PL2663638T3 - Sposób hodowli w celu uzyskania i utrzymania czystej lub wzbogaconej populacji ssaczych nerwowych komórek macierzystych i/lub nerwowych komórek progenitorowych, które są podatne na różnicowanie w komórki linii oligodendrocytarnej in vitro - Google Patents
Sposób hodowli w celu uzyskania i utrzymania czystej lub wzbogaconej populacji ssaczych nerwowych komórek macierzystych i/lub nerwowych komórek progenitorowych, które są podatne na różnicowanie w komórki linii oligodendrocytarnej in vitroInfo
- Publication number
- PL2663638T3 PL2663638T3 PL12701024T PL12701024T PL2663638T3 PL 2663638 T3 PL2663638 T3 PL 2663638T3 PL 12701024 T PL12701024 T PL 12701024T PL 12701024 T PL12701024 T PL 12701024T PL 2663638 T3 PL2663638 T3 PL 2663638T3
- Authority
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- Poland
- Prior art keywords
- cells
- oligodendrocyte
- differentiate
- prone
- vitro
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A61P27/02—Ophthalmic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/32—Polylysine, polyornithine
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161431944P | 2011-01-12 | 2011-01-12 | |
US201161558527P | 2011-11-11 | 2011-11-11 | |
PCT/IB2012/000030 WO2012095730A1 (en) | 2011-01-12 | 2012-01-12 | Culture method to obtain and maintain a pure or enriched population of mammalian neural stem cells and/or neural progenitor cells that are prone to differentiate into oligodendrocyte-lineage cells in vitro |
EP12701024.7A EP2663638B1 (en) | 2011-01-12 | 2012-01-12 | Culture method to obtain and maintain a pure or enriched population of mammalian neural stem cells and/or neural progenitor cells that are prone to differentiate into oligodendrocyte-lineage cells in vitro |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2663638T3 true PL2663638T3 (pl) | 2020-02-28 |
Family
ID=45529155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL12701024T PL2663638T3 (pl) | 2011-01-12 | 2012-01-12 | Sposób hodowli w celu uzyskania i utrzymania czystej lub wzbogaconej populacji ssaczych nerwowych komórek macierzystych i/lub nerwowych komórek progenitorowych, które są podatne na różnicowanie w komórki linii oligodendrocytarnej in vitro |
Country Status (21)
Country | Link |
---|---|
US (1) | US8993320B2 (pl) |
EP (1) | EP2663638B1 (pl) |
JP (1) | JP5649745B2 (pl) |
KR (1) | KR102099807B1 (pl) |
CN (2) | CN103687941A (pl) |
AR (1) | AR084835A1 (pl) |
AU (2) | AU2012206411B2 (pl) |
BR (1) | BR112013017685A2 (pl) |
CA (1) | CA2821065C (pl) |
CL (1) | CL2013002029A1 (pl) |
DK (1) | DK2663638T3 (pl) |
EA (1) | EA034058B1 (pl) |
ES (1) | ES2732938T3 (pl) |
IL (1) | IL227361B (pl) |
MX (1) | MX364742B (pl) |
MY (1) | MY173219A (pl) |
PH (1) | PH12013501496B1 (pl) |
PL (1) | PL2663638T3 (pl) |
SG (1) | SG191729A1 (pl) |
TW (1) | TWI586805B (pl) |
WO (1) | WO2012095730A1 (pl) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1480521B1 (en) | 2002-02-15 | 2015-02-25 | Cornell Research Foundation, Inc. | Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells |
