PL3122775T3 - Przeciwciała monoklonalne przeciwko czynnikowi wzrostu i różnicowania 15 (gdf-15) oraz ich zastosowanie do leczenia kacheksji nowotworowej i nowotworu - Google Patents

Przeciwciała monoklonalne przeciwko czynnikowi wzrostu i różnicowania 15 (gdf-15) oraz ich zastosowanie do leczenia kacheksji nowotworowej i nowotworu

Info

Publication number: PL3122775T3
Authority: PL; Poland
Prior art keywords: gdf; cachexia; cancer; treatment; difference
Prior art date: 2014-03-26

Application number

PL15712629T

Other languages

English (en)

Inventor

Jörg WISCHHUSEN

Markus JUNKER

Tina SCHÄFER

Dirk PÜHRINGER

Original Assignee

Julius-Maximilians-Universität Würzburg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-03-26

Filing date

2015-03-26

Publication date

2020-05-18

2014-03-26 Priority claimed from GB1405477.9A external-priority patent/GB2524553C/en

2014-03-26 Priority claimed from GB1405475.3A external-priority patent/GB2524552B/en

2015-03-26 Application filed by Julius-Maximilians-Universität Würzburg filed Critical Julius-Maximilians-Universität Würzburg

2020-05-18 Publication of PL3122775T3 publication Critical patent/PL3122775T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compositions Of Macromolecular Compounds (AREA)
Cosmetics (AREA)

PL15712629T 2014-03-26 2015-03-26 Przeciwciała monoklonalne przeciwko czynnikowi wzrostu i różnicowania 15 (gdf-15) oraz ich zastosowanie do leczenia kacheksji nowotworowej i nowotworu PL3122775T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB1405477.9A GB2524553C (en)	2014-03-26	2014-03-26	Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia
GB1405475.3A GB2524552B (en)	2014-03-26	2014-03-26	Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and use thereof for treating cancer
PCT/EP2015/056654 WO2015144855A1 (en)	2014-03-26	2015-03-26	Monoclonal antibodies to growth and differentiation factor 15 (gdf-15), and uses thereof for treating cancer cachexia and cancer
EP15712629.3A EP3122775B1 (en)	2014-03-26	2015-03-26	Monoclonal antibodies to growth and differentiation factor 15 (gdf-15), and uses thereof for treating cancer cachexia and cancer

Publications (1)

Publication Number	Publication Date
PL3122775T3 true PL3122775T3 (pl)	2020-05-18

Family

ID=52745885

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL15712629T PL3122775T3 (pl)	2014-03-26	2015-03-26	Przeciwciała monoklonalne przeciwko czynnikowi wzrostu i różnicowania 15 (gdf-15) oraz ich zastosowanie do leczenia kacheksji nowotworowej i nowotworu
PL19205321.3T PL3653644T3 (pl)	2014-03-26	2015-03-26	Przeciwciała monoklonalne przeciwko czynnikowi wzrostu i różnicowania 15 (gdf-15) oraz ich zastosowanie do leczenia kacheksji nowotworowej i nowotworów

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL19205321.3T PL3653644T3 (pl)	2014-03-26	2015-03-26	Przeciwciała monoklonalne przeciwko czynnikowi wzrostu i różnicowania 15 (gdf-15) oraz ich zastosowanie do leczenia kacheksji nowotworowej i nowotworów

Country Status (22)

