
piperazin
benzamide
pyran
Prior art date
Application number
PL17192138T
Other languages
English (en)
Inventor
Natale Alvaro Barbugian
Romualdo Forino
Tiziano FUMAGALLI
Paolo Orsini
Original Assignee
Nerviano Medical Sciences S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences S.R.L. filed Critical Nerviano Medical Sciences S.R.L.
Publication of PL3290414T3 publication Critical patent/PL3290414T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL17192138T 2012-05-23 2013-05-22 Sposób otrzymywania n-[5-(3,5-difluorobenzylo)-1h-indazol-3-ilo]-4-(4-metylopiperazyn-1-ylo)-2-(tetrahydropiran-4-yloamino)benzamidu PL3290414T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12169139 2012-05-23
PCT/EP2013/060534 WO2013174876A1 (en) 2012-05-23 2013-05-22 Process for the preparation of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
EP13724270.7A EP2855460B1 (en) 2012-05-23 2013-05-22 Process for the preparation of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
EP17192138.0A EP3290414B1 (en) 2012-05-23 2013-05-22 Crystalline form of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide

Publications (1)

Publication Number Publication Date
PL3290414T3 true PL3290414T3 (pl) 2020-01-31

Family

ID=48470987

Family Applications (2)

Application Number Title Priority Date Filing Date
PL17192138T PL3290414T3 (pl) 2012-05-23 2013-05-22 Sposób otrzymywania n-[5-(3,5-difluorobenzylo)-1h-indazol-3-ilo]-4-(4-metylopiperazyn-1-ylo)-2-(tetrahydropiran-4-yloamino)benzamidu
PL17195806T PL3333166T3 (pl) 2012-05-23 2013-05-22 Proces otrzymywania n-[5-(3,5-difluorobenzylo)-1h-indazol-3-ilo]- 4-(4-metylopiperazyn-1-ylo)-2-(tetrahydropiran- 4-yloamino)benzamidu

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL17195806T PL3333166T3 (pl) 2012-05-23 2013-05-22 Proces otrzymywania n-[5-(3,5-difluorobenzylo)-1h-indazol-3-ilo]- 4-(4-metylopiperazyn-1-ylo)-2-(tetrahydropiran- 4-yloamino)benzamidu

Country Status (17)

Country Link
US (3) US9085565B2 (pl)
EP (4) EP2855460B1 (pl)
JP (1) JP6231556B2 (pl)
KR (1) KR102151963B1 (pl)
CN (2) CN104395308B (pl)
AR (1) AR091138A1 (pl)
AU (2) AU2013265288B2 (pl)
BR (1) BR112014028841B1 (pl)
CA (1) CA2873979C (pl)
ES (2) ES2751944T3 (pl)
IL (2) IL235761B (pl)
MX (1) MX355409B (pl)
NZ (2) NZ703124A (pl)
PL (2) PL3290414T3 (pl)
RU (1) RU2602071C2 (pl)
TW (1) TWI579280B (pl)
WO (1) WO2013174876A1 (pl)

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Also Published As

Publication number Publication date
AU2018201037B2 (en) 2019-07-04
US20150051222A1 (en) 2015-02-19
TWI579280B (zh) 2017-04-21
CA2873979C (en) 2019-11-12
RU2014151565A (ru) 2016-07-20
US9649306B2 (en) 2017-05-16
KR20150016352A (ko) 2015-02-11
IL235761A0 (en) 2015-02-01
CN106167485A (zh) 2016-11-30
AR091138A1 (es) 2015-01-14
AU2013265288B2 (en) 2017-12-21
BR112014028841A2 (pt) 2017-06-27
US9085565B2 (en) 2015-07-21
JP6231556B2 (ja) 2017-11-15
AU2013265288A2 (en) 2015-01-29
HK1207077A1 (en) 2016-01-22
CA2873979A1 (en) 2013-11-28
KR102151963B1 (ko) 2020-09-07
EP3333166B1 (en) 2019-11-06
AU2013265288A1 (en) 2015-01-22
TW201400479A (zh) 2014-01-01
IL235761B (en) 2018-07-31
EP3290414B1 (en) 2019-07-24
AU2018201037A1 (en) 2018-03-01
MX355409B (es) 2018-04-18
PL3333166T3 (pl) 2020-09-07
MX2014013924A (es) 2015-02-17
CN104395308B (zh) 2016-08-24
EP2855460A1 (en) 2015-04-08
CN104395308A (zh) 2015-03-04
EP3581571A1 (en) 2019-12-18
WO2013174876A1 (en) 2013-11-28
RU2602071C2 (ru) 2016-11-10
NZ716487A (en) 2017-01-27
ES2771100T3 (es) 2020-07-06
EP2855460B1 (en) 2017-11-08
ES2751944T3 (es) 2020-04-02
IL260297A (en) 2018-08-30
EP3290414A1 (en) 2018-03-07
NZ703124A (en) 2016-07-29
EP3333166A1 (en) 2018-06-13
JP2015517551A (ja) 2015-06-22
US9382235B2 (en) 2016-07-05
US20160279125A1 (en) 2016-09-29
US20150274707A1 (en) 2015-10-01
BR112014028841B1 (pt) 2021-01-12

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