US9709553B2 (en) | 2008-05-08 | 2017-07-18 | University Of Rochester | Treating myelin diseases with optimized cell preparations |
US10450546B2 (en) | 2013-02-06 | 2019-10-22 | University Of Rochester | Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders |
JP2016515403A (ja) * | 2013-04-17 | 2016-05-30 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ニューロン細胞培養のための培地組成物 |
JP6615616B2 (ja) * | 2014-01-21 | 2019-12-04 | 国立研究開発法人科学技術振興機構 | アダルト型オリゴデンドロサイト前駆細胞の製造方法 |
CN105154386B (zh) * | 2014-05-30 | 2018-04-24 | 中国人民解放军第二军医大学东方肝胆外科医院 | 人肝细胞长期维持和增殖传代培养的专用培养基和培养方法 |
KR101675123B1 (ko) * | 2014-06-27 | 2016-11-14 | 연세대학교 산학협력단 | Psa-ncam-양성 신경전구세포를 유효성분으로 포함하는 허혈성 질환 또는 신경염증 질환 치료용 조성물 |
KR101793722B1 (ko) | 2014-08-25 | 2017-11-03 | 한국생명공학연구원 | 성상세포의 생산방법 |
US20180037867A1 (en) | 2015-03-04 | 2018-02-08 | Mesoblast International Sàrl | Cell culture method for mesenchymal stem cells |
EP3279318A4 (en) * | 2015-03-30 | 2018-08-29 | Ajinomoto Co., Inc. | Human serum albumin-containing culture medium for growth of neural stem cells |
CA2982959C (en) * | 2015-04-16 | 2021-08-31 | The Board Of Regents, The University Of Texas System | Cd133+ cells and method for expanding |
JP6844953B2 (ja) * | 2015-04-22 | 2021-03-17 | 公益財団法人東京都医学総合研究所 | アルツハイマー病研究を標的にしたグリア細胞システム |
US9724432B2 (en) | 2015-04-30 | 2017-08-08 | University Of Rochester | Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder |
CN107921068A (zh) * | 2015-06-26 | 2018-04-17 | S生物医药公司 | 包含神经前体细胞的分泌蛋白质组作为有效成分的用于治疗缺血性疾病或神经炎症疾病的组合物 |
JP7018877B2 (ja) * | 2015-08-15 | 2022-02-14 | アステリアス バイオセラピューティクス インコーポレイテッド | 白質卒中の治療のための幹細胞由来オリゴデンドロサイト前駆細胞 |
WO2017156762A1 (en) | 2016-03-18 | 2017-09-21 | Institute Of Biophysics, Chinese Academy Of Sciences | A cell culture medium and culture medium supplement |
CN109219657A (zh) | 2016-03-30 | 2019-01-15 | 阿斯特利亚斯生物治疗股份公司 | 少突胶质细胞祖细胞组合物 |
CN106929474B (zh) * | 2017-03-31 | 2021-09-14 | 北京恒峰铭成生物科技有限公司 | 一种m2巨噬细胞诱导剂 |
EP3621434A4 (en) | 2017-05-10 | 2021-03-31 | University of Rochester | TREATMENT METHODS FOR NEUROPSYCHIATRIC DISORDERS |
KR101889228B1 (ko) * | 2017-09-29 | 2018-08-16 | 연세대학교 산학협력단 | Psa-ncam-양성 신경전구세포를 유효성분으로 포함하는 척수손상 치료용 조성물 |
CN107760649B (zh) * | 2017-11-02 | 2021-03-30 | 北京全式金生物技术有限公司 | 一种用于人神经系统细胞培养和人多能性干细胞向神经系统细胞分化的营养添加剂 |
CN108070558B (zh) * | 2017-11-24 | 2022-01-28 | 吉林省拓华生物科技有限公司 | 一种临床级神经干细胞的制备方法 |
KR101994640B1 (ko) | 2018-03-16 | 2019-07-02 | (주)메디노 | 신경줄기세포의 고효율 분리배양 방법 |
JP2021521790A (ja) * | 2018-04-17 | 2021-08-30 | ケース ウェスタン リザーブ ユニバーシティCase Western Reserve University | ヒト皮質スフェロイドでのミエリン形成オリゴデンドロサイトの誘導 |
CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
CA3113640A1 (en) * | 2018-09-19 | 2020-03-26 | Lineage Cell Therapeutics, Inc. | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
CA3127213A1 (en) | 2019-01-23 | 2020-07-30 | Asterias Biotherapeutics, Inc. | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
WO2022005463A1 (en) * | 2020-06-30 | 2022-01-06 | National Yang-Ming University | A glia cell and neuron co-culture system and method |
CN114540301B (zh) * | 2020-11-20 | 2024-02-27 | 上海纽仁生物医药科技有限公司 | 少突胶质前体细胞亚群及其用途 |