Country	Link
US (6)	US20170204174A1 (pl)
EP (3)	EP3122775B1 (pl)
JP (3)	JP6865585B2 (pl)
KR (1)	KR102520978B1 (pl)
CN (1)	CN106536553B (pl)
AU (2)	AU2015238264B2 (pl)
BR (1)	BR122023027559A2 (pl)
CY (1)	CY1122456T1 (pl)
DK (2)	DK3653644T5 (pl)
ES (2)	ES2763859T3 (pl)
FI (1)	FI3653644T3 (pl)
HR (2)	HRP20231514T1 (pl)
HU (2)	HUE064573T2 (pl)
IL (2)	IL248038B (pl)
LT (2)	LT3653644T (pl)
NZ (1)	NZ724649A (pl)
PL (2)	PL3122775T3 (pl)
PT (2)	PT3653644T (pl)
RS (1)	RS59700B1 (pl)
SI (1)	SI3122775T1 (pl)
SM (1)	SMT202000064T1 (pl)
WO (1)	WO2015144855A1 (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL3122775T3 (pl)	2014-03-26	2020-05-18	Julius-Maximilians-Universität Würzburg	Przeciwciała monoklonalne przeciwko czynnikowi wzrostu i różnicowania 15 (gdf-15) oraz ich zastosowanie do leczenia kacheksji nowotworowej i nowotworu
ES2872534T3 (es)	2014-09-25	2021-11-02	Aveo Pharmaceuticals Inc	Métodos para revertir la caquexia y prolongar la supervivencia que comprenden administrar un modulador de GDF15 y un agente anticanceroso
SMT202300017T1 (it) *	2015-10-02	2023-03-17	Univ Wuerzburg J Maximilians	Terapia in combinazione usando inibitori del fattore della crescita e della differenziazione 15 (gdf-15) umano e bloccanti del punto di controllo immunitario
GB201517528D0 (en) *	2015-10-02	2015-11-18	Julius Maximillians Universitãt Würzburg	GDF-15 as a diagnosis marker for melanoma
KR102621034B1 (ko) *	2015-10-02	2024-01-03	율리우스-막시밀리안스 우니버지태트 뷔르츠부르크	면역 체크포인트 차단제를 이용한 치료의 임상적인 경과를 예측하기 위한 진단 마커로서의 gdf-15
EP3448887A1 (en) *	2016-04-27	2019-03-06	Novartis AG	Antibodies against growth differentiation factor 15 and uses thereof
MX389765B (es) *	2016-07-06	2025-03-20	Nat Res Council Canada	Anticuerpos humanizados que transmigran a traves de la barrera hematoencefalica y usos de los mismos.
KR20190059312A (ko) *	2016-10-12	2019-05-30	얀센 바이오테크 인코포레이티드	Gdf15-유사 생물학적 활성의 조절제에 대한 스크리닝 방법
CN110072541B (zh) *	2016-12-06	2023-05-02	圣文森特医院悉尼有限公司	肥胖和饮食失调的治疗
JP7155403B2 (ja)	2018-08-20	2022-10-18	ファイザー・インク	抗ｇｄｆ１５抗体、組成物および使用の方法
KR20230107309A (ko)	2020-11-10	2023-07-14	카탈임 게엠베하	항-gdf15 항체 및 암 치료용 투여 용법
AU2022251923A1 (en)	2021-03-31	2023-11-16	Cambridge Enterprise Limited	Therapeutic inhibitors of gdf15 signalling
EP4384545A1 (en)	2021-08-10	2024-06-19	BYOMass Inc.	Anti-gdf15 antibodies, compositions and uses thereof
EP4452316A1 (en)	2021-12-22	2024-10-30	BYOMass Inc.	Targeting gdf15-gfral pathway
US20250092124A1 (en) *	2022-01-26	2025-03-20	Yunnan Baiyao Group Co., Ltd.	Antibody molecule against growth and differentiation factor 15 and use thereof
EP4524158A4 (en)	2022-05-09	2025-12-17	Staidson Beijing Biopharmaceuticals Co Ltd	Antibody that specifically recognizes gdf15 and use thereof
CN116462757A (zh) *	2023-03-24	2023-07-21	科兴生物制药股份有限公司	Gdf15的单域抗体及其应用
WO2025223473A1 (zh) *	2024-04-23	2025-10-30	劲方医药科技(上海)股份有限公司	抗gdf-15抗体及其应用
CN118878677A (zh) *	2024-09-29	2024-11-01	江苏凯基生物技术股份有限公司	一种IgM亚型单克隆抗体及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6455677B1 (en) *	1998-04-30	2002-09-24	Boehringer Ingelheim International Gmbh	FAPα-specific antibody with improved producibility
EP0953639A1 (en) *	1998-04-30	1999-11-03	Boehringer Ingelheim International GmbH	FAPalpha-specific antibody with improved producibility
US6465181B2 (en)	1999-03-25	2002-10-15	Abbott Laboratories	Reagents and methods useful for detecting diseases of the prostate
ES2275513T3 (es)	1999-05-17	2007-06-16	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Und Zum Vertrieb Von Pharmaka Mbh	Propiedades neuroprotectoras de gdf-15, un miembro de la superfamilia de tgf-beta.
AU2001288770A1 (en)	2000-09-08	2002-03-22	The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services	A non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties
SI2311873T1 (sl) *	2004-01-07	2018-12-31	Novartis Vaccines And Diagnostics, Inc.	M-CSF-specifična monoklonska protitelesa in njihova uporaba
DK2929891T3 (da) *	2004-04-13	2020-05-11	St Vincents Hospital Sydney Ltd	Fremgangsmåde til modulering af appetitten
EP2783698A1 (en) *	2007-08-16	2014-10-01	St Vincent's Hospital Sydney Limited	Agents and methods for modulating macrophage inhibitory cytokine (MIC-1) activity
US20100266707A1 (en) *	2007-10-09	2010-10-21	Samuel Norbert Breit	Method of treating cachexia with the removal or inactivation of macrophage inhibitory cytokine-1
NZ591484A (en)	2008-09-29	2012-09-28	Roche Glycart Ag	Antibodies against human il 17 and uses thereof
US20120309697A1 (en)	2009-10-28	2012-12-06	Samuel Norbert Breit	Methods of diagnosing and prognosing colonic polyps
US9212221B2 (en) *	2010-03-03	2015-12-15	Detroit R & D, Inc.	Form-specific antibodies for NAG-1 (MIC-1, GDF-15), H6D and other TGF-β subfamily and heart disease and cancer diagnoses
CA2817964C (en) *	2010-11-17	2018-06-12	Chugai Seiyaku Kabushiki Kaisha	Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
US8790651B2 (en) *	2011-07-21	2014-07-29	Zoetis Llc	Interleukin-31 monoclonal antibody
CN102321173B (zh)	2011-08-12	2013-04-03	中国医学科学院肿瘤研究所	人源化巨噬细胞抑制因子1单克隆抗体及其应用
EP2565262A1 (en)	2011-08-31	2013-03-06	VTU Holding GmbH	Protein expression
EP2807266B1 (en)	2012-01-26	2020-01-15	Amgen Inc.	Growth differentiation factor 15 (gdf-15) polypeptides
SG11201502279YA (en) *	2012-09-26	2015-04-29	Julius Maximilians Universität Würzburg	Monoclonal antibodies to growth and differentiation factor 15 (gdf-15)
CN105073133B (zh) *	2012-12-21	2021-04-20	Aveo制药公司	抗gdf15抗体
PL3122775T3 (pl)	2014-03-26	2020-05-18	Julius-Maximilians-Universität Würzburg	Przeciwciała monoklonalne przeciwko czynnikowi wzrostu i różnicowania 15 (gdf-15) oraz ich zastosowanie do leczenia kacheksji nowotworowej i nowotworu

2015
- 2015-03-26 PL PL15712629T patent/PL3122775T3/pl unknown
- 2015-03-26 WO PCT/EP2015/056654 patent/WO2015144855A1/en not_active Ceased
- 2015-03-26 ES ES15712629T patent/ES2763859T3/es active Active
- 2015-03-26 DK DK19205321.3T patent/DK3653644T5/da active
- 2015-03-26 NZ NZ724649A patent/NZ724649A/en unknown
- 2015-03-26 LT LTEP19205321.3T patent/LT3653644T/lt unknown
- 2015-03-26 EP EP15712629.3A patent/EP3122775B1/en active Active
- 2015-03-26 US US15/128,604 patent/US20170204174A1/en not_active Abandoned
- 2015-03-26 FI FIEP19205321.3T patent/FI3653644T3/fi active
- 2015-03-26 HR HRP20231514TT patent/HRP20231514T1/hr unknown
- 2015-03-26 HU HUE19205321A patent/HUE064573T2/hu unknown
- 2015-03-26 ES ES19205321T patent/ES2965626T3/es active Active
- 2015-03-26 PL PL19205321.3T patent/PL3653644T3/pl unknown
- 2015-03-26 AU AU2015238264A patent/AU2015238264B2/en active Active
- 2015-03-26 RS RS20191652A patent/RS59700B1/sr unknown
- 2015-03-26 HU HUE15712629A patent/HUE047398T2/hu unknown
- 2015-03-26 HR HRP20200034TT patent/HRP20200034T1/hr unknown
- 2015-03-26 JP JP2016559286A patent/JP6865585B2/ja active Active
- 2015-03-26 SI SI201531059T patent/SI3122775T1/sl unknown
- 2015-03-26 DK DK15712629.3T patent/DK3122775T3/da active
- 2015-03-26 EP EP23203704.4A patent/EP4316596A3/en active Pending
- 2015-03-26 SM SM20200064T patent/SMT202000064T1/it unknown
- 2015-03-26 LT LTEP15712629.3T patent/LT3122775T/lt unknown
- 2015-03-26 PT PT192053213T patent/PT3653644T/pt unknown
- 2015-03-26 PT PT157126293T patent/PT3122775T/pt unknown
- 2015-03-26 KR KR1020167029710A patent/KR102520978B1/ko active Active
- 2015-03-26 BR BR122023027559-4A patent/BR122023027559A2/pt not_active Application Discontinuation
- 2015-03-26 EP EP19205321.3A patent/EP3653644B1/en active Active
- 2015-03-26 CN CN201580027932.8A patent/CN106536553B/zh active Active
2016
- 2016-09-26 IL IL248038A patent/IL248038B/en active IP Right Grant
2018
- 2018-03-05 US US15/912,358 patent/US10604565B2/en active Active
2020
- 2020-01-08 CY CY20201100008T patent/CY1122456T1/el unknown
- 2020-02-19 US US16/794,406 patent/US11760795B2/en active Active
- 2020-02-19 US US16/794,401 patent/US11634482B2/en active Active
- 2020-07-30 IL IL276405A patent/IL276405B/en unknown
- 2020-10-28 AU AU2020260440A patent/AU2020260440B2/en active Active
2021
- 2021-04-06 JP JP2021064572A patent/JP7607498B2/ja active Active
2023
- 2023-04-06 JP JP2023062338A patent/JP2023098966A/ja not_active Withdrawn
- 2023-08-02 US US18/364,173 patent/US20230382987A1/en not_active Abandoned
2025
- 2025-06-13 US US19/237,241 patent/US20260008841A1/en active Pending

Also Published As

Publication number	Publication date
IL248038A0 (en)	2016-11-30
EP3653644B1 (en)	2023-11-15
US20180298091A1 (en)	2018-10-18
RS59700B1 (sr)	2020-01-31
CY1122456T1 (el)	2021-01-27
HRP20231514T1 (hr)	2024-03-01
PT3653644T (pt)	2023-12-19
AU2020260440B2 (en)	2024-03-21
HRP20200034T1 (hr)	2020-03-20
JP7607498B2 (ja)	2024-12-27
JP2023098966A (ja)	2023-07-11
ES2763859T3 (es)	2020-06-01
US11760795B2 (en)	2023-09-19
SMT202000064T1 (it)	2020-03-13
US20230382987A1 (en)	2023-11-30
US10604565B2 (en)	2020-03-31
BR112016022013A2 (pt)	2017-10-31
LT3122775T (lt)	2020-02-10
US20260008841A1 (en)	2026-01-08
CN106536553B (zh)	2021-03-12
US20170204174A1 (en)	2017-07-20
DK3122775T3 (da)	2020-02-03
AU2015238264B2 (en)	2020-09-03
CN106536553A (zh)	2017-03-22
ES2965626T3 (es)	2024-04-16
EP3122775A1 (en)	2017-02-01
US20200308264A1 (en)	2020-10-01
KR102520978B1 (ko)	2023-04-11
EP4316596A3 (en)	2024-04-17
PT3122775T (pt)	2019-12-26
CA2943694A1 (en)	2015-10-01
US20200308265A1 (en)	2020-10-01
FI3653644T3 (fi)	2023-12-12
IL276405B (en)	2021-07-29
DK3653644T5 (da)	2024-08-26
HUE047398T2 (hu)	2020-04-28
JP2017508475A (ja)	2017-03-30
SI3122775T1 (sl)	2020-02-28
EP3122775B1 (en)	2019-11-13
JP2021119138A (ja)	2021-08-12
US11634482B2 (en)	2023-04-25
BR122023027559A2 (pt)	2024-01-30
EP3653644A1 (en)	2020-05-20
LT3653644T (lt)	2024-01-25
IL276405A (en)	2020-09-30
WO2015144855A1 (en)	2015-10-01
HUE064573T2 (hu)	2024-03-28
NZ724649A (en)	2022-07-01
PL3653644T3 (pl)	2024-03-04
JP6865585B2 (ja)	2021-04-28
AU2015238264A1 (en)	2016-10-20
KR20160139005A (ko)	2016-12-06
AU2020260440A1 (en)	2020-11-26
DK3653644T3 (da)	2023-12-18
IL248038B (en)	2020-08-31
EP4316596A2 (en)	2024-02-07

Publication	Publication Date	Title
PL3122775T3 (pl)	2020-05-18	Przeciwciała monoklonalne przeciwko czynnikowi wzrostu i różnicowania 15 (gdf-15) oraz ich zastosowanie do leczenia kacheksji nowotworowej i nowotworu
IL294982B1 (en)	2023-04-01	nk-2 cells and genetically engineered monoclonal antibodies for cancer treatment
IL272470A (en)	2020-03-31	Methods and materials for assessing and treating cancer
IL269150A (en)	2019-11-28	Compositions and methods for treating cancer
IL267803A (en)	2019-09-26	Methods for treating cancer with anti-tim-3 antibodies
HUE053452T2 (hu)	2021-07-28	Anti-PD-1 és anti-LAG3 antitestek rák kezelésére
IL264674B1 (en)	2023-05-01	Antibodies to siglec7 for cancer treatment
IL268814A (en)	2019-10-31	Compositions and methods for treatment of cancer
PL3601358T3 (pl)	2023-10-02	Przeciwciała anty-trem2 i sposoby ich wykorzystania
IL258955A (en)	2018-06-28	Compositions and methods for treatment of cancer
IL263224A (en)	2018-12-31	Methods and compositions for treating cancers
IL253462A0 (en)	2017-09-28	Cancer treatment with monoclonal antibodies against latency-associated peptide
KR20180084817A (ko)	2018-07-25	항-siglec-9 항체 및 이의 이용 방법
IL286208A (en)	2021-10-31	Humanized influenza monoclonal antibodies and methods of use thereof
SG11201705585QA (en)	2018-05-30	Anti-myostatin antibodies and methods of use
IL271260A (en)	2020-01-30	Multi-specific antibodies and methods of making and using thereof
DK3508502T3 (da)	2023-07-31	Kombination af anti-lag-3-antistoffer og anti-pd-1-antistoffer til behandling af tumorer
DK3826667T3 (da)	2024-07-22	Claudin6-antistoffer og fremgangsmåder til behandling af kræft
IL271257A (en)	2020-01-30	Multi-specific antibodies and methods of making and using thereof
PL3280440T3 (pl)	2023-06-19	Humanizowane przeciwciała anty-c1s i sposoby ich zastosowania
IL269157A (en)	2019-11-28	Compositions and methods for treating cancer
IL282478A (en)	2021-06-30	Materials and methods for treating cancer
IL272147A (en)	2020-03-31	Methods and compositions for the treatment of cancer
GB2524553C (en)	2017-07-19	Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia
IL256763A (en)	2018-03-29	Compositions and methods for treating cancer