KR20250007548A (ko) | 2022-04-15 | 2025-01-14 | 아스펜 뉴로사이언스 인코포레이티드 | 세포의 분화 상태를 분류하는 방법 및 관련 분화된 세포 조성물 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990003430A1 (en) * | 1988-09-23 | 1990-04-05 | Cetus Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
DE19756864C5 (de) * | 1997-12-19 | 2014-07-10 | Oliver Brüstle | Neurale Vorläuferzellen, Verfahren zu ihrer Herstellung und ihre Verwendung zur Therapie von neuralen Defekten |
EP1263932A4 (en) * | 2000-03-14 | 2004-06-23 | Es Cell Int Pte Ltd | EMBRYONIC CELLS AND NEURONAL STEM CELLS DERIVED THEREFROM |
IL152741A0 (en) * | 2000-05-17 | 2003-06-24 | Geron Corp | Neural progenitor cell populations |
JP2004529621A (ja) * | 2001-02-14 | 2004-09-30 | ティー ファークト,レオ | 多能性成体幹細胞、その起源、それを得る方法および維持する方法、それを分化させる方法、その使用法、ならびにそれ由来の細胞 |
US9446073B2 (en) * | 2005-05-15 | 2016-09-20 | Biodontos, Llc | Non-lineage committed precursor cells from the dental papillary tissue of teeth |
US20080153167A1 (en) * | 2006-06-21 | 2008-06-26 | The Trustees Of Columbia University In The City Of New York | In vivo amplification of neural progenitor cells |
EP2089510B1 (en) * | 2006-06-28 | 2021-02-24 | The University of Medicine and Dentistry of New Jersey | Amnion-derived stem cells and uses thereof |
US20110236971A2 (en) * | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
CN102325878A (zh) * | 2008-12-23 | 2012-01-18 | 斯特姆塞尔思加利福尼亚有限公司 | 少突胶质前体细胞的靶向细胞群及制备与使用方法 |
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2012
- 2012-01-12 MY MYPI2013701211A patent/MY173219A/en unknown
- 2012-01-12 DK DK12701024.7T patent/DK2663638T3/da active
- 2012-01-12 MX MX2013008208A patent/MX364742B/es active IP Right Grant
- 2012-01-12 AU AU2012206411A patent/AU2012206411B2/en active Active
- 2012-01-12 CN CN201280004915.9A patent/CN103687941A/zh active Pending
- 2012-01-12 TW TW101101245A patent/TWI586805B/zh active
- 2012-01-12 SG SG2013045810A patent/SG191729A1/en unknown
- 2012-01-12 EP EP12701024.7A patent/EP2663638B1/en active Active
- 2012-01-12 CN CN201811129309.5A patent/CN109749996A/zh active Pending
- 2012-01-12 AR ARP120100101A patent/AR084835A1/es not_active Application Discontinuation
- 2012-01-12 CA CA2821065A patent/CA2821065C/en active Active
- 2012-01-12 JP JP2013548899A patent/JP5649745B2/ja active Active
- 2012-01-12 BR BR112013017685A patent/BR112013017685A2/pt not_active Application Discontinuation
- 2012-01-12 ES ES12701024T patent/ES2732938T3/es active Active
- 2012-01-12 EA EA201390801A patent/EA034058B1/ru not_active IP Right Cessation
- 2012-01-12 PL PL12701024T patent/PL2663638T3/pl unknown
- 2012-01-12 WO PCT/IB2012/000030 patent/WO2012095730A1/en active Search and Examination
- 2012-01-12 US US13/349,089 patent/US8993320B2/en active Active
- 2012-01-12 PH PH1/2013/501496A patent/PH12013501496B1/en unknown
- 2012-01-12 KR KR1020137018381A patent/KR102099807B1/ko active Active
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2013
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2017